Paul A Northcott

Paul A Northcott

UNVERIFIED PROFILE

Are you Paul A Northcott?   Register this Author

Register author
Paul A Northcott

Paul A Northcott

Publications by authors named "Paul A Northcott"

Are you Paul A Northcott?   Register this Author

100Publications

4732Reads

42Profile Views

Tumour-associated macrophages exhibit anti-tumoural properties in Sonic Hedgehog medulloblastoma.

Nat Commun 2019 06 3;10(1):2410. Epub 2019 Jun 3.

Department of Pediatrics, Neuro-Oncology Division and Aflac Cancer and Blood Disorders Center of Children's Healthcare of Atlanta, Emory University, Atlanta, 30322, GA, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-019-10458-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546707PMC
June 2019

Medulloblastoma.

Nat Rev Dis Primers 2019 02 14;5(1):11. Epub 2019 Feb 14.

Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41572-019-0063-6DOI Listing
February 2019

Advances in the classification of pediatric brain tumors through DNA methylation profiling: From research tool to frontline diagnostic.

Cancer 2018 11 26;124(21):4168-4180. Epub 2018 Sep 26.

Division of Neuro-Oncology, Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/cncr.31583
Publisher Site
http://dx.doi.org/10.1002/cncr.31583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263826PMC
November 2018

A Single-Cell Transcriptional Atlas of the Developing Murine Cerebellum.

Curr Biol 2018 Sep 13;28(18):2910-2920.e2. Epub 2018 Sep 13.

Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cub.2018.07.062DOI Listing
September 2018

Author Correction: The landscape of genomic alterations across childhood cancers.

Nature 2018 07;559(7714):E10

Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41586-018-0167-2DOI Listing
July 2018

Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort.

Lancet Oncol 2018 06 9;19(6):785-798. Epub 2018 May 9.

Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany; Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany; Hopp Children's Cancer Center at the NCT Heidelberg, Heidelberg, Germany. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S14702045183024
Publisher Site
http://dx.doi.org/10.1016/S1470-2045(18)30242-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984248PMC
June 2018

MLL4 Is Required to Maintain Broad H3K4me3 Peaks and Super-Enhancers at Tumor Suppressor Genes.

Mol Cell 2018 06 31;70(5):825-841.e6. Epub 2018 May 31.

Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA; The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX 77030, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molcel.2018.04.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528658PMC
June 2018

Proteomic analysis of Medulloblastoma reveals functional biology with translational potential.

Acta Neuropathol Commun 2018 06 7;6(1):48. Epub 2018 Jun 7.

Center for Cancer and Immunology Research, Children's Research Institute, Children's National Health System, Washington, DC, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40478-018-0548-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992829PMC
June 2018

The landscape of genomic alterations across childhood cancers.

Nature 2018 03 28;555(7696):321-327. Epub 2018 Feb 28.

Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature25480DOI Listing
March 2018

NRL and CRX Define Photoreceptor Identity and Reveal Subgroup-Specific Dependencies in Medulloblastoma.

Cancer Cell 2018 03;33(3):435-449.e6

Institut Curie - Recherche, Laboratoire 110, Centre Universitaire, Orsay Cedex 91405, France; INSERM U1021, Centre Universitaire, Orsay 91405, France; CNRS UMR 3347, Centre Universitaire, Orsay 91405, France; Université Paris Sud-11, 91405 Orsay, France; PSL Research University, Paris, France. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15356108183005
Publisher Site
http://dx.doi.org/10.1016/j.ccell.2018.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368680PMC
March 2018

DNA methylation-based classification of central nervous system tumours.

Authors:
David Capper David T W Jones Martin Sill Volker Hovestadt Daniel Schrimpf Dominik Sturm Christian Koelsche Felix Sahm Lukas Chavez David E Reuss Annekathrin Kratz Annika K Wefers Kristin Huang Kristian W Pajtler Leonille Schweizer Damian Stichel Adriana Olar Nils W Engel Kerstin Lindenberg Patrick N Harter Anne K Braczynski Karl H Plate Hildegard Dohmen Boyan K Garvalov Roland Coras Annett Hölsken Ekkehard Hewer Melanie Bewerunge-Hudler Matthias Schick Roger Fischer Rudi Beschorner Jens Schittenhelm Ori Staszewski Khalida Wani Pascale Varlet Melanie Pages Petra Temming Dietmar Lohmann Florian Selt Hendrik Witt Till Milde Olaf Witt Eleonora Aronica Felice Giangaspero Elisabeth Rushing Wolfram Scheurlen Christoph Geisenberger Fausto J Rodriguez Albert Becker Matthias Preusser Christine Haberler Rolf Bjerkvig Jane Cryan Michael Farrell Martina Deckert Jürgen Hench Stephan Frank Jonathan Serrano Kasthuri Kannan Aristotelis Tsirigos Wolfgang Brück Silvia Hofer Stefanie Brehmer Marcel Seiz-Rosenhagen Daniel Hänggi Volkmar Hans Stephanie Rozsnoki Jordan R Hansford Patricia Kohlhof Bjarne W Kristensen Matt Lechner Beatriz Lopes Christian Mawrin Ralf Ketter Andreas Kulozik Ziad Khatib Frank Heppner Arend Koch Anne Jouvet Catherine Keohane Helmut Mühleisen Wolf Mueller Ute Pohl Marco Prinz Axel Benner Marc Zapatka Nicholas G Gottardo Pablo Hernáiz Driever Christof M Kramm Hermann L Müller Stefan Rutkowski Katja von Hoff Michael C Frühwald Astrid Gnekow Gudrun Fleischhack Stephan Tippelt Gabriele Calaminus Camelia-Maria Monoranu Arie Perry Chris Jones Thomas S Jacques Bernhard Radlwimmer Marco Gessi Torsten Pietsch Johannes Schramm Gabriele Schackert Manfred Westphal Guido Reifenberger Pieter Wesseling Michael Weller Vincent Peter Collins Ingmar Blümcke Martin Bendszus Jürgen Debus Annie Huang Nada Jabado Paul A Northcott Werner Paulus Amar Gajjar Giles W Robinson Michael D Taylor Zane Jaunmuktane Marina Ryzhova Michael Platten Andreas Unterberg Wolfgang Wick Matthias A Karajannis Michel Mittelbronn Till Acker Christian Hartmann Kenneth Aldape Ulrich Schüller Rolf Buslei Peter Lichter Marcel Kool Christel Herold-Mende David W Ellison Martin Hasselblatt Matija Snuderl Sebastian Brandner Andrey Korshunov Andreas von Deimling Stefan M Pfister

Nature 2018 03 14;555(7697):469-474. Epub 2018 Mar 14.

Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature26000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093218PMC
March 2018

Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling.

Nature 2018 01 20;553(7686):101-105. Epub 2017 Dec 20.

Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature25169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993422PMC
January 2018

DNA-methylation profiling discloses significant advantages over NanoString method for molecular classification of medulloblastoma.

Acta Neuropathol 2017 Dec 13;134(6):965-967. Epub 2017 Oct 13.

German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00401-017-1776-9DOI Listing
December 2017

Genomic Analysis of Childhood Brain Tumors: Methods for Genome-Wide Discovery and Precision Medicine Become Mainstream.

J Clin Oncol 2017 Jul 22;35(21):2346-2354. Epub 2017 Jun 22.

Stephen C. Mack, Cleveland Clinic, Cleveland, OH; and Paul A. Northcott, St Jude Children's Research Hospital, Memphis, TN.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/JCO.2017.72.9921DOI Listing
July 2017

Cancer: Keeping it real to kill glioblastoma.

Authors:
Paul A Northcott

Nature 2017 07 5;547(7663):291-292. Epub 2017 Jul 5.

Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature23095DOI Listing
July 2017

The whole-genome landscape of medulloblastoma subtypes.

Nature 2017 07;547(7663):311-317

Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature22973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905700PMC
July 2017

Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis.

Authors:
Eric M Thompson Thomas Hielscher Eric Bouffet Marc Remke Betty Luu Sridharan Gururangan Roger E McLendon Darell D Bigner Eric S Lipp Sebastien Perreault Yoon-Jae Cho Gerald Grant Seung-Ki Kim Ji Yeoun Lee Amulya A Nageswara Rao Caterina Giannini Kay Ka Wai Li Ho-Keung Ng Yu Yao Toshihiro Kumabe Teiji Tominaga Wieslawa A Grajkowska Marta Perek-Polnik David C Y Low Wan Tew Seow Kenneth T E Chang Jaume Mora Ian F Pollack Ronald L Hamilton Sarah Leary Andrew S Moore Wendy J Ingram Andrew R Hallahan Anne Jouvet Michelle Fèvre-Montange Alexandre Vasiljevic Cecile Faure-Conter Tomoko Shofuda Naoki Kagawa Naoya Hashimoto Nada Jabado Alexander G Weil Tenzin Gayden Takafumi Wataya Tarek Shalaby Michael Grotzer Karel Zitterbart Jaroslav Sterba Leos Kren Tibor Hortobágyi Almos Klekner Bognár László Tímea Pócza Peter Hauser Ulrich Schüller Shin Jung Woo-Youl Jang Pim J French Johan M Kros Marie-Lise C van Veelen Luca Massimi Jeffrey R Leonard Joshua B Rubin Rajeev Vibhakar Lola B Chambless Michael K Cooper Reid C Thompson Claudia C Faria Alice Carvalho Sofia Nunes José Pimentel Xing Fan Karin M Muraszko Enrique López-Aguilar David Lyden Livia Garzia David J H Shih Noriyuki Kijima Christian Schneider Jennifer Adamski Paul A Northcott Marcel Kool David T W Jones Jennifer A Chan Ana Nikolic Maria Luisa Garre Erwin G Van Meir Satoru Osuka Jeffrey J Olson Arman Jahangiri Brandyn A Castro Nalin Gupta William A Weiss Iska Moxon-Emre Donald J Mabbott Alvaro Lassaletta Cynthia E Hawkins Uri Tabori James Drake Abhaya Kulkarni Peter Dirks James T Rutka Andrey Korshunov Stefan M Pfister Roger J Packer Vijay Ramaswamy Michael D Taylor

Lancet Oncol 2016 04 12;17(4):484-495. Epub 2016 Mar 12.

Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON, Canada; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S14702045150058
Publisher Site
http://dx.doi.org/10.1016/S1470-2045(15)00581-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907853PMC
April 2016

New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs.

Authors:
Dominik Sturm Brent A Orr Umut H Toprak Volker Hovestadt David T W Jones David Capper Martin Sill Ivo Buchhalter Paul A Northcott Irina Leis Marina Ryzhova Christian Koelsche Elke Pfaff Sariah J Allen Gnanaprakash Balasubramanian Barbara C Worst Kristian W Pajtler Sebastian Brabetz Pascal D Johann Felix Sahm Jüri Reimand Alan Mackay Diana M Carvalho Marc Remke Joanna J Phillips Arie Perry Cynthia Cowdrey Rachid Drissi Maryam Fouladi Felice Giangaspero Maria Łastowska Wiesława Grajkowska Wolfram Scheurlen Torsten Pietsch Christian Hagel Johannes Gojo Daniela Lötsch Walter Berger Irene Slavc Christine Haberler Anne Jouvet Stefan Holm Silvia Hofer Marco Prinz Catherine Keohane Iris Fried Christian Mawrin David Scheie Bret C Mobley Matthew J Schniederjan Mariarita Santi Anna M Buccoliero Sonika Dahiya Christof M Kramm André O von Bueren Katja von Hoff Stefan Rutkowski Christel Herold-Mende Michael C Frühwald Till Milde Martin Hasselblatt Pieter Wesseling Jochen Rößler Ulrich Schüller Martin Ebinger Jens Schittenhelm Stephan Frank Rainer Grobholz Istvan Vajtai Volkmar Hans Reinhard Schneppenheim Karel Zitterbart V Peter Collins Eleonora Aronica Pascale Varlet Stephanie Puget Christelle Dufour Jacques Grill Dominique Figarella-Branger Marietta Wolter Martin U Schuhmann Tarek Shalaby Michael Grotzer Timothy van Meter Camelia-Maria Monoranu Jörg Felsberg Guido Reifenberger Matija Snuderl Lynn Ann Forrester Jan Koster Rogier Versteeg Richard Volckmann Peter van Sluis Stephan Wolf Tom Mikkelsen Amar Gajjar Kenneth Aldape Andrew S Moore Michael D Taylor Chris Jones Nada Jabado Matthias A Karajannis Roland Eils Matthias Schlesner Peter Lichter Andreas von Deimling Stefan M Pfister David W Ellison Andrey Korshunov Marcel Kool

Cell 2016 Feb;164(5):1060-1072

Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://www.cell.com/cell/pdf/S0092-8674(16)00055-6.pdf
Web Search
http://www.cell.com/cms/attachment/2048488015/2058390163/mmc
Web Search
http://linkinghub.elsevier.com/retrieve/pii/S009286741600055
Publisher Site
http://dx.doi.org/10.1016/j.cell.2016.01.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5139621PMC
February 2016

Divergent clonal selection dominates medulloblastoma at recurrence.

Authors:
A Sorana Morrissy Livia Garzia David J H Shih Scott Zuyderduyn Xi Huang Patryk Skowron Marc Remke Florence M G Cavalli Vijay Ramaswamy Patricia E Lindsay Salomeh Jelveh Laura K Donovan Xin Wang Betty Luu Kory Zayne Yisu Li Chelsea Mayoh Nina Thiessen Eloi Mercier Karen L Mungall Yusanne Ma Kane Tse Thomas Zeng Karey Shumansky Andrew J L Roth Sohrab Shah Hamza Farooq Noriyuki Kijima Borja L Holgado John J Y Lee Stuart Matan-Lithwick Jessica Liu Stephen C Mack Alex Manno K A Michealraj Carolina Nor John Peacock Lei Qin Juri Reimand Adi Rolider Yuan Y Thompson Xiaochong Wu Trevor Pugh Adrian Ally Mikhail Bilenky Yaron S N Butterfield Rebecca Carlsen Young Cheng Eric Chuah Richard D Corbett Noreen Dhalla An He Darlene Lee Haiyan I Li William Long Michael Mayo Patrick Plettner Jenny Q Qian Jacqueline E Schein Angela Tam Tina Wong Inanc Birol Yongjun Zhao Claudia C Faria José Pimentel Sofia Nunes Tarek Shalaby Michael Grotzer Ian F Pollack Ronald L Hamilton Xiao-Nan Li Anne E Bendel Daniel W Fults Andrew W Walter Toshihiro Kumabe Teiji Tominaga V Peter Collins Yoon-Jae Cho Caitlin Hoffman David Lyden Jeffrey H Wisoff James H Garvin Duncan S Stearns Luca Massimi Ulrich Schüller Jaroslav Sterba Karel Zitterbart Stephanie Puget Olivier Ayrault Sandra E Dunn Daniela P C Tirapelli Carlos G Carlotti Helen Wheeler Andrew R Hallahan Wendy Ingram Tobey J MacDonald Jeffrey J Olson Erwin G Van Meir Ji-Yeoun Lee Kyu-Chang Wang Seung-Ki Kim Byung-Kyu Cho Torsten Pietsch Gudrun Fleischhack Stephan Tippelt Young Shin Ra Simon Bailey Janet C Lindsey Steven C Clifford Charles G Eberhart Michael K Cooper Roger J Packer Maura Massimino Maria Luisa Garre Ute Bartels Uri Tabori Cynthia E Hawkins Peter Dirks Eric Bouffet James T Rutka Robert J Wechsler-Reya William A Weiss Lara S Collier Adam J Dupuy Andrey Korshunov David T W Jones Marcel Kool Paul A Northcott Stefan M Pfister David A Largaespada Andrew J Mungall Richard A Moore Nada Jabado Gary D Bader Steven J M Jones David Malkin Marco A Marra Michael D Taylor

Nature 2016 Jan 13;529(7586):351-7. Epub 2016 Jan 13.

Developmental &Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature16478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936195PMC
January 2016

Next-generation (epi)genetic drivers of childhood brain tumours and the outlook for targeted therapies.

Lancet Oncol 2015 Jun 27;16(6):e293-302. Epub 2015 May 27.

Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S1470-2045(14)71206-9DOI Listing
June 2015

Aberrant immunostaining pattern of the CD24 glycoprotein in clinical samples and experimental models of pediatric medulloblastomas.

J Neurooncol 2015 May 29;123(1):1-13. Epub 2015 Mar 29.

Glioma Immunotherapy Group, Division of Neurosurgery, Department of Clinical Sciences Lund, Lund University, Barngatan 2B, 221 85, Lund, Sweden,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11060-015-1758-5DOI Listing
May 2015

Deep sequencing identifies IDH1 R132S mutation in adult medulloblastoma.

J Clin Oncol 2015 Feb 10;33(6):e27-31. Epub 2014 Mar 10.

University of British Columbia, Vancouver, British Columbia, Canada

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/JCO.2013.49.4864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517370PMC
February 2015

Foretinib is effective therapy for metastatic sonic hedgehog medulloblastoma.

Cancer Res 2015 Jan 12;75(1):134-46. Epub 2014 Nov 12.

Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Canada. Division of Neurosurgery, Hospital for Sick Children, Toronto, Canada. Department of Surgery, University of Toronto, Toronto, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-13-3629DOI Listing
January 2015

The Shh receptor Boc promotes progression of early medulloblastoma to advanced tumors.

Dev Cell 2014 Oct 25;31(1):34-47. Epub 2014 Sep 25.

Molecular Biology of Neural Development, Institut de Recherches Cliniques de Montréal (IRCM), 110 Pine Avenue West, Montreal QC H2W 1R7, Canada; Department of Medicine, University of Montreal, 2900 Boulevard Edouard-Montpetit, Montréal QC H3T 1J4, Canada; Integrated Program in Neuroscience, McGill University, 845 Sherbrooke Street West, Montréal QC H3A 0G4, Canada; Department of Anatomy and Cell Biology, Department of Biology, and Division of Experimental Medicine, McGill University, 845 Sherbrooke Street West, Montréal QC H3A 0G4, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.devcel.2014.08.010DOI Listing
October 2014

Duration of the pre-diagnostic interval in medulloblastoma is subgroup dependent.

Pediatr Blood Cancer 2014 Jul 25;61(7):1190-4. Epub 2014 Feb 25.

Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario, M5G 1X8, Canada; Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario, M5G 1X8, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, M5S 1A1, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pbc.25002DOI Listing
July 2014

Genomic and transcriptomic analyses match medulloblastoma mouse models to their human counterparts.

Acta Neuropathol 2014 Jul 29;128(1):123-36. Epub 2014 May 29.

Center for Neuropathology and Prion Research, Ludwig-Maximilians-University, Feodor-Lynen-Strasse 23, 81377, Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00401-014-1297-8DOI Listing
July 2014

Quiescent sox2(+) cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma.

Cancer Cell 2014 Jul 19;26(1):33-47. Epub 2014 Jun 19.

Arthur and Sonia Labatt Brain Tumour Research Centre and Division of Neurosurgery, Hospital for Sick Children (HSC), Toronto, ON M5G 1L7, Canada; Program in Developmental and Stem Cell Biology, HSC, Toronto, ON M5G 1X8, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccr.2014.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441014PMC
July 2014

Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma.

Nature 2014 Jul 22;511(7510):428-34. Epub 2014 Jun 22.

1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany [2] Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, Heidelberg 69120, Germany.

View Article

Download full-text PDF

Source
http://www.abta.org/resources/enhancers-hijacking-activates.
Web Search
http://www.nature.com/doifinder/10.1038/nature13379
Publisher Site
http://dx.doi.org/10.1038/nature13379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201514PMC
July 2014

Cytogenetic prognostication within medulloblastoma subgroups.

J Clin Oncol 2014 Mar 3;32(9):886-96. Epub 2014 Feb 3.

David J.H. Shih, Marc Remke, Vijay Ramaswamy, Betty Luu, Yuan Yao, Xin Wang, Adrian M. Dubuc, Livia Garzia, John Peacock, Stephen C. Mack, Xiaochong Wu, Adi Rolider, A. Sorana Morrissy, Florence M.G. Cavalli, Claudia C. Faria, Stephen W. Scherer, Uri Tabori, Cynthia E. Hawkins, David Malkin, Eric Bouffet, James T. Rutka, and Michael D. Taylor, Hospital for Sick Children; David J.H. Shih, Marc Remke, Vijay Ramaswamy, Yuan Yao, Xin Wang, Adrian M. Dubuc, John Peacock, Stephen C. Mack, and Michael D. Taylor, University of Toronto, Toronto; Boleslaw Lach, McMaster University, Hamilton, Ontario; Jennifer A. Chan, University of Calgary, Calgary, Alberta; Steffen Albrecht, Adam Fontebasso, and Nada Jabado, McGill University, Montreal, Quebec, Canada; Paul A. Northcott, Andrey Korshunov, Marcel Kool, David T.W. Jones, and Stefan M. Pfister, German Cancer Research Center; Stefan M. Pfister, University Hospital Heidelberg, Heidelberg; Ulrich Schüller, Ludwig-Maximilians-University, Munich; Stefan Rutkowski, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Karel Zitterbart, Masaryk University School of Medicine; Karel Zitterbart and Leos Kren, University Hospital Brno, Brno, Czech Republic; Toshihiro Kumabe and Teiji Tominaga, Tohoku University Graduate School of Medicine, Sendai, Japan; Young Shin Ra, University of Ulsan, Asan Medical Center; Ji-Yeoun Lee, Byung-Kyu Cho, Seung-Ki Kim, and Kyu-Chang Wang, Seoul National University Children's Hospital, Seoul; Shin Jung, Chonnam National University Research Institute of Medical Sciences, Chonnam National University Hwasun Hospital and Medical School, Chonnam, South Korea; Peter Hauser and Miklós Garami, Semmelweis University, Budapest; László Bognár and Almos Klekner, University of Debrecen, Medical and Health Science Centre, Debrecen, Hungary; Shenandoah Robinson, Boston Children's Hospital; Scott L. Pomeroy, Harvard Medical School, Boston, MA; Ali G. Saad, University of Arkansas for Medical Sciences, Little

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/JCO.2013.50.9539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948094PMC
March 2014

Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition.

Cancer Cell 2014 Mar;25(3):393-405

Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany; Department of Pediatric Oncology, Hematology and Immunology, University Hospital Heidelberg, 69120 Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccr.2014.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493053PMC
March 2014

TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma.

Acta Neuropathol 2013 Dec 31;126(6):917-29. Epub 2013 Oct 31.

The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00401-013-1198-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830749PMC
December 2013

MyoD is a tumor suppressor gene in medulloblastoma.

Cancer Res 2013 Nov 3;73(22):6828-37. Epub 2013 Oct 3.

Authors' Affiliations: Molecular and Cellular Biology Program, University of Washington; Clinical Research Division, Human Biology Division, and Public Health Sciences Division, Fred Hutchinson Cancer Research Center; Presage Biosciences; Sage Bionetworks; Seattle Children's Hospital, Seattle, Washington; Arthur and Sonia Labatt Brain Tumor Research Center and Division of Neurosurgery, The Hospital for Sick Children, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-13-0730-TDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014678PMC
November 2013

Targeting sonic hedgehog-associated medulloblastoma through inhibition of Aurora and Polo-like kinases.

Cancer Res 2013 Oct 25;73(20):6310-22. Epub 2013 Sep 25.

Authors' Affiliations: Tumor Initiation and Maintenance Program, National Cancer Institute (NCI)-Designated Cancer Center, Sanford-Burnham Medical Research Institute; Sanford Consortium for Regenerative Medicine; Departments of Pediatrics, Neurosciences, and Neurosurgery, University of California San Diego, La Jolla; Rady Children's Hospital, San Diego, California; Departments of Pharmacology and Cancer Biology, Medicine, Division of Pulmonary, Allergy, and Critical Care, Pediatrics, Division of Pediatric Hematology/Oncology, and Surgery, Duke University Medical Center, Durham, North Carolina; German Cancer Research Center (DKFZ), Heidelberg, Germany; and Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-12-4258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800039PMC
October 2013

Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma.

Nat Genet 2013 Aug 30;45(8):927-32. Epub 2013 Jun 30.

Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://pubman.mpdl.mpg.de/pubman/item/escidoc:1982973/compon
Web Search
http://www.nature.com/doifinder/10.1038/ng.2682
Publisher Site
http://dx.doi.org/10.1038/ng.2682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951336PMC
August 2013

Signatures of mutational processes in human cancer.

Nature 2013 Aug 14;500(7463):415-21. Epub 2013 Aug 14.

Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature12477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776390PMC
August 2013

Canonical TGF-β pathway activity is a predictor of SHH-driven medulloblastoma survival and delineates putative precursors in cerebellar development.

Brain Pathol 2013 Mar 11;23(2):178-91. Epub 2012 Oct 11.

Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1750-3639.2012.00631.xDOI Listing
March 2013

The role of chromatin remodeling in medulloblastoma.

Brain Pathol 2013 Mar;23(2):193-9

Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bpa.12019DOI Listing
March 2013

Medulloblastomics: the end of the beginning.

Nat Rev Cancer 2012 Dec;12(12):818-34

Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrc3410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3889646PMC
December 2012

Targeting the enhancer of zeste homologue 2 in medulloblastoma.

Int J Cancer 2012 Oct 30;131(8):1800-9. Epub 2012 Jul 30.

Department of Pediatrics, The Children's Hospital and University of Colorado, Anschutz Medical Campus, CO, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ijc.27455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375399PMC
October 2012

Functional genomics identifies drivers of medulloblastoma dissemination.

Cancer Res 2012 Oct 8;72(19):4944-53. Epub 2012 Aug 8.

Department of Neurosurgery, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-12-1629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463769PMC
October 2012

Subgroup-specific structural variation across 1,000 medulloblastoma genomes.

Authors:
Paul A Northcott David J H Shih John Peacock Livia Garzia A Sorana Morrissy Thomas Zichner Adrian M Stütz Andrey Korshunov Jüri Reimand Steven E Schumacher Rameen Beroukhim David W Ellison Christian R Marshall Anath C Lionel Stephen Mack Adrian Dubuc Yuan Yao Vijay Ramaswamy Betty Luu Adi Rolider Florence M G Cavalli Xin Wang Marc Remke Xiaochong Wu Readman Y B Chiu Andy Chu Eric Chuah Richard D Corbett Gemma R Hoad Shaun D Jackman Yisu Li Allan Lo Karen L Mungall Ka Ming Nip Jenny Q Qian Anthony G J Raymond Nina T Thiessen Richard J Varhol Inanc Birol Richard A Moore Andrew J Mungall Robert Holt Daisuke Kawauchi Martine F Roussel Marcel Kool David T W Jones Hendrick Witt Africa Fernandez-L Anna M Kenney Robert J Wechsler-Reya Peter Dirks Tzvi Aviv Wieslawa A Grajkowska Marta Perek-Polnik Christine C Haberler Olivier Delattre Stéphanie S Reynaud François F Doz Sarah S Pernet-Fattet Byung-Kyu Cho Seung-Ki Kim Kyu-Chang Wang Wolfram Scheurlen Charles G Eberhart Michelle Fèvre-Montange Anne Jouvet Ian F Pollack Xing Fan Karin M Muraszko G Yancey Gillespie Concezio Di Rocco Luca Massimi Erna M C Michiels Nanne K Kloosterhof Pim J French Johan M Kros James M Olson Richard G Ellenbogen Karel Zitterbart Leos Kren Reid C Thompson Michael K Cooper Boleslaw Lach Roger E McLendon Darell D Bigner Adam Fontebasso Steffen Albrecht Nada Jabado Janet C Lindsey Simon Bailey Nalin Gupta William A Weiss László Bognár Almos Klekner Timothy E Van Meter Toshihiro Kumabe Teiji Tominaga Samer K Elbabaa Jeffrey R Leonard Joshua B Rubin Linda M Liau Erwin G Van Meir Maryam Fouladi Hideo Nakamura Giuseppe Cinalli Miklós Garami Peter Hauser Ali G Saad Achille Iolascon Shin Jung Carlos G Carlotti Rajeev Vibhakar Young Shin Ra Shenandoah Robinson Massimo Zollo Claudia C Faria Jennifer A Chan Michael L Levy Poul H B Sorensen Matthew Meyerson Scott L Pomeroy Yoon-Jae Cho Gary D Bader Uri Tabori Cynthia E Hawkins Eric Bouffet Stephen W Scherer James T Rutka David Malkin Steven C Clifford Steven J M Jones Jan O Korbel Stefan M Pfister Marco A Marra Michael D Taylor

Nature 2012 Aug;488(7409):49-56

Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.

View Article

Download full-text PDF

Source
http://is.muni.cz/repo/990835/nature11327.pdf
Web Search
http://www.nature.com/doifinder/10.1038/nature11327
Publisher Site
http://dx.doi.org/10.1038/nature11327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683624PMC
August 2012

Dissecting the genomic complexity underlying medulloblastoma.

Nature 2012 Aug;488(7409):100-5

Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature11284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662966PMC
August 2012

Molecular subgroups of medulloblastoma.

Expert Rev Neurother 2012 Jul;12(7):871-84

The Arthur & Sonia Labatt Brain Tumour Research Center, Hospital for Sick Children, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1586/ern.12.66DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334443PMC
July 2012

The epigenetics of brain tumors.

Methods Mol Biol 2012 ;863:139-53

Department of Laboratory Medicine and Pathobiology, Division of Neurosurgery, University of Toronto, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-61779-612-8_8DOI Listing
June 2012

The clinical implications of medulloblastoma subgroups.

Nat Rev Neurol 2012 May 8;8(6):340-51. Epub 2012 May 8.

Division Molecular Genetics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/nrneurol.2012.78
Publisher Site
http://dx.doi.org/10.1038/nrneurol.2012.78DOI Listing
May 2012

Distinct neural stem cell populations give rise to disparate brain tumors in response to N-MYC.

Cancer Cell 2012 May;21(5):601-13

University of California, Department of Neurology, Brain Tumor Research Center and Helen Diller Family Comprehensive Cancer Center, San Francisco, CA 94158, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccr.2012.04.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360885PMC
May 2012

Subgroup-specific alternative splicing in medulloblastoma.

Acta Neuropathol 2012 Apr 23;123(4):485-499. Epub 2012 Feb 23.

Division of Neurosurgery, Arthur & Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00401-012-0959-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984840PMC
April 2012

FISH and chips: the recipe for improved prognostication and outcomes for children with medulloblastoma.

Cancer Genet 2011 Nov;204(11):577-88

Developmental and Stem Cell Biology and Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cancergen.2011.11.001DOI Listing
November 2011