Paul D Lampe

Paul D Lampe

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Paul D Lampe

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Identification of serine residues in the Connexin43 carboxyl tail important for BCR-mediated spreading of B-lymphocytes.

J Cell Sci 2020 Feb 5. Epub 2020 Feb 5.

CELL and Developmental Biology Graduate Program, University of British Columbia (UBC), 2350 Health Sciences Mall, Vancouver, B.C, V6T 1Z3 Canada

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http://dx.doi.org/10.1242/jcs.237925DOI Listing
February 2020

Phosphorylation of connexin 43 at MAPK, PKC or CK1 sites each distinctly alter the kinetics of epidermal wound repair.

J Cell Sci 2019 Sep 23;132(18). Epub 2019 Sep 23.

Translational Research Program, Public Health Sciences and Human Biology Divisions, Fred Hutchinson Cancer Research Center Seattle, WA 98109, USA

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http://dx.doi.org/10.1242/jcs.234633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765181PMC
September 2019

Connexin 43 Functions as a Positive Regulator of Stem Cell Differentiation into Definitive Endoderm and Pancreatic Progenitors.

iScience 2019 Sep 24;19:450-460. Epub 2019 Jul 24.

Department of Medicine, UW Diabetes Institute, University of Washington, 850 Republican Street, S475, Seattle, WA 98109, USA; Institute for Stem Cell and Regenerative Medicine, University of Washington, 850 Republican Street, S480, Seattle, WA 98109, USA; Department of Pharmacology, University of Washington, Seattle, WA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.isci.2019.07.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708988PMC
September 2019

Cx43 phosphorylation-mediated effects on ERK and Akt protect against ischemia reperfusion injury and alter the stability of the stress-inducible protein NDRG1.

J Biol Chem 2019 Aug 12;294(31):11762-11771. Epub 2019 Jun 12.

Translational Research Program, Public Health Sciences and Human Biology Divisions, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109

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http://dx.doi.org/10.1074/jbc.RA119.009162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682735PMC
August 2019

Targeting MAPK phosphorylation of Connexin43 provides neuroprotection in stroke.

J Exp Med 2019 Apr 14;216(4):916-935. Epub 2019 Mar 14.

Cellular & Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada

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http://dx.doi.org/10.1084/jem.20171452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446879PMC
April 2019

Differences in serum biomarkers between combined glucosamine and chondroitin versus celecoxib in a randomized, double-blind trial in osteoarthritis patients.

Antiinflamm Antiallergy Agents Med Chem 2019 Jan 14. Epub 2019 Jan 14.

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA. United States.

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http://dx.doi.org/10.2174/1871523018666190115094512DOI Listing
January 2019

Therapeutic strategies targeting connexins.

Nat Rev Drug Discov 2018 12 12;17(12):905-921. Epub 2018 Oct 12.

Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

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http://dx.doi.org/10.1038/nrd.2018.138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461534PMC
December 2018

Desmoplakin maintains gap junctions by inhibiting Ras/MAPK and lysosomal degradation of connexin-43.

J Cell Biol 2018 09 29;217(9):3219-3235. Epub 2018 Jun 29.

Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL

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http://dx.doi.org/10.1083/jcb.201710161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123000PMC
September 2018

Suppression of connexin 43 phosphorylation promotes astrocyte survival and vascular regeneration in proliferative retinopathy.

Proc Natl Acad Sci U S A 2018 06 11;115(26):E5934-E5943. Epub 2018 Jun 11.

Department of Biological Sciences, State University of New York College of Optometry, New York, NY 10036;

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http://dx.doi.org/10.1073/pnas.1803907115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042062PMC
June 2018

Spatio-temporal regulation of connexin43 phosphorylation and gap junction dynamics.

Biochim Biophys Acta Biomembr 2018 Jan 13;1860(1):83-90. Epub 2017 Apr 13.

Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bbamem.2017.04.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640473PMC
January 2018

An update on minding the gap in cancer.

Biochim Biophys Acta Biomembr 2018 Jan 24;1860(1):237-243. Epub 2017 Jun 24.

Department of Cellular & Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, BC V6T 1Z3, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bbamem.2017.06.015DOI Listing
January 2018

Newly Identified NO-Sensor Guanylyl Cyclase/Connexin 43 Association Is Involved in Cardiac Electrical Function.

J Am Heart Assoc 2017 12 21;6(12). Epub 2017 Dec 21.

Department of Pharmacology, Physiology and Neuroscience, New Jersey Medical School-Rutgers, Newark, NJ

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http://dx.doi.org/10.1161/JAHA.117.006397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778997PMC
December 2017

Regulation of Cx37 channel and growth-suppressive properties by phosphorylation.

J Cell Sci 2017 Oct 17;130(19):3308-3321. Epub 2017 Aug 17.

Department of Physiology, University of Arizona, Tucson, Arizona 85724-5051, USA

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http://dx.doi.org/10.1242/jcs.202572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5665438PMC
October 2017

Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological Implications.

Pharmacol Rev 2017 10;69(4):396-478

Physiology Group, Department of Basic Medical Sciences, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium (L.L.); Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, Washington (P.D.L.); Institute for Pharmacology, University of Leipzig, Leipzig, Germany (S.D.); Department of Pathology and Immunology, Department of Medical Specialization-Cardiology, University of Geneva, Geneva, Switzerland (B.R.K.); Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary (P.F.); Pharmahungary Group, Szeged, Hungary (P.F.); Department of Pediatrics, University of Chicago, Chicago, Illinois (E.C.B.); Department of Anatomy and Cell Biology, University of Western Ontario, Dental Science Building, London, Ontario, Canada (D.W.L.); Cellular and Physiological Sciences, Faculty of Medicine, The University of British Columbia, Vancouver, British Columbia, Canada (C.C.N.); Department of Ophthalmology and The New Zealand National Eye Centre, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand (C.R.G.); and Physiologisches Institut, Justus-Liebig-Universität Giessen, Giessen, Germany (R.S.).

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http://dx.doi.org/10.1124/pr.115.012062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612248PMC
October 2017

SnapShot: Connexins and Disease.

Cell 2017 Sep;170(6):1260-1260.e1

Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

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http://dx.doi.org/10.1016/j.cell.2017.08.034DOI Listing
September 2017

Proteomic Analysis, Immune Dysregulation, and Pathway Interconnections with Obesity.

J Proteome Res 2017 01 14;16(1):274-287. Epub 2016 Nov 14.

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center , Seattle, Washington 98109, United States.

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http://dx.doi.org/10.1021/acs.jproteome.6b00611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5234688PMC
January 2017

Gap junctions and cancer: communicating for 50 years.

Nat Rev Cancer 2016 12 21;16(12):775-788. Epub 2016 Oct 21.

Department of Anatomy and Cell Biology, The University of Western Ontario, London, Ontario N6A 5C1, Canada.

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http://dx.doi.org/10.1038/nrc.2016.105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5279857PMC
December 2016

Regulation of gap junction conductance by calcineurin through Cx43 phosphorylation: implications for action potential conduction.

Pflugers Arch 2016 11 19;468(11-12):1945-1955. Epub 2016 Oct 19.

Institute of Cardiovascular Research, Ashford & St Peter's NHS Foundation Trust, Surrey, Chertsey, KT16 0PZ, UK.

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http://dx.doi.org/10.1007/s00424-016-1885-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138272PMC
November 2016

Linoleic acid permeabilizes gastric epithelial cells by increasing connexin 43 levels in the cell membrane via a GPR40- and Akt-dependent mechanism.

Biochim Biophys Acta 2016 May 8;1861(5):439-48. Epub 2016 Feb 8.

Departamento de Fisiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile; Instituto Milenio, Centro Interdisciplinario de Neurociencias de Valparaíso, Universidad de Valparaíso, Valparaíso, Chile. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2016.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821727PMC
May 2016

Sphingosine-1-phosphate reduces ischaemia-reperfusion injury by phosphorylating the gap junction protein Connexin43.

Cardiovasc Res 2016 Mar 13;109(3):385-96. Epub 2016 Jan 13.

Department of Pathology and Immunology, University of Geneva, CMU, F06.2747.a, Rue Michel-Servet 1, Geneva 1211, Switzerland Department of Medical Specialties-Cardiology, University of Geneva, Geneva 1211, Switzerland.

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https://cardiovascres.oxfordjournals.org/content/cardiovascr
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http://cardiovascres.oxfordjournals.org/lookup/doi/10.1093/c
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http://dx.doi.org/10.1093/cvr/cvw004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752044PMC
March 2016

Kinase programs spatiotemporally regulate gap junction assembly and disassembly: Effects on wound repair.

Semin Cell Dev Biol 2016 Feb 17;50:40-8. Epub 2015 Dec 17.

Translational Research Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M5C800, Box 19024, Seattle, WA 98109, United States. Electronic address:

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http://dx.doi.org/10.1016/j.semcdb.2015.12.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779375PMC
February 2016

MAPRE1 as a plasma biomarker for early-stage colorectal cancer and adenomas.

Cancer Prev Res (Phila) 2015 Nov 4;8(11):1112-9. Epub 2015 Sep 4.

Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/1940-6207.CAPR-15-0077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633385PMC
November 2015

Mitogen-activated Protein Kinase (MAPK) Activated by Prostaglandin E2 Phosphorylates Connexin 43 and Closes Osteocytic Hemichannels in Response to Continuous Flow Shear Stress.

J Biol Chem 2015 Nov 6;290(47):28321-8. Epub 2015 Oct 6.

From the Department of Biochemistry, University of Texas Health Science Center, San Antonio, Texas 78229-3900 and

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http://dx.doi.org/10.1074/jbc.M115.683417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653687PMC
November 2015

Candidate early detection protein biomarkers for ER+/PR+ invasive ductal breast carcinoma identified using pre-clinical plasma from the WHI observational study.

Breast Cancer Res Treat 2015 Sep 30;153(2):445-54. Epub 2015 Aug 30.

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA,

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http://dx.doi.org/10.1007/s10549-015-3554-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721565PMC
September 2015

Role of Akt and Ca2+ on cell permeabilization via connexin43 hemichannels induced by metabolic inhibition.

Biochim Biophys Acta 2015 Jul 14;1852(7):1268-77. Epub 2015 Mar 14.

Departamento de Fisiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile; Instituto Milenio, Centro Interdisciplinario de Neurociencias de Valparaíso, Valparaíso, Chile. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2015.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476395PMC
July 2015

CELLULAR SMALL TALK.

Sci Am 2015 May;312(5):70-7

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http://dx.doi.org/10.1038/scientificamerican0515-70DOI Listing
May 2015

Cross-species antibody microarray interrogation identifies a 3-protein panel of plasma biomarkers for early diagnosis of pancreas cancer.

Clin Cancer Res 2015 Apr 14;21(7):1764-71. Epub 2015 Jan 14.

Translational Research Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington. Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-3474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391639PMC
April 2015

Intercellular signaling via cyclic GMP diffusion through gap junctions restarts meiosis in mouse ovarian follicles.

Proc Natl Acad Sci U S A 2015 Apr 16;112(17):5527-32. Epub 2015 Mar 16.

Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030;

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http://dx.doi.org/10.1073/pnas.1423598112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418852PMC
April 2015

Gap junction regulation of vascular tone: implications of modulatory intercellular communication during gestation.

Adv Exp Med Biol 2014 ;814:117-32

Perinatal Research Laboratories, Department of Obstetrics & Gynecology, School Medicine and Public Health, University of Wisconsin - Madison, Madison, WI, 53715, USA.

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http://dx.doi.org/10.1007/978-1-4939-1031-1_11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5761329PMC
December 2014

Spatiotemporal proteomic analyses during pancreas cancer progression identifies serine/threonine stress kinase 4 (STK4) as a novel candidate biomarker for early stage disease.

Mol Cell Proteomics 2014 Dec 15;13(12):3484-96. Epub 2014 Sep 15.

From the ‡Translational Research Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109; **Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109; ‡‡Division of Medical Oncology, University of Washington School of Medicine, Seattle, Washington 98195

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http://dx.doi.org/10.1074/mcp.M113.036517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256499PMC
December 2014

Specific Cx43 phosphorylation events regulate gap junction turnover in vivo.

FEBS Lett 2014 Apr 4;588(8):1423-9. Epub 2014 Feb 4.

Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, United States. Electronic address:

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http://dx.doi.org/10.1016/j.febslet.2014.01.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989505PMC
April 2014

Dermcidin expression is associated with disease progression and survival among breast cancer patients.

Breast Cancer Res Treat 2014 Apr 22;144(2):299-306. Epub 2014 Feb 22.

Molecular and Cellular Biology Program, University of Washington, Seattle, WA, 98195, USA,

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http://dx.doi.org/10.1007/s10549-014-2880-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403631PMC
April 2014

Discovery of sialyl Lewis A and Lewis X modified protein cancer biomarkers using high density antibody arrays.

J Proteomics 2014 Jan 1;96:291-9. Epub 2013 Nov 1.

Translational Research Program, Human Biology and Public Health Sciences Divisions, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S18743919130054
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http://dx.doi.org/10.1016/j.jprot.2013.10.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946870PMC
January 2014

Injury-triggered Akt phosphorylation of Cx43: a ZO-1-driven molecular switch that regulates gap junction size.

J Cell Sci 2014 Jan 8;127(Pt 2):455-64. Epub 2013 Nov 8.

Translational Research Program, Human Biology and Public Health Sciences Divisions, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA.

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http://jcs.biologists.org/cgi/doi/10.1242/jcs.142497
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http://dx.doi.org/10.1242/jcs.142497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3889401PMC
January 2014

High-Throughput Analysis of Plasma Hybrid Markers for Early Detection of Cancers.

Proteomes 2014 Jan 13;2(1):1-17. Epub 2014 Jan 13.

Translational Research Program, Human Biology and Public Health Sciences Divisions, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA.

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http://dx.doi.org/10.3390/proteomes2010001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302729PMC
January 2014

Cardiomyocyte FGF signaling is required for Cx43 phosphorylation and cardiac gap junction maintenance.

Exp Cell Res 2013 Aug 4;319(14):2152-65. Epub 2013 Jun 4.

Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06511, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00144827130022
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http://dx.doi.org/10.1016/j.yexcr.2013.05.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783259PMC
August 2013

High-throughput screening for native autoantigen-autoantibody complexes using antibody microarrays.

J Proteome Res 2013 May 29;12(5):2311-20. Epub 2013 Mar 29.

Translational Research Program, Human Biology and Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA.

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http://dx.doi.org/10.1021/pr4001674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680356PMC
May 2013

Phosphorylation of connexin43 on S279/282 may contribute to laminopathy-associated conduction defects.

Exp Cell Res 2013 Apr 21;319(6):888-96. Epub 2012 Dec 21.

Fred Hutchinson Cancer Research Center (FHCRC), Public Health Sciences Division, 1100 Fairview Ave. N., Seattle, WA 98109, USA.

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http://dx.doi.org/10.1016/j.yexcr.2012.12.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594536PMC
April 2013

Histone deacetylase inhibition reduces cardiac connexin43 expression and gap junction communication.

Front Pharmacol 2013 15;4:44. Epub 2013 Apr 15.

Department of Pharmacology, State University of New York Upstate Medical University Syracuse, NY, USA.

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http://dx.doi.org/10.3389/fphar.2013.00044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625725PMC
April 2013

Connexins and steroidogenesis in mouse Leydig cells.

Can J Physiol Pharmacol 2013 Feb 25;91(2):157-64. Epub 2013 Feb 25.

Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON N6A 5C1, Canada.

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http://dx.doi.org/10.1139/cjpp-2012-0385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624991PMC
February 2013

Connexin43 phosphorylation in brain, cardiac, endothelial and epithelial tissues.

Biochim Biophys Acta 2012 Aug 26;1818(8):1985-92. Epub 2011 Jul 26.

Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

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http://dx.doi.org/10.1016/j.bbamem.2011.07.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3241956PMC
August 2012

Discovery and validation of ovarian cancer biomarkers utilizing high density antibody microarrays.

Cancer Biomark 2010-2011;8(4-5):293-307

Molecular Diagnostics Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

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http://www.medra.org/servlet/aliasResolver?alias=iospress&am
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http://dx.doi.org/10.3233/CBM-2011-0215DOI Listing
July 2012

Changes in connexin43 expression and localization during pancreatic cancer progression.

J Membr Biol 2012 Jun 23;245(5-6):255-62. Epub 2012 Jun 23.

Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M5C800, Box 19024, Seattle, WA 98109, USA.

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http://dx.doi.org/10.1007/s00232-012-9446-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518378PMC
June 2012

Phosphorylation of serine residues in the C-terminal cytoplasmic tail of connexin43 regulates proliferation of ovarian granulosa cells.

J Membr Biol 2012 Jun 24;245(5-6):291-301. Epub 2012 Jun 24.

Department of Physiology and Pharmacology, The University of Western Ontario and Children's Health Research Institute, London, ON N6C 2V5, Canada.

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http://dx.doi.org/10.1007/s00232-012-9450-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578320PMC
June 2012

Introductory paper of the special issue on gap junctions in honor of Ross Johnson.

J Membr Biol 2012 Jun;245(5-6):217-9

Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M5C800, Box 19024, Seattle, WA 98109, USA.

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http://link.springer.com/10.1007/s00232-012-9486-7
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http://dx.doi.org/10.1007/s00232-012-9486-7DOI Listing
June 2012

Increased plasma levels of the APC-interacting protein MAPRE1, LRG1, and IGFBP2 preceding a diagnosis of colorectal cancer in women.

Cancer Prev Res (Phila) 2012 Apr 25;5(4):655-64. Epub 2012 Jan 25.

Molecular Diagnostics Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA.

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http://dx.doi.org/10.1158/1940-6207.CAPR-11-0412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419141PMC
April 2012

CASK (LIN2) interacts with Cx43 in wounded skin and their coexpression affects cell migration.

J Cell Sci 2012 Feb;125(Pt 3):695-702

Molecular Diagnostics Program, Human Biology and Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA.

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http://dx.doi.org/10.1242/jcs.084400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367831PMC
February 2012

Activation of Akt, not connexin 43 protein ubiquitination, regulates gap junction stability.

J Biol Chem 2012 Jan 2;287(4):2600-7. Epub 2011 Dec 2.

Molecular Diagnostics Program, Human Biology and Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.

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http://dx.doi.org/10.1074/jbc.M111.276261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268419PMC
January 2012

Trafficking and recycling of the connexin43 gap junction protein during mitosis.

Traffic 2010 Nov 10;11(11):1471-86. Epub 2010 Sep 10.

National Center for Microscopy and Imaging Research, Center for Research in Biological Systems, University of California San Diego, La Jolla, CA, USA.

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http://dx.doi.org/10.1111/j.1600-0854.2010.01109.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272544PMC
November 2010

Use of a single-chain antibody library for ovarian cancer biomarker discovery.

Mol Cell Proteomics 2010 Jul 13;9(7):1449-60. Epub 2010 May 13.

Molecular Diagnostics Program, Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.

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http://dx.doi.org/10.1074/mcp.M900496-MCP200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938096PMC
July 2010

Matricellular protein CCN3 (NOV) regulates actin cytoskeleton reorganization.

J Biol Chem 2009 Oct 25;284(43):29935-44. Epub 2009 Aug 25.

Department of Cellular and Physiological Sciences and The Life Sciences Institute, University of British Columbia, Vancouver, British Columbia V6T1Z3, Canada.

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http://dx.doi.org/10.1074/jbc.M109.042630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785622PMC
October 2009

Connexin43 phosphorylation: structural changes and biological effects.

Biochem J 2009 Apr;419(2):261-72

Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M5C800 Box 19024, Seattle, WA 98109, USA.

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http://dx.doi.org/10.1042/BJ20082319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2669545PMC
April 2009

Gap junction remodeling and spironolactone-dependent reverse remodeling in the hypertrophied heart.

Circ Res 2009 Feb 18;104(3):365-71. Epub 2008 Dec 18.

Leon H. Charney Division of Cardiology, New York University School of Medicine, 522 First Ave, Smilow 801, New York, NY 10016, USA.

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http://dx.doi.org/10.1161/CIRCRESAHA.108.184044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2652889PMC
February 2009

A cautionary note on the evaluation of biomarkers of subtypes of a single disease.

Am J Epidemiol 2008 Sep 15;168(6):559-62. Epub 2008 Jul 15.

Merck Research Laboratories, North Wales, PA, USA.

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http://dx.doi.org/10.1093/aje/kwn183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139966PMC
September 2008

Use of cancer-specific yeast-secreted in vivo biotinylated recombinant antibodies for serum biomarker discovery.

J Transl Med 2008 Jul 24;6:41. Epub 2008 Jul 24.

Center for Research on Early Detection and Cure of Ovarian Cancer, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1186/1479-5876-6-41DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2503970PMC
July 2008

Connexin 43 in LA-25 cells with active v-src is phosphorylated on Y247, Y265, S262, S279/282, and S368 via multiple signaling pathways.

Cell Commun Adhes 2008 May;15(1):75-84

Molecular Diagnostics Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.

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http://www.tandfonline.com/doi/full/10.1080/1541906080201401
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http://dx.doi.org/10.1080/15419060802014016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597569PMC
May 2008

The C-terminus of connexin43 adopts different conformations in the Golgi and gap junction as detected with structure-specific antibodies.

Biochem J 2007 Dec;408(3):375-85

National Center for Microscopy and Imaging Research, Center for Research in Biological Systems, University of California, San Diego, La Jolla, CA 92093-0608, USA.

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http://dx.doi.org/10.1042/BJ20070550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2267357PMC
December 2007

Use of high density antibody arrays to validate and discover cancer serum biomarkers.

Mol Oncol 2007 Dec 30;1(3):313-20. Epub 2007 Aug 30.

Molecular Diagnostics Program, Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA.

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http://dx.doi.org/10.1016/j.molonc.2007.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671017PMC
December 2007

Gap junction remodeling and cardiac arrhythmogenesis in a murine model of oculodentodigital dysplasia.

Proc Natl Acad Sci U S A 2007 Dec 11;104(51):20512-6. Epub 2007 Dec 11.

Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, NY 10016, USA.

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http://dx.doi.org/10.1073/pnas.0705472105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2154462PMC
December 2007

Phosphorylation at S365 is a gatekeeper event that changes the structure of Cx43 and prevents down-regulation by PKC.

J Cell Biol 2007 Dec;179(6):1301-9

Molecular Diagnostics Program and 2Proteomics Shared Resource, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

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http://www.jcb.org/lookup/doi/10.1083/jcb.200707060
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http://dx.doi.org/10.1083/jcb.200707060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2140020PMC
December 2007

Exercise effect on weight and body fat in men and women.

Obesity (Silver Spring) 2007 Jun;15(6):1496-512

Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, M4-B402, Seattle, WA 98109-1024, USA.

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http://dx.doi.org/10.1038/oby.2007.178DOI Listing
June 2007

Key connexin 43 phosphorylation events regulate the gap junction life cycle.

J Membr Biol 2007 Jun 15;217(1-3):35-41. Epub 2007 Jul 15.

Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

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http://dx.doi.org/10.1007/s00232-007-9035-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2596931PMC
June 2007

Altered tumor biology and tumorigenesis in irradiated and chemical carcinogen-treated single and combined connexin32/p27Kip1-deficient mice.

Cell Commun Adhes 2005 Jul-Dec;12(5-6):293-305

Molecular Diagnostics Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

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http://www.tandfonline.com/doi/full/10.1080/1541906050051416
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http://dx.doi.org/10.1080/15419060500514168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1570041PMC
May 2007

Methodologies for characterizing phosphoproteins by mass spectrometry.

Cell Commun Adhes 2006 Sep-Dec;13(5-6):249-62

Proteomics Facility, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.

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http://dx.doi.org/10.1080/15419060601077917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2185548PMC
March 2007

Effect of a 12-month exercise intervention on patterns of cellular proliferation in colonic crypts: a randomized controlled trial.

Cancer Epidemiol Biomarkers Prev 2006 Sep;15(9):1588-97

Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M4-B402, Seattle, WA 98109-1024, USA.

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http://dx.doi.org/10.1158/1055-9965.EPI-06-0223DOI Listing
September 2006

Analysis of Connexin43 phosphorylated at S325, S328 and S330 in normoxic and ischemic heart.

J Cell Sci 2006 Aug 1;119(Pt 16):3435-42. Epub 2006 Aug 1.

Molecular Diagnostics Program, Fred Hutchinson Cancer Research Center, Department of Pathobiology, University of Washington, 1100 Fairview Avenue N., M5C800, PO Box 19024, Seattle, WA 98109, USA.

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http://dx.doi.org/10.1242/jcs.03089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1570025PMC
August 2006

Selectivity of connexin 43 channels is regulated through protein kinase C-dependent phosphorylation.

Circ Res 2006 Jun 18;98(12):1498-505. Epub 2006 May 18.

Department of Physiology, University of Arizona, Tucson 85724, USA.

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http://dx.doi.org/10.1161/01.RES.0000227572.45891.2cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1783838PMC
June 2006

Quantifying peptide signal in MALDI-TOF mass spectrometry data.

Mol Cell Proteomics 2005 Dec 29;4(12):1990-9. Epub 2005 Sep 29.

Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA.

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http://dx.doi.org/10.1074/mcp.M500130-MCP200DOI Listing
December 2005