Paul B Lai

Paul B S Lai

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Paul B S Lai

Publications by authors named "Paul B S Lai"

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1PubMed Central Citations

Impact of Intermittent Pringle Maneuver on Long-Term Survival After Hepatectomy for Hepatocellular Carcinoma: Result from Two Combined Randomized Controlled Trials.

Authors:
Kit Fai Lee Charing C N Chong Sunny Y S Cheung John Wong Andrew K Y Fung Hon Ting Lok Paul B S Lai

World J Surg 2019 Dec;43(12):3101-3109

Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, 30-32, Ngan Shing Street, Shatin, N.T., Hong Kong SAR, China.

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http://dx.doi.org/10.1007/s00268-019-05130-8DOI Listing
December 2019

Genomic and Epigenomic Features of Primary and Recurrent Hepatocellular Carcinomas.

Authors:
Xiaofan Ding Mian He Anthony W H Chan Qi Xiu Song Siu Ching Sze Hui Chen Matthew K H Man Kwan Man Stephen L Chan Paul B S Lai Xin Wang Nathalie Wong

Gastroenterology 2019 Dec 24;157(6):1630-1645.e6. Epub 2019 Sep 24.

Department of Anatomical and Cellular Pathology at Sir Y.K. Pao Centre for Cancer, The Chinese University of Hong Kong, Shatin, Hong Kong, China; Department of Surgery, The Chinese University of Hong Kong, Shatin, Hong Kong, China; State Key Laboratory of Translational Oncology, The Chinese University of Hong Kong, Shatin, Hong Kong, China; State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Shatin, Hong Kong, China. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2019.09.005DOI Listing
December 2019

The chances of hepatic resection curing hepatocellular carcinoma.

Authors:
Alessandro Cucchetti Jianhong Zhong Sarah Berhane Hidenori Toyoda KeQing Shi Toshifumi Tada Charing C N Chong Bang-De Xiang Le-Qun Li Paul B S Lai Giorgio Ercolani Vincenzo Mazzaferro Masatoshi Kudo Matteo Cescon Antonio Daniele Pinna Takashi Kumada Philip J Johnson

J Hepatol 2019 Nov 29. Epub 2019 Nov 29.

Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2019.11.016DOI Listing
November 2019

Robotic versus laparoscopic hepatectomy: application of the difficulty scoring system.

Authors:
Charing C N Chong H T Lok Andrew K Y Fung Anthony K W Fong Y S Cheung John Wong K F Lee Paul B S Lai

Surg Endosc 2019 Jul 16. Epub 2019 Jul 16.

Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.

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http://dx.doi.org/10.1007/s00464-019-06976-8DOI Listing
July 2019

ER-residential Nogo-B accelerates NAFLD-associated HCC mediated by metabolic reprogramming of oxLDL lipophagy.

Authors:
Yuan Tian Bin Yang Weinan Qiu Yajing Hao Zhenxing Zhang Bo Yang Nan Li Shuqun Cheng Zhangjun Lin Yao-Cheng Rui Otto K W Cheung Weiqin Yang William K K Wu Yue-Sun Cheung Paul B S Lai Jianjun Luo Joseph J Y Sung Runsheng Chen Hong-Yang Wang Alfred S L Cheng Pengyuan Yang

Nat Commun 2019 07 29;10(1):3391. Epub 2019 Jul 29.

Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, China.

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http://dx.doi.org/10.1038/s41467-019-11274-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662851PMC
July 2019

Successful robotic extirpation of diaphragmatic seeding of hepatocellular carcinoma after previous rupture.

Authors:
Kit Fai Lee Hon Ting Lok Andrew K Y Fung Charing C N Chong Yue Sun Cheung John Wong Paul B S Lai

J Robot Surg 2019 Jun 29;13(3):525-528. Epub 2018 Sep 29.

Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, 30-32, Ngan Shing Street, Shatin, N.T., Hong Kong SAR, China.

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http://dx.doi.org/10.1007/s11701-018-0880-8DOI Listing
June 2019

Correlations of health-related quality of life with serum inflammatory indicators IL-8 and mIBI in patients with hepatocellular carcinoma.

Authors:
Leung Li Stephen L Chan Frankie Mo Edwin P Hui Jane Koh Allen K C Chan Nelson L S Tang Kit F Lee Paul B S Lai Simon C H Yu Winnie Yeo

Cancer Manag Res 2019 4;11:2719-2727. Epub 2019 Apr 4.

Department of Clinical Oncology, Prince of Wales Hospital, Faculty of Medicine, Hong Kong Cancer Institute, State Key Laboratory of Translational Oncology, The Chinese University of Hong Kong, Hong Kong SAR,

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https://www.dovepress.com/correlations-of-health-related-qua
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http://dx.doi.org/10.2147/CMAR.S178482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452825PMC
April 2019

Orientation-aware plasma cell-free DNA fragmentation analysis in open chromatin regions informs tissue of origin.

Authors:
Kun Sun Peiyong Jiang Suk Hang Cheng Timothy H T Cheng John Wong Vincent W S Wong Simon S M Ng Brigette B Y Ma Tak Y Leung Stephen L Chan Tony S K Mok Paul B S Lai Henry L Y Chan Hao Sun K C Allen Chan Rossa W K Chiu Y M Dennis Lo

Genome Res 2019 03;29(3):418-427

Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, 999077, China.

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http://dx.doi.org/10.1101/gr.242719.118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396422PMC
March 2019

Development of pre and post-operative models to predict early recurrence of hepatocellular carcinoma after surgical resection.

Authors:
Anthony W H Chan Jianhong Zhong Sarah Berhane Hidenori Toyoda Alessandro Cucchetti KeQing Shi Toshifumi Tada Charing C N Chong Bang-De Xiang Le-Qun Li Paul B S Lai Vincenzo Mazzaferro Marta García-Fiñana Masatoshi Kudo Takashi Kumada Sasan Roayaie Philip J Johnson

J Hepatol 2018 12 18;69(6):1284-1293. Epub 2018 Sep 18.

Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2018.08.027DOI Listing
December 2018

An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma.

Authors:
Hanyong Sun Weiqin Yang Yuan Tian Xuezhen Zeng Jingying Zhou Myth T S Mok Wenshu Tang Yu Feng Liangliang Xu Anthony W H Chan Joanna H Tong Yue-Sun Cheung Paul B S Lai Hector K S Wang Shun-Wa Tsang King-Lau Chow Mengying Hu Rihe Liu Leaf Huang Bing Yang Pengyuan Yang Ka-Fai To Joseph J Y Sung Grace L H Wong Vincent W S Wong Alfred S L Cheng

Nat Commun 2018 12 6;9(1):5214. Epub 2018 Dec 6.

School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1038/s41467-018-07402-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283830PMC
December 2018

Homology-independent multiallelic disruption via CRISPR/Cas9-based knock-in yields distinct functional outcomes in human cells.

Authors:
Chenzi Zhang Xiangjun He Yvonne K Kwok Feng Wang Junyi Xue Hui Zhao Kin Wah Suen Chi Chiu Wang Jianwei Ren George G Chen Paul B S Lai Jiangchao Li Yin Xia Andrew M Chan Wai-Yee Chan Bo Feng

BMC Biol 2018 12 28;16(1):151. Epub 2018 Dec 28.

School of Biomedical Sciences, CUHK-GIBH CAS Joint Laboratory on Stem Cell and Regenerative Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, Special Administrative Region of China.

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http://dx.doi.org/10.1186/s12915-018-0616-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310992PMC
December 2018

Cancer stem cells in hepatocellular carcinoma: an overview and promising therapeutic strategies.

Authors:
Nuozhou Wang Shanshan Wang Ming-Yue Li Bao-Guang Hu Li-Ping Liu Sheng-Li Yang Shucai Yang Zhongqin Gong Paul B S Lai George G Chen

Ther Adv Med Oncol 2018 21;10:1758835918816287. Epub 2018 Dec 21.

Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China.

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http://dx.doi.org/10.1177/1758835918816287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304707PMC
December 2018

Does Intermittent Pringle Maneuver Increase Postoperative Complications After Hepatectomy for Hepatocellular Carcinoma? A Randomized Controlled Trial.

Authors:
Kit Fai Lee John Wong Sunny Y S Cheung Charing C N Chong Joyce W Y Hui Vivian Y F Leung Simon C H Yu Paul B S Lai

World J Surg 2018 10;42(10):3302-3311

Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, 30-32, Ngan Shing Street, Shatin, N.T., Hong Kong SAR, China.

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http://dx.doi.org/10.1007/s00268-018-4637-3DOI Listing
October 2018

Targeting ZBP-89 for the treatment of hepatocellular carcinoma.

Authors:
Nuozhou Wang Shanshan Wang Sheng-Li Yang Li-Ping Liu Ming-Yue Li Paul B S Lai George G Chen

Expert Opin Ther Targets 2018 10 6;22(10):817-822. Epub 2018 Sep 6.

a Department of Surgery, Faculty of Medicine , The Chinese University of Hong Kong, Prince of Wales Hospital , Hong Kong , China.

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http://dx.doi.org/10.1080/14728222.2018.1516753DOI Listing
October 2018

Pattern of disease recurrence and its implications for postoperative surveillance after curative hepatectomy for hepatocellular carcinoma: experience from a single center.

Authors:
Kit-Fai Lee Charing C N Chong Anthony K W Fong Andrew K Y Fung Hon-Ting Lok Yue-Sun Cheung John Wong Paul B S Lai

Hepatobiliary Surg Nutr 2018 Oct;7(5):320-330

Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, Prince of Wales Hospital, the Chinese University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.21037/hbsn.2018.03.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230848PMC
October 2018

Loss of tumor suppressor IGFBP4 drives epigenetic reprogramming in hepatic carcinogenesis.

Authors:
Ying-Ying Lee Myth Ts Mok Wei Kang Weiqin Yang Wenshu Tang Feng Wu Liangliang Xu Mingfei Yan Zhuo Yu Sau-Dan Lee Joanna H M Tong Yue-Sun Cheung Paul B S Lai Dae-Yeul Yu Qianben Wang Grace L H Wong Andrew M Chan Kevin Y Yip Ka-Fai To Alfred S L Cheng

Nucleic Acids Res 2018 09;46(17):8832-8847

School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1093/nar/gky589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158508PMC
September 2018

Liver- and Colon-Specific DNA Methylation Markers in Plasma for Investigation of Colorectal Cancers with or without Liver Metastases.

Authors:
Wanxia Gai Lu Ji W K Jacky Lam Kun Sun Peiyong Jiang Anthony W H Chan John Wong Paul B S Lai Simon S M Ng Brigette B Y Ma Grace L H Wong Vincent W S Wong Henry L Y Chan Rossa W K Chiu Y M Dennis Lo K C Allen Chan

Clin Chem 2018 08 14;64(8):1239-1249. Epub 2018 Jun 14.

Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China;

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http://dx.doi.org/10.1373/clinchem.2018.290304DOI Listing
August 2018

ID1-induced p16/IL6 axis activation contributes to the resistant of hepatocellular carcinoma cells to sorafenib.

Authors:
Lei-Lei Niu Chuan-le Cheng Ming-Yue Li Sheng-Li Yang Bao-Guang Hu Charing C N Chong Stephen L Chan Jianwei Ren George G Chen Paul B S Lai

Cell Death Dis 2018 08 28;9(9):852. Epub 2018 Aug 28.

Department of Surgery, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong, China.

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http://dx.doi.org/10.1038/s41419-018-0926-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113298PMC
August 2018

Microwave ablation provides better survival than liver resection for hepatocellular carcinoma in patients with borderline liver function: application of ALBI score to patient selection.

Authors:
Charing C N Chong Kit-Fai Lee Cheuk-Man Chu Anthony W H Chan John Wong Stephen L Chan Hon-Ting Lok Andrew K Y Fung Anthony K W Fong Yue S Cheung Simon C H Yu Philip Johnson Paul B S Lai

HPB (Oxford) 2018 06 17;20(6):546-554. Epub 2018 Jan 17.

Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The Chinese University of Hong Kong, Hong Kong; Institute of Digestive Disease, Partner State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong. Electronic address:

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http://dx.doi.org/10.1016/j.hpb.2017.12.001DOI Listing
June 2018

Robot-assisted minimally invasive procedures for complicated biliary stone disease.

Authors:
Kit Fai Lee Andrew K Y Fung Hon Ting Lok Anthony K W Fong Charing C N Chong Paul B S Lai

Hepatobiliary Surg Nutr 2018 Jun;7(3):185-188

Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China.

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http://dx.doi.org/10.21037/hbsn.2017.05.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036073PMC
June 2018

Hepatoma-intrinsic CCRK inhibition diminishes myeloid-derived suppressor cell immunosuppression and enhances immune-checkpoint blockade efficacy.

Authors:
Jingying Zhou Man Liu Hanyong Sun Yu Feng Liangliang Xu Anthony W H Chan Joanna H Tong John Wong Charing Ching Ning Chong Paul B S Lai Hector Kwong-Sang Wang Shun-Wa Tsang Tyler Goodwin Rihe Liu Leaf Huang Zhiwei Chen Joseph Jy Sung King Lau Chow Ka Fai To Alfred Sze-Lok Cheng

Gut 2018 05 22;67(5):931-944. Epub 2017 Sep 22.

School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China.

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http://gut.bmj.com/lookup/doi/10.1136/gutjnl-2017-314032
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http://dx.doi.org/10.1136/gutjnl-2017-314032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5961939PMC
May 2018

Circulating Tumor Cells from Different Vascular Sites Exhibit Spatial Heterogeneity in Epithelial and Mesenchymal Composition and Distinct Clinical Significance in Hepatocellular Carcinoma.

Authors:
Yun-Fan Sun Wei Guo Yang Xu Yin-Hong Shi Zi-Jun Gong Yuan Ji Min Du Xin Zhang Bo Hu Ao Huang George G Chen Paul B S Lai Ya Cao Shuang-Jian Qiu Jian Zhou Xin-Rong Yang Jia Fan

Clin Cancer Res 2018 02 25;24(3):547-559. Epub 2017 Oct 25.

Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, P.R. China.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-1063DOI Listing
February 2018

A new VLAD-based control chart for detecting surgical outcomes.

Authors:
Jin Yue Xin Lai Liu Liu Paul B S Lai

Stat Med 2017 Dec 7;36(28):4540-4547. Epub 2017 Jun 7.

Department of Surgery, The Chinese University of Hong Kong, Shatin, Hong Kong.

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http://dx.doi.org/10.1002/sim.7362DOI Listing
December 2017

New insights into sorafenib resistance in hepatocellular carcinoma: Responsible mechanisms and promising strategies.

Authors:
Leilei Niu Liping Liu Shengli Yang Jianwei Ren Paul B S Lai George G Chen

Biochim Biophys Acta Rev Cancer 2017 Dec 17;1868(2):564-570. Epub 2017 Oct 17.

Department of Surgery, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, China; Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, Guangdong, China. Electronic address:

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http://dx.doi.org/10.1016/j.bbcan.2017.10.002DOI Listing
December 2017

A phase 2 study of the efficacy and biomarker on the combination of transarterial chemoembolization and axitinib in the treatment of inoperable hepatocellular carcinoma.

Authors:
Stephen L Chan Winnie Yeo Frankie Mo Anthony W H Chan Jane Koh Leung Li Edwin P Hui Charing C N Chong Paul B S Lai Tony S K Mok Simon C H Yu

Cancer 2017 Oct 22;123(20):3977-3985. Epub 2017 Jun 22.

Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong.

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http://dx.doi.org/10.1002/cncr.30825DOI Listing
October 2017

Positive Expression of Programmed Death Ligand 1 in Peritumoral Liver Tissue is Associated with Poor Survival after Curative Resection of Hepatocellular Carcinoma.

Authors:
Xiaomeng Dai Jun Xue Jianli Hu Sheng-Li Yang George G Chen Paul B S Lai Chao Yu Cui Zeng Xiefan Fang Xiaoli Pan Tao Zhang

Transl Oncol 2017 Aug 27;10(4):511-517. Epub 2017 May 27.

Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. Electronic address:

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http://dx.doi.org/10.1016/j.tranon.2017.03.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447656PMC
August 2017

Topical Therapy with Mesenchymal Stem Cells Following an Acute Experimental Head Injury Has Benefits in Motor-Behavioral Tests for Rodents.

Authors:
P K Lam Kevin K W Wang Anthony W I Ip Don W C Ching Cindy S W Tong Henry C H Lau Themis H C S Kong Paul B S Lai George K C Wong W S Poon

Acta Neurochir Suppl 2016 ;122:21-4

Division of Neurosurgery, Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China.

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http://dx.doi.org/10.1007/978-3-319-22533-3_4DOI Listing
July 2017

Interactome and reciprocal activation of pathways in topical mesenchymal stem cells and the recipient cerebral cortex following traumatic brain injury.

Authors:
Ping K Lam Kevin K W Wang Anthony W I Lo Cindy S W Tong Don W C Ching Kenneth Wong Zhihui Yang Themis Kong Kin K Y Lo Richard K W Choy Paul B S Lai George K C Wong Wai S Poon

Sci Rep 2017 07 10;7(1):5017. Epub 2017 Jul 10.

Department of Surgery, The Chinese University of Hong Kong, Hong Kong, SAR, China.

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http://dx.doi.org/10.1038/s41598-017-01772-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504061PMC
July 2017

Incorporating albumin-bilirubin grade into the cancer of the liver Italian program system for hepatocellular carcinoma.

Authors:
Anthony W H Chan Charing C N Chong Frankie K F Mo John Wong Winnie Yeo Philip J Johnson Shuangni Yu Paul B S Lai Anthony T C Chan Ka-Fai To Stephen L Chan

J Gastroenterol Hepatol 2017 Jan;32(1):221-228

Department of Clinical Oncology, State Key Laboratory in Oncology in South China, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.

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http://dx.doi.org/10.1111/jgh.13457DOI Listing
January 2017

Exome and genome sequencing of nasopharynx cancer identifies NF-κB pathway activating mutations.

Authors:
Yvonne Y Li Grace T Y Chung Vivian W Y Lui Ka-Fai To Brigette B Y Ma Chit Chow John K S Woo Kevin Y Yip Jeongsun Seo Edwin P Hui Michael K F Mak Maria Rusan Nicole G Chau Yvonne Y Y Or Marcus H N Law Peggy P Y Law Zoey W Y Liu Hoi-Lam Ngan Pok-Man Hau Krista R Verhoeft Peony H Y Poon Seong-Keun Yoo Jong-Yeon Shin Sau-Dan Lee Samantha W M Lun Lin Jia Anthony W H Chan Jason Y K Chan Paul B S Lai Choi-Yi Fung Suet-Ting Hung Lin Wang Ann Margaret V Chang Simion I Chiosea Matthew L Hedberg Sai-Wah Tsao Andrew C van Hasselt Anthony T C Chan Jennifer R Grandis Peter S Hammerman Kwok-Wai Lo

Nat Commun 2017 01 18;8:14121. Epub 2017 Jan 18.

Department of Anatomical &Cellular Pathology, State Key Laboratory in Oncology in South China and Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1038/ncomms14121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5253631PMC
January 2017

Steatotic hepatocellular carcinoma: a variant associated with metabolic factors and late tumour relapse.

Authors:
Anthony W H Chan Shuangni Yu Yau-Hei Yu Joanna H M Tong Lei Wang Edith K Y Tin Charing C N Chong Stephen L Chan Grace L H Wong Vincent W S Wong Henry L Y Chan Paul B S Lai Ka-Fai To

Histopathology 2016 Dec 9;69(6):971-984. Epub 2016 Sep 9.

Department of Anatomical and Cellular Pathology, State Key Laboratory in Oncology in South China, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.

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http://doi.wiley.com/10.1111/his.13029
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http://dx.doi.org/10.1111/his.13029DOI Listing
December 2016

Alternative splicing of estrogen receptor alpha in hepatocellular carcinoma.

Authors:
Jian Zhang Jianwei Ren Jiamin Wei Charing C N Chong Dongjie Yang Yulong He George G Chen Paul B S Lai

BMC Cancer 2016 11 30;16(1):926. Epub 2016 Nov 30.

Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, Special Administrative Region of China.

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http://dx.doi.org/10.1186/s12885-016-2928-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129602PMC
November 2016

Robotic Liver Resection For Primary Hepatolithiasis: Is It Beneficial?

Authors:
Kit-Fai Lee Anthony K W Fong Charing C N Chong Sunny Y S Cheung John Wong Paul B S Lai

World J Surg 2016 Oct;40(10):2490-6

Division of Hepato-biliary and Pancreatic Surgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, 30-32, Ngan Shing Street, Shatin N.T., Hong Kong, SAR, China.

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http://dx.doi.org/10.1007/s00268-016-3528-8DOI Listing
October 2016

Applicability of albumin-bilirubin-based Japan integrated staging score in hepatitis B-associated hepatocellular carcinoma.

Authors:
Anthony W H Chan Charing C N Chong Frankie K F Mo John Wong Winnie Yeo Philip J Johnson Shuangni Yu Paul B S Lai Anthony T C Chan Ka-Fai To Stephen L Chan

J Gastroenterol Hepatol 2016 Oct;31(10):1766-1772

Department of Clinical Oncology, State Key Laboratory in Oncology in South China, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.

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http://dx.doi.org/10.1111/jgh.13339DOI Listing
October 2016

Cytochrome P450 1A2 Metabolizes 17β-Estradiol to Suppress Hepatocellular Carcinoma.

Authors:
Jianwai Ren George G Chen Yi Liu Xianwei Su Baoguang Hu Billy C S Leung Y Wang Rocky L K Ho Shengli Yang Gang Lu C G Lee Paul B S Lai

PLoS One 2016 19;11(4):e0153863. Epub 2016 Apr 19.

Department of Surgery, Faculty of Medicine, The Chinese University of Hong Kong; New Territories, Hong Kong, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0153863PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836701PMC
September 2016

Distinguished prognosis after hepatectomy of HBV-related hepatocellular carcinoma with or without cirrhosis: a long-term follow-up analysis.

Authors:
Sheng-Li Yang Li-Ping Liu Yun-Fan Sun Xing-Rong Yang Jia Fan Jian-Wei Ren George G Chen Paul B S Lai

J Gastroenterol 2016 Jul 25;51(7):722-32. Epub 2015 Nov 25.

Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China.

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http://dx.doi.org/10.1007/s00535-015-1146-0DOI Listing
July 2016

Integration of albumin-bilirubin (ALBI) score into Barcelona Clinic Liver Cancer (BCLC) system for hepatocellular carcinoma.

Authors:
Anthony W H Chan Takshi Kumada Hidenori Toyoda Toshifumi Tada Charing C N Chong Frankie K F Mo Winnie Yeo Philip J Johnson Paul B S Lai Anthony T C Chan Ka-Fai To Stephen L Chan

J Gastroenterol Hepatol 2016 Jul;31(7):1300-6

Department of Clinical Oncology, State Key Laboratory in Oncology in South China, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong kong.

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http://doi.wiley.com/10.1111/jgh.13291
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http://dx.doi.org/10.1111/jgh.13291DOI Listing
July 2016

Cancer Specific Long Noncoding RNAs Show Differential Expression Patterns and Competing Endogenous RNA Potential in Hepatocellular Carcinoma.

Authors:
Jian Zhang Dahua Fan Zhixiang Jian George G Chen Paul B S Lai

PLoS One 2015 22;10(10):e0141042. Epub 2015 Oct 22.

Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0141042PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619599PMC
June 2016

Downregulation and pro-apoptotic effect of hypoxia-inducible factor 2 alpha in hepatocellular carcinoma.

Authors:
Sheng-Li Yang Li-Ping Liu Leilei Niu Yun-Fan Sun Xing-Rong Yang Jia Fan Jian-Wei Ren George G Chen Paul B S Lai

Oncotarget 2016 Jun;7(23):34571-81

Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong, China.

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http://dx.doi.org/10.18632/oncotarget.8952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085177PMC
June 2016

Yin Yang 1-mediated epigenetic silencing of tumour-suppressive microRNAs activates nuclear factor-κB in hepatocellular carcinoma.

Authors:
Daisy P F Tsang William K K Wu Wei Kang Ying-Ying Lee Feng Wu Zhuo Yu Lei Xiong Anthony W Chan Joanna H Tong Weiqin Yang May S M Li Suki S Lau Xiangchun Li Sau-Dan Lee Yihua Yang Paul B S Lai Dae-Yeul Yu Gang Xu Kwok-Wai Lo Matthew T V Chan Huating Wang Tin L Lee Jun Yu Nathalie Wong Kevin Y Yip Ka-Fai To Alfred S L Cheng

J Pathol 2016 Apr;238(5):651-64

Institute of Digestive Disease and State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China.

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http://dx.doi.org/10.1002/path.4688DOI Listing
April 2016

A Seven-microRNA Expression Signature Predicts Survival in Hepatocellular Carcinoma.

Authors:
Jian Zhang Charing C N Chong George G Chen Paul B S Lai

PLoS One 2015 5;10(6):e0128628. Epub 2015 Jun 5.

Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0128628PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457814PMC
March 2016

Laparoscopic and robotic hepatectomy: experience from a single centre.

Authors:
Kit-Fai Lee Yue-Sun Cheung Charing C N Chong John Wong Anthony K W Fong Paul B S Lai

ANZ J Surg 2016 Mar 30;86(3):122-6. Epub 2015 Sep 30.

Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China.

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http://dx.doi.org/10.1111/ans.13339DOI Listing
March 2016

Long-term impact of liver function on curative therapy for hepatocellular carcinoma: application of the ALBI grade.

Authors:
Hidenori Toyoda Paul B S Lai James O'Beirne Charing C Chong Sarah Berhane Helen Reeves Derek Manas Richard P Fox Winnie Yeo Frankie Mo Anthony W H Chan Toshifumi Tada Mercedes Iñarrairaegui Arndt Vogel Nora Schweitzer Stephen L Chan Bruno Sangro Takashi Kumada Philip J Johnson

Br J Cancer 2016 Mar;114(7):744-50

Department of Molecular and Clinical Cancer Medicine, The Duncan Building, Daulby Street, University of Liverpool, Liverpool L69 3GA, UK.

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http://dx.doi.org/10.1038/bjc.2016.33DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4984858PMC
March 2016

Prognostic Nutritional Index (PNI) Predicts Tumor Recurrence of Very Early/Early Stage Hepatocellular Carcinoma After Surgical Resection.

Authors:
Anthony W H Chan Stephen L Chan Grace L H Wong Vincent W S Wong Charing C N Chong Paul B S Lai Henry L Y Chan Ka-Fai To

Ann Surg Oncol 2015 Dec 24;22(13):4138-48. Epub 2015 Mar 24.

Department of Anatomical and Cellular Pathology, State Key Laboratory in Oncology in South China, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong.

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http://dx.doi.org/10.1245/s10434-015-4516-1DOI Listing
December 2015

The practice of mediation to resolve clinical, bioethical, and medical malpractice disputes.

Authors:
Danny W H Lee Paul B S Lai

Hong Kong Med J 2015 Dec;21(6):560-4

Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.

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http://dx.doi.org/10.12809/hkmj154615DOI Listing
December 2015

Histone Deacetylase HDAC8 Promotes Insulin Resistance and β-Catenin Activation in NAFLD-Associated Hepatocellular Carcinoma.

Authors:
Yuan Tian Vincent W S Wong Grace L H Wong Weiqin Yang Hanyong Sun Jiayun Shen Joanna H M Tong Minnie Y Y Go Yue S Cheung Paul B S Lai Mingyan Zhou Gang Xu Tim H M Huang Jun Yu Ka F To Alfred S L Cheng Henry L Y Chan

Cancer Res 2015 Nov 17;75(22):4803-16. Epub 2015 Sep 17.

Department of Medicine and Therapeutics and Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, PR China. State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, PR China.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-3786DOI Listing
November 2015

Albumin-to-alkaline phosphatase ratio: a novel prognostic index for hepatocellular carcinoma.

Authors:
Anthony W H Chan Stephen L Chan Frankie K F Mo Grace L H Wong Vincent W S Wong Yue-Sun Cheung Henry L Y Chan Winnie Yeo Paul B S Lai Ka-Fai To

Dis Markers 2015 9;2015:564057. Epub 2015 Feb 9.

Department of Anatomical and Cellular Pathology, State Key Laboratory in Oncology in South China, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong ; Institute of Digestive Disease, Partner State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Shatin, Hong Kong ; Li Ka Shing Institute of Health Science, Sir Y. K. Pao Cancer Centre, The Chinese University of Hong Kong, Shatin, Hong Kong.

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http://dx.doi.org/10.1155/2015/564057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337043PMC
October 2015

Plasma DNA tissue mapping by genome-wide methylation sequencing for noninvasive prenatal, cancer, and transplantation assessments.

Authors:
Kun Sun Peiyong Jiang K C Allen Chan John Wong Yvonne K Y Cheng Raymond H S Liang Wai-kong Chan Edmond S K Ma Stephen L Chan Suk Hang Cheng Rebecca W Y Chan Yu K Tong Simon S M Ng Raymond S M Wong David S C Hui Tse Ngong Leung Tak Y Leung Paul B S Lai Rossa W K Chiu Yuk Ming Dennis Lo

Proc Natl Acad Sci U S A 2015 Oct 21;112(40):E5503-12. Epub 2015 Sep 21.

Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China; Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China; State Key Laboratory in Oncology in South China, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China;

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http://dx.doi.org/10.1073/pnas.1508736112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603482PMC
October 2015

Truncated HBx-dependent silencing of GAS2 promotes hepatocarcinogenesis through deregulation of cell cycle, senescence and p53-mediated apoptosis.

Authors:
Ranxu Zhu Myth T S Mok Wei Kang Suki S K Lau Wing-Kit Yip Yangchao Chen Paul B S Lai Vincent W S Wong Ka-Fai To Joseph J Y Sung Alfred S L Cheng Henry L Y Chan

J Pathol 2015 Sep 28;237(1):38-49. Epub 2015 May 28.

Institute of Digestive Disease and State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, SAR, China.

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http://dx.doi.org/10.1002/path.4554DOI Listing
September 2015

Endoscopic Resection for Early Gastric Cancer: What is the Limit?

Authors:
Philip W Y Chiu Paul B S Lai

Ann Surg Oncol 2015 Jun 10;22(6):1753-4. Epub 2015 Feb 10.

Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China.

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http://dx.doi.org/10.1245/s10434-014-4312-3DOI Listing
June 2015

A CCRK-EZH2 epigenetic circuitry drives hepatocarcinogenesis and associates with tumor recurrence and poor survival of patients.

Authors:
Hai Feng Zhuo Yu Yuan Tian Ying-Ying Lee May S Li Minnie Y Y Go Yue-Sun Cheung Paul B S Lai Andrew M L Chan Ka-Fai To Henry L Y Chan Joseph J Y Sung Alfred S L Cheng

J Hepatol 2015 May 9;62(5):1100-11. Epub 2014 Dec 9.

School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China; State Key Laboratory of Digestive Disease and Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2014.11.040DOI Listing
May 2015

Novel recurrently mutated genes and a prognostic mutation signature in colorectal cancer.

Authors:
Jun Yu William K K Wu Xiangchun Li Jun He Xiao-Xing Li Simon S M Ng Chang Yu Zhibo Gao Jie Yang Miao Li Qiaoxiu Wang Qiaoyi Liang Yi Pan Joanna H Tong Ka F To Nathalie Wong Ning Zhang Jie Chen Youyong Lu Paul B S Lai Francis K L Chan Yingrui Li Hsiang-Fu Kung Huanming Yang Jun Wang Joseph J Y Sung

Gut 2015 Apr 20;64(4):636-45. Epub 2014 Jun 20.

Department of Medicine & Therapeutics, State Key Laboratory of Digestive Disease, Institute of Digestive Disease and LKS Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong.

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http://dx.doi.org/10.1136/gutjnl-2013-306620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392212PMC
April 2015

Lengthening and shortening of plasma DNA in hepatocellular carcinoma patients.

Authors:
Peiyong Jiang Carol W M Chan K C Allen Chan Suk Hang Cheng John Wong Vincent Wai-Sun Wong Grace L H Wong Stephen L Chan Tony S K Mok Henry L Y Chan Paul B S Lai Rossa W K Chiu Y M Dennis Lo

Proc Natl Acad Sci U S A 2015 Mar 2;112(11):E1317-25. Epub 2015 Feb 2.

Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong; Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong; State Key Laboratory in Oncology in South China, Sir Y. K. Pao Centre for Cancer, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong;

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http://dx.doi.org/10.1073/pnas.1500076112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372002PMC
March 2015

Lymphoepithelioma-like hepatocellular carcinoma: an uncommon variant of hepatocellular carcinoma with favorable outcome.

Authors:
Anthony W H Chan Joanna H M Tong Yi Pan Stephen L Chan Grace L H Wong Vincent W S Wong Paul B S Lai Ka-Fai To

Am J Surg Pathol 2015 Mar;39(3):304-12

Departments of *Anatomical and Cellular Pathology §Clinical Oncology, State Key Laboratory in Oncology in South China, Prince of Wales Hospital †Institute of Digestive Disease, Partner State Key Laboratory of Digestive Disease ‡Li Ka Shing Institute of Health Science, Sir Y.K. Pao Cancer Center ∥Department of Medicine and Therapeutics ¶Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, The Chinese University of Hong Kong, Hong Kong.

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http://dx.doi.org/10.1097/PAS.0000000000000376DOI Listing
March 2015

ZBP-89 reduces histone deacetylase 3 by degrading IkappaB in the presence of Pin1.

Authors:
Cai Guo Ye Liping Liu George G Chen Xiao Lin Tang Zhiwei He Ming-Liang He Paul B S Lai

J Transl Med 2015 Jan 27;13:23. Epub 2015 Jan 27.

Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, NT, P. R. China.

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http://dx.doi.org/10.1186/s12967-015-0382-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311446PMC
January 2015

Cell cycle-related kinase mediates viral-host signalling to promote hepatitis B virus-associated hepatocarcinogenesis.

Authors:
Zhuo Yu Yue-Qiu Gao Hai Feng Ying-Ying Lee May S Li Yuan Tian Minnie Y Y Go Dae-Yeul Yu Yue-Sun Cheung Paul B S Lai Jun Yu Vincent W S Wong Joseph J Y Sung Henry L Y Chan Alfred S L Cheng

Gut 2014 Nov 17;63(11):1793-804. Epub 2014 Jan 17.

School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong SAR, P. R. China State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, P. R. China.

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http://dx.doi.org/10.1136/gutjnl-2013-305584DOI Listing
November 2014

Epstein-Barr virus-associated lymphoepithelioma-like cholangiocarcinoma: a rare variant of intrahepatic cholangiocarcinoma with favourable outcome.

Authors:
Anthony W H Chan Joanna H M Tong Mandy Y M Sung Paul B S Lai Ka-Fai To

Histopathology 2014 Nov 2;65(5):674-83. Epub 2014 Sep 2.

State Key Laboratory in Oncology in South China, Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong.

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http://dx.doi.org/10.1111/his.12455DOI Listing
November 2014

Overexpression of ZFX confers self-renewal and chemoresistance properties in hepatocellular carcinoma.

Authors:
Keng Po Lai Jiawei Chen Mian He Arthur K K Ching Coleen Lau Paul B S Lai Ka-Fai To Nathalie Wong

Int J Cancer 2014 Oct 11;135(8):1790-9. Epub 2014 Mar 11.

Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong, China.

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http://dx.doi.org/10.1002/ijc.28819DOI Listing
October 2014

International validation of the Chinese university prognostic index for staging of hepatocellular carcinoma: a joint United Kingdom and Hong Kong study.

Authors:
Stephen L Chan Philip J Johnson Frankie Mo Sarah Berhane Mabel Teng Anthony W H Chan Ming C Poon Paul B S Lai Simon Yu Anthony T C Chan Winnie Yeo

Chin J Cancer 2014 Oct 16;33(10):481-91. Epub 2014 Sep 16.

State Key Laboratory in Oncology in South China, Sir YK Pao Center for Cancer, Department of Clinical Oncology, Hong Kong Cancer Institute and Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China.

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http://dx.doi.org/10.5732/cjc.014.10133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198751PMC
October 2014

Expression of stemness markers (CD133 and EpCAM) in prognostication of hepatocellular carcinoma.

Authors:
Anthony W H Chan Joanna H M Tong Stephen L Chan Paul B S Lai Ka-Fai To

Histopathology 2014 Jun 7;64(7):935-50. Epub 2014 Feb 7.

Department of Anatomical and Cellular Pathology, State Key Laboratory in Oncology in South China, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.

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http://dx.doi.org/10.1111/his.12342DOI Listing
June 2014

Therapeutic efficacy of improved α-fetoprotein promoter-mediated tBid delivered by folate-PEI600-cyclodextrin nanopolymer vector in hepatocellular carcinoma.

Authors:
Bao-guang Hu Li-ping Liu George G Chen Cai Guo Ye Kevin K C Leung Rocky L K Ho Marie C Lin Paul B S Lai

Exp Cell Res 2014 Jun 13;324(2):183-91. Epub 2014 Apr 13.

Department of Surgery, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China.

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http://dx.doi.org/10.1016/j.yexcr.2014.04.005DOI Listing
June 2014

Performance of serum α-fetoprotein levels in the diagnosis of hepatocellular carcinoma in patients with a hepatic mass.

Authors:
Stephen L Chan Frankie Mo Philip J Johnson Deyond Y W Siu Michael H M Chan Wan Y Lau Paul B S Lai Christopher W K Lam Winnie Yeo Simon C H Yu

HPB (Oxford) 2014 Apr 26;16(4):366-72. Epub 2013 Aug 26.

State Key Laboratory in Oncology in South China, Sir Y. K. Pao Centre for Cancer, Department of Clinical Oncology, Hong Kong Cancer Institute, Hong Kong, China.

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http://dx.doi.org/10.1111/hpb.12146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967889PMC
April 2014

Viral-human chimeric transcript predisposes risk to liver cancer development and progression.

Authors:
Chi-Chiu Lau Tingting Sun Arthur K K Ching Mian He Jing-Woei Li Alissa M Wong Ngai Na Co Anthony W H Chan Pik-Shan Li Raymond W M Lung Joanna H M Tong Paul B S Lai Henry L Y Chan Ka-Fai To Ting-Fung Chan Nathalie Wong

Cancer Cell 2014 Mar 27;25(3):335-49. Epub 2014 Feb 27.

Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Shatin, Hong Kong, China; State Key Laboratory in Oncology in South China, The Chinese University of Hong Kong, Shatin, Hong Kong, China; State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Shatin, Hong Kong, China. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2014.01.030DOI Listing
March 2014

Epigenetic upregulation of Bak by ZBP-89 inhibits the growth of hepatocellular carcinoma.

Authors:
Cai Guo Ye George G Chen Rocky L K Ho Juanita L Merchant Ming-Liang He Paul B S Lai

Biochim Biophys Acta 2013 Dec 13;1833(12):2970-2979. Epub 2013 Aug 13.

Department of Surgery, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.

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http://dx.doi.org/10.1016/j.bbamcr.2013.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160027PMC
December 2013

Noninvasive detection of cancer-associated genome-wide hypomethylation and copy number aberrations by plasma DNA bisulfite sequencing.

Authors:
K C Allen Chan Peiyong Jiang Carol W M Chan Kun Sun John Wong Edwin P Hui Stephen L Chan Wing Cheong Chan David S C Hui Simon S M Ng Henry L Y Chan Cesar S C Wong Brigette B Y Ma Anthony T C Chan Paul B S Lai Hao Sun Rossa W K Chiu Y M Dennis Lo

Proc Natl Acad Sci U S A 2013 Nov 4;110(47):18761-8. Epub 2013 Nov 4.

Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.

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http://dx.doi.org/10.1073/pnas.1313995110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839703PMC
November 2013

SIRT2 overexpression in hepatocellular carcinoma mediates epithelial to mesenchymal transition by protein kinase B/glycogen synthase kinase-3β/β-catenin signaling.

Authors:
Juan Chen Anthony W H Chan Ka-Fai To Weixian Chen Zhenzhen Zhang Jihua Ren Chunli Song Yue-Sun Cheung Paul B S Lai Suk-Hang Cheng Margaret H L Ng Ailong Huang Ben C B Ko

Hepatology 2013 Jun 26;57(6):2287-98. Epub 2013 Apr 26.

The Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, China.

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http://dx.doi.org/10.1002/hep.26278DOI Listing
June 2013

Enhancer of zeste homolog 2 silences microRNA-218 in human pancreatic ductal adenocarcinoma cells by inducing formation of heterochromatin.

Authors:
Chi Han Li Ka-Fai To Joanna Hung-Man Tong Zhangang Xiao Tian Xia Paul B S Lai Sheung Ching Chow Yin-Xin Zhu Stephen L Chan Victor E Marquez Yangchao Chen

Gastroenterology 2013 May 7;144(5):1086-1097.e9. Epub 2013 Feb 7.

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong.

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http://dx.doi.org/10.1053/j.gastro.2013.01.058DOI Listing
May 2013

Identification and characterization of tropomyosin 3 associated with granulin-epithelin precursor in human hepatocellular carcinoma.

Authors:
Ching Yan Lam Chi Wai Yip Terence C W Poon Christine K C Cheng Eddy W Y Ng Nicholas C L Wong Phyllis F Y Cheung Paul B S Lai Irene O L Ng Sheung Tat Fan Siu Tim Cheung

PLoS One 2012 6;7(7):e40324. Epub 2012 Jul 6.

Department of Surgery, The University of Hong Kong, Hong Kong.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0040324PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3391266PMC
April 2013

Enzyme kinetic and molecular docking studies for the inhibitions of miltirone on major human cytochrome P450 isozymes.

Authors:
Xuelin Zhou Yan Wang Tao Hu Penelope M Y Or John Wong Yiu Wa Kwan David C C Wan Pui Man Hoi Paul B S Lai John H K Yeung

Phytomedicine 2013 Feb 25;20(3-4):367-74. Epub 2012 Oct 25.

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China.

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http://dx.doi.org/10.1016/j.phymed.2012.09.021DOI Listing
February 2013

Histone deacetylase inhibitors facilitate dihydroartemisinin-induced apoptosis in liver cancer in vitro and in vivo.

Authors:
Chris Zhiyi Zhang Yinghua Pan Yun Cao Paul B S Lai Lili Liu George Gong Chen Jingping Yun

PLoS One 2012 28;7(6):e39870. Epub 2012 Jun 28.

State Key Laboratory of Oncology in Southern China, Sun Yat-Sen University Cancer Center, Guangzhou, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0039870PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386188PMC
January 2013

Cancer genome scanning in plasma: detection of tumor-associated copy number aberrations, single-nucleotide variants, and tumoral heterogeneity by massively parallel sequencing.

Authors:
K C Allen Chan Peiyong Jiang Yama W L Zheng Gary J W Liao Hao Sun John Wong Shing Shun N Siu Wing C Chan Stephen L Chan Anthony T C Chan Paul B S Lai Rossa W K Chiu Y M D Lo

Clin Chem 2013 Jan 11;59(1):211-24. Epub 2012 Oct 11.

Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China.

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http://dx.doi.org/10.1373/clinchem.2012.196014DOI Listing
January 2013

Ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic-acid inhibits hepatocellular carcinoma in vitro and in vivo via stabilizing IkBα.

Authors:
George G Chen Jackie Leung Nian Ci Liang Li Li Kefeng Wu Ursula P F Chan Billy C S Leung Mingyue Li Jing Du Yi Feng Deng Xianling Gong Yingnian Lv Ernest C W Chak Paul B S Lai

Invest New Drugs 2012 Dec 7;30(6):2210-8. Epub 2012 Jan 7.

Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.

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http://dx.doi.org/10.1007/s10637-011-9791-5DOI Listing
December 2012

GEF-H1 over-expression in hepatocellular carcinoma promotes cell motility via activation of RhoA signalling.

Authors:
Ibis K C Cheng Bruce C K Tsang Keng Po Lai Arthur K K Ching Anthony W H Chan Ka-Fai To Paul B S Lai Nathalie Wong

J Pathol 2012 Dec 28;228(4):575-85. Epub 2012 Sep 28.

Department of Anatomical and Cellular Pathology, Li Ka-Shing Institute of Health Sciences, Chinese University of Hong Kong, Shatin, Hong Kong, People's Republic of China; Department of Nutrition and Food Management, HKU SPACE Po Leung Kuk Community College, Hong Kong, People's Republic of China.

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http://doi.wiley.com/10.1002/path.4084
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December 2012

Sorafenib inhibits hypoxia-inducible factor-1α synthesis: implications for antiangiogenic activity in hepatocellular carcinoma.

Authors:
Li-ping Liu Rocky L K Ho George G Chen Paul B S Lai

Clin Cancer Res 2012 Oct 28;18(20):5662-71. Epub 2012 Aug 28.

Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-12-0552DOI Listing
October 2012

Increased expression of ZBP-89 and its prognostic significance in hepatocellular carcinoma.

Authors:
Chris Z Y Zhang Yun Cao Jing-Ping Yun George G Chen Paul B S Lai

Histopathology 2012 Jun 28;60(7):1114-24. Epub 2012 Feb 28.

Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong.

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http://dx.doi.org/10.1111/j.1365-2559.2011.04136.xDOI Listing
June 2012

Induction of autophagy in hepatocellular carcinoma cells by SB203580 requires activation of AMPK and DAPK but not p38 MAPK.

Authors:
Haitao Zhang George G Chen Zhiyi Zhang Sukying Chun Billy Cheuk Sing Leung Paul B S Lai

Apoptosis 2012 Apr;17(4):325-34

Department of Surgery, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, China.

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http://link.springer.com/10.1007/s10495-011-0685-y
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April 2012

Surgical ablation of hepatocellular carcinoma with 2.45-GHz microwave: a critical appraisal of treatment outcomes.

Authors:
K F Lee Joyce W Y Hui Y S Cheung Jeff S W Wong C N Chong J Wong Simon C H Yu Paul B S Lai

Hong Kong Med J 2012 Apr;18(2):85-91

Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong.

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April 2012

Nonhematopoietically derived DNA is shorter than hematopoietically derived DNA in plasma: a transplantation model.

Authors:
Yama W L Zheng K C Allen Chan Hao Sun Peiyong Jiang Xiaoxi Su Eric Z Chen Fiona M F Lun Emily C W Hung Vincent Lee John Wong Paul B S Lai Chi-Kong Li Rossa W K Chiu Y M Dennis Lo

Clin Chem 2012 Mar 3;58(3):549-58. Epub 2011 Nov 3.

Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.

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http://www.clinchem.org/cgi/doi/10.1373/clinchem.2011.169318
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March 2012

Bone morphogenic protein-4 induces endothelial cell apoptosis through oxidative stress-dependent p38MAPK and JNK pathway.

Authors:
Xiao Yu Tian Lai Hang Yung Wing Tak Wong Jian Liu Fung Ping Leung Limei Liu Yangchao Chen Siu Kai Kong Kin Ming Kwan Siu Man Ng Paul B S Lai Lai Ming Yung Xiaoqiang Yao Yu Huang

J Mol Cell Cardiol 2012 Jan 25;52(1):237-44. Epub 2011 Oct 25.

Institute of Vascular Medicine, Li Ka Shing Institute of Health Sciences, School of Biomedical Sciences, Chinese University of Hong Kong, Hong Kong SAR, China.

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http://dx.doi.org/10.1016/j.yjmcc.2011.10.013DOI Listing
January 2012

Interaction between ZBP-89 and p53 mutants and its contribution to effects of HDACi on hepatocellular carcinoma.

Authors:
Chris Z Y Zhang George G Chen Juanita L Merchant Paul B S Lai

Cell Cycle 2012 Jan 15;11(2):322-34. Epub 2012 Jan 15.

Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT Hong Kong.

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http://www.tandfonline.com/doi/abs/10.4161/cc.11.2.18758
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293381PMC
January 2012

Utility of a preoperative assessment clinic in a tertiary care hospital.

Authors:
Frank W K Chan Fiona Y Y Wong Y S Cheung P T Chui Paul B S Lai

Hong Kong Med J 2011 Dec;17(6):441-5

School of Public Health and Primary Care, The Chinese University of Hong Kong, Shatin, Hong Kong.

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December 2011

Single-incision laparoscopic cholecystectomy: from four wounds to one.

Authors:
Jeff S W Wong Y S Cheung K W Chan Charing C N Chong K F Lee John Wong Paul B S Lai

Hong Kong Med J 2011 Dec;17(6):465-8

Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong.

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December 2011

Malpractice claims: corrections.

Authors:
David S Y Wong Paul B S Lai

Hong Kong Med J 2011 Dec;17(6):516-7

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December 2011

Malpractice claims: prevention is often a better strategy.

Authors:
David S Y Wong Paul B S Lai

Hong Kong Med J 2011 Oct;17(5):425-6

Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.

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October 2011

Trichostatin A sensitizes HBx-expressing liver cancer cells to etoposide treatment.

Authors:
Chris Z Y Zhang H T Zhang George G Chen Paul B S Lai

Apoptosis 2011 Jul;16(7):683-95

Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong.

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http://link.springer.com/10.1007/s10495-011-0597-x
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http://dx.doi.org/10.1007/s10495-011-0597-xDOI Listing
July 2011

Block of proliferation 1 (BOP1) plays an oncogenic role in hepatocellular carcinoma by promoting epithelial-to-mesenchymal transition.

Authors:
Kit-Ying Chung Ibis K-C Cheng Arthur K-K Ching Jian-Hong Chu Paul B-S Lai Nathalie Wong

Hepatology 2011 Jul;54(1):307-18

Department of Anatomical and Cellular Pathology, Li Ka-Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1002/hep.24372DOI Listing
July 2011

Early risk stratification of patients with major trauma requiring massive blood transfusion.

Authors:
Timothy H Rainer Anthony M-H Ho Janice H H Yeung Nai Kwong Cheung Raymond S M Wong Ning Tang Siu Keung Ng George K C Wong Paul B S Lai Colin A Graham

Resuscitation 2011 Jun 1;82(6):724-9. Epub 2011 Apr 1.

Department of Accident and Emergency Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong.

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http://dx.doi.org/10.1016/j.resuscitation.2011.02.016DOI Listing
June 2011

Sirtuin 1 is upregulated in a subset of hepatocellular carcinomas where it is essential for telomere maintenance and tumor cell growth.

Authors:
Juan Chen Bin Zhang Nathalie Wong Anthony W I Lo Ka-Fai To Anthony W H Chan Margaret H L Ng Cecilia Y S Ho Suk-Hang Cheng Paul B S Lai Jun Yu Ho-Keung Ng Ming-Tat Ling Ai-Long Huang Xue-Fei Cai Ben C B Ko

Cancer Res 2011 Jun 28;71(12):4138-49. Epub 2011 Apr 28.

The State Key Laboratory in Oncology in South China, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-4274DOI Listing
June 2011

Heat-shock protein 60 translocates to the surface of apoptotic cells and differentiated megakaryocytes and stimulates phagocytosis.

Authors:
Yaw Chong Goh Celestial T Yap Bao Hua Huang Andrew D Cronshaw Bernard P Leung Paul B S Lai Simon P Hart Ian Dransfield James A Ross

Cell Mol Life Sci 2011 May 16;68(9):1581-92. Epub 2010 Oct 16.

Department of Surgery, Singapore General Hospital, Singapore, Singapore.

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http://dx.doi.org/10.1007/s00018-010-0534-0DOI Listing
May 2011

Novel therapeutic potential in targeting microtubules by nanoparticle albumin-bound paclitaxel in hepatocellular carcinoma.

Authors:
Qian Zhou Arthur K-K Ching Wilson K-C Leung Carol Y-Y Szeto Shuk-Mei Ho Paul K-S Chan Yun-Fei Yuan Paul B-S Lai Winnie Yeo Nathalie Wong

Int J Oncol 2011 Mar 14;38(3):721-31. Epub 2011 Jan 14.

Department of Clinical Oncology, Chinese University of Hong Kong, Shatin, Hong Kong, People's Republic of China.

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http://dx.doi.org/10.3892/ijo.2011.902DOI Listing
March 2011

Prospective validation of the Chinese University Prognostic Index and comparison with other staging systems for hepatocellular carcinoma in an Asian population.

Authors:
Stephen L Chan Frankie K F Mo Philip J Johnson Giok S Liem Tung C Chan Ming C Poon Brigette B Y Ma Thomas W T Leung Paul B S Lai Anthony T C Chan Tony S K Mok Winnie Yeo

J Gastroenterol Hepatol 2011 Feb;26(2):340-7

State Key Laboratory in Oncology in South China, Sir YK Pao Centre for Cancer, Department of Clinical Oncology, Hong Kong Cancer Institute, Hong Kong, China.

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http://dx.doi.org/10.1111/j.1440-1746.2010.06329.xDOI Listing
February 2011

ZBP-89 enhances Bak expression and causes apoptosis in hepatocellular carcinoma cells.

Authors:
Ann K Y To George G Chen Ursula P F Chan Caiguo Ye Jing P Yun Rocky L K Ho Art Tessier Juanita L Merchant Paul B S Lai

Biochim Biophys Acta 2011 Jan 17;1813(1):222-30. Epub 2010 Sep 17.

Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong.

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http://dx.doi.org/10.1016/j.bbamcr.2010.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051301PMC
January 2011

Susceptibility of Hep3B cells in different phases of cell cycle to tBid.

Authors:
Shi-Hong Ma George G Chen Caiguo Ye Billy C S Leung Rocky L K Ho Paul B S Lai

Biochim Biophys Acta 2011 Jan 20;1813(1):179-85. Epub 2010 Oct 20.

Department of Surgery, The Chinese University of Hong Kong, Shatin, Hong Kong.

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http://dx.doi.org/10.1016/j.bbamcr.2010.10.009DOI Listing
January 2011

A proteomic approach in investigating the hepatoprotective mechanism of Schisandrin B: role of raf kinase inhibitor protein.

Authors:
Yan Chen Siu-Po Ip Kam-Ming Ko Terence C W Poon Eddy W Y Ng Paul B S Lai Qing-Qiu Mao Yan-Fang Xian Chun-Tao Che

J Proteome Res 2011 Jan 14;10(1):299-304. Epub 2010 Dec 14.

School of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.

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http://dx.doi.org/10.1021/pr100871hDOI Listing
January 2011

miR-130b Promotes CD133(+) liver tumor-initiating cell growth and self-renewal via tumor protein 53-induced nuclear protein 1.

Authors:
Stephanie Ma Kwan Ho Tang Yuen Piu Chan Terence K Lee Pak Shing Kwan Antonia Castilho Irene Ng Kwan Man Nathalie Wong Ka-Fai To Bo-Jian Zheng Paul B S Lai Chung Mau Lo Kwok Wah Chan Xin-Yuan Guan

Cell Stem Cell 2010 Dec;7(6):694-707

Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong.

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http://dx.doi.org/10.1016/j.stem.2010.11.010DOI Listing
December 2010

Resection margin in laparoscopic hepatectomy: a comparative study between wedge resection and anatomic left lateral sectionectomy.

Authors:
Kit-fai Lee Jeff Wong Yue-sun Cheung Philip Ip John Wong Paul B S Lai

HPB (Oxford) 2010 Nov;12(9):649-53

Division of Hepato-biliary and Pancreatic Surgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1111/j.1477-2574.2010.00221.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999793PMC
November 2010

Enhanced detection of early hepatocellular carcinoma by serum SELDI-TOF proteomic signature combined with alpha-fetoprotein marker.

Authors:
Lei Chen David W Y Ho Nikki P Y Lee Stella Sun Brian Lam Kwong-Fai Wong Xin Yi George K Lau Eddy W Y Ng Terence C W Poon Paul B S Lai Zongwei Cai Jirun Peng Xisheng Leng Ronnie T P Poon John M Luk

Ann Surg Oncol 2010 Sep 31;17(9):2518-25. Epub 2010 Mar 31.

Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China.

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http://dx.doi.org/10.1245/s10434-010-1038-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924503PMC
September 2010

Apoptosis in carcinogenesis and cancer therapy.

Authors:
George G Chen Paul B S Lai

Curr Cancer Drug Targets 2010 Sep;10(6):554

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http://dx.doi.org/10.2174/156800910791859470DOI Listing
September 2010

A community-acquired methicillin-resistant Staphylococcus aureus liver abscess.

Authors:
Vivien W Y Wong Y S Cheung John Wong K F Lee Paul B S Lai

Hong Kong Med J 2010 Jun;16(3):227-9

Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.

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June 2010

Cytotoxic effects of tanshinones from Salvia miltiorrhiza on doxorubicin-resistant human liver cancer cells.

Authors:
Wayne Y W Lee Chartia C M Cheung Ken W K Liu K P Fung John Wong Paul B S Lai John H K Yeung

J Nat Prod 2010 May;73(5):854-9

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, People's Republic of China.

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http://pubs.acs.org/doi/abs/10.1021/np900792p
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May 2010