Paul Bowness

Paul Bowness

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Paul Bowness

Paul Bowness

Publications by authors named "Paul Bowness"

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Inhibiting ex-vivo Th17 responses in Ankylosing Spondylitis by targeting Janus kinases.

Sci Rep 2018 10 23;8(1):15645. Epub 2018 Oct 23.

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Windmill Road, OX3 7LD, Oxford, UK.

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http://dx.doi.org/10.1038/s41598-018-34026-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199284PMC
October 2018

Incidence of Total Hip and Knee Replacement in UK Patients with Ankylosing Spondylitis.

J Rheumatol 2018 08;45(9):1334-1336

Associate Professor of Epidemiology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and Grup de Recerca en Malalties Prevalents de l'Aparell Locomotor (GREMPAL) Research Group, IDIAP Jordi Gol Primary Care Research Institute, and CIBERFES, Universitat Autònoma de Barcelona, and Instituto de Salud Carlos III Universitat Autònoma de Barcelona, Instituto de Salud Carlos III, Barcelona, Spain.

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http://dx.doi.org/10.3899/jrheum.171387DOI Listing
August 2018

Progress in our understanding of the pathogenesis of ankylosing spondylitis.

Rheumatology (Oxford) 2018 08;57(suppl_6):vi4-vi9

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.

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http://fdslive.oup.com/www.oup.com/pdf/production_in_progres
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http://dx.doi.org/10.1093/rheumatology/key001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238220PMC
August 2018

Novel Therapeutic Targets in Axial Spondyloarthritis.

Curr Treatm Opt Rheumatol 2018 12;4(2):174-182. Epub 2018 Apr 12.

Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, OX3 7HE UK.

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http://dx.doi.org/10.1007/s40674-018-0095-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5978800PMC
April 2018

Position 97 of HLA-B, a residue implicated in pathogenesis of ankylosing spondylitis, plays a key role in cell surface free heavy chain expression.

Ann Rheum Dis 2017 Mar 11;76(3):593-601. Epub 2016 Aug 11.

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1136/annrheumdis-2016-209512DOI Listing
March 2017

The genetic association of RUNX3 with ankylosing spondylitis can be explained by allele-specific effects on IRF4 recruitment that alter gene expression.

Ann Rheum Dis 2016 08 9;75(8):1534-40. Epub 2015 Oct 9.

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK National Institute for Health Research Oxford Musculoskeletal Biomedical Research Unit, Oxford, UK National Institute for Health Research Oxford Comprehensive Biomedical Research Centre, Botnar Research Centre, Nuffield Orthopaedic Centre, Oxford, UK.

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2015-20749
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http://dx.doi.org/10.1136/annrheumdis-2015-207490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975853PMC
August 2016

Non-conventional forms of HLA-B27 are expressed in spondyloarthritis joints and gut tissue.

J Autoimmun 2016 06 29;70:12-21. Epub 2016 Mar 29.

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1016/j.jaut.2016.03.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871811PMC
June 2016

Activation-Induced Killer Cell Immunoglobulin-like Receptor 3DL2 Binding to HLA-B27 Licenses Pathogenic T Cell Differentiation in Spondyloarthritis.

Arthritis Rheumatol 2016 Apr;68(4):901-14

Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, Oxford University, Oxford, UK, and Cardiff University School of Medicine, Cardiff, UK.

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http://dx.doi.org/10.1002/art.39515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855641PMC
April 2016

RORγt inhibitors suppress T(H)17 responses in inflammatory arthritis and inflammatory bowel disease.

J Allergy Clin Immunol 2016 Mar 21;137(3):960-3. Epub 2015 Nov 21.

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom; National Institute for Health Research, Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2015.09.048DOI Listing
March 2016

HLA-B27.

Authors:
Paul Bowness

Annu Rev Immunol 2015 ;33:29-48

Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Science (NDORMS), Botnar Research Center, University of Oxford, Headington, Oxford OX3 9DL, United Kingdom; email:

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http://dx.doi.org/10.1146/annurev-immunol-032414-112110DOI Listing
December 2015

CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses.

Proc Natl Acad Sci U S A 2015 Aug 10;112(34):10768-73. Epub 2015 Aug 10.

Botnar Research Institute, Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Science, University of Oxford, Oxford OX3 7LD, United Kingdom;

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http://dx.doi.org/10.1073/pnas.1501956112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4553799PMC
August 2015

Expression of aberrant HLA-B27 molecules is dependent on B27 dosage and peptide supply.

Ann Rheum Dis 2014 04 26;73(4):763-70. Epub 2013 Apr 26.

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, , Oxford, UK.

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2012-20308
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http://dx.doi.org/10.1136/annrheumdis-2012-203080DOI Listing
April 2014

Two birds with one stone: doing metabolomics with your proteomics kit.

Proteomics 2013 Dec 21;13(23-24):3371-86. Epub 2013 Nov 21.

Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1002/pmic.201300192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265265PMC
December 2013

The role of natural killer cells, gamma delta T-cells and other innate immune cells in spondyloarthritis.

Curr Opin Rheumatol 2013 Jul;25(4):434-9

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Headington, Oxford, UK.

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http://dx.doi.org/10.1097/BOR.0b013e3283620163DOI Listing
July 2013

The phenotype of circulating follicular-helper T cells in patients with rheumatoid arthritis defines CD200 as a potential therapeutic target.

Clin Dev Immunol 2012 4;2012:948218. Epub 2012 Oct 4.

School of Medicine and Pharmacology, Sir Charles Gairdner Hospital, The University of Western Australia, 4th Floor G Block, Hospital Avenue, Nedlands, Perth, WA 6009, Australia.

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http://www.hindawi.com/journals/jir/2012/948218/
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http://dx.doi.org/10.1155/2012/948218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471455PMC
May 2013

Evolution of CD8+ T cell responses after acute PARV4 infection.

J Virol 2013 Mar 2;87(6):3087-96. Epub 2013 Jan 2.

Nuffield Department of Medicine, University of Oxford, Oxford, UK.

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http://jvi.asm.org/cgi/doi/10.1128/JVI.02793-12
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http://dx.doi.org/10.1128/JVI.02793-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3592128PMC
March 2013

The link between HLA-B27 and SpA--new ideas on an old problem.

Rheumatology (Oxford) 2012 Sep 17;51(9):1529-39. Epub 2012 Apr 17.

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1093/rheumatology/kes061DOI Listing
September 2012

Parvovirus 4 infection and clinical outcome in high-risk populations.

J Infect Dis 2012 Jun 5;205(12):1816-20. Epub 2012 Apr 5.

Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, University of Oxford, Oxford.

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http://dx.doi.org/10.1093/infdis/jis291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357136PMC
June 2012

HLA-B27 homodimers and free H chains are stronger ligands for leukocyte Ig-like receptor B2 than classical HLA class I.

J Immunol 2012 Jun 16;188(12):6184-93. Epub 2012 May 16.

Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.1102711DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622243PMC
June 2012

Discovery of candidate serum proteomic and metabolomic biomarkers in ankylosing spondylitis.

Mol Cell Proteomics 2012 Feb 13;11(2):M111.013904. Epub 2011 Oct 13.

Henry Wellcome Building for Cellular and Molecular Physiology, Oxford, OX3 7BN, UK.

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http://dx.doi.org/10.1074/mcp.M111.013904DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277768PMC
February 2012

Detection of multiple autoantibodies in patients with ankylosing spondylitis using nucleic acid programmable protein arrays.

Mol Cell Proteomics 2012 Feb;11(2):M9.00384

Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, United Kingdom.

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http://dx.doi.org/10.1074/mcp.M9.00384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277774PMC
February 2012

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility.

Nat Genet 2011 Jul 10;43(8):761-7. Epub 2011 Jul 10.

Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1038/ng.873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640413PMC
July 2011

Th17 cells expressing KIR3DL2+ and responsive to HLA-B27 homodimers are increased in ankylosing spondylitis.

J Immunol 2011 Feb 19;186(4):2672-80. Epub 2011 Jan 19.

Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.1002653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210561PMC
February 2011

The role of B27 heavy chain dimer immune receptor interactions in spondyloarthritis.

Adv Exp Med Biol 2009 ;649:277-85

MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, UK.

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http://dx.doi.org/10.1007/978-1-4419-0298-6_21DOI Listing
September 2009

MHC molecules lead many lives. Workshop on MHC Class I Molecules at the interface between Biology & Medicine.

EMBO Rep 2009 Jan 5;10(1):30-4. Epub 2008 Dec 5.

Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, UK.

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http://dx.doi.org/10.1038/embor.2008.215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613203PMC
January 2009

Mediation of the proinflammatory cytokine response in rheumatoid arthritis and spondylarthritis by interactions between fibroblast-like synoviocytes and natural killer cells.

Arthritis Rheum 2008 Mar;58(3):707-17

Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK.

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http://dx.doi.org/10.1002/art.23264DOI Listing
March 2008

CD56bright human NK cells differentiate into CD56dim cells: role of contact with peripheral fibroblasts.

J Immunol 2007 Jul;179(1):89-94

Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, UK.

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http://dx.doi.org/10.4049/jimmunol.179.1.89DOI Listing
July 2007

Human keratinocyte induction of rapid effector function in antigen-specific memory CD4+ and CD8+ T cells.

Eur J Immunol 2007 Jun;37(6):1485-93

MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.

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http://dx.doi.org/10.1002/eji.200636915DOI Listing
June 2007

Tracking of peptide-specific CD4+ T-cell responses after an acute resolving viral infection: a study of parvovirus B19.

J Virol 2006 Nov 30;80(22):11209-17. Epub 2006 Aug 30.

Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1128/JVI.01173-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1642156PMC
November 2006

Aberrant cellular immune responses in humans infected persistently with parvovirus B19.

J Med Virol 2006 Jan;78(1):129-33

Institution for Medicine, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1002/jmv.20514DOI Listing
January 2006

Prolonged activation of virus-specific CD8+T cells after acute B19 infection.

PLoS Med 2005 Dec 1;2(12):e343. Epub 2005 Nov 1.

Institution for Medicine, Infectious Disease Unit, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1371/journal.pmed.0020343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1274280PMC
December 2005

Use of HLA-B27 tetramers to identify low-frequency antigen-specific T cells in Chlamydia-triggered reactive arthritis.

Arthritis Res Ther 2004 23;6(6):R521-34. Epub 2004 Sep 23.

Charite Berlin, Campus Benjamin Franklin, Department for Gastroenterology, Infectiology and Rheumatology, Berlin, Germany.

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http://arthritis-research.biomedcentral.com/articles/10.1186
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http://dx.doi.org/10.1186/ar1221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1064864PMC
November 2005

Anti-tumour necrosis factor therapy in seronegative spondyloarthritis.

Clin Med (Lond) 2005 May-Jun;5(3):219-22

Nuffield Orthopoedic Centre NHS Trust, Headington, Oxford.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4952201PMC
http://dx.doi.org/10.7861/clinmedicine.5-3-219DOI Listing
October 2005

Sustained CD8+ T-cell responses induced after acute parvovirus B19 infection in humans.

J Virol 2005 Sep;79(18):12117-21

Infectious Diseases Unit, Center of Molecular Medicine, Karolinska Institutet, Karolinska University Hospital L08:03, SE-17177 Stockholm, Sweden.

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http://dx.doi.org/10.1128/JVI.79.18.12117-12121.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1212640PMC
September 2005

Crystal structures and KIR3DL1 recognition of three immunodominant viral peptides complexed to HLA-B*2705.

Eur J Immunol 2005 Feb;35(2):341-51

The Division of Structural Biology, The Wellcome Trust Centre for Human Genetics, Oxford, UK.

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http://dx.doi.org/10.1002/eji.200425724DOI Listing
February 2005

The solvent-inaccessible Cys67 residue of HLA-B27 contributes to T cell recognition of HLA-B27/peptide complexes.

J Immunol 2004 Dec;173(11):6564-73

Division of Gastroenterology, Infectiology and Rheumatology, Charité Berlin, Campus Benjamin Franklin, Free University Berlin, Germany.

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http://dx.doi.org/10.4049/jimmunol.173.11.6564DOI Listing
December 2004

HLA-B27 heavy chain homodimers are expressed in HLA-B27 transgenic rodent models of spondyloarthritis and are ligands for paired Ig-like receptors.

J Immunol 2004 Aug;173(3):1699-710

Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.173.3.1699DOI Listing
August 2004

Fully functional HLA B27-restricted CD4+ as well as CD8+ T cell responses in TCR transgenic mice.

J Immunol 2004 Jan;172(1):155-61

Edward Jenner Institute for Vaccine Research, Compton, Nr. Newbury, Berkshire RG 20 7NN, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.172.1.155DOI Listing
January 2004

HLA-B27: natural function and pathogenic role in spondyloarthritis.

Arthritis Res 2002 9;4 Suppl 3:S153-8. Epub 2002 May 9.

MRC Human Immunology Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3240147PMC
http://dx.doi.org/10.1186/ar571DOI Listing
May 2003

Lymphoblastoid cells express HLA-B27 homodimers both intracellularly and at the cell surface following endosomal recycling.

Eur J Immunol 2003 Mar;33(3):748-59

MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, Great Britain.

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http://dx.doi.org/10.1002/eji.200323678DOI Listing
March 2003

Cell-surface expression and immune receptor recognition of HLA-B27 homodimers.

Arthritis Rheum 2002 Nov;46(11):2972-82

Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK.

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http://doi.wiley.com/10.1002/art.10605
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http://dx.doi.org/10.1002/art.10605DOI Listing
November 2002