Publications by authors named "Paul C Norris"

38Publications

Lack of resolution sensor drives age-related cardiometabolic and cardiorenal defects and impedes inflammation-resolution in heart failure.

Mol Metab 2020 01 16;31:138-149. Epub 2019 Nov 16.

Division of Cardiovascular Disease, Department of Medicine, The University of Alabama at Birmingham, Alabama, 35294, United States. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2019.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920298PMC
January 2020

Resolution metabolomes activated by hypoxic environment.

Sci Adv 2019 10 23;5(10):eaax4895. Epub 2019 Oct 23.

Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/sciadv.aax4895DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6810174PMC
October 2019

Cysteinyl maresins regulate the prophlogistic lung actions of cysteinyl leukotrienes.

J Allergy Clin Immunol 2020 01 14;145(1):335-344. Epub 2019 Oct 14.

Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesia, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2019.09.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308163PMC
January 2020

Biosynthetic metabolomes of cysteinyl-containing immunoresolvents.

FASEB J 2019 12 5;33(12):13794-13807. Epub 2019 Oct 5.

Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1096/fj.201902003RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6894058PMC
December 2019

Endogenous Specialized Proresolving Mediator Profiles in a Novel Experimental Model of Lymphatic Obstruction and Intestinal Inflammation in African Green Monkeys.

Am J Pathol 2019 10;189(10):1953-1972

Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, Louisiana; Department of Life Sciences, Brunel University London, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2019.05.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880773PMC
October 2019

Resolvin D4 attenuates the severity of pathological thrombosis in mice.

Blood 2019 10;134(17):1458-1468

Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; and.

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http://dx.doi.org/10.1182/blood.2018886317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839959PMC
October 2019

Aspirin-triggered proresolving mediators stimulate resolution in cancer.

Proc Natl Acad Sci U S A 2019 03 12;116(13):6292-6297. Epub 2019 Mar 12.

Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215;

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http://dx.doi.org/10.1073/pnas.1804000116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442621PMC
March 2019

Identification of proresolving and inflammatory lipid mediators in human psoriasis.

J Clin Lipidol 2018 Jul - Aug;12(4):1047-1060. Epub 2018 Apr 6.

Section of Inflammation and Cardiometabolic Diseases, Cardio-Pulmonary Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19332874183019
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http://dx.doi.org/10.1016/j.jacl.2018.03.091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112609PMC
October 2019

Identification and Complete Stereochemical Assignments of the New Resolvin Conjugates in Tissue Regeneration in Human Tissues that Stimulate Proresolving Phagocyte Functions and Tissue Regeneration.

Am J Pathol 2018 04;188(4):950-966

Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Building for Transformative Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2018.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866152PMC
April 2018

Metabololipidomic profiling of functional immunoresolvent clusters and eicosanoids in mammalian tissues.

Biochem Biophys Res Commun 2018 10 15;504(3):553-561. Epub 2018 Mar 15.

Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, 60 Fenwood Road, BTM 3016, Boston, MA, 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2018.03.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139088PMC
October 2018

Splenic leukocytes define the resolution of inflammation in heart failure.

Sci Signal 2018 03 6;11(520). Epub 2018 Mar 6.

Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

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http://dx.doi.org/10.1126/scisignal.aao1818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145858PMC
March 2018

Structural insights into Resolvin D4 actions and further metabolites via a new total organic synthesis and validation.

J Leukoc Biol 2018 Jan 29. Epub 2018 Jan 29.

Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Building for Transformative Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://doi.wiley.com/10.1002/JLB.3MI0617-254R
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http://dx.doi.org/10.1002/JLB.3MI0617-254RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136982PMC
January 2018

Human macrophages differentially produce specific resolvin or leukotriene signals that depend on bacterial pathogenicity.

Nat Commun 2018 01 4;9(1):59. Epub 2018 Jan 4.

Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesia, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, 60 Fenwood Road, BTM 3016, Boston, MA, 02115, USA.

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http://www.nature.com/articles/s41467-017-02538-5
Publisher Site
http://dx.doi.org/10.1038/s41467-017-02538-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754355PMC
January 2018

A cluster of immunoresolvents links coagulation to innate host defense in human blood.

Sci Signal 2017 Aug 1;10(490). Epub 2017 Aug 1.

Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/scisignal.aan1471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683850PMC
August 2017

Identification and Profiling of Specialized Pro-Resolving Mediators in Human Tears by Lipid Mediator Metabolomics.

Prostaglandins Leukot Essent Fatty Acids 2017 02 19;117:17-27. Epub 2017 Jan 19.

Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesia, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115. Electronic address:

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http://dx.doi.org/10.1016/j.plefa.2017.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5329889PMC
February 2017

Computational Modeling of Competitive Metabolism between ω3- and ω6-Polyunsaturated Fatty Acids in Inflammatory Macrophages.

J Phys Chem B 2016 08 26;120(33):8346-53. Epub 2016 Apr 26.

Department of Bioengineering and San Diego Supercomputer Center, University of California at San Diego , 9500 Gilman Drive, La Jolla, California 92093-0412, United States.

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http://dx.doi.org/10.1021/acs.jpcb.6b02036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5024554PMC
August 2016

Resolvin D3 multi-level proresolving actions are host protective during infection.

Prostaglandins Leukot Essent Fatty Acids 2018 11 22;138:81-89. Epub 2016 Jan 22.

Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Harvard Institutes of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.plefa.2016.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958045PMC
November 2018

Eicosanoid storm in infection and inflammation.

Nat Rev Immunol 2015 Aug 3;15(8):511-23. Epub 2015 Jul 3.

Department of Chemistry and Biochemistry and Department of Pharmacology, School of Medicine, University of California at San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1038/nri3859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606863PMC
August 2015

Novel proresolving and tissue-regenerative resolvin and protectin sulfido-conjugated pathways.

FASEB J 2015 May 20;29(5):2120-36. Epub 2015 Feb 20.

Center for Experimental Therapeutics and Reperfusion Injury, Harvard Institutes of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA

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http://dx.doi.org/10.1096/fj.14-268441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415017PMC
May 2015

Phospholipase A2 regulates eicosanoid class switching during inflammasome activation.

Proc Natl Acad Sci U S A 2014 Sep 19;111(35):12746-51. Epub 2014 Aug 19.

Departments of Chemistry/Biochemistry and Pharmacology, and

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http://dx.doi.org/10.1073/pnas.1404372111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156727PMC
September 2014

Targeted deletion and lipidomic analysis identify epithelial cell COX-2 as a major driver of chemically induced skin cancer.

Mol Cancer Res 2014 Nov 25;12(11):1677-88. Epub 2014 Jul 25.

Departments of Molecular & Medical Pharmacology, University of California, Los Angeles, Los Angeles, California. Biological Chemistry, University of California, Los Angeles, Los Angeles, California.

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http://dx.doi.org/10.1158/1541-7786.MCR-14-0397-TDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233191PMC
November 2014

A lipidomic perspective on inflammatory macrophage eicosanoid signaling.

Adv Biol Regul 2014 Jan 25;54:99-110. Epub 2013 Sep 25.

Departments of Chemistry/Biochemistry and Pharmacology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0601, USA. Electronic address:

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http://escholarship.org/uc/item/2rz6b9wk.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S221249261300073
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http://dx.doi.org/10.1016/j.jbior.2013.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946543PMC
January 2014

Omega-3 fatty acids cause dramatic changes in TLR4 and purinergic eicosanoid signaling.

Proc Natl Acad Sci U S A 2012 May 14;109(22):8517-22. Epub 2012 May 14.

Department of Chemistry/Biochemistry, School of Medicine, University of California at San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1073/pnas.1200189109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365225PMC
May 2012

High-throughput lipidomic analysis of fatty acid derived eicosanoids and N-acylethanolamines.

Biochim Biophys Acta 2011 Nov 13;1811(11):724-36. Epub 2011 Jun 13.

Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA.

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http://dx.doi.org/10.1016/j.bbalip.2011.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205334PMC
November 2011

Specificity of eicosanoid production depends on the TLR-4-stimulated macrophage phenotype.

J Leukoc Biol 2011 Sep 7;90(3):563-74. Epub 2011 Jun 7.

Department of Chemistry, University of California, San Diego, La Jolla, CA 92093-0601, USA.

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http://doi.wiley.com/10.1189/jlb.0311153
Publisher Site
http://dx.doi.org/10.1189/jlb.0311153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157897PMC
September 2011