Paul B Lai

Paul B S Lai

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Paul B S Lai

Publications by authors named "Paul B S Lai"

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1PubMed Central Citations

Impact of Intermittent Pringle Maneuver on Long-Term Survival After Hepatectomy for Hepatocellular Carcinoma: Result from Two Combined Randomized Controlled Trials.

World J Surg 2019 Dec;43(12):3101-3109

Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, 30-32, Ngan Shing Street, Shatin, N.T., Hong Kong SAR, China.

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http://dx.doi.org/10.1007/s00268-019-05130-8DOI Listing
December 2019

Genomic and Epigenomic Features of Primary and Recurrent Hepatocellular Carcinomas.

Gastroenterology 2019 Dec 24;157(6):1630-1645.e6. Epub 2019 Sep 24.

Department of Anatomical and Cellular Pathology at Sir Y.K. Pao Centre for Cancer, The Chinese University of Hong Kong, Shatin, Hong Kong, China; Department of Surgery, The Chinese University of Hong Kong, Shatin, Hong Kong, China; State Key Laboratory of Translational Oncology, The Chinese University of Hong Kong, Shatin, Hong Kong, China; State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Shatin, Hong Kong, China. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2019.09.005DOI Listing
December 2019

Robotic versus laparoscopic hepatectomy: application of the difficulty scoring system.

Surg Endosc 2019 Jul 16. Epub 2019 Jul 16.

Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.

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http://dx.doi.org/10.1007/s00464-019-06976-8DOI Listing
July 2019

ER-residential Nogo-B accelerates NAFLD-associated HCC mediated by metabolic reprogramming of oxLDL lipophagy.

Nat Commun 2019 07 29;10(1):3391. Epub 2019 Jul 29.

Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, China.

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http://dx.doi.org/10.1038/s41467-019-11274-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662851PMC
July 2019

Successful robotic extirpation of diaphragmatic seeding of hepatocellular carcinoma after previous rupture.

J Robot Surg 2019 Jun 29;13(3):525-528. Epub 2018 Sep 29.

Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, 30-32, Ngan Shing Street, Shatin, N.T., Hong Kong SAR, China.

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http://dx.doi.org/10.1007/s11701-018-0880-8DOI Listing
June 2019

Correlations of health-related quality of life with serum inflammatory indicators IL-8 and mIBI in patients with hepatocellular carcinoma.

Cancer Manag Res 2019 4;11:2719-2727. Epub 2019 Apr 4.

Department of Clinical Oncology, Prince of Wales Hospital, Faculty of Medicine, Hong Kong Cancer Institute, State Key Laboratory of Translational Oncology, The Chinese University of Hong Kong, Hong Kong SAR,

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https://www.dovepress.com/correlations-of-health-related-qua
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http://dx.doi.org/10.2147/CMAR.S178482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452825PMC
April 2019

Homology-independent multiallelic disruption via CRISPR/Cas9-based knock-in yields distinct functional outcomes in human cells.

BMC Biol 2018 12 28;16(1):151. Epub 2018 Dec 28.

School of Biomedical Sciences, CUHK-GIBH CAS Joint Laboratory on Stem Cell and Regenerative Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, Special Administrative Region of China.

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http://dx.doi.org/10.1186/s12915-018-0616-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310992PMC
December 2018

Cancer stem cells in hepatocellular carcinoma: an overview and promising therapeutic strategies.

Ther Adv Med Oncol 2018 21;10:1758835918816287. Epub 2018 Dec 21.

Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China.

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http://dx.doi.org/10.1177/1758835918816287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304707PMC
December 2018

Does Intermittent Pringle Maneuver Increase Postoperative Complications After Hepatectomy for Hepatocellular Carcinoma? A Randomized Controlled Trial.

World J Surg 2018 10;42(10):3302-3311

Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, 30-32, Ngan Shing Street, Shatin, N.T., Hong Kong SAR, China.

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http://dx.doi.org/10.1007/s00268-018-4637-3DOI Listing
October 2018

Targeting ZBP-89 for the treatment of hepatocellular carcinoma.

Expert Opin Ther Targets 2018 10 6;22(10):817-822. Epub 2018 Sep 6.

a Department of Surgery, Faculty of Medicine , The Chinese University of Hong Kong, Prince of Wales Hospital , Hong Kong , China.

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http://dx.doi.org/10.1080/14728222.2018.1516753DOI Listing
October 2018

Pattern of disease recurrence and its implications for postoperative surveillance after curative hepatectomy for hepatocellular carcinoma: experience from a single center.

Hepatobiliary Surg Nutr 2018 Oct;7(5):320-330

Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, Prince of Wales Hospital, the Chinese University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.21037/hbsn.2018.03.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230848PMC
October 2018

Liver- and Colon-Specific DNA Methylation Markers in Plasma for Investigation of Colorectal Cancers with or without Liver Metastases.

Clin Chem 2018 08 14;64(8):1239-1249. Epub 2018 Jun 14.

Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China;

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http://dx.doi.org/10.1373/clinchem.2018.290304DOI Listing
August 2018

ID1-induced p16/IL6 axis activation contributes to the resistant of hepatocellular carcinoma cells to sorafenib.

Cell Death Dis 2018 08 28;9(9):852. Epub 2018 Aug 28.

Department of Surgery, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong, China.

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http://dx.doi.org/10.1038/s41419-018-0926-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113298PMC
August 2018

Microwave ablation provides better survival than liver resection for hepatocellular carcinoma in patients with borderline liver function: application of ALBI score to patient selection.

HPB (Oxford) 2018 06 17;20(6):546-554. Epub 2018 Jan 17.

Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The Chinese University of Hong Kong, Hong Kong; Institute of Digestive Disease, Partner State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong. Electronic address:

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http://dx.doi.org/10.1016/j.hpb.2017.12.001DOI Listing
June 2018

Robot-assisted minimally invasive procedures for complicated biliary stone disease.

Hepatobiliary Surg Nutr 2018 Jun;7(3):185-188

Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China.

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http://dx.doi.org/10.21037/hbsn.2017.05.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036073PMC
June 2018

Circulating Tumor Cells from Different Vascular Sites Exhibit Spatial Heterogeneity in Epithelial and Mesenchymal Composition and Distinct Clinical Significance in Hepatocellular Carcinoma.

Clin Cancer Res 2018 02 25;24(3):547-559. Epub 2017 Oct 25.

Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, P.R. China.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-1063DOI Listing
February 2018

A new VLAD-based control chart for detecting surgical outcomes.

Stat Med 2017 Dec 7;36(28):4540-4547. Epub 2017 Jun 7.

Department of Surgery, The Chinese University of Hong Kong, Shatin, Hong Kong.

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http://dx.doi.org/10.1002/sim.7362DOI Listing
December 2017

New insights into sorafenib resistance in hepatocellular carcinoma: Responsible mechanisms and promising strategies.

Biochim Biophys Acta Rev Cancer 2017 Dec 17;1868(2):564-570. Epub 2017 Oct 17.

Department of Surgery, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, China; Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, Guangdong, China. Electronic address:

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http://dx.doi.org/10.1016/j.bbcan.2017.10.002DOI Listing
December 2017

A phase 2 study of the efficacy and biomarker on the combination of transarterial chemoembolization and axitinib in the treatment of inoperable hepatocellular carcinoma.

Cancer 2017 Oct 22;123(20):3977-3985. Epub 2017 Jun 22.

Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong.

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http://dx.doi.org/10.1002/cncr.30825DOI Listing
October 2017

Positive Expression of Programmed Death Ligand 1 in Peritumoral Liver Tissue is Associated with Poor Survival after Curative Resection of Hepatocellular Carcinoma.

Transl Oncol 2017 Aug 27;10(4):511-517. Epub 2017 May 27.

Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. Electronic address:

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http://dx.doi.org/10.1016/j.tranon.2017.03.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447656PMC
August 2017

Topical Therapy with Mesenchymal Stem Cells Following an Acute Experimental Head Injury Has Benefits in Motor-Behavioral Tests for Rodents.

Acta Neurochir Suppl 2016 ;122:21-4

Division of Neurosurgery, Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China.

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http://dx.doi.org/10.1007/978-3-319-22533-3_4DOI Listing
July 2017

Incorporating albumin-bilirubin grade into the cancer of the liver Italian program system for hepatocellular carcinoma.

J Gastroenterol Hepatol 2017 Jan;32(1):221-228

Department of Clinical Oncology, State Key Laboratory in Oncology in South China, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.

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http://dx.doi.org/10.1111/jgh.13457DOI Listing
January 2017

Steatotic hepatocellular carcinoma: a variant associated with metabolic factors and late tumour relapse.

Histopathology 2016 Dec 9;69(6):971-984. Epub 2016 Sep 9.

Department of Anatomical and Cellular Pathology, State Key Laboratory in Oncology in South China, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.

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http://doi.wiley.com/10.1111/his.13029
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http://dx.doi.org/10.1111/his.13029DOI Listing
December 2016

Alternative splicing of estrogen receptor alpha in hepatocellular carcinoma.

BMC Cancer 2016 11 30;16(1):926. Epub 2016 Nov 30.

Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, Special Administrative Region of China.

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http://dx.doi.org/10.1186/s12885-016-2928-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129602PMC
November 2016

Robotic Liver Resection For Primary Hepatolithiasis: Is It Beneficial?

World J Surg 2016 Oct;40(10):2490-6

Division of Hepato-biliary and Pancreatic Surgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, 30-32, Ngan Shing Street, Shatin N.T., Hong Kong, SAR, China.

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http://dx.doi.org/10.1007/s00268-016-3528-8DOI Listing
October 2016

Applicability of albumin-bilirubin-based Japan integrated staging score in hepatitis B-associated hepatocellular carcinoma.

J Gastroenterol Hepatol 2016 Oct;31(10):1766-1772

Department of Clinical Oncology, State Key Laboratory in Oncology in South China, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.

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http://dx.doi.org/10.1111/jgh.13339DOI Listing
October 2016

Cytochrome P450 1A2 Metabolizes 17β-Estradiol to Suppress Hepatocellular Carcinoma.

PLoS One 2016 19;11(4):e0153863. Epub 2016 Apr 19.

Department of Surgery, Faculty of Medicine, The Chinese University of Hong Kong; New Territories, Hong Kong, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0153863PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836701PMC
September 2016

Distinguished prognosis after hepatectomy of HBV-related hepatocellular carcinoma with or without cirrhosis: a long-term follow-up analysis.

J Gastroenterol 2016 Jul 25;51(7):722-32. Epub 2015 Nov 25.

Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China.

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http://dx.doi.org/10.1007/s00535-015-1146-0DOI Listing
July 2016

Integration of albumin-bilirubin (ALBI) score into Barcelona Clinic Liver Cancer (BCLC) system for hepatocellular carcinoma.

J Gastroenterol Hepatol 2016 Jul;31(7):1300-6

Department of Clinical Oncology, State Key Laboratory in Oncology in South China, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong kong.

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http://doi.wiley.com/10.1111/jgh.13291
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http://dx.doi.org/10.1111/jgh.13291DOI Listing
July 2016

Cancer Specific Long Noncoding RNAs Show Differential Expression Patterns and Competing Endogenous RNA Potential in Hepatocellular Carcinoma.

PLoS One 2015 22;10(10):e0141042. Epub 2015 Oct 22.

Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0141042PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619599PMC
June 2016

Downregulation and pro-apoptotic effect of hypoxia-inducible factor 2 alpha in hepatocellular carcinoma.

Oncotarget 2016 Jun;7(23):34571-81

Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong, China.

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http://dx.doi.org/10.18632/oncotarget.8952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085177PMC
June 2016

A Seven-microRNA Expression Signature Predicts Survival in Hepatocellular Carcinoma.

PLoS One 2015 5;10(6):e0128628. Epub 2015 Jun 5.

Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0128628PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457814PMC
March 2016

Laparoscopic and robotic hepatectomy: experience from a single centre.

ANZ J Surg 2016 Mar 30;86(3):122-6. Epub 2015 Sep 30.

Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China.

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http://dx.doi.org/10.1111/ans.13339DOI Listing
March 2016

Prognostic Nutritional Index (PNI) Predicts Tumor Recurrence of Very Early/Early Stage Hepatocellular Carcinoma After Surgical Resection.

Ann Surg Oncol 2015 Dec 24;22(13):4138-48. Epub 2015 Mar 24.

Department of Anatomical and Cellular Pathology, State Key Laboratory in Oncology in South China, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong.

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http://dx.doi.org/10.1245/s10434-015-4516-1DOI Listing
December 2015

The practice of mediation to resolve clinical, bioethical, and medical malpractice disputes.

Hong Kong Med J 2015 Dec;21(6):560-4

Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.

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http://dx.doi.org/10.12809/hkmj154615DOI Listing
December 2015

Histone Deacetylase HDAC8 Promotes Insulin Resistance and β-Catenin Activation in NAFLD-Associated Hepatocellular Carcinoma.

Cancer Res 2015 Nov 17;75(22):4803-16. Epub 2015 Sep 17.

Department of Medicine and Therapeutics and Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, PR China. State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, PR China.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-3786DOI Listing
November 2015

Albumin-to-alkaline phosphatase ratio: a novel prognostic index for hepatocellular carcinoma.

Dis Markers 2015 9;2015:564057. Epub 2015 Feb 9.

Department of Anatomical and Cellular Pathology, State Key Laboratory in Oncology in South China, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong ; Institute of Digestive Disease, Partner State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Shatin, Hong Kong ; Li Ka Shing Institute of Health Science, Sir Y. K. Pao Cancer Centre, The Chinese University of Hong Kong, Shatin, Hong Kong.

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http://dx.doi.org/10.1155/2015/564057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337043PMC
October 2015

Plasma DNA tissue mapping by genome-wide methylation sequencing for noninvasive prenatal, cancer, and transplantation assessments.

Proc Natl Acad Sci U S A 2015 Oct 21;112(40):E5503-12. Epub 2015 Sep 21.

Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China; Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China; State Key Laboratory in Oncology in South China, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China;

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http://dx.doi.org/10.1073/pnas.1508736112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603482PMC
October 2015

Truncated HBx-dependent silencing of GAS2 promotes hepatocarcinogenesis through deregulation of cell cycle, senescence and p53-mediated apoptosis.

J Pathol 2015 Sep 28;237(1):38-49. Epub 2015 May 28.

Institute of Digestive Disease and State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, SAR, China.

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http://dx.doi.org/10.1002/path.4554DOI Listing
September 2015

Endoscopic Resection for Early Gastric Cancer: What is the Limit?

Ann Surg Oncol 2015 Jun 10;22(6):1753-4. Epub 2015 Feb 10.

Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China.

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http://dx.doi.org/10.1245/s10434-014-4312-3DOI Listing
June 2015

A CCRK-EZH2 epigenetic circuitry drives hepatocarcinogenesis and associates with tumor recurrence and poor survival of patients.

J Hepatol 2015 May 9;62(5):1100-11. Epub 2014 Dec 9.

School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China; State Key Laboratory of Digestive Disease and Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2014.11.040DOI Listing
May 2015

Novel recurrently mutated genes and a prognostic mutation signature in colorectal cancer.

Gut 2015 Apr 20;64(4):636-45. Epub 2014 Jun 20.

Department of Medicine & Therapeutics, State Key Laboratory of Digestive Disease, Institute of Digestive Disease and LKS Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong.

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http://dx.doi.org/10.1136/gutjnl-2013-306620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392212PMC
April 2015

Lengthening and shortening of plasma DNA in hepatocellular carcinoma patients.

Proc Natl Acad Sci U S A 2015 Mar 2;112(11):E1317-25. Epub 2015 Feb 2.

Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong; Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong; State Key Laboratory in Oncology in South China, Sir Y. K. Pao Centre for Cancer, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong;

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http://dx.doi.org/10.1073/pnas.1500076112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372002PMC
March 2015

Lymphoepithelioma-like hepatocellular carcinoma: an uncommon variant of hepatocellular carcinoma with favorable outcome.

Am J Surg Pathol 2015 Mar;39(3):304-12

Departments of *Anatomical and Cellular Pathology §Clinical Oncology, State Key Laboratory in Oncology in South China, Prince of Wales Hospital †Institute of Digestive Disease, Partner State Key Laboratory of Digestive Disease ‡Li Ka Shing Institute of Health Science, Sir Y.K. Pao Cancer Center ∥Department of Medicine and Therapeutics ¶Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, The Chinese University of Hong Kong, Hong Kong.

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http://pdfs.journals.lww.com/ajsp/2015/03000/Lymphoepithelio
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/PAS.0000000000000376DOI Listing
March 2015

ZBP-89 reduces histone deacetylase 3 by degrading IkappaB in the presence of Pin1.

J Transl Med 2015 Jan 27;13:23. Epub 2015 Jan 27.

Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, NT, P. R. China.

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http://dx.doi.org/10.1186/s12967-015-0382-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311446PMC
January 2015

Cell cycle-related kinase mediates viral-host signalling to promote hepatitis B virus-associated hepatocarcinogenesis.

Gut 2014 Nov 17;63(11):1793-804. Epub 2014 Jan 17.

School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong SAR, P. R. China State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, P. R. China.

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http://dx.doi.org/10.1136/gutjnl-2013-305584DOI Listing
November 2014

Epstein-Barr virus-associated lymphoepithelioma-like cholangiocarcinoma: a rare variant of intrahepatic cholangiocarcinoma with favourable outcome.

Histopathology 2014 Nov 2;65(5):674-83. Epub 2014 Sep 2.

State Key Laboratory in Oncology in South China, Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong.

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http://dx.doi.org/10.1111/his.12455DOI Listing
November 2014

Overexpression of ZFX confers self-renewal and chemoresistance properties in hepatocellular carcinoma.

Int J Cancer 2014 Oct 11;135(8):1790-9. Epub 2014 Mar 11.

Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong, China.

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http://dx.doi.org/10.1002/ijc.28819DOI Listing
October 2014

International validation of the Chinese university prognostic index for staging of hepatocellular carcinoma: a joint United Kingdom and Hong Kong study.

Chin J Cancer 2014 Oct 16;33(10):481-91. Epub 2014 Sep 16.

State Key Laboratory in Oncology in South China, Sir YK Pao Center for Cancer, Department of Clinical Oncology, Hong Kong Cancer Institute and Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China.

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http://dx.doi.org/10.5732/cjc.014.10133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198751PMC
October 2014

Expression of stemness markers (CD133 and EpCAM) in prognostication of hepatocellular carcinoma.

Histopathology 2014 Jun 7;64(7):935-50. Epub 2014 Feb 7.

Department of Anatomical and Cellular Pathology, State Key Laboratory in Oncology in South China, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.

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http://dx.doi.org/10.1111/his.12342DOI Listing
June 2014

Therapeutic efficacy of improved α-fetoprotein promoter-mediated tBid delivered by folate-PEI600-cyclodextrin nanopolymer vector in hepatocellular carcinoma.

Exp Cell Res 2014 Jun 13;324(2):183-91. Epub 2014 Apr 13.

Department of Surgery, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China.

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http://dx.doi.org/10.1016/j.yexcr.2014.04.005DOI Listing
June 2014

Performance of serum α-fetoprotein levels in the diagnosis of hepatocellular carcinoma in patients with a hepatic mass.

HPB (Oxford) 2014 Apr 26;16(4):366-72. Epub 2013 Aug 26.

State Key Laboratory in Oncology in South China, Sir Y. K. Pao Centre for Cancer, Department of Clinical Oncology, Hong Kong Cancer Institute, Hong Kong, China.

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http://dx.doi.org/10.1111/hpb.12146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967889PMC
April 2014

Viral-human chimeric transcript predisposes risk to liver cancer development and progression.

Cancer Cell 2014 Mar 27;25(3):335-49. Epub 2014 Feb 27.

Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Shatin, Hong Kong, China; State Key Laboratory in Oncology in South China, The Chinese University of Hong Kong, Shatin, Hong Kong, China; State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Shatin, Hong Kong, China. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2014.01.030DOI Listing
March 2014

Epigenetic upregulation of Bak by ZBP-89 inhibits the growth of hepatocellular carcinoma.

Biochim Biophys Acta 2013 Dec 13;1833(12):2970-2979. Epub 2013 Aug 13.

Department of Surgery, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.

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http://dx.doi.org/10.1016/j.bbamcr.2013.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160027PMC
December 2013

SIRT2 overexpression in hepatocellular carcinoma mediates epithelial to mesenchymal transition by protein kinase B/glycogen synthase kinase-3β/β-catenin signaling.

Hepatology 2013 Jun 26;57(6):2287-98. Epub 2013 Apr 26.

The Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, China.

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http://dx.doi.org/10.1002/hep.26278DOI Listing
June 2013

Enhancer of zeste homolog 2 silences microRNA-218 in human pancreatic ductal adenocarcinoma cells by inducing formation of heterochromatin.

Gastroenterology 2013 May 7;144(5):1086-1097.e9. Epub 2013 Feb 7.

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong.

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http://dx.doi.org/10.1053/j.gastro.2013.01.058DOI Listing
May 2013

Enzyme kinetic and molecular docking studies for the inhibitions of miltirone on major human cytochrome P450 isozymes.

Phytomedicine 2013 Feb 25;20(3-4):367-74. Epub 2012 Oct 25.

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China.

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http://dx.doi.org/10.1016/j.phymed.2012.09.021DOI Listing
February 2013

Histone deacetylase inhibitors facilitate dihydroartemisinin-induced apoptosis in liver cancer in vitro and in vivo.

PLoS One 2012 28;7(6):e39870. Epub 2012 Jun 28.

State Key Laboratory of Oncology in Southern China, Sun Yat-Sen University Cancer Center, Guangzhou, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0039870PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386188PMC
January 2013

Cancer genome scanning in plasma: detection of tumor-associated copy number aberrations, single-nucleotide variants, and tumoral heterogeneity by massively parallel sequencing.

Clin Chem 2013 Jan 11;59(1):211-24. Epub 2012 Oct 11.

Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China.

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http://dx.doi.org/10.1373/clinchem.2012.196014DOI Listing
January 2013

Ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic-acid inhibits hepatocellular carcinoma in vitro and in vivo via stabilizing IkBα.

Invest New Drugs 2012 Dec 7;30(6):2210-8. Epub 2012 Jan 7.

Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.

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http://dx.doi.org/10.1007/s10637-011-9791-5DOI Listing
December 2012

GEF-H1 over-expression in hepatocellular carcinoma promotes cell motility via activation of RhoA signalling.

J Pathol 2012 Dec 28;228(4):575-85. Epub 2012 Sep 28.

Department of Anatomical and Cellular Pathology, Li Ka-Shing Institute of Health Sciences, Chinese University of Hong Kong, Shatin, Hong Kong, People's Republic of China; Department of Nutrition and Food Management, HKU SPACE Po Leung Kuk Community College, Hong Kong, People's Republic of China.

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http://doi.wiley.com/10.1002/path.4084
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http://dx.doi.org/10.1002/path.4084DOI Listing
December 2012

Sorafenib inhibits hypoxia-inducible factor-1α synthesis: implications for antiangiogenic activity in hepatocellular carcinoma.

Clin Cancer Res 2012 Oct 28;18(20):5662-71. Epub 2012 Aug 28.

Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-12-0552DOI Listing
October 2012

Increased expression of ZBP-89 and its prognostic significance in hepatocellular carcinoma.

Histopathology 2012 Jun 28;60(7):1114-24. Epub 2012 Feb 28.

Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong.

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http://dx.doi.org/10.1111/j.1365-2559.2011.04136.xDOI Listing
June 2012

Induction of autophagy in hepatocellular carcinoma cells by SB203580 requires activation of AMPK and DAPK but not p38 MAPK.

Apoptosis 2012 Apr;17(4):325-34

Department of Surgery, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, China.

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http://link.springer.com/10.1007/s10495-011-0685-y
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http://dx.doi.org/10.1007/s10495-011-0685-yDOI Listing
April 2012

Surgical ablation of hepatocellular carcinoma with 2.45-GHz microwave: a critical appraisal of treatment outcomes.

Hong Kong Med J 2012 Apr;18(2):85-91

Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong.

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April 2012

Bone morphogenic protein-4 induces endothelial cell apoptosis through oxidative stress-dependent p38MAPK and JNK pathway.

J Mol Cell Cardiol 2012 Jan 25;52(1):237-44. Epub 2011 Oct 25.

Institute of Vascular Medicine, Li Ka Shing Institute of Health Sciences, School of Biomedical Sciences, Chinese University of Hong Kong, Hong Kong SAR, China.

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http://dx.doi.org/10.1016/j.yjmcc.2011.10.013DOI Listing
January 2012

Interaction between ZBP-89 and p53 mutants and its contribution to effects of HDACi on hepatocellular carcinoma.

Cell Cycle 2012 Jan 15;11(2):322-34. Epub 2012 Jan 15.

Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT Hong Kong.

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http://www.tandfonline.com/doi/abs/10.4161/cc.11.2.18758
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http://dx.doi.org/10.4161/cc.11.2.18758DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293381PMC
January 2012

Utility of a preoperative assessment clinic in a tertiary care hospital.

Hong Kong Med J 2011 Dec;17(6):441-5

School of Public Health and Primary Care, The Chinese University of Hong Kong, Shatin, Hong Kong.

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December 2011

Single-incision laparoscopic cholecystectomy: from four wounds to one.

Hong Kong Med J 2011 Dec;17(6):465-8

Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong.

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December 2011

Malpractice claims: corrections.

Hong Kong Med J 2011 Dec;17(6):516-7

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December 2011

Malpractice claims: prevention is often a better strategy.

Hong Kong Med J 2011 Oct;17(5):425-6

Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.

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October 2011

Trichostatin A sensitizes HBx-expressing liver cancer cells to etoposide treatment.

Apoptosis 2011 Jul;16(7):683-95

Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong.

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http://link.springer.com/10.1007/s10495-011-0597-x
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http://dx.doi.org/10.1007/s10495-011-0597-xDOI Listing
July 2011

Block of proliferation 1 (BOP1) plays an oncogenic role in hepatocellular carcinoma by promoting epithelial-to-mesenchymal transition.

Hepatology 2011 Jul;54(1):307-18

Department of Anatomical and Cellular Pathology, Li Ka-Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1002/hep.24372DOI Listing
July 2011

Early risk stratification of patients with major trauma requiring massive blood transfusion.

Resuscitation 2011 Jun 1;82(6):724-9. Epub 2011 Apr 1.

Department of Accident and Emergency Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong.

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http://dx.doi.org/10.1016/j.resuscitation.2011.02.016DOI Listing
June 2011

Sirtuin 1 is upregulated in a subset of hepatocellular carcinomas where it is essential for telomere maintenance and tumor cell growth.

Cancer Res 2011 Jun 28;71(12):4138-49. Epub 2011 Apr 28.

The State Key Laboratory in Oncology in South China, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-4274DOI Listing
June 2011

Heat-shock protein 60 translocates to the surface of apoptotic cells and differentiated megakaryocytes and stimulates phagocytosis.

Cell Mol Life Sci 2011 May 16;68(9):1581-92. Epub 2010 Oct 16.

Department of Surgery, Singapore General Hospital, Singapore, Singapore.

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http://dx.doi.org/10.1007/s00018-010-0534-0DOI Listing
May 2011

Novel therapeutic potential in targeting microtubules by nanoparticle albumin-bound paclitaxel in hepatocellular carcinoma.

Int J Oncol 2011 Mar 14;38(3):721-31. Epub 2011 Jan 14.

Department of Clinical Oncology, Chinese University of Hong Kong, Shatin, Hong Kong, People's Republic of China.

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http://dx.doi.org/10.3892/ijo.2011.902DOI Listing
March 2011

Prospective validation of the Chinese University Prognostic Index and comparison with other staging systems for hepatocellular carcinoma in an Asian population.

J Gastroenterol Hepatol 2011 Feb;26(2):340-7

State Key Laboratory in Oncology in South China, Sir YK Pao Centre for Cancer, Department of Clinical Oncology, Hong Kong Cancer Institute, Hong Kong, China.

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http://dx.doi.org/10.1111/j.1440-1746.2010.06329.xDOI Listing
February 2011

ZBP-89 enhances Bak expression and causes apoptosis in hepatocellular carcinoma cells.

Biochim Biophys Acta 2011 Jan 17;1813(1):222-30. Epub 2010 Sep 17.

Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong.

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http://dx.doi.org/10.1016/j.bbamcr.2010.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051301PMC
January 2011

Susceptibility of Hep3B cells in different phases of cell cycle to tBid.

Biochim Biophys Acta 2011 Jan 20;1813(1):179-85. Epub 2010 Oct 20.

Department of Surgery, The Chinese University of Hong Kong, Shatin, Hong Kong.

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http://dx.doi.org/10.1016/j.bbamcr.2010.10.009DOI Listing
January 2011

A proteomic approach in investigating the hepatoprotective mechanism of Schisandrin B: role of raf kinase inhibitor protein.

J Proteome Res 2011 Jan 14;10(1):299-304. Epub 2010 Dec 14.

School of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.

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http://dx.doi.org/10.1021/pr100871hDOI Listing
January 2011

Resection margin in laparoscopic hepatectomy: a comparative study between wedge resection and anatomic left lateral sectionectomy.

HPB (Oxford) 2010 Nov;12(9):649-53

Division of Hepato-biliary and Pancreatic Surgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1111/j.1477-2574.2010.00221.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999793PMC
November 2010

Apoptosis in carcinogenesis and cancer therapy.

Curr Cancer Drug Targets 2010 Sep;10(6):554

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http://dx.doi.org/10.2174/156800910791859470DOI Listing
September 2010

A community-acquired methicillin-resistant Staphylococcus aureus liver abscess.

Hong Kong Med J 2010 Jun;16(3):227-9

Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.

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June 2010

Cytotoxic effects of tanshinones from Salvia miltiorrhiza on doxorubicin-resistant human liver cancer cells.

J Nat Prod 2010 May;73(5):854-9

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, People's Republic of China.

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http://pubs.acs.org/doi/abs/10.1021/np900792p
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May 2010