Paul A Townsend

Paul A Townsend

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Paul A Townsend

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Defective NOTCH signalling drives smooth muscle cell death and differentiation in bicuspid aortic valve aortopathy.

Eur J Cardiothorac Surg 2019 Jul;56(1):117-125

Institute of Developmental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.

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https://academic.oup.com/ejcts/advance-article/doi/10.1093/e
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http://dx.doi.org/10.1093/ejcts/ezy464DOI Listing
July 2019

Cysteine Cathepsin Protease Inhibition: An update on its Diagnostic, Prognostic and Therapeutic Potential in Cancer.

Pharmaceuticals (Basel) 2019 Jun 11;12(2). Epub 2019 Jun 11.

Institute of Molecular Medicine, Sechenov First Moscow State Medical University, Trubetskaya str. 8-2, 119991 Moscow, Russia.

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http://dx.doi.org/10.3390/ph12020087DOI Listing
June 2019

Author Correction: Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.

Authors:
Fredrick R Schumacher Ali Amin Al Olama Sonja I Berndt Sara Benlloch Mahbubl Ahmed Edward J Saunders Tokhir Dadaev Daniel Leongamornlert Ezequiel Anokian Clara Cieza-Borrella Chee Goh Mark N Brook Xin Sheng Laura Fachal Joe Dennis Jonathan Tyrer Kenneth Muir Artitaya Lophatananon Victoria L Stevens Susan M Gapstur Brian D Carter Catherine M Tangen Phyllis J Goodman Ian M Thompson Jyotsna Batra Suzanne Chambers Leire Moya Judith Clements Lisa Horvath Wayne Tilley Gail P Risbridger Henrik Gronberg Markus Aly Tobias Nordström Paul Pharoah Nora Pashayan Johanna Schleutker Teuvo L J Tammela Csilla Sipeky Anssi Auvinen Demetrius Albanes Stephanie Weinstein Alicja Wolk Niclas Håkansson Catharine M L West Alison M Dunning Neil Burnet Lorelei A Mucci Edward Giovannucci Gerald L Andriole Olivier Cussenot Géraldine Cancel-Tassin Stella Koutros Laura E Beane Freeman Karina Dalsgaard Sorensen Torben Falck Orntoft Michael Borre Lovise Maehle Eli Marie Grindedal David E Neal Jenny L Donovan Freddie C Hamdy Richard M Martin Ruth C Travis Tim J Key Robert J Hamilton Neil E Fleshner Antonio Finelli Sue Ann Ingles Mariana C Stern Barry S Rosenstein Sarah L Kerns Harry Ostrer Yong-Jie Lu Hong-Wei Zhang Ninghan Feng Xueying Mao Xin Guo Guomin Wang Zan Sun Graham G Giles Melissa C Southey Robert J MacInnis Liesel M FitzGerald Adam S Kibel Bettina F Drake Ana Vega Antonio Gómez-Caamaño Robert Szulkin Martin Eklund Manolis Kogevinas Javier Llorca Gemma Castaño-Vinyals Kathryn L Penney Meir Stampfer Jong Y Park Thomas A Sellers Hui-Yi Lin Janet L Stanford Cezary Cybulski Dominika Wokolorczyk Jan Lubinski Elaine A Ostrander Milan S Geybels Børge G Nordestgaard Sune F Nielsen Maren Weischer Rasmus Bisbjerg Martin Andreas Røder Peter Iversen Hermann Brenner Katarina Cuk Bernd Holleczek Christiane Maier Manuel Luedeke Thomas Schnoeller Jeri Kim Christopher J Logothetis Esther M John Manuel R Teixeira Paula Paulo Marta Cardoso Susan L Neuhausen Linda Steele Yuan Chun Ding Kim De Ruyck Gert De Meerleer Piet Ost Azad Razack Jasmine Lim Soo-Hwang Teo Daniel W Lin Lisa F Newcomb Davor Lessel Marija Gamulin Tomislav Kulis Radka Kaneva Nawaid Usmani Sandeep Singhal Chavdar Slavov Vanio Mitev Matthew Parliament Frank Claessens Steven Joniau Thomas Van den Broeck Samantha Larkin Paul A Townsend Claire Aukim-Hastie Manuela Gago-Dominguez Jose Esteban Castelao Maria Elena Martinez Monique J Roobol Guido Jenster Ron H N van Schaik Florence Menegaux Thérèse Truong Yves Akoli Koudou Jianfeng Xu Kay-Tee Khaw Lisa Cannon-Albright Hardev Pandha Agnieszka Michael Stephen N Thibodeau Shannon K McDonnell Daniel J Schaid Sara Lindstrom Constance Turman Jing Ma David J Hunter Elio Riboli Afshan Siddiq Federico Canzian Laurence N Kolonel Loic Le Marchand Robert N Hoover Mitchell J Machiela Zuxi Cui Peter Kraft Christopher I Amos David V Conti Douglas F Easton Fredrik Wiklund Stephen J Chanock Brian E Henderson Zsofia Kote-Jarai Christopher A Haiman Rosalind A Eeles

Nat Genet 2019 02;51(2):363

Institute of Cancer Research, London, UK.

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http://www.nature.com/articles/s41588-018-0330-6
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http://dx.doi.org/10.1038/s41588-018-0330-6DOI Listing
February 2019

Circulating Metabolic Biomarkers of Screen-Detected Prostate Cancer in the ProtecT Study.

Cancer Epidemiol Biomarkers Prev 2019 Jan 23;28(1):208-216. Epub 2018 Oct 23.

MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom.

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http://cebp.aacrjournals.org/lookup/doi/10.1158/1055-9965.EP
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http://dx.doi.org/10.1158/1055-9965.EPI-18-0079DOI Listing
January 2019

Author Correction: Germline variation at 8q24 and prostate cancer risk in men of European ancestry.

Nat Commun 2019 01 17;10(1):382. Epub 2019 Jan 17.

Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, 90033, USA.

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http://dx.doi.org/10.1038/s41467-019-08293-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336778PMC
January 2019

Shared heritability and functional enrichment across six solid cancers.

Authors:
Xia Jiang Hilary K Finucane Fredrick R Schumacher Stephanie L Schmit Jonathan P Tyrer Younghun Han Kyriaki Michailidou Corina Lesseur Karoline B Kuchenbaecker Joe Dennis David V Conti Graham Casey Mia M Gaudet Jeroen R Huyghe Demetrius Albanes Melinda C Aldrich Angeline S Andrew Irene L Andrulis Hoda Anton-Culver Antonis C Antoniou Natalia N Antonenkova Susanne M Arnold Kristan J Aronson Banu K Arun Elisa V Bandera Rosa B Barkardottir Daniel R Barnes Jyotsna Batra Matthias W Beckmann Javier Benitez Sara Benlloch Andrew Berchuck Sonja I Berndt Heike Bickeböller Stephanie A Bien Carl Blomqvist Stefania Boccia Natalia V Bogdanova Stig E Bojesen Manjeet K Bolla Hiltrud Brauch Hermann Brenner James D Brenton Mark N Brook Joan Brunet Hans Brunnström Daniel D Buchanan Barbara Burwinkel Ralf Butzow Gabriella Cadoni Trinidad Caldés Maria A Caligo Ian Campbell Peter T Campbell Géraldine Cancel-Tassin Lisa Cannon-Albright Daniele Campa Neil Caporaso André L Carvalho Andrew T Chan Jenny Chang-Claude Stephen J Chanock Chu Chen David C Christiani Kathleen B M Claes Frank Claessens Judith Clements J Margriet Collée Marcia Cruz Correa Fergus J Couch Angela Cox Julie M Cunningham Cezary Cybulski Kamila Czene Mary B Daly Anna deFazio Peter Devilee Orland Diez Manuela Gago-Dominguez Jenny L Donovan Thilo Dörk Eric J Duell Alison M Dunning Miriam Dwek Diana M Eccles Christopher K Edlund Digna R Velez Edwards Carolina Ellberg D Gareth Evans Peter A Fasching Robert L Ferris Triantafillos Liloglou Jane C Figueiredo Olivia Fletcher Renée T Fortner Florentia Fostira Silvia Franceschi Eitan Friedman Steven J Gallinger Patricia A Ganz Judy Garber José A García-Sáenz Simon A Gayther Graham G Giles Andrew K Godwin Mark S Goldberg David E Goldgar Ellen L Goode Marc T Goodman Gary Goodman Kjell Grankvist Mark H Greene Henrik Gronberg Jacek Gronwald Pascal Guénel Niclas Håkansson Per Hall Ute Hamann Freddie C Hamdy Robert J Hamilton Jochen Hampe Aage Haugen Florian Heitz Rolando Herrero Peter Hillemanns Michael Hoffmeister Estrid Høgdall Yun-Chul Hong John L Hopper Richard Houlston Peter J Hulick David J Hunter David G Huntsman Gregory Idos Evgeny N Imyanitov Sue Ann Ingles Claudine Isaacs Anna Jakubowska Paul James Mark A Jenkins Mattias Johansson Mikael Johansson Esther M John Amit D Joshi Radka Kaneva Beth Y Karlan Linda E Kelemen Tabea Kühl Kay-Tee Khaw Elza Khusnutdinova Adam S Kibel Lambertus A Kiemeney Jeri Kim Susanne K Kjaer Julia A Knight Manolis Kogevinas Zsofia Kote-Jarai Stella Koutros Vessela N Kristensen Jolanta Kupryjanczyk Martin Lacko Stephan Lam Diether Lambrechts Maria Teresa Landi Philip Lazarus Nhu D Le Eunjung Lee Flavio Lejbkowicz Heinz-Josef Lenz Goska Leslie Davor Lessel Jenny Lester Douglas A Levine Li Li Christopher I Li Annika Lindblom Noralane M Lindor Geoffrey Liu Fotios Loupakis Jan Lubiński Lovise Maehle Christiane Maier Arto Mannermaa Loic Le Marchand Sara Margolin Taymaa May Lesley McGuffog Alfons Meindl Pooja Middha Austin Miller Roger L Milne Robert J MacInnis Francesmary Modugno Marco Montagna Victor Moreno Kirsten B Moysich Lorelei Mucci Kenneth Muir Anna Marie Mulligan Katherine L Nathanson David E Neal Andrew R Ness Susan L Neuhausen Heli Nevanlinna Polly A Newcomb Lisa F Newcomb Finn Cilius Nielsen Liene Nikitina-Zake Børge G Nordestgaard Robert L Nussbaum Kenneth Offit Edith Olah Ali Amin Al Olama Olufunmilayo I Olopade Andrew F Olshan Håkan Olsson Ana Osorio Hardev Pandha Jong Y Park Nora Pashayan Michael T Parsons Tanja Pejovic Kathryn L Penney Wilbert H M Peters Catherine M Phelan Amanda I Phipps Dijana Plaseska-Karanfilska Miranda Pring Darya Prokofyeva Paolo Radice Kari Stefansson Susan J Ramus Leon Raskin Gad Rennert Hedy S Rennert Elizabeth J van Rensburg Marjorie J Riggan Harvey A Risch Angela Risch Monique J Roobol Barry S Rosenstein Mary Anne Rossing Kim De Ruyck Emmanouil Saloustros Dale P Sandler Elinor J Sawyer Matthew B Schabath Johanna Schleutker Marjanka K Schmidt V Wendy Setiawan Hongbing Shen Erin M Siegel Weiva Sieh Christian F Singer Martha L Slattery Karina Dalsgaard Sorensen Melissa C Southey Amanda B Spurdle Janet L Stanford Victoria L Stevens Sebastian Stintzing Jennifer Stone Karin Sundfeldt Rebecca Sutphen Anthony J Swerdlow Eloiza H Tajara Catherine M Tangen Adonina Tardon Jack A Taylor M Dawn Teare Manuel R Teixeira Mary Beth Terry Kathryn L Terry Stephen N Thibodeau Mads Thomassen Line Bjørge Marc Tischkowitz Amanda E Toland Diana Torres Paul A Townsend Ruth C Travis Nadine Tung Shelley S Tworoger Cornelia M Ulrich Nawaid Usmani Celine M Vachon Els Van Nieuwenhuysen Ana Vega Miguel Elías Aguado-Barrera Qin Wang Penelope M Webb Clarice R Weinberg Stephanie Weinstein Mark C Weissler Jeffrey N Weitzel Catharine M L West Emily White Alice S Whittemore H-Erich Wichmann Fredrik Wiklund Robert Winqvist Alicja Wolk Penella Woll Michael Woods Anna H Wu Xifeng Wu Drakoulis Yannoukakos Wei Zheng Shanbeh Zienolddiny Argyrios Ziogas Kristin K Zorn Jacqueline M Lane Richa Saxena Duncan Thomas Rayjean J Hung Brenda Diergaarde James McKay Ulrike Peters Li Hsu Montserrat García-Closas Rosalind A Eeles Georgia Chenevix-Trench Paul J Brennan Christopher A Haiman Jacques Simard Douglas F Easton Stephen B Gruber Paul D P Pharoah Alkes L Price Bogdan Pasaniuc Christopher I Amos Peter Kraft Sara Lindström

Nat Commun 2019 01 25;10(1):431. Epub 2019 Jan 25.

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., Seattle, WA, 98109-1024, USA.

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http://dx.doi.org/10.1038/s41467-018-08054-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347624PMC
January 2019

Germline variation at 8q24 and prostate cancer risk in men of European ancestry.

Nat Commun 2018 11 5;9(1):4616. Epub 2018 Nov 5.

Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, 90033, USA.

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http://www.nature.com/articles/s41467-018-06863-1
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http://dx.doi.org/10.1038/s41467-018-06863-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218483PMC
November 2018

Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.

Authors:
Fredrick R Schumacher Ali Amin Al Olama Sonja I Berndt Sara Benlloch Mahbubl Ahmed Edward J Saunders Tokhir Dadaev Daniel Leongamornlert Ezequiel Anokian Clara Cieza-Borrella Chee Goh Mark N Brook Xin Sheng Laura Fachal Joe Dennis Jonathan Tyrer Kenneth Muir Artitaya Lophatananon Victoria L Stevens Susan M Gapstur Brian D Carter Catherine M Tangen Phyllis J Goodman Ian M Thompson Jyotsna Batra Suzanne Chambers Leire Moya Judith Clements Lisa Horvath Wayne Tilley Gail P Risbridger Henrik Gronberg Markus Aly Tobias Nordström Paul Pharoah Nora Pashayan Johanna Schleutker Teuvo L J Tammela Csilla Sipeky Anssi Auvinen Demetrius Albanes Stephanie Weinstein Alicja Wolk Niclas Håkansson Catharine M L West Alison M Dunning Neil Burnet Lorelei A Mucci Edward Giovannucci Gerald L Andriole Olivier Cussenot Géraldine Cancel-Tassin Stella Koutros Laura E Beane Freeman Karina Dalsgaard Sorensen Torben Falck Orntoft Michael Borre Lovise Maehle Eli Marie Grindedal David E Neal Jenny L Donovan Freddie C Hamdy Richard M Martin Ruth C Travis Tim J Key Robert J Hamilton Neil E Fleshner Antonio Finelli Sue Ann Ingles Mariana C Stern Barry S Rosenstein Sarah L Kerns Harry Ostrer Yong-Jie Lu Hong-Wei Zhang Ninghan Feng Xueying Mao Xin Guo Guomin Wang Zan Sun Graham G Giles Melissa C Southey Robert J MacInnis Liesel M FitzGerald Adam S Kibel Bettina F Drake Ana Vega Antonio Gómez-Caamaño Robert Szulkin Martin Eklund Manolis Kogevinas Javier Llorca Gemma Castaño-Vinyals Kathryn L Penney Meir Stampfer Jong Y Park Thomas A Sellers Hui-Yi Lin Janet L Stanford Cezary Cybulski Dominika Wokolorczyk Jan Lubinski Elaine A Ostrander Milan S Geybels Børge G Nordestgaard Sune F Nielsen Maren Weischer Rasmus Bisbjerg Martin Andreas Røder Peter Iversen Hermann Brenner Katarina Cuk Bernd Holleczek Christiane Maier Manuel Luedeke Thomas Schnoeller Jeri Kim Christopher J Logothetis Esther M John Manuel R Teixeira Paula Paulo Marta Cardoso Susan L Neuhausen Linda Steele Yuan Chun Ding Kim De Ruyck Gert De Meerleer Piet Ost Azad Razack Jasmine Lim Soo-Hwang Teo Daniel W Lin Lisa F Newcomb Davor Lessel Marija Gamulin Tomislav Kulis Radka Kaneva Nawaid Usmani Sandeep Singhal Chavdar Slavov Vanio Mitev Matthew Parliament Frank Claessens Steven Joniau Thomas Van den Broeck Samantha Larkin Paul A Townsend Claire Aukim-Hastie Manuela Gago-Dominguez Jose Esteban Castelao Maria Elena Martinez Monique J Roobol Guido Jenster Ron H N van Schaik Florence Menegaux Thérèse Truong Yves Akoli Koudou Jianfeng Xu Kay-Tee Khaw Lisa Cannon-Albright Hardev Pandha Agnieszka Michael Stephen N Thibodeau Shannon K McDonnell Daniel J Schaid Sara Lindstrom Constance Turman Jing Ma David J Hunter Elio Riboli Afshan Siddiq Federico Canzian Laurence N Kolonel Loic Le Marchand Robert N Hoover Mitchell J Machiela Zuxi Cui Peter Kraft Christopher I Amos David V Conti Douglas F Easton Fredrik Wiklund Stephen J Chanock Brian E Henderson Zsofia Kote-Jarai Christopher A Haiman Rosalind A Eeles

Nat Genet 2018 07 11;50(7):928-936. Epub 2018 Jun 11.

Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.1038/s41588-018-0142-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6568012PMC
July 2018

Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants.

Authors:
Tokhir Dadaev Edward J Saunders Paul J Newcombe Ezequiel Anokian Daniel A Leongamornlert Mark N Brook Clara Cieza-Borrella Martina Mijuskovic Sarah Wakerell Ali Amin Al Olama Fredrick R Schumacher Sonja I Berndt Sara Benlloch Mahbubl Ahmed Chee Goh Xin Sheng Zhuo Zhang Kenneth Muir Koveela Govindasami Artitaya Lophatananon Victoria L Stevens Susan M Gapstur Brian D Carter Catherine M Tangen Phyllis Goodman Ian M Thompson Jyotsna Batra Suzanne Chambers Leire Moya Judith Clements Lisa Horvath Wayne Tilley Gail Risbridger Henrik Gronberg Markus Aly Tobias Nordström Paul Pharoah Nora Pashayan Johanna Schleutker Teuvo L J Tammela Csilla Sipeky Anssi Auvinen Demetrius Albanes Stephanie Weinstein Alicja Wolk Niclas Hakansson Catharine West Alison M Dunning Neil Burnet Lorelei Mucci Edward Giovannucci Gerald Andriole Olivier Cussenot Géraldine Cancel-Tassin Stella Koutros Laura E Beane Freeman Karina Dalsgaard Sorensen Torben Falck Orntoft Michael Borre Lovise Maehle Eli Marie Grindedal David E Neal Jenny L Donovan Freddie C Hamdy Richard M Martin Ruth C Travis Tim J Key Robert J Hamilton Neil E Fleshner Antonio Finelli Sue Ann Ingles Mariana C Stern Barry Rosenstein Sarah Kerns Harry Ostrer Yong-Jie Lu Hong-Wei Zhang Ninghan Feng Xueying Mao Xin Guo Guomin Wang Zan Sun Graham G Giles Melissa C Southey Robert J MacInnis Liesel M FitzGerald Adam S Kibel Bettina F Drake Ana Vega Antonio Gómez-Caamaño Laura Fachal Robert Szulkin Martin Eklund Manolis Kogevinas Javier Llorca Gemma Castaño-Vinyals Kathryn L Penney Meir Stampfer Jong Y Park Thomas A Sellers Hui-Yi Lin Janet L Stanford Cezary Cybulski Dominika Wokolorczyk Jan Lubinski Elaine A Ostrander Milan S Geybels Børge G Nordestgaard Sune F Nielsen Maren Weisher Rasmus Bisbjerg Martin Andreas Røder Peter Iversen Hermann Brenner Katarina Cuk Bernd Holleczek Christiane Maier Manuel Luedeke Thomas Schnoeller Jeri Kim Christopher J Logothetis Esther M John Manuel R Teixeira Paula Paulo Marta Cardoso Susan L Neuhausen Linda Steele Yuan Chun Ding Kim De Ruyck Gert De Meerleer Piet Ost Azad Razack Jasmine Lim Soo-Hwang Teo Daniel W Lin Lisa F Newcomb Davor Lessel Marija Gamulin Tomislav Kulis Radka Kaneva Nawaid Usmani Chavdar Slavov Vanio Mitev Matthew Parliament Sandeep Singhal Frank Claessens Steven Joniau Thomas Van den Broeck Samantha Larkin Paul A Townsend Claire Aukim-Hastie Manuela Gago-Dominguez Jose Esteban Castelao Maria Elena Martinez Monique J Roobol Guido Jenster Ron H N van Schaik Florence Menegaux Thérèse Truong Yves Akoli Koudou Jianfeng Xu Kay-Tee Khaw Lisa Cannon-Albright Hardev Pandha Agnieszka Michael Andrzej Kierzek Stephen N Thibodeau Shannon K McDonnell Daniel J Schaid Sara Lindstrom Constance Turman Jing Ma David J Hunter Elio Riboli Afshan Siddiq Federico Canzian Laurence N Kolonel Loic Le Marchand Robert N Hoover Mitchell J Machiela Peter Kraft Matthew Freedman Fredrik Wiklund Stephen Chanock Brian E Henderson Douglas F Easton Christopher A Haiman Rosalind A Eeles David V Conti Zsofia Kote-Jarai

Nat Commun 2018 06 11;9(1):2256. Epub 2018 Jun 11.

The Institute of Cancer Research, London, SW7 3RP, UK.

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http://dx.doi.org/10.1038/s41467-018-04109-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995836PMC
June 2018

Candidate plasma biomarkers for predicting ascending aortic aneurysm in bicuspid aortic valve disease.

J Cardiothorac Surg 2018 Jun 22;13(1):76. Epub 2018 Jun 22.

Stoller Biomarker Discovery Centre, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1186/s13019-018-0762-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013884PMC
June 2018

Integrated Cellular and Plasma Proteomics of Contrasting B-cell Cancers Reveals Common, Unique and Systemic Signatures.

Mol Cell Proteomics 2017 03 4;16(3):386-406. Epub 2017 Jan 4.

From the ‡Antibody and Vaccine Group, Cancer Sciences Unit, Faculty of Medicine, General Hospital, University of Southampton, Southampton SO16 6YD, UK;

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http://dx.doi.org/10.1074/mcp.M116.063511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341001PMC
March 2017

Urocortin suppresses endometrial cancer cell migration via CRFR2 and its system components are differentially modulated by estrogen.

Cancer Med 2017 02 21;6(2):408-415. Epub 2017 Jan 21.

Division of Molecular & Clinical Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine & Health, Manchester Cancer Research Centre, University of Manchester, Wilmslow Road, Manchester, M20 4QL, United Kingdom.

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http://dx.doi.org/10.1002/cam4.967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5313640PMC
February 2017

Regulation of osteoblast development by Bcl-2-associated athanogene-1 (BAG-1).

Sci Rep 2016 09 16;6:33504. Epub 2016 Sep 16.

Centre for Human Development, Stem Cells and Regeneration, Institute of Developmental Sciences, University of Southampton, Southampton SO16 6YD, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025845PMC
http://dx.doi.org/10.1038/srep33504DOI Listing
September 2016

Role of stress-activated OCT4A in the cell fate decisions of embryonal carcinoma cells treated with etoposide.

Cell Cycle 2015 23;14(18):2969-84. Epub 2015 Jun 23.

b Institute of Cancer Sciences; Manchester Cancer Research Center; University of Manchester; Manchester Academic Health Science Center ; Manchester , UK.

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https://www.tandfonline.com/doi/full/10.1080/15384101.2015.1
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http://dx.doi.org/10.1080/15384101.2015.1056948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825594PMC
August 2016

MultiElec: A MATLAB Based Application for MEA Data Analysis.

PLoS One 2015 15;10(6):e0129389. Epub 2015 Jun 15.

Institute of Cancer Sciences, University of Manchester, Manchester, United Kingdom; Manchester Centre for Cellular Metabolism, Manchester Cancer Research Centre, Faculty of Medical and Human Sciences, University of Manchester, Manchester, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0129389PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468069PMC
March 2016

Clinical proteomics and breast cancer.

Surgeon 2015 Oct 24;13(5):271-8. Epub 2015 Feb 24.

Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton University Hospitals NHS Foundation Trust, Southampton, SO16 6YD, UK. Electronic address:

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http://dx.doi.org/10.1016/j.surge.2014.12.003DOI Listing
October 2015

The DNA damage response and immune signaling alliance: Is it good or bad? Nature decides when and where.

Pharmacol Ther 2015 Oct 3;154:36-56. Epub 2015 Jul 3.

Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, University of Athens, Athens, Greece; Biomedical Research Foundation, Academy of Athens, Athens, Greece; Institute for Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, UK; Manchester Centre for Cellular Metabolism, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK. Electronic address:

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http://dx.doi.org/10.1016/j.pharmthera.2015.06.011DOI Listing
October 2015

Whole serum 3D LC-nESI-FTMS quantitative proteomics reveals sexual dimorphism in the milieu intérieur of overweight and obese adults.

J Proteome Res 2014 Nov 29;13(11):5094-105. Epub 2014 Jul 29.

Biomarkers Research Program, Biochemistry Department, College of Science, ‡Prince Mutaib Chair for Biomarkers of Osteoporosis, Biochemistry Department, College of Science, §Center of Excellence in Biotechnology Research, and #Department of Clinical Pharmacy, College of Pharmacy, King Saud University , Riyadh 12372, Kingdom of Saudi Arabia.

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http://dx.doi.org/10.1021/pr5003406DOI Listing
November 2014

Regulation of myocardial interleukin-6 expression by p53 and STAT1.

J Interferon Cytokine Res 2013 Sep 15;33(9):542-8. Epub 2013 May 15.

Research Programs Unit, Molecular Neurology, Biomedicum-Helsinki, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1089/jir.2012.0165DOI Listing
September 2013

Proteomics of human prostate cancer biospecimens: the global, systems-wide perspective for protein markers with potential clinical utility.

Expert Rev Proteomics 2013 Aug;10(4):337-54

Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.

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http://dx.doi.org/10.1586/14789450.2013.827408DOI Listing
August 2013

p90(RSK)s mediate the activation of ribosomal RNA synthesis by the hypertrophic agonist phenylephrine in adult cardiomyocytes.

J Mol Cell Cardiol 2013 Jun 17;59:139-47. Epub 2013 Mar 17.

Centre for Biological Sciences, University of Southampton, Southampton, UK.

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http://dx.doi.org/10.1016/j.yjmcc.2013.03.006DOI Listing
June 2013

The effect of ultrasound-related stimuli on cell viability in microfluidic channels.

J Nanobiotechnology 2013 Jun 28;11:20. Epub 2013 Jun 28.

Electromechanical Engineering Group, Faculty of Engineering and the Environment, University of Southampton, Southampton SO17 1BJ, UK.

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http://dx.doi.org/10.1186/1477-3155-11-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706218PMC
June 2013

Proteomic profiling to identify prognostic biomarkers in heart failure.

In Vivo 2012 Nov-Dec;26(6):875-82

Wessex Cardiothoracic Unit, Southampton University Hospitals NHS Trust, UK.

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May 2013

Pharmacoproteomic study of the natural product Ebenfuran III in DU-145 prostate cancer cells: the quantitative and temporal interrogation of chemically induced cell death at the protein level.

J Proteome Res 2013 Apr 12;12(4):1591-603. Epub 2013 Mar 12.

Institute for Life Sciences, ‡Cancer Sciences Unit, Cancer Research U.K., Faculty of Medicine, University of Southampton , Southampton, United Kingdom.

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http://dx.doi.org/10.1021/pr300968qDOI Listing
April 2013

Heart failure: the pivotal role of histone deacetylases.

Int J Biochem Cell Biol 2013 Feb 22;45(2):448-53. Epub 2012 Nov 22.

Cancer Sciences, Faculty of Medicine, Southampton General Hospital, University of Southampton, Southampton SO16 6YD, UK.

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http://dx.doi.org/10.1016/j.biocel.2012.11.006DOI Listing
February 2013

Role of STAT1 in the breast.

JAKSTAT 2012 Jul;1(3):197-9

Cancer Sciences Unit; Cancer Research UK Centre; Faculty of Medicine; University of Southampton; Southampton General Hospital; Southampton, UK.

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http://dx.doi.org/10.4161/jkst.20967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670245PMC
July 2012

Defining potential to benefit from implantable cardioverter defibrillator therapy: the role of biomarkers.

Europace 2011 Oct 21;13(10):1419-27. Epub 2011 Jul 21.

Wessex Cardiothoracic Unit, Southampton University Hospitals NHS Trust, Tremona Road, Southampton SO16 6YD, UK.

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https://academic.oup.com/europace/article-lookup/doi/10.1093
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http://dx.doi.org/10.1093/europace/eur147DOI Listing
October 2011

Family friction as ΔNp73 antagonises p73 and p53.

Int J Biochem Cell Biol 2011 Apr 7;43(4):482-6. Epub 2011 Jan 7.

Human Genetics Division, University of Southampton, School of Medicine, Tremona Road, Southampton SO16 6YD, UK.

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http://dx.doi.org/10.1016/j.biocel.2010.12.022DOI Listing
April 2011

Effect of sex and dietary fat intake on the fatty acid composition of phospholipids and triacylglycerol in rat heart.

Prostaglandins Leukot Essent Fatty Acids 2010 Oct-Dec;83(4-6):219-23. Epub 2010 Aug 16.

Institute of Human Nutrition, University of Southampton School of Medicine, Institute of Developmental Sciences Building, MP887, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK.

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http://dx.doi.org/10.1016/j.plefa.2010.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000522PMC
March 2011

What causes a broken heart--molecular insights into heart failure.

Int Rev Cell Mol Biol 2010 ;284:113-79

Institute of Molecular Medicine, St. James's Hospital, Trinity College Dublin, Dublin 8, Ireland.

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http://dx.doi.org/10.1016/S1937-6448(10)84003-1DOI Listing
January 2011

Transgenic overexpression of HSP56 does not result in cardiac hypertrophy nor protect from ischaemia/reperfusion injury.

Int J Biochem Cell Biol 2011 Jan 29;43(1):74-9. Epub 2010 Oct 29.

Medical Molecular Biology Unit, Institute of Child Health, University College London, London WC1N 1EH, UK.

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http://dx.doi.org/10.1016/j.biocel.2010.09.020DOI Listing
January 2011

STAT3 modulates the DNA damage response pathway.

Int J Exp Pathol 2010 Dec 27;91(6):506-14. Epub 2010 Aug 27.

Medical Molecular Biology Unit, Institute of Child Health, University College London, London, UK.

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http://dx.doi.org/10.1111/j.1365-2613.2010.00734.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3010549PMC
December 2010

Histone Deacetylase inhibitors: new promise in the treatment of immune and inflammatory diseases.

Curr Drug Targets 2010 Nov;11(11):1430-8

Karus Therapeutics Ltd, Southampton Science Park, Southampton, SO16 7NP, UK.

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November 2010

New targets of urocortin-mediated cardioprotection.

J Mol Endocrinol 2010 Aug 25;45(2):69-85. Epub 2010 May 25.

Medical Molecular Biology Unit, Institute of Child Health, University College London, London, WC1N 1EH, UK.

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http://dx.doi.org/10.1677/JME-09-0148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069736PMC
August 2010

Discovery of serum protein biomarkers for prostate cancer progression by proteomic analysis.

Cancer Genomics Proteomics 2010 Mar-Apr;7(2):93-103

School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, PO1 2DT, Hampshire, U.K.

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June 2010

Regulating the genome surveillance system: miRNAs and the p53 super family.

Apoptosis 2010 May;15(5):541-52

School of Medicine, University of Southampton, Southampton, SO16 6YD, UK.

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http://dx.doi.org/10.1007/s10495-010-0456-1DOI Listing
May 2010

Allele-specific regulation of matrix metalloproteinase-3 gene by transcription factor NFkappaB.

PLoS One 2010 Mar 25;5(3):e9902. Epub 2010 Mar 25.

William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845631PMC
March 2010

Proteomics in prostate cancer biomarker discovery.

Expert Rev Proteomics 2010 Feb;7(1):93-102

Human Genetics Division, MP808, Duthie Building, School of Medicine, University of Southampton, Southampton, SO16 6YD, UK.

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http://dx.doi.org/10.1586/epr.09.89DOI Listing
February 2010

Mechanisms of action and clinical implications of cardiac urocortin: a journey from the heart to the systemic circulation, with a stopover in the mitochondria.

Int J Cardiol 2009 Nov 29;137(3):189-94. Epub 2009 Apr 29.

Center for Heart and Vessel Preclinical Studies, St John Hospital and Medical Center, Wayne State University Medical School, Detroit, MI, USA.

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http://dx.doi.org/10.1016/j.ijcard.2009.03.112DOI Listing
November 2009

Thioflavin S (NSC71948) interferes with Bcl-2-associated athanogene (BAG-1)-mediated protein-protein interactions.

J Pharmacol Exp Ther 2009 Nov 18;331(2):680-9. Epub 2009 Aug 18.

Cancer Research UK Centre, Cancer Sciences Division, University of Southampton School of Medicine, Southampton General Hospital, Southampton, United Kingdom.

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http://dx.doi.org/10.1124/jpet.109.153601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2775257PMC
November 2009

Short peptides derived from the BAG-1 C-terminus inhibit the interaction between BAG-1 and HSC70 and decrease breast cancer cell growth.

FEBS Lett 2009 Nov 1;583(21):3405-11. Epub 2009 Oct 1.

Cancer Research UK Centre, Cancer Sciences Division, University of Southampton, School of Medicine, Southampton General Hospital, Southampton S016 6YD, UK.

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http://dx.doi.org/10.1016/j.febslet.2009.09.047DOI Listing
November 2009

STAT3 deletion sensitizes cells to oxidative stress.

Biochem Biophys Res Commun 2009 Jul 18;385(3):324-9. Epub 2009 May 18.

Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N1EH, UK.

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http://dx.doi.org/10.1016/j.bbrc.2009.05.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2706948PMC
July 2009

Proteomic analysis of archival breast cancer serum.

Cancer Genomics Proteomics 2009 May-Jun;6(3):141-7

Human Genetics Division, Southampton General Hospital, University of Southampton, Southampton, SO16 6YD, UK.

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July 2009

The powerful cardioprotective effects of urocortin and the corticotropin releasing hormone (CRH) family.

Biochem Pharmacol 2009 Jan 6;77(2):141-50. Epub 2008 Sep 6.

The Hatter Cardiovascular Institute, University College London Hospital and Medical School, London, UK.

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http://dx.doi.org/10.1016/j.bcp.2008.08.033DOI Listing
January 2009

Molecular regulation of cardiac hypertrophy.

Int J Biochem Cell Biol 2008 26;40(10):2023-39. Epub 2008 Feb 26.

Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N IEH, United Kingdom.

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October 2008

ERK and the F-box protein betaTRCP target STAT1 for degradation.

J Biol Chem 2008 Jun 31;283(23):16077-83. Epub 2008 Mar 31.

Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M800384200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3259647PMC
June 2008

Bcl-2-associated athanogene-1 (BAG-1): a transcriptional regulator mediating chondrocyte survival and differentiation during endochondral ossification.

Bone 2008 Jan 4;42(1):113-28. Epub 2007 Sep 4.

Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Institute of Developmental Sciences, University of Southampton, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK.

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http://dx.doi.org/10.1016/j.bone.2007.08.032DOI Listing
January 2008

STAT1 regulates p73-mediated Bax gene expression.

FEBS Lett 2007 Mar 1;581(6):1217-26. Epub 2007 Mar 1.

Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK.

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http://dx.doi.org/10.1016/j.febslet.2007.02.049DOI Listing
March 2007

Role of the JAK-STAT pathway in myocardial injury.

Trends Mol Med 2007 Feb 27;13(2):82-9. Epub 2006 Dec 27.

Medical Molecular Biology Unit, The Institute of Child Health, University College London, 30 Guilford Street, London, UK.

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http://dx.doi.org/10.1016/j.molmed.2006.12.002DOI Listing
February 2007

Free radical scavenging inhibits STAT phosphorylation following in vivo ischemia/reperfusion injury.

FASEB J 2006 Oct 25;20(12):2115-7. Epub 2006 Aug 25.

Department of Medical Molecular Biology, The Institute of Child Health, University College London, 30 Guilford St., London, WC1N 1EH, UK.

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October 2006

Urocortin inhibits Beclin1-mediated autophagic cell death in cardiac myocytes exposed to ischaemia/reperfusion injury.

J Mol Cell Cardiol 2006 Jun 12;40(6):846-52. Epub 2006 May 12.

Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, London, WC1N 1EH, UK.

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http://dx.doi.org/10.1016/j.yjmcc.2006.03.428DOI Listing
June 2006

STAT-1 facilitates the ATM activated checkpoint pathway following DNA damage.

J Cell Sci 2005 Apr 22;118(Pt 8):1629-39. Epub 2005 Mar 22.

Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, London, WC1N 1EH, UK.

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http://jcs.biologists.org/cgi/doi/10.1242/jcs.01728
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April 2005

Hypertrophic effects of urocortin homologous peptides are mediated via activation of the Akt pathway.

Biochem Biophys Res Commun 2005 Mar;328(2):442-8

Medical Molecular Biology Unit, Institute of Child Health, University College London, London WC1N 1EH, UK.

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http://dx.doi.org/10.1016/j.bbrc.2005.01.001DOI Listing
March 2005

BAG-1: a multi-functional pro-survival molecule.

Int J Biochem Cell Biol 2005 Feb;37(2):251-9

Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK.

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http://dx.doi.org/10.1016/j.biocel.2004.03.016DOI Listing
February 2005

PIAS-1 is a checkpoint regulator which affects exit from G1 and G2 by sumoylation of p73.

Mol Cell Biol 2004 Dec;24(24):10593-610

Medical Research Council, Toxicology Unit, Hodgkin Building, Leicester University, Lancaster Road, P.O. Box 138, Leicester LE1 9HN, United Kingdom.

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http://dx.doi.org/10.1128/MCB.24.24.10593-10610.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC533962PMC
December 2004

Epigallocatechin-3-gallate inhibits STAT-1 activation and protects cardiac myocytes from ischemia/reperfusion-induced apoptosis.

FASEB J 2004 Oct 19;18(13):1621-3. Epub 2004 Aug 19.

Medical Molecular Biology Unit, Institute of Child Health, University College London, London, England.

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October 2004

The cardioprotective effect of urocortin during ischaemia/reperfusion involves the prevention of mitochondrial damage.

Biochem Biophys Res Commun 2004 Aug;321(2):479-86

Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK.

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http://dx.doi.org/10.1016/j.bbrc.2004.06.170DOI Listing
August 2004

BAG-1 in carcinogenesis.

Expert Rev Mol Med 2004 Mar 22;6(7):1-15. Epub 2004 Mar 22.

Cancer Research UK Oncology Unit, The Somers Cancer Research Building, University of Southampton School of Medicine, Southampton General Hospital, Southampton, S016 6YD, UK.

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http://dx.doi.org/10.1017/S1462399404007537DOI Listing
March 2004

STAT-1 interacts with p53 to enhance DNA damage-induced apoptosis.

J Biol Chem 2004 Feb 5;279(7):5811-20. Epub 2003 Nov 5.

Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, United Kingdom.

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February 2004

The retinoblastoma protein interacts with Bag-1 in human colonic adenoma and carcinoma derived cell lines.

Int J Cancer 2003 Sep;106(3):364-71

Cancer Research UK Colorectal Tumour Biology Research Group, Department of Pathology and Microbiology, University of Bristol, School of Medical Sciences, Bristol BS8 1TD, United Kingdom.

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September 2003

The nuclear BAG-1 isoform, BAG-1L, enhances oestrogen-dependent transcription.

Oncogene 2003 Aug;22(32):4973-82

Cancer Research UK Oncology Unit, Cancer Sciences Division, School of Medicine, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK.

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http://dx.doi.org/10.1038/sj.onc.1206688DOI Listing
August 2003

BAG-1 prevents stress-induced long-term growth inhibition in breast cancer cells via a chaperone-dependent pathway.

Cancer Res 2003 Jul;63(14):4150-7

Cancer Research UK Oncology Unit, Cancer Sciences Division, University of Southampton School of Medicine, Southampton General Hospital, Southampton S016 6YD, United Kingdom.

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July 2003

BAG-1: a multifunctional regulator of cell growth and survival.

Biochim Biophys Acta 2003 Mar;1603(2):83-98

Cancer Research UK Oncology Unit, Cancer Sciences Division, School of Medicine, University of Southampton, Southampton SO16 6YD, UK.

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http://dx.doi.org/10.1016/s0304-419x(03)00002-7DOI Listing
March 2003

The carboxyl-terminal activation domain of the STAT-1 transcription factor enhances ischemia/reperfusion-induced apoptosis in cardiac myocytes.

FASEB J 2002 Nov 5;16(13):1841-3. Epub 2002 Sep 5.

Medical Molecular Biology Unit, Institute of Child Health, University College London, London WC1N 1EH, UK.

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http://dx.doi.org/10.1096/fj.02-0150fjeDOI Listing
November 2002