Paul A Slesinger

Paul A Slesinger

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Paul A Slesinger

Publications by authors named "Paul A Slesinger"

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GIRK currents in VTA dopamine neurons control the sensitivity of mice to cocaine-induced locomotor sensitization.

Proc Natl Acad Sci U S A 2018 10 18;115(40):E9479-E9488. Epub 2018 Sep 18.

Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029;

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http://dx.doi.org/10.1073/pnas.1807788115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176583PMC
October 2018

Genetics of Alcohol Use Disorder: A Role for Induced Pluripotent Stem Cells?

Alcohol Clin Exp Res 2018 09 5;42(9):1572-1590. Epub 2018 Jul 5.

Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.

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http://dx.doi.org/10.1111/acer.13811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120805PMC
September 2018

Gain-of-function KCNJ6 Mutation in a Severe Hyperkinetic Movement Disorder Phenotype.

Neuroscience 2018 08 29;384:152-164. Epub 2018 May 29.

Division of Biochemical Diseases, Department of Pediatrics, B.C. Children's Hospital, University of British Columbia, Vancouver, Canada; BC Children's Hospital Research Institute, University of British Columbia, Vancouver, Canada; Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, Canada; Department of Pediatrics and Clinical Genetics, Emma Children's Hospital, Academic Medical Centre, Amsterdam, The Netherlands.

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https://linkinghub.elsevier.com/retrieve/pii/S03064522183038
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http://dx.doi.org/10.1016/j.neuroscience.2018.05.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679957PMC
August 2018

An Efficient Platform for Astrocyte Differentiation from Human Induced Pluripotent Stem Cells.

Stem Cell Reports 2017 08 27;9(2):600-614. Epub 2017 Jul 27.

Department of Neuroscience & Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2017.06.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550034PMC
August 2017

Dual activation of neuronal G protein-gated inwardly rectifying potassium (GIRK) channels by cholesterol and alcohol.

Sci Rep 2017 07 4;7(1):4592. Epub 2017 Jul 4.

Fishberg Dept. of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA.

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http://dx.doi.org/10.1038/s41598-017-04681-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496853PMC
July 2017

G Protein-Gated Potassium Channels: A Link to Drug Addiction.

Trends Pharmacol Sci 2017 04 7;38(4):378-392. Epub 2017 Feb 7.

Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tips.2017.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368012PMC
April 2017

Structural Insights into GIRK Channel Function.

Int Rev Neurobiol 2015 22;123:117-60. Epub 2015 Jun 22.

Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA. Electronic address:

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http://dx.doi.org/10.1016/bs.irn.2015.05.014DOI Listing
July 2016

Preface.

Int Rev Neurobiol 2015 ;123:xi-xii

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http://dx.doi.org/10.1016/S0074-7742(15)00092-6DOI Listing
July 2016

Stress and Cocaine Trigger Divergent and Cell Type-Specific Regulation of Synaptic Transmission at Single Spines in Nucleus Accumbens.

Biol Psychiatry 2016 06 6;79(11):898-905. Epub 2015 Jun 6.

Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2015.05.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670821PMC
June 2016

Rapid Ngn2-induction of excitatory neurons from hiPSC-derived neural progenitor cells.

Methods 2016 05 25;101:113-24. Epub 2015 Nov 25.

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2015.11.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860098PMC
May 2016

A Role for the GIRK3 Subunit in Methamphetamine-Induced Attenuation of GABAB Receptor-Activated GIRK Currents in VTA Dopamine Neurons.

J Neurosci 2016 Mar;36(11):3106-14

Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York 10029, The Salk Institute for Biological Studies, La Jolla, California 92037, Department of Biology, University of California-San Diego, La Jolla, California 92037,

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http://dx.doi.org/10.1523/JNEUROSCI.1327-15.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792929PMC
March 2016

GIRK3 gates activation of the mesolimbic dopaminergic pathway by ethanol.

Proc Natl Acad Sci U S A 2015 Jun 11;112(22):7091-6. Epub 2015 May 11.

Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037;

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http://dx.doi.org/10.1073/pnas.1416146112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460485PMC
June 2015

Novel mechanism of voltage-gated N-type (Cav2.2) calcium channel inhibition revealed through α-conotoxin Vc1.1 activation of the GABA(B) receptor.

Mol Pharmacol 2015 Feb 25;87(2):240-50. Epub 2014 Nov 25.

Health Innovations Research Institute, RMIT University, Melbourne, Victoria, Australia (T.G.H., H.C., D.J.A.); and Peptide Biology Laboratories, The Salk Institute for Biological Studies, La Jolla, California (P.A.S.).

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http://dx.doi.org/10.1124/mol.114.096156DOI Listing
February 2015

Chromatin landscape defined by repressive histone methylation during oligodendrocyte differentiation.

J Neurosci 2015 Jan;35(1):352-65

Department of Neuroscience, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, and

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http://dx.doi.org/10.1523/JNEUROSCI.2606-14.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287153PMC
January 2015

Cell-based reporters reveal in vivo dynamics of dopamine and norepinephrine release in murine cortex.

Nat Methods 2014 Dec 26;11(12):1245-52. Epub 2014 Oct 26.

1] Department of Physics, University of California at San Diego, La Jolla, California, USA. [2] Graduate Program in Neurosciences, University of California at San Diego, La Jolla, California, USA. [3] Section of Neurobiology, University of California at San Diego, La Jolla, California, USA. [4] Department of Electrical and Computer Engineering, University of California at San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.1038/nmeth.3151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245316PMC
December 2014

Alcohol modulation of G-protein-gated inwardly rectifying potassium channels: from binding to therapeutics.

Front Physiol 2014 25;5:76. Epub 2014 Feb 25.

Structural Biology and Peptide Biology Laboratories, The Salk Institute for Biological Studies La Jolla, CA, USA ; Department of Neuroscience, Icahn School of Medicine at Mount Sinai New York, NY, USA.

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http://dx.doi.org/10.3389/fphys.2014.00076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933770PMC
June 2014

Sorting nexin 27 regulation of G protein-gated inwardly rectifying K⁺ channels attenuates in vivo cocaine response.

Neuron 2014 May;82(3):659-69

Peptide Biology Laboratories, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Graduate Program in Biology, University of California, San Diego, La Jolla, CA 92093, USA; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2014.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141045PMC
May 2014

Firing modes of dopamine neurons drive bidirectional GIRK channel plasticity.

J Neurosci 2014 Apr;34(15):5107-14

Department of Basis Neurosciences, Medical Faculty, University of Geneva, CH-1211 Geneva, Switzerland, Peptide Biology Laboratories, Salk Institute for Biological Studies, La Jolla, California 92037, Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York 10029, and Department of Clinical Neurosciences, Clinic of Neurology, Geneva University Hospital, CH-1211 Geneva, Switzerland.

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http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.5203-13.2
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http://dx.doi.org/10.1523/JNEUROSCI.5203-13.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983796PMC
April 2014

Molecular mechanism underlying ethanol activation of G-protein-gated inwardly rectifying potassium channels.

Proc Natl Acad Sci U S A 2013 Nov 21;110(45):18309-14. Epub 2013 Oct 21.

Peptide Biology and Structural Biology Laboratories, The Salk Institute for Biological Studies, La Jolla, CA 92037.

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http://dx.doi.org/10.1073/pnas.1311406110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831446PMC
November 2013

In vivo expression of a light-activatable potassium channel using unnatural amino acids.

Neuron 2013 Oct;80(2):358-70

The Jack H. Skirball Center for Chemical Biology and Proteomics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.neuron.2013.08.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3815458PMC
October 2013

Alcohol-binding sites in distinct brain proteins: the quest for atomic level resolution.

Alcohol Clin Exp Res 2011 Sep 15;35(9):1561-73. Epub 2011 Jun 15.

Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Texas 77812, USA.

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http://dx.doi.org/10.1111/j.1530-0277.2011.01502.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201783PMC
September 2011

Organotypic cerebellar cultures: apoptotic challenges and detection.

J Vis Exp 2011 May 17(51). Epub 2011 May 17.

Laboratory of Genetics, The Salk Institute for Biological Studies.

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http://dx.doi.org/10.3791/2564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197101PMC
May 2011

Mechanism underlying selective regulation of G protein-gated inwardly rectifying potassium channels by the psychostimulant-sensitive sorting nexin 27.

Proc Natl Acad Sci U S A 2011 Apr 21;108(14):5831-6. Epub 2011 Mar 21.

Clayton Foundation Laboratories for Peptide Biology, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1073/pnas.1018645108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078414PMC
April 2011

GABAB receptor coupling to G-proteins and ion channels.

Adv Pharmacol 2010 ;58:123-47

Peptide Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.

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http://dx.doi.org/10.1016/S1054-3589(10)58006-2DOI Listing
November 2010

Mutagenesis and functional analysis of ion channels heterologously expressed in mammalian cells.

J Vis Exp 2010 Oct 1(44). Epub 2010 Oct 1.

Clayton Foundation Laboratories for Peptide Biology, Salk Institute for Biological Studies.

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http://dx.doi.org/10.3791/2189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185640PMC
October 2010

Basal GABA regulates GABA(B)R conformation and release probability at single hippocampal synapses.

Neuron 2010 Jul;67(2):253-67

Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

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http://dx.doi.org/10.1016/j.neuron.2010.06.022DOI Listing
July 2010

Probing novel GPCR interactions using a combination of FRET and TIRF.

Commun Integr Biol 2010 Jul;3(4):343-6

Peptide Biology Laboratory; The Salk Institute for Biological Studies; La Jolla, CA USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928313PMC
http://dx.doi.org/10.4161/cib.3.4.11764DOI Listing
July 2010

Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease.

Nat Rev Neurosci 2010 May 14;11(5):301-15. Epub 2010 Apr 14.

Department of Basic Neurosciences, Medical Faculty, University of Geneva, 1 Michel Servet, CH-1211 Geneva, Switzerland.

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http://www.nature.com/articles/nrn2834
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http://dx.doi.org/10.1038/nrn2834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3052907PMC
May 2010

A discrete alcohol pocket involved in GIRK channel activation.

Nat Neurosci 2009 Aug 28;12(8):988-95. Epub 2009 Jun 28.

Peptide Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California, USA.

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http://dx.doi.org/10.1038/nn.2358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717173PMC
August 2009

Regulation of Kir2.1 channels by the Rho-GTPase, Rac1.

J Cell Physiol 2009 Feb;218(2):385-93

Peptide Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California, USA.

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http://dx.doi.org/10.1002/jcp.21610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871676PMC
February 2009

Subunit-specific regulation of Kir3 channels by sorting nexin 27.

Channels (Austin) 2007 Sep-Oct;1(5):331-3. Epub 2007 Oct 20.

The Salk Institute for Biological Studies, La Jolla, California 92037, USA.

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http://dx.doi.org/10.4161/chan.5191DOI Listing
November 2008

Addictive drugs modulate GIRK-channel signaling by regulating RGS proteins.

Trends Pharmacol Sci 2008 Nov 12;29(11):544-9. Epub 2008 Sep 12.

Department of Basic Neurosciences, Medical Faculty, University of Geneva, 1, Michel-Servet, CH-1211 Geneva, Switzerland.

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http://dx.doi.org/10.1016/j.tips.2008.07.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2818288PMC
November 2008

RGS2 modulates coupling between GABAB receptors and GIRK channels in dopamine neurons of the ventral tegmental area.

Nat Neurosci 2007 Dec 28;10(12):1559-68. Epub 2007 Oct 28.

Department of Basic Neurosciences, Medical Faculty, University of Geneva, 1, Michel- Servet, CH-1211 Geneva, Switzerland.

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http://dx.doi.org/10.1038/nn2006DOI Listing
December 2007

A unique sorting nexin regulates trafficking of potassium channels via a PDZ domain interaction.

Nat Neurosci 2007 Oct 2;10(10):1249-59. Epub 2007 Sep 2.

Peptide Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Rd., La Jolla, California 92037, USA.

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http://dx.doi.org/10.1038/nn1953DOI Listing
October 2007

Genetically encoding unnatural amino acids for cellular and neuronal studies.

Nat Neurosci 2007 Aug 1;10(8):1063-72. Epub 2007 Jul 1.

Jack H. Skirball Center for Chemical Biology and Proteomics, 10010 North Torrey Pines Road, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1038/nn1932DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2692200PMC
August 2007

The role of the cytoplasmic pore in inward rectification of Kir2.1 channels.

J Gen Physiol 2007 Aug 16;130(2):145-55. Epub 2007 Jul 16.

Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1085/jgp.200709742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151631PMC
August 2007

Coregulation of natively expressed pertussis toxin-sensitive muscarinic receptors with G-protein-activated potassium channels.

J Neurosci 2007 Jun;27(24):6388-99

Peptide Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.1190-07.2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6672446PMC
June 2007

NMR studies of interactions between C-terminal tail of Kir2.1 channel and PDZ1,2 domains of PSD95.

Biochemistry 2007 May 17;46(18):5315-22. Epub 2007 Apr 17.

Structural Biology, The Salk Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1021/bi062228qDOI Listing
May 2007

Andersen's syndrome mutation effects on the structure and assembly of the cytoplasmic domains of Kir2.1.

Biochemistry 2006 Jul;45(28):8599-606

Structural Biology Laboratory, The Salk Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1021/bi060653dDOI Listing
July 2006

Endogenous RGS proteins enhance acute desensitization of GABA(B) receptor-activated GIRK currents in HEK-293T cells.

Pflugers Arch 2005 Apr 10;450(1):61-73. Epub 2004 Dec 10.

The Salk Institute for Biological Studies, La Jolla, CA, 92037, USA.

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http://dx.doi.org/10.1007/s00424-004-1367-1DOI Listing
April 2005

Cytoplasmic domain structures of Kir2.1 and Kir3.1 show sites for modulating gating and rectification.

Nat Neurosci 2005 Mar 20;8(3):279-87. Epub 2005 Feb 20.

Structural Biology, The Salk Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1038/nn1411DOI Listing
March 2005

Pertussis-toxin-sensitive Galpha subunits selectively bind to C-terminal domain of neuronal GIRK channels: evidence for a heterotrimeric G-protein-channel complex.

Mol Cell Neurosci 2005 Feb;28(2):375-89

Peptide Biology Laboratory, The Salk Institute for Biological Studies, 10010 N. Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.mcn.2004.10.009DOI Listing
February 2005

Minimal structural rearrangement of the cytoplasmic pore during activation of the 5-HT3A receptor.

J Biol Chem 2004 Jul 6;279(27):28149-58. Epub 2004 May 6.

Peptide Biology Laboratory, The Salk Institute for Biological Studies, 10010 N. Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1074/jbc.M403545200DOI Listing
July 2004

betaL-betaM loop in the C-terminal domain of G protein-activated inwardly rectifying K(+) channels is important for G(betagamma) subunit activation.

J Physiol 2004 Mar 14;555(Pt 3):643-57. Epub 2004 Jan 14.

Peptide Biology Laboratory, The Salk Institute, 10010 N. Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1113/jphysiol.2003.056101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1664862PMC
March 2004

Bi-directional effects of GABA(B) receptor agonists on the mesolimbic dopamine system.

Nat Neurosci 2004 Feb 25;7(2):153-9. Epub 2004 Jan 25.

Department of Basic Neurosciences, University of Geneva, 1 Michel Servet, CH-1211 Geneva 4, Switzerland.

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http://dx.doi.org/10.1038/nn1181DOI Listing
February 2004

Evidence for a centrally located gate in the pore of a serotonin-gated ion channel.

J Neurosci 2002 Mar;22(5):1629-39

The Salk Institute for Biological Studies, La Jolla, California 92037, USA.

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March 2002