Paul A Lyons

Paul A Lyons

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Paul A Lyons

Paul A Lyons

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Reduced monocyte and macrophage TNFSF15/TL1A expression is associated with susceptibility to inflammatory bowel disease.

PLoS Genet 2018 09 10;14(9):e1007458. Epub 2018 Sep 10.

Department of Medicine, University of Cambridge School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom.

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https://dx.plos.org/10.1371/journal.pgen.1007458
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http://dx.doi.org/10.1371/journal.pgen.1007458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130856PMC
September 2018

Belimumab in kidney transplantation: an experimental medicine, randomised, placebo-controlled phase 2 trial.

Lancet 2018 06 14;391(10140):2619-2630. Epub 2018 Jun 14.

Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK; National Institute of Health Research (NIHR) Cambridge Biomedical Research Centre, Cambridge, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01406736183098
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http://dx.doi.org/10.1016/S0140-6736(18)30984-XDOI Listing
June 2018

Peripheral Immune Cell Populations Associated with Cognitive Deficits and Negative Symptoms of Treatment-Resistant Schizophrenia.

PLoS One 2016 31;11(5):e0155631. Epub 2016 May 31.

NIHR Cambridge Biomedical Research Centre, Cambridge University Hospitals NHS Foundation Trust and the University of Cambridge, Cambridge, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0155631PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887013PMC
July 2017

Targeted genomic analysis reveals widespread autoimmune disease association with regulatory variants in the TNF superfamily cytokine signalling network.

Genome Med 2016 07 19;8(1):76. Epub 2016 Jul 19.

Department of Medicine and Cambridge Institute for Medical Research, The University of Cambridge, Box 139, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0XY, UK.

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http://dx.doi.org/10.1186/s13073-016-0329-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4952362PMC
July 2016

Leucocyte subset-specific type 1 interferon signatures in SLE and other immune-mediated diseases.

RMD Open 2016 16;2(1):e000183. Epub 2016 May 16.

Department of Medicine, The University of Cambridge, Cambridge, UK; Cambridge Institute of Medical Research, The University of Cambridge, Cambridge, UK; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

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http://dx.doi.org/10.1136/rmdopen-2015-000183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879345PMC
June 2016

The Contribution of Transcriptomics to Biomarker Development in Systemic Vasculitis and SLE.

Curr Pharm Des 2015 ;21(17):2225-35

Cambridge Institute for Medical Research, and Department of Medicine, The University of Cambridge, Box 139, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0XY, United Kingdom.

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http://dx.doi.org/10.2174/1381612821666150313130256DOI Listing
May 2016

T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection.

Nature 2015 Jul 29;523(7562):612-6. Epub 2015 Jun 29.

1] Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK [2] Cambridge Institute for Medical Research, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.

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http://dx.doi.org/10.1038/nature14468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623162PMC
July 2015

Molecular and functional definition of the developing human striatum.

Nat Neurosci 2014 Dec 10;17(12):1804-15. Epub 2014 Nov 10.

Department of Biosciences and Center for Stem Cell Research, Università degli Studi di Milano, Italy.

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http://dx.doi.org/10.1038/nn.3860DOI Listing
December 2014

Comparison of gene expression microarray data with count-based RNA measurements informs microarray interpretation.

BMC Genomics 2014 Aug 4;15:649. Epub 2014 Aug 4.

Cambridge Institute for Medical Research and Department of Medicine, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1186/1471-2164-15-649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143561PMC
August 2014

Genetics of ANCA-associated vasculitides: HLA and beyond.

Clin Exp Rheumatol 2014 May-Jun;32(3 Suppl 82):S90-7. Epub 2014 May 15.

Department of Medicine, University of Cambridge, UK.

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July 2014

Fine mapping of type 1 diabetes regions Idd9.1 and Idd9.2 reveals genetic complexity.

Mamm Genome 2013 Oct 11;24(9-10):358-75. Epub 2013 Aug 11.

Department of Immunology and Microbial Sciences, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA.

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http://dx.doi.org/10.1007/s00335-013-9466-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824839PMC
October 2013

MiR-210 is induced by Oct-2, regulates B cells, and inhibits autoantibody production.

J Immunol 2013 Sep 19;191(6):3037-3048. Epub 2013 Aug 19.

Cambridge Institute for Medical Research and Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0XY, UK.

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http://dx.doi.org/10.4049/jimmunol.1301289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162006PMC
September 2013

Human SNP links differential outcomes in inflammatory and infectious disease to a FOXO3-regulated pathway.

Cell 2013 Sep 12;155(1):57-69. Epub 2013 Sep 12.

Cambridge Institute for Medical Research, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK; Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.

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http://dx.doi.org/10.1016/j.cell.2013.08.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790457PMC
September 2013

L31. A GWAS in ANCA-associated vasculitis: will genetics help re-define clinical classification?

Presse Med 2013 Apr 11;42(4 Pt 2):589-91. Epub 2013 Mar 11.

Cambridge Institute for Medical Research and Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0XY, United Kingdom.

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http://dx.doi.org/10.1016/j.lpm.2013.02.303DOI Listing
April 2013

Increased red cell turnover in a line of CD22-deficient mice is caused by Gpi1c: a model for hereditary haemolytic anaemia.

Eur J Immunol 2012 Dec 16;42(12):3212-22. Epub 2012 Oct 16.

Cambridge Institute for Medical Research and Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Cambridge, UK.

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http://doi.wiley.com/10.1002/eji.201242633
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http://dx.doi.org/10.1002/eji.201242633DOI Listing
December 2012

Gene expression profiling of CD8+ T cells predicts prognosis in patients with Crohn disease and ulcerative colitis.

J Clin Invest 2011 Oct 26;121(10):4170-9. Epub 2011 Sep 26.

Cambridge Institute for Medical Research, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom.

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http://dx.doi.org/10.1172/JCI59255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196314PMC
October 2011

The contribution of genetic variation and infection to the pathogenesis of ANCA-associated systemic vasculitis.

Arthritis Res Ther 2010 15;12(1):202. Epub 2010 Feb 15.

Cambridge Institute for Medical Research and Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0XY, UK.

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http://arthritis-research.biomedcentral.com/articles/10.1186
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http://dx.doi.org/10.1186/ar2928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875655PMC
August 2010

Copy number, linkage disequilibrium and disease association in the FCGR locus.

Hum Mol Genet 2010 Aug 27;19(16):3282-94. Epub 2010 May 27.

Department of Medicine, Cambridge Institute for Medical Research, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0XY, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2908468PMC
http://dx.doi.org/10.1093/hmg/ddq216DOI Listing
August 2010

Efficient inhibition of miR-155 function in vivo by peptide nucleic acids.

Nucleic Acids Res 2010 Jul 11;38(13):4466-75. Epub 2010 Mar 11.

Medical Research Council, Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.

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http://dx.doi.org/10.1093/nar/gkq160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2910044PMC
July 2010

A CD8+ T cell transcription signature predicts prognosis in autoimmune disease.

Nat Med 2010 May 18;16(5):586-91, 1p following 591. Epub 2010 Apr 18.

Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge Institute for Medical Research, Addenbrooke's Hospital, Cambridge, UK.

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http://dx.doi.org/10.1038/nm.2130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504359PMC
May 2010

A defunctioning polymorphism in FCGR2B is associated with protection against malaria but susceptibility to systemic lupus erythematosus.

Proc Natl Acad Sci U S A 2010 Apr 12;107(17):7881-5. Epub 2010 Apr 12.

Department of Medicine, Cambridge Institute for Medical Research, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Cambridge CB2 0XY, United Kingdom.

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http://www.pnas.org/lookup/doi/10.1073/pnas.0915133107
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http://dx.doi.org/10.1073/pnas.0915133107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867866PMC
April 2010

Idd9.1 locus controls the suppressive activity of FoxP3+CD4+CD25+ regulatory T-cells.

Diabetes 2010 Jan 15;59(1):272-81. Epub 2009 Oct 15.

Julia McFarlane Diabetes Research Centre (JMDRC) and Department of Microbiology and Infectious Diseases, Institute for Infection, Immunity and Inflammation, Faculty of Medicine, The University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.2337/db09-0648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797933PMC
January 2010

Confirmation of the genetic association of CTLA4 and PTPN22 with ANCA-associated vasculitis.

BMC Med Genet 2009 Dec 1;10:121. Epub 2009 Dec 1.

Cambridge Institute for Medical Research, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Hills Road, Cambridge CB20XY, UK.

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http://dx.doi.org/10.1186/1471-2350-10-121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3224698PMC
December 2009

Contrasting genetic association of IL2RA with SLE and ANCA-associated vasculitis.

BMC Med Genet 2009 Mar 5;10:22. Epub 2009 Mar 5.

Cambridge Institute for Medical Research, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0XY, UK.

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http://dx.doi.org/10.1186/1471-2350-10-22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662820PMC
March 2009

Complement abnormalities in acquired lipodystrophy revisited.

J Clin Endocrinol Metab 2009 Jan 14;94(1):10-6. Epub 2008 Oct 14.

Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, United Kingdom.

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http://dx.doi.org/10.1210/jc.2008-1703DOI Listing
January 2009

Distinct cell-specific control of autoimmunity and infection by FcgammaRIIb.

J Exp Med 2008 Apr 24;205(4):883-95. Epub 2008 Mar 24.

Cambridge Institute for Medical Research and the Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Cambridge CB2 2OY, England, UK.

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http://dx.doi.org/10.1084/jem.20072565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2292226PMC
April 2008

The nervous spleen: The nervous spleen.

Immunol Cell Biol 2008 Jan;86(1):1-2

Department of Medicine, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2XY, UK.

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http://doi.wiley.com/10.1038/sj.icb.7100150
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http://dx.doi.org/10.1038/sj.icb.7100150DOI Listing
January 2008

The novel inhibitory receptor G6B is expressed on the surface of platelets and attenuates platelet function in vitro.

Blood 2007 Jun 20;109(11):4806-9. Epub 2007 Feb 20.

Department of Medicine, Cambridge Institute for Medical Research, University of Cambridge, Addembrookes Hospital, Hills Road, Cambridge, UK.

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http://dx.doi.org/10.1182/blood-2006-09-047449DOI Listing
June 2007

Control of Rta expression critically determines transcription of viral and cellular genes following gammaherpesvirus infection.

J Gen Virol 2007 Jun;88(Pt 6):1689-97

Cambridge Institute for Medical Research and the Department of Medicine, Wellcome Trust/MRC Building, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 2XY, UK.

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http://dx.doi.org/10.1099/vir.0.82548-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2884955PMC
June 2007

Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity.

Nat Genet 2007 Mar 4;39(3):329-37. Epub 2007 Feb 4.

Julia McFarlane Diabetes Research Centre (JMDRC) and Department of Microbiology and Infectious Diseases, Institute of Inflammation, Infection and Immunity, Faculty of Medicine, The University of Calgary, Calgary, Alberta T2N 4N1, Canada.

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http://dx.doi.org/10.1038/ng1958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2886969PMC
March 2007

Microarray analysis of human leucocyte subsets: the advantages of positive selection and rapid purification.

BMC Genomics 2007 Mar 5;8:64. Epub 2007 Mar 5.

Department of Medicine, and Cambridge Institute for Medical Research, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2XY, UK.

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http://dx.doi.org/10.1186/1471-2164-8-64DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1828063PMC
March 2007

Polymorphism discovery and association analyses of the interferon genes in type 1 diabetes.

BMC Genet 2006 Feb 22;7:12. Epub 2006 Feb 22.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, Cambridge, CB2 2XY, UK.

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http://dx.doi.org/10.1186/1471-2156-7-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1402321PMC
February 2006

Natural genetic variants influencing type 1 diabetes in humans and in the NOD mouse.

Novartis Found Symp 2005 ;267:57-65; discussion 65-75

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes & Inflammation Laboratory, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Addenbrooke's Hospital, University of Cambridge, Cambridge CB2 2XY, UK.

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November 2005

The cell surface receptor G6b, a member of the immunoglobulin superfamily, binds heparin.

FEBS Lett 2005 Apr;579(11):2355-8

MRC Rosalind Franklin Centre for Genomics Research, Hinxton, Cambridge, UK.

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http://doi.wiley.com/10.1016/j.febslet.2005.03.032
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http://dx.doi.org/10.1016/j.febslet.2005.03.032DOI Listing
April 2005

The murine cytomegalovirus M73.5 gene, a member of a 3' co-terminal alternatively spliced gene family, encodes the gp24 virion glycoprotein.

Virology 2004 Nov;329(2):234-50

Immunology and Virology Program, Centre for Ophthalmology and Visual Science, The University of Western Australia, Nedlands, WA 6009, Australia.

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http://dx.doi.org/10.1016/j.virol.2004.08.015DOI Listing
November 2004

Fine mapping, gene content, comparative sequencing, and expression analyses support Ctla4 and Nramp1 as candidates for Idd5.1 and Idd5.2 in the nonobese diabetic mouse.

J Immunol 2004 Jul;173(1):164-73

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 2XY, UK.

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http://dx.doi.org/10.4049/jimmunol.173.1.164DOI Listing
July 2004

Identification of a structurally distinct CD101 molecule encoded in the 950-kb Idd10 region of NOD mice.

Diabetes 2003 Jun;52(6):1551-6

Juvenile Diabetes Research Foundation/Wellcome Trust (JDRF/WT) Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 2XY, U.K.

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http://dx.doi.org/10.2337/diabetes.52.6.1551DOI Listing
June 2003

Continued discovery of transcriptional units expressed in cells of the mouse mononuclear phagocyte lineage.

Genome Res 2003 Jun;13(6B):1360-5

Institute for Molecular Bioscience and ARC Special Research Centre for Functional and Applied Genomics, Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, Australia.

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http://dx.doi.org/10.1101/gr.1056103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC403663PMC
June 2003

Discovery of imprinted transcripts in the mouse transcriptome using large-scale expression profiling.

Genome Res 2003 Jun;13(6B):1402-9

Laboratory for Genome Exploration Research Group, RIKEN Genomic Sciences Center (GSC), RIKEN Yokohama Institute, Suehiro-cho, Tsurumi-ku Yokohama, Kanagawa 230-0045, Japan.

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http://dx.doi.org/10.1101/gr.1055303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC403673PMC
June 2003

Real-time analysis of Polymyxa betae GST expression in infected sugar beet.

Mol Plant Pathol 2003 May;4(3):171-6

Broom's Barn Research Station, Higham, Bury St Edmunds, Suffolk, IP28 6NP, UK.

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http://dx.doi.org/10.1046/j.1364-3703.2003.00160.xDOI Listing
May 2003

Gene-expression profiling and the genetic dissection of complex disease.

Authors:
Paul A Lyons

Curr Opin Immunol 2002 Oct;14(5):627-30

Juvenile Diabetes Research Foundation/Wellcome Trust, Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, Addenbrookes Hospital, Hills Road, Cambridge, CB2 2XY, UK.

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http://dx.doi.org/10.1016/s0952-7915(02)00383-7DOI Listing
October 2002

Combining mouse congenic strains and microarray gene expression analyses to study a complex trait: the NOD model of type 1 diabetes.

Genome Res 2002 Feb;12(2):232-43

Juvenile Diabetes Research Foundation/ Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/Medical Research Council Building, Addenbrooke's Hospital, Cambridge, CB2 2XY, UK.

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http://dx.doi.org/10.1101/gr.214102. Article published online before print in January 2002DOI Listing
February 2002