Paul A Nyquist

Paul A Nyquist

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Paul A Nyquist

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White Matter Lesion Progression and Cognitive Function Over 5 Years in a Young Susceptible Population.

Neuroepidemiology 2017 30;49(1-2):62-63. Epub 2017 Aug 30.

The Johns Hopkins GeneSTAR Research Program, Departments of Neurology and Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1159/000480238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634942PMC
June 2019

Haptoglobin genotype and aneurysmal subarachnoid hemorrhage: Individual patient data analysis.

Neurology 2019 Apr 5;92(18):e2150-e2164. Epub 2019 Apr 5.

From the Wessex Neurological Centre (B.G., D.O.B., I.G.), University Hospital Southampton NHS Foundation Trust, UK; School of Nursing (D.R., S.A.) and Department of Biostatistics (D.R., T.E.), University of Pittsburgh, PA; Department of Neurology (E.R.B.), Duke University School of Medicine, Durham, NC; NeuroSpring (D.M.B., M.K.B.), Dover, DE; Department of Neurosurgery (S.L.B.), University of Texas Health Science Center at Houston; Department of Anesthesiology, Neurology, Psychiatry, Psychology, Pharmaceutics, and Neuroscience (S.D., J.L.L.), College of Medicine, Center for Translational Research in Neurodegenerative Disease, McKnight Brain Institute, University of Florida, Gainesville; Brain Injury Research Group (J.G.), Division of Cardiovascular Sciences (University of Manchester), Salford Royal NHS Foundation Trust, UK; Clinical Neurosciences, Clinical & Experimental Sciences (P.G., I.G.), Faculty of Medicine, University of Southampton, UK; Department of Neurosurgery (K.I., Y.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Department of Neurology (J.F.M., M.A.P.), Mayo Clinic, Jacksonville, FL; and Division of Cerebrovascular Neurosurgery (R.J.T.) and Departments of Neurology, Anesthesia/Critical Care Medicine, and Neurosurgery (W.Y., P.A.N.), Johns Hopkins University School of Medicine, Baltimore, MD.

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http://dx.doi.org/10.1212/WNL.0000000000007397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512887PMC
April 2019

Intensive Care Unit Readmission in Patients With Primary Brain Injury and Tracheostomy.

Am J Crit Care 2019 Jan;28(1):56-63

Vinciya Pandian is an assistant professor in the Department of Acute and Chronic Care, Johns Hopkins School of Nursing, Baltimore, Maryland, and in the Outcomes After Critical Illness and Surgery (OACIS) Research Group, Johns Hopkins University, Baltimore, Maryland. Mohit Datta is an assistant professor in the Department of Surgery, Palmetto Health USC, University of South Carolina, Columbia, South Carolina. Sajan Nakka is research assistant and Patricia M. Davidson is a dean and professor in the Department of Acute and Chronic Care, Johns Hopkins School of Nursing. Devi S. Tammineedi is a research assistant in the Department of Anesthesia and Critical Care Medicine, Johns Hopkins School of Medicine. Paul A. Nyquist is an associate professor in the departments of neurology, anesthesia/critical care medicine, neurosurgery, and general internal medicine, Johns Hopkins School of Medicine.

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http://dx.doi.org/10.4037/ajcc2019883DOI Listing
January 2019

Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume.

Nat Commun 2018 09 26;9(1):3945. Epub 2018 Sep 26.

The University of Texas Health Science Center at Houston Institute of Molecular Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1038/s41467-018-06234-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158214PMC
September 2018

Exome Chip Analysis Identifies Low-Frequency and Rare Variants in MRPL38 for White Matter Hyperintensities on Brain Magnetic Resonance Imaging.

Stroke 2018 Aug;49(8):1812-1819

From the Institute of Molecular Medicine, McGovern Medical School at The University of Texas Health Science Center at Houston (M.F., X.J.).

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http://dx.doi.org/10.1161/STROKEAHA.118.020689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202149PMC
August 2018

Genetics, white matter, and cognition: The effects of methylation on .

Neurology 2017 05 5;88(22):2070-2071. Epub 2017 May 5.

From the Departments of Neurology (P.A.N.), Anesthesia/Critical Care Medicine, Neurosurgery, and General Internal Medicine, Johns Hopkins School of Medicine, Baltimore, MD; and MIND Institute (R.H.), Departments of Pediatrics, University of California at Davis, Sacramento.

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http://dx.doi.org/10.1212/WNL.0000000000003994DOI Listing
May 2017

Novel genetic loci underlying human intracranial volume identified through genome-wide association.

Authors:
Hieab H H Adams Derrek P Hibar Vincent Chouraki Jason L Stein Paul A Nyquist Miguel E Rentería Stella Trompet Alejandro Arias-Vasquez Sudha Seshadri Sylvane Desrivières Ashley H Beecham Neda Jahanshad Katharina Wittfeld Sven J Van der Lee Lucija Abramovic Saud Alhusaini Najaf Amin Micael Andersson Konstantinos Arfanakis Benjamin S Aribisala Nicola J Armstrong Lavinia Athanasiu Tomas Axelsson Alexa Beiser Manon Bernard Joshua C Bis Laura M E Blanken Susan H Blanton Marc M Bohlken Marco P Boks Janita Bralten Adam M Brickman Owen Carmichael M Mallar Chakravarty Ganesh Chauhan Qiang Chen Christopher R K Ching Gabriel Cuellar-Partida Anouk Den Braber Nhat Trung Doan Stefan Ehrlich Irina Filippi Tian Ge Sudheer Giddaluru Aaron L Goldman Rebecca F Gottesman Corina U Greven Oliver Grimm Michael E Griswold Tulio Guadalupe Johanna Hass Unn K Haukvik Saima Hilal Edith Hofer David Hoehn Avram J Holmes Martine Hoogman Deborah Janowitz Tianye Jia Dalia Kasperaviciute Sungeun Kim Marieke Klein Bernd Kraemer Phil H Lee Jiemin Liao David C M Liewald Lorna M Lopez Michelle Luciano Christine Macare Andre Marquand Mar Matarin Karen A Mather Manuel Mattheisen Bernard Mazoyer David R McKay Rebekah McWhirter Yuri Milaneschi Nazanin Mirza-Schreiber Ryan L Muetzel Susana Muñoz Maniega Kwangsik Nho Allison C Nugent Loes M Olde Loohuis Jaap Oosterlaan Martina Papmeyer Irene Pappa Lukas Pirpamer Sara Pudas Benno Pütz Kumar B Rajan Adaikalavan Ramasamy Jennifer S Richards Shannon L Risacher Roberto Roiz-Santiañez Nanda Rommelse Emma J Rose Natalie A Royle Tatjana Rundek Philipp G Sämann Claudia L Satizabal Lianne Schmaal Andrew J Schork Li Shen Jean Shin Elena Shumskaya Albert V Smith Emma Sprooten Lachlan T Strike Alexander Teumer Russell Thomson Diana Tordesillas-Gutierrez Roberto Toro Daniah Trabzuni Dhananjay Vaidya Jeroen Van der Grond Dennis Van der Meer Marjolein M J Van Donkelaar Kristel R Van Eijk Theo G M Van Erp Daan Van Rooij Esther Walton Lars T Westlye Christopher D Whelan Beverly G Windham Anderson M Winkler Girma Woldehawariat Christiane Wolf Thomas Wolfers Bing Xu Lisa R Yanek Jingyun Yang Alex Zijdenbos Marcel P Zwiers Ingrid Agartz Neelum T Aggarwal Laura Almasy David Ames Philippe Amouyel Ole A Andreassen Sampath Arepalli Amelia A Assareh Sandra Barral Mark E Bastin Diane M Becker James T Becker David A Bennett John Blangero Hans van Bokhoven Dorret I Boomsma Henry Brodaty Rachel M Brouwer Han G Brunner Randy L Buckner Jan K Buitelaar Kazima B Bulayeva Wiepke Cahn Vince D Calhoun Dara M Cannon Gianpiero L Cavalleri Christopher Chen Ching-Yu Cheng Sven Cichon Mark R Cookson Aiden Corvin Benedicto Crespo-Facorro Joanne E Curran Michael Czisch Anders M Dale Gareth E Davies Eco J C De Geus Philip L De Jager Greig I de Zubicaray Norman Delanty Chantal Depondt Anita L DeStefano Allissa Dillman Srdjan Djurovic Gary Donohoe Wayne C Drevets Ravi Duggirala Thomas D Dyer Susanne Erk Thomas Espeseth Denis A Evans Iryna O Fedko Guillén Fernández Luigi Ferrucci Simon E Fisher Debra A Fleischman Ian Ford Tatiana M Foroud Peter T Fox Clyde Francks Masaki Fukunaga J Raphael Gibbs David C Glahn Randy L Gollub Harald H H Göring Hans J Grabe Robert C Green Oliver Gruber Vilmundur Gudnason Sebastian Guelfi Narelle K Hansell John Hardy Catharina A Hartman Ryota Hashimoto Katrin Hegenscheid Andreas Heinz Stephanie Le Hellard Dena G Hernandez Dirk J Heslenfeld Beng-Choon Ho Pieter J Hoekstra Wolfgang Hoffmann Albert Hofman Florian Holsboer Georg Homuth Norbert Hosten Jouke-Jan Hottenga Hilleke E Hulshoff Pol Masashi Ikeda M Kamran Ikram Clifford R Jack Mark Jenkinson Robert Johnson Erik G Jönsson J Wouter Jukema René S Kahn Ryota Kanai Iwona Kloszewska David S Knopman Peter Kochunov John B Kwok Stephen M Lawrie Hervé Lemaître Xinmin Liu Dan L Longo W T Longstreth Oscar L Lopez Simon Lovestone Oliver Martinez Jean-Luc Martinot Venkata S Mattay Colm McDonald Andrew M McIntosh Katie L McMahon Francis J McMahon Patrizia Mecocci Ingrid Melle Andreas Meyer-Lindenberg Sebastian Mohnke Grant W Montgomery Derek W Morris Thomas H Mosley Thomas W Mühleisen Bertram Müller-Myhsok Michael A Nalls Matthias Nauck Thomas E Nichols Wiro J Niessen Markus M Nöthen Lars Nyberg Kazutaka Ohi Rene L Olvera Roel A Ophoff Massimo Pandolfo Tomas Paus Zdenka Pausova Brenda W J H Penninx G Bruce Pike Steven G Potkin Bruce M Psaty Simone Reppermund Marcella Rietschel Joshua L Roffman Nina Romanczuk-Seiferth Jerome I Rotter Mina Ryten Ralph L Sacco Perminder S Sachdev Andrew J Saykin Reinhold Schmidt Peter R Schofield Sigurdur Sigurdsson Andy Simmons Andrew Singleton Sanjay M Sisodiya Colin Smith Jordan W Smoller Hilkka Soininen Velandai Srikanth Vidar M Steen David J Stott Jessika E Sussmann Anbupalam Thalamuthu Henning Tiemeier Arthur W Toga Bryan J Traynor Juan Troncoso Jessica A Turner Christophe Tzourio Andre G Uitterlinden Maria C Valdés Hernández Marcel Van der Brug Aad Van der Lugt Nic J A Van der Wee Cornelia M Van Duijn Neeltje E M Van Haren Dennis Van T Ent Marie-Jose Van Tol Badri N Vardarajan Dick J Veltman Meike W Vernooij Henry Völzke Henrik Walter Joanna M Wardlaw Thomas H Wassink Michael E Weale Daniel R Weinberger Michael W Weiner Wei Wen Eric Westman Tonya White Tien Y Wong Clinton B Wright H Ronald Zielke Alan B Zonderman Ian J Deary Charles DeCarli Helena Schmidt Nicholas G Martin Anton J M De Craen Margaret J Wright Lenore J Launer Gunter Schumann Myriam Fornage Barbara Franke Stéphanie Debette Sarah E Medland M Arfan Ikram Paul M Thompson

Nat Neurosci 2016 12 3;19(12):1569-1582. Epub 2016 Oct 3.

Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, California, USA.

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http://dx.doi.org/10.1038/nn.4398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5227112PMC
December 2016

Ventriculostomy and Lytic Therapy for Intracerebral Hemorrhage.

Front Neurol Neurosci 2015 12;37:130-47. Epub 2015 Nov 12.

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http://dx.doi.org/10.1159/000437118DOI Listing
September 2016

Haptoglobin 2-2 Genotype Is Associated With Cerebral Salt Wasting Syndrome in Aneurysmal Subarachnoid Hemorrhage.

Neurosurgery 2016 Jan;78(1):71-6

*Division of Neurosciences Critical Care and‡Department of Neurological Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland;§Department of Medicine, Technion Institute of Technology, Haifa, Israel;¶Department of Neurological Surgery, Emory University, Atlanta, Georgia;‖Center for Surgical Trials and Outcomes Research, Johns Hopkins University, Baltimore, Maryland.

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http://dx.doi.org/10.1227/NEU.0000000000001000DOI Listing
January 2016

Effect of white matter lesions on manual dexterity in healthy middle-aged persons.

Neurology 2015 May 10;84(19):1920-6. Epub 2015 Apr 10.

From the Departments of Neurology (P.A.N.), Anesthesiology and Critical Care Medicine (P.A.N.), and Neurosurgery (P.A.N.), and Department of Medicine, Division of General Internal Medicine (L.R.Y., L.C.B., K.C.-D., B.G.K., D.V., D.M.B.), GeneSTAR Research Program; Department of Biomedical Engineering (M.B., J.L.C., J.P.), Johns Hopkins School of Medicine; and Department of Medicine, Division of Cardiology (L.C.B., B.G.K.), and Department of Radiology, Divisions of Diagnostic Radiology and Neuroradiology (D.Y.), The Johns Hopkins Medical Institutions, Baltimore, MD.

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http://dx.doi.org/10.1212/WNL.0000000000001557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433457PMC
May 2015

Presence of haptoglobin-2 allele is associated with worse functional outcomes after spontaneous intracerebral hemorrhage.

World Neurosurg 2015 Apr 17;83(4):583-7. Epub 2014 Dec 17.

Division of Neurosciences Critical Care, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1016/j.wneu.2014.12.013DOI Listing
April 2015

Age differences in periventricular and deep white matter lesions.

Neurobiol Aging 2015 Apr 7;36(4):1653-1658. Epub 2015 Jan 7.

Division of General Internal Medicine, Department of Medicine, GeneSTAR Research Program, Johns Hopkins School of Medicine, Baltimore, MD, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S01974580150000
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http://dx.doi.org/10.1016/j.neurobiolaging.2015.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380525PMC
April 2015

Toxicity with hyperoxia in brain injury? Retrospection identifies unforeseen obstacles.

Authors:
Paul A Nyquist

Crit Care Med 2014 Feb;42(2):469-70

Department of Neurology; Department of Anesthesiology and Critical Care Medicine; and, Department of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, MD.

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https://insights.ovid.com/crossref?an=00003246-201402000-000
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http://dx.doi.org/10.1097/CCM.0b013e3182a525a4DOI Listing
February 2014

Management of intracerebral pressure in the neurosciences critical care unit.

Neurosurg Clin N Am 2013 Jul 24;24(3):361-73. Epub 2013 Apr 24.

Neurology and Critical Care, Department of Medicine, San Antonio Military Medical Center, 3551 Roger Brooke Drive, Fort Sam Houston, Texas, TX 78234, USA.

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http://dx.doi.org/10.1016/j.nec.2013.03.004DOI Listing
July 2013

Strategies for the use of mechanical ventilation in the neurologic intensive care unit.

Neurosurg Clin N Am 2013 Jul 29;24(3):407-16. Epub 2013 Mar 29.

Department of Neurology, The Johns Hopkins School of Medicine, Baltimore, MD, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S10423680130000
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http://dx.doi.org/10.1016/j.nec.2013.02.004DOI Listing
July 2013

Use of Transcranial Doppler (TCD) ultrasound in the Neurocritical Care Unit.

Neurosurg Clin N Am 2013 Jul 17;24(3):441-56. Epub 2013 Apr 17.

Division of Neurocritical care, Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Hospital, 600 N. Wolfe Street, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1016/j.nec.2013.02.005DOI Listing
July 2013

Neurocritical care in neurosurgery.

Neurosurg Clin N Am 2013 Jul 21;24(3):xiii-xiv. Epub 2013 Mar 21.

The Johns Hopkins Hospital, Department of Neurology, Meyer 8-140, 600 North Wolfe Street, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1016/j.nec.2013.02.006DOI Listing
July 2013

AUTOMATED ANATOMICAL LABELING OF THE CEREBRAL ARTERIES USING BELIEF PROPAGATION.

Proc SPIE Int Soc Opt Eng 2013 Mar;866918

Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1117/12.2006460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824264PMC
March 2013

Protein biomarkers in patients with subarachnoid hemorrhage, vasospasm, and delayed ischemic neurological deficits.

Acta Neurochir Suppl 2013 ;115:23-5

Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA.

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http://dx.doi.org/10.1007/978-3-7091-1192-5_6DOI Listing
December 2012

Ethnic-specific determinants of exercise capacity in a healthy high-risk population.

Med Sci Sports Exerc 2012 Jun;44(6):1150-6

Division of General Internal Medicine, Johns Hopkins Medical Institutions, Baltimore,MD 21287, USA.

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https://insights.ovid.com/crossref?an=00005768-201206000-000
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http://dx.doi.org/10.1249/MSS.0b013e3182456990DOI Listing
June 2012

Acute lung injury in critical neurological illness.

Crit Care Med 2012 Feb;40(2):587-93

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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https://insights.ovid.com/crossref?an=00003246-201202000-000
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http://dx.doi.org/10.1097/CCM.0b013e3182329617DOI Listing
February 2012

Really small vascular disease of the brain.

Neurology 2012 Jan 14;78(2):82-3. Epub 2011 Dec 14.

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http://www.neurology.org/cgi/doi/10.1212/WNL.0b013e3182447e7
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http://dx.doi.org/10.1212/WNL.0b013e3182447e7cDOI Listing
January 2012

Intra-aortic balloon pump counterpulsation in the setting of subarachnoid hemorrhage, cerebral vasospasm, and neurogenic stress cardiomyopathy. Case report and review of the literature.

Neurocrit Care 2010 Aug;13(1):101-8

Neurosciences Intensive Care Unit, Departments of Neurology and Neurosurgery, Medical University of South Carolina, Charleston, SC 29425, USA.

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http://dx.doi.org/10.1007/s12028-010-9358-xDOI Listing
August 2010

The "ivy sign" of adult moyamoya disease.

Neurologist 2009 Nov;15(6):367-8

Department of Neurosciences Critical Care, Johns Hopkins University, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1097/NRL.0b013e3181963d05DOI Listing
November 2009

Single nucleotide polymorphisms in monocyte chemoattractant protein-1 and its receptor act synergistically to increase the risk of carotid atherosclerosis.

Cerebrovasc Dis 2009 5;28(2):124-30. Epub 2009 Jun 5.

Department of Anesthesiology/Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1159/000223437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2914430PMC
September 2009

Management of spontaneous intracerebral hemorrhage.

Neurosurg Clin N Am 2008 Jul;19(3):415-23, v

Department of Neurology, Division of Neurosciences Critical Care, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S104236800800042
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http://dx.doi.org/10.1016/j.nec.2008.07.014DOI Listing
July 2008

Management of spontaneous intracerebral hemorrhage.

Neurol Clin 2008 May;26(2):373-84, vii

Department of Neurology, Division of Neurosciences Critical Care, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S073386190800031
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http://dx.doi.org/10.1016/j.ncl.2008.03.002DOI Listing
May 2008

Types of brain dysfunction in critical illness.

Neurol Clin 2008 May;26(2):469-86, ix

Department of Anesthesiology Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1016/j.ncl.2008.02.004DOI Listing
May 2008

The systemic implications of aneurysmal subarachnoid hemorrhage.

J Neurol Sci 2007 Oct 4;261(1-2):143-56. Epub 2007 Jun 4.

Department of Anesthesiology/Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1016/j.jns.2007.04.047DOI Listing
October 2007

Advances in the management of spontaneous intracerebral hemorrhage.

Crit Care Clin 2006 Oct;22(4):607-17; abstract vii-viii

Department of Neurology, Division of Neurosciences Critical Care, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1016/j.ccc.2006.11.007DOI Listing
October 2006

Coma, delirium, and cognitive dysfunction in critical illness.

Crit Care Clin 2006 Oct;22(4):787-804; abstract x

Department of Anesthesiology, Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1016/j.ccc.2006.11.006DOI Listing
October 2006

Detection of leukocyte activation in pigs with neurologic decompression sickness.

Aviat Space Environ Med 2004 Mar;75(3):211-4

Naval Medical Research Center, Bethesda, MD, USA.

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March 2004

Interleukin-1 receptor antagonist gene polymorphisms in carotid atherosclerosis.

Stroke 2003 Mar 20;34(3):790-3. Epub 2003 Feb 20.

University of Virginia, Departments of Neurology, Charlottesville, Va, USA.

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http://dx.doi.org/10.1161/01.STR.0000057815.79289.ECDOI Listing
March 2003

Incidence of seizures in patients with multiple sclerosis: a population-based study.

Mayo Clin Proc 2002 Sep;77(9):910-2

Department of Neurology, Mayo Clinic, Rochester, Minn 55905, USA.

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http://dx.doi.org/10.4065/77.9.910DOI Listing
September 2002