Publications by authors named "Paul A W Edwards"

36Publications

Fbxl17 is rearranged in breast cancer and loss of its activity leads to increased global O-GlcNAcylation.

Cell Mol Life Sci 2020 Jul 27;77(13):2605-2620. Epub 2019 Sep 27.

Department of Pathology at Tennis Court Road, University of Cambridge, Cambridge, CB2 1QP, UK.

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http://dx.doi.org/10.1007/s00018-019-03306-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320043PMC
July 2020

Complex multi-enhancer contacts captured by genome architecture mapping.

Nature 2017 03 8;543(7646):519-524. Epub 2017 Mar 8.

Epigenetic Regulation and Chromatin Architecture Group, Berlin Institute for Medical Systems Biology, Max-Delbrück Centre for Molecular Medicine, Robert-Rössle Straße, Berlin-Buch 13125, Germany.

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http://dx.doi.org/10.1038/nature21411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5366070PMC
March 2017

The relative timing of mutations in a breast cancer genome.

PLoS One 2013 10;8(6):e64991. Epub 2013 Jun 10.

Hutchison/MRC Research Centre and Department of Pathology, University of Cambridge, Cambridge, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0064991PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677865PMC
February 2014

Tumor initiating but differentiated luminal-like breast cancer cells are highly invasive in the absence of basal-like activity.

Proc Natl Acad Sci U S A 2012 Apr 27;109(16):6124-9. Epub 2012 Mar 27.

Department of Cellular and Molecular Medicine, Centre for Biological Disease Analysis and Danish Stem Cell Centre, Faculty of Health Sciences, University of Copenhagen, DK-2200 Copenhagen N, Denmark.

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http://dx.doi.org/10.1073/pnas.1203203109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341000PMC
April 2012

Are breast cancers driven by fusion genes?

Breast Cancer Res 2012 Mar 16;14(2):303. Epub 2012 Mar 16.

Hutchison/MRC Research Centre and Department of Pathology, University of Cambridge, Hills Road, Cambridge, CB2 0XZ, UK.

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http://breast-cancer-research.biomedcentral.com/articles/10.
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http://dx.doi.org/10.1186/bcr3122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446366PMC
March 2012

The role of tandem duplicator phenotype in tumour evolution in high-grade serous ovarian cancer.

J Pathol 2012 Apr 9;226(5):703-12. Epub 2012 Feb 9.

Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, UK.

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http://dx.doi.org/10.1002/path.3980DOI Listing
April 2012

Estimation of rearrangement phylogeny for cancer genomes.

Genome Res 2012 Feb 12;22(2):346-61. Epub 2011 Oct 12.

Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, United Kingdom.

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http://dx.doi.org/10.1101/gr.118414.110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266042PMC
February 2012

Single-molecule analysis of genome rearrangements in cancer.

Nucleic Acids Res 2011 Jul 27;39(13):e85. Epub 2011 Apr 27.

Hutchison/MRC Research Centre and Department of Pathology, University of Cambridge, Hills Road, Cambridge, CB2 0XZ, UK.

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http://dx.doi.org/10.1093/nar/gkr227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141271PMC
July 2011

Amplification of the driving oncogene, KRAS or BRAF, underpins acquired resistance to MEK1/2 inhibitors in colorectal cancer cells.

Sci Signal 2011 Mar 29;4(166):ra17. Epub 2011 Mar 29.

Laboratory of Molecular Signalling, Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK.

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http://dx.doi.org/10.1126/scisignal.2001752DOI Listing
March 2011

Fusion genes and chromosome translocations in the common epithelial cancers.

Authors:
Paul A W Edwards

J Pathol 2010 Jan;220(2):244-54

Department of Pathology and Hutchison/MRC Research Centre, University of Cambridge, Cambridge CB2 0XZ, UK.

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http://dx.doi.org/10.1002/path.2632DOI Listing
January 2010

High-resolution array CGH clarifies events occurring on 8p in carcinogenesis.

BMC Cancer 2008 Oct 7;8:288. Epub 2008 Oct 7.

Department of Pathology and Hutchison/MRC Research Centre, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1186/1471-2407-8-288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2576333PMC
October 2008

Molecular cytogenetic characterization of a unique and complex de novo 8p rearrangement.

Am J Med Genet A 2008 May;146A(9):1166-72

Department of Pathology, Cambridge University, Cambridge, UK.

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http://dx.doi.org/10.1002/ajmg.a.32248DOI Listing
May 2008

Homozygous deletions may be markers of nearby heterozygous mutations: The complex deletion at FRA16D in the HCT116 colon cancer cell line removes exons of WWOX.

Genes Chromosomes Cancer 2008 May;47(5):437-47

Hutchison/MRC Research Centre and Department of Pathology, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1002/gcc.20548DOI Listing
May 2008

Co-amplification of 8p12 and 11q13 in breast cancers is not the result of a single genomic event.

Genes Chromosomes Cancer 2007 May;46(5):427-39

Hutchison-MRC Research Centre, Department of Pathology, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1002/gcc.20424DOI Listing
May 2007

Sister chromatid junctions in the hyperthermophilic archaeon Sulfolobus solfataricus.

EMBO J 2007 Feb 25;26(3):816-24. Epub 2007 Jan 25.

Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, Cambridge, UK.

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http://dx.doi.org/10.1038/sj.emboj.7601529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1794387PMC
February 2007

A quantum leap in our knowledge of breast cancer mutations.

Breast Cancer Res 2006 ;8(6):304

Cancer Research UK Cambridge Research Institute and Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 0RE, UK.

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http://dx.doi.org/10.1186/bcr1624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1797027PMC
February 2007

Genomic analysis of the 8p11-12 amplicon in familial breast cancer.

Int J Cancer 2007 Feb;120(3):714-7

Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Center (CNIO), Madrid, Spain.

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http://dx.doi.org/10.1002/ijc.22354DOI Listing
February 2007

Distribution of breakpoints on chromosome 18 in breast, colorectal, and pancreatic carcinoma cell lines.

Cancer Genet Cytogenet 2006 Jan;164(2):97-109

Cancer Genomics Program, Hutchison-MRC Research Centre, Department of Pathology and Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, United Kingdom.

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http://linkinghub.elsevier.com/retrieve/pii/S016546080500557
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http://dx.doi.org/10.1016/j.cancergencyto.2005.09.011DOI Listing
January 2006

Chromosome abnormalities in 10 lung cancer cell lines of the NCI-H series analyzed with spectral karyotyping.

Cancer Genet Cytogenet 2005 Oct;162(1):1-9

Cancer Genomics Program, Hutchison-MRC Research Centre, Departments of Pathology and Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK.

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http://dx.doi.org/10.1016/j.cancergencyto.2005.03.007DOI Listing
October 2005

A 1 Mb minimal amplicon at 8p11-12 in breast cancer identifies new candidate oncogenes.

Oncogene 2005 Aug;24(33):5235-45

Department of Oncology, Hutchison/MRC Research Centre, Cancer Genomics Program, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK.

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http://www.nature.com/articles/1208741
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http://dx.doi.org/10.1038/sj.onc.1208741DOI Listing
August 2005

Evidence that both genetic instability and selection contribute to the accumulation of chromosome alterations in cancer.

Carcinogenesis 2005 May 27;26(5):923-30. Epub 2005 Jan 27.

Cancer Genomics Program, Department of Oncology, Hutchison/MRC Research Centre, University of Cambridge, Cambridge CB2 2XZ, UK.

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http://dx.doi.org/10.1093/carcin/bgi032DOI Listing
May 2005

A recurrent chromosome translocation breakpoint in breast and pancreatic cancer cell lines targets the neuregulin/NRG1 gene.

Genes Chromosomes Cancer 2003 Aug;37(4):333-45

Département d'Oncologie Moléculaire, Laboratoires de Cytogénétique Moléculaire et de Pathologie Moléculaire, U119 Institut National de la Santé et de la Recherche Médicale (INSERM) and Institut Paoli-Calmettes (IPC), Marseille, France.

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http://dx.doi.org/10.1002/gcc.10218DOI Listing
August 2003

Metastasis: the role of chance in malignancy.

Authors:
Paul A W Edwards

Nature 2002 Oct;419(6907):559-60; author reply 560

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http://dx.doi.org/10.1038/419559bDOI Listing
October 2002