Paul Clapham

Paul Clapham

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Paul Clapham

Paul Clapham

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No detection of CD4-independent human immunodeficiency virus 1 envelope glycoproteins in brain tissue of patients with or without neurological complications.

Arch Virol 2019 Feb 10;164(2):473-482. Epub 2018 Nov 10.

Biotech 2, Program in Molecular Medicine, University of Massachusetts Medical School, Suite 315, 373 Plantation Street, Worcester, MA, 01605, USA.

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http://dx.doi.org/10.1007/s00705-018-4094-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369005PMC
February 2019

Screening of primary gp120 immunogens to formulate the next generation polyvalent DNA prime-protein boost HIV-1 vaccines.

Hum Vaccin Immunother 2017 12 21;13(12):2996-3009. Epub 2017 Sep 21.

a Laboratory of Nucleic Acid Vaccines, Department of Medicine , University of Massachusetts Medical School , Worcester , MA , USA.

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http://dx.doi.org/10.1080/21645515.2017.1380137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718816PMC
December 2017

Saturation Mutagenesis of the HIV-1 Envelope CD4 Binding Loop Reveals Residues Controlling Distinct Trimer Conformations.

PLoS Pathog 2016 Nov 7;12(11):e1005988. Epub 2016 Nov 7.

Program in Molecular Medicine, Biotech 2, University of Massachusetts Medical School, Worcester, United States of America.

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https://dx.plos.org/10.1371/journal.ppat.1005988
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http://dx.doi.org/10.1371/journal.ppat.1005988DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098743PMC
November 2016

Targeted Delivery of Glucan Particle Encapsulated Gallium Nanoparticles Inhibits HIV Growth in Human Macrophages.

J Drug Deliv 2016 14;2016:8520629. Epub 2016 Nov 14.

Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA.

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http://dx.doi.org/10.1155/2016/8520629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5124674PMC
November 2016

Infection of ectocervical tissue and universal targeting of T-cells mediated by primary non-macrophage-tropic and highly macrophage-tropic HIV-1 R5 envelopes.

Retrovirology 2015 Jun 9;12:48. Epub 2015 Jun 9.

Program in Molecular Medicine and Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Biotech 2, 373 Plantation Street, Worcester, MA, 01605-2377, USA.

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http://dx.doi.org/10.1186/s12977-015-0176-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459458PMC
June 2015

Human immunodeficiency viruses: propagation, quantification, and storage.

Curr Protoc Microbiol 2013 ;Chapter 15:Unit 15J.1

Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

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http://dx.doi.org/10.1002/9780471729259.mc15j01s28DOI Listing
July 2013

Independent evolution of macrophage-tropism and increased charge between HIV-1 R5 envelopes present in brain and immune tissue.

Retrovirology 2012 Mar 15;9:20. Epub 2012 Mar 15.

Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts 01605-2377, USA.

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http://dx.doi.org/10.1186/1742-4690-9-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362761PMC
March 2012

The W100 pocket on HIV-1 gp120 penetrated by b12 is not a target for other CD4bs monoclonal antibodies.

Retrovirology 2012 Jan 27;9. Epub 2012 Jan 27.

Center for AIDS Research, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, MA 01605, USA.

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http://dx.doi.org/10.1186/1742-4690-9-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292835PMC
January 2012

Vaccinology: precisely tuned antibodies nab HIV.

Nature 2011 Sep 21;477(7365):416-7. Epub 2011 Sep 21.

Program in Molecular Medicine and Department of Microbiology and Physiological Systems, Worcester, Massachusetts 01605, USA.

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http://dx.doi.org/10.1038/477416aDOI Listing
September 2011

Genotypic and functional properties of early infant HIV-1 envelopes.

Retrovirology 2011 Aug 15;8:67. Epub 2011 Aug 15.

Graduate School of Biomedical Sciences, University of Massachusetts Medical School, Worcester, MA, USA.

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http://dx.doi.org/10.1186/1742-4690-8-67DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189118PMC
August 2011

Two closely related Env antigens from the same patient elicited different spectra of neutralizing antibodies against heterologous HIV-1 isolates.

J Virol 2011 May 16;85(10):4927-36. Epub 2011 Mar 16.

Room 304, LRB, Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Lazare Research Building, Worcester, MA 01605, USA.

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http://jvi.asm.org/cgi/doi/10.1128/JVI.00081-11
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http://dx.doi.org/10.1128/JVI.00081-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3126169PMC
May 2011

HIV-1 gp120 determinants proximal to the CD4 binding site shift protective glycans that are targeted by monoclonal antibody 2G12.

J Virol 2010 Sep 7;84(18):9608-12. Epub 2010 Jul 7.

Department of Molecular Genetics and Microbiology, Biotech 2, 373 Plantation Street, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.

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http://dx.doi.org/10.1128/JVI.00185-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2937615PMC
September 2010

Variation in the biological properties of HIV-1 R5 envelopes: implications of envelope structure, transmission and pathogenesis.

Future Virol 2010 Jul;5(4):435-451

Program in Molecular Medicine & Department of Molecular Genetics & Microbiology, Biotech 2, 373 Plantation Street, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.

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http://dx.doi.org/10.2217/fvl.10.34DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949073PMC
July 2010

Protection against HIV-envelope-induced neuronal cell destruction by HIV attachment inhibitors.

Arch Virol 2010 May 19;155(5):777-81. Epub 2010 Mar 19.

Department of Virology, Bristol Myers Squibb, 5 Research Parkway, Wallingford, CT 06492, USA.

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http://link.springer.com/content/pdf/10.1007/s00705-010-0644
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http://link.springer.com/10.1007/s00705-010-0644-x
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http://dx.doi.org/10.1007/s00705-010-0644-xDOI Listing
May 2010

Modulation of HIV-1 macrophage-tropism among R5 envelopes occurs before detection of neutralizing antibodies.

Retrovirology 2010 May 27;7:48. Epub 2010 May 27.

Program in Molecular Medicine and Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Biotech 2, 373 Plantation Street, Worcester, MA 01605, USA.

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http://dx.doi.org/10.1186/1742-4690-7-48DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890664PMC
May 2010

Determinants flanking the CD4 binding loop modulate macrophage tropism of human immunodeficiency virus type 1 R5 envelopes.

J Virol 2009 Mar 7;83(6):2575-83. Epub 2009 Jan 7.

Program in Molecular Medicine and Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.

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http://dx.doi.org/10.1128/JVI.02133-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2648272PMC
March 2009

Plugging gp120s cavity.

Structure 2008 Nov;16(11):1603-4

Program in Molecular Medicine and Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01605, USA.

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http://dx.doi.org/10.1016/j.str.2008.10.003DOI Listing
November 2008

Natural resistance of human immunodeficiency virus type 1 to the CD4bs antibody b12 conferred by a glycan and an arginine residue close to the CD4 binding loop.

J Virol 2008 Jun 2;82(12):5807-14. Epub 2008 Apr 2.

Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.

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http://dx.doi.org/10.1128/JVI.02585-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2395159PMC
June 2008

Variation in HIV-1 R5 macrophage-tropism correlates with sensitivity to reagents that block envelope: CD4 interactions but not with sensitivity to other entry inhibitors.

Retrovirology 2008 Jan 18;5. Epub 2008 Jan 18.

Center for AIDS Research, Program in Molecular Medicine and Department of Molecular Genetics and Microbiology, 373 Plantation Street, University of Massachusetts Medical School, Worcester, MA 01605, USA.

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http://dx.doi.org/10.1186/1742-4690-5-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268948PMC
January 2008

Effects of vpu start-codon mutations on human immunodeficiency virus type 1 replication in macrophages.

J Gen Virol 2007 Oct;88(Pt 10):2780-92

Biotech 2, Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA.

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http://dx.doi.org/10.1099/vir.0.83120-0DOI Listing
October 2007

Variation of macrophage tropism among HIV-1 R5 envelopes in brain and other tissues.

J Neuroimmune Pharmacol 2007 Mar 7;2(1):32-41. Epub 2006 Nov 7.

Center for AIDS Research, Program in Molecular Medicine and Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 373 Plantation Street Biotech II Suite 315, Worcester, MA 01605, USA.

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http://dx.doi.org/10.1007/s11481-006-9042-2DOI Listing
March 2007

The promise of CCR5 antagonists as new therapies for HIV-1.

Curr Opin Investig Drugs 2007 Feb;8(2):130-9

University of Massachusetts Medical School, Suite 315, Biotech 2, Program in Molecular Medicine, 373 Plantation Street, Worcester, MA 01605, USA.

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February 2007

Human immunodeficiency viruses: propagation, quantification, and storage.

Curr Protoc Microbiol 2006 Sep;Chapter 15:Unit15J.1

University of Massachusetts, Medical School, Worcester, Massachusetts, USA.

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http://dx.doi.org/10.1002/9780471729259.mc15j01s02DOI Listing
September 2006

Gag regulates association of human immunodeficiency virus type 1 envelope with detergent-resistant membranes.

J Virol 2006 Jun;80(11):5292-300

Program in Molecular Medicine, Center for AIDS Research, University of Massachusetts Medical School, Worcester, MA 01605, USA.

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http://dx.doi.org/10.1128/JVI.01469-05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1472128PMC
June 2006

Inhibition of CCR5-mediated infection by diverse R5 and R5X4 HIV and SIV isolates using novel small molecule inhibitors of CCR5: effects of viral diversity, target cell and receptor density.

Antiviral Res 2005 Nov 30;68(2):96-108. Epub 2005 Aug 30.

Center for AIDS Research, Program in Molecular Medicine, Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Biotech II, 373 Plantation St, Worcester, MA 01605, USA.

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http://dx.doi.org/10.1016/j.antiviral.2005.07.006DOI Listing
November 2005

Use of alternate coreceptors on primary cells by two HIV-1 isolates.

Virology 2005 Aug;339(1):136-44

AIDS Virus Research Unit, National Institute for Communicable Diseases, Private Bag X4, Sandringham 2131, Johannesburg, South Africa.

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http://dx.doi.org/10.1016/j.virol.2005.05.027DOI Listing
August 2005

Evolutionary genetics: Ambiguous role of CCR5 in Y. pestis infection.

Nature 2004 Jul;430(6998):417

Defence Science and Technology Laboratories, Porton Down, Salisbury SP4 0JQ, UK.

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http://dx.doi.org/10.1038/nature02822DOI Listing
July 2004

CD4-independent infection of HIV and SIV: implications for envelope conformation and cell tropism in vivo.

AIDS 2003 ;17 Suppl 4:S35-43

Suite 315, Program in Molecular Medicine and Department of Molecular Genetics and Microbiology, 373 Plantation Street, University of Massachusetts Medical School, Worcester, MA 01605, USA.

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http://pdfs.journals.lww.com/aidsonline/2003/17004/CD4_indep
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http://dx.doi.org/10.1097/00002030-200317004-00004DOI Listing
June 2004

Human immunodeficiency virus type 1 envelope glycoproteins that lack cytoplasmic domain cysteines: impact on association with membrane lipid rafts and incorporation onto budding virus particles.

J Virol 2004 May;78(10):5500-6

Program in Molecular Medicine and Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Biotech 2, 373 Plantation Street, Worcester, MA 01605, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400338PMC
http://dx.doi.org/10.1128/jvi.78.10.5500-5506.2004DOI Listing
May 2004

CD4-dependent and CD4-independent HIV-2: consequences for neutralization.

AIDS 2003 Feb;17(3):291-300

The Wohl Virion Centre, Windeyer Institute of Medical Sciences, University College London, London W1T 4JF, UK.

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http://dx.doi.org/10.1097/00002030-200302140-00002DOI Listing
February 2003

Repression of the HIV-1 5' LTR promoter and inhibition of HIV-1 replication by using engineered zinc-finger transcription factors.

Proc Natl Acad Sci U S A 2003 Feb 6;100(4):1615-20. Epub 2003 Feb 6.

Gendaq Ltd., Sangamo Biosciences, Inc., 1-3 Burtonhole Lane, Mill Hill, London NW7 1AD, United Kingdom.

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http://dx.doi.org/10.1073/pnas.252770699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC149881PMC
February 2003

Cell surface receptors, virus entry and tropism of primate lentiviruses.

J Gen Virol 2002 Aug;83(Pt 8):1809-1829

The Wohl Virion Center, Department of Immunology and Molecular Pathology, The Windeyer Institute for Medical Sciences, University College London, 46 Cleveland Street, London W1P 6DB, UK2.

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http://jgv.microbiologyresearch.org/content/journal/jgv/10.1
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http://dx.doi.org/10.1099/0022-1317-83-8-1809DOI Listing
August 2002

T-cell line adaptation of human immunodeficiency virus type 1 strain SF162: effects on envelope, vpu and macrophage-tropism.

J Gen Virol 2000 Dec;81(Pt 12):2899-2904

The Wohl Virion Centre, Department of Immunology and Molecular Pathology, The Windeyer Institute of Medical Sciences, University College London, 46 Cleveland Street, London W1P 6DB, UK1.

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http://dx.doi.org/10.1099/0022-1317-81-12-2899DOI Listing
December 2000