Pau Serra

Pau Serra

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Pau Serra

Publications by authors named "Pau Serra"

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Suppression of a broad spectrum of liver autoimmune pathologies by single peptide-MHC-based nanomedicines.

Nat Commun 2019 05 14;10(1):2150. Epub 2019 May 14.

Julia McFarlane Diabetes Research Centre (JMDRC) and Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases and Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, T2N 4N1, Canada.

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http://dx.doi.org/10.1038/s41467-019-09893-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6517389PMC
May 2019

Antigen-specific therapeutic approaches for autoimmunity.

Nat Biotechnol 2019 03 25;37(3):238-251. Epub 2019 Feb 25.

Institut D'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.

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http://www.nature.com/articles/s41587-019-0015-4
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http://dx.doi.org/10.1038/s41587-019-0015-4DOI Listing
March 2019

MPZL2, Encoding the Epithelial Junctional Protein Myelin Protein Zero-like 2, Is Essential for Hearing in Man and Mouse.

Am J Hum Genet 2018 07 28;103(1):74-88. Epub 2018 Jun 28.

Hearing and Genes Division, Department of Otorhinolaryngology, Radboud University Medical Center, 6500 HB Nijmegen, the Netherlands; Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, 6500 HB Nijmegen, the Netherlands; Department of Human Genetics, Radboud University Medical Center, 6500 HB Nijmegen, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2018.05.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037131PMC
July 2018

Nanoparticle-based approaches to immune tolerance for the treatment of autoimmune diseases.

Eur J Immunol 2018 05 26;48(5):751-756. Epub 2018 Feb 26.

Institut D'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.

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http://doi.wiley.com/10.1002/eji.201747059
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http://dx.doi.org/10.1002/eji.201747059DOI Listing
May 2018

A Gut Microbial Mimic that Hijacks Diabetogenic Autoreactivity to Suppress Colitis.

Cell 2017 Oct;171(3):655-667.e17

Julia McFarlane Diabetes Research Centre (JMDRC), University of Calgary, Calgary AB T2N 4N1, Canada; Autoimmunity Research Group, Institut D'Investigacions Biomèdiques August Pi i Sunyer, 08036 Barcelona, Spain; Department of Microbiology, Immunology, and Infectious Diseases, Snyder Institute for Chronic Diseases, University of Calgary, Calgary AB T2N 4N1, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.09.022DOI Listing
October 2017

Peptide-MHC-based nanomedicines for autoimmunity function as T-cell receptor microclustering devices.

Nat Nanotechnol 2017 07 24;12(7):701-710. Epub 2017 Apr 24.

Julia McFarlane Diabetes Research Centre (JMDRC) and Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases and Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada.

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http://dx.doi.org/10.1038/nnano.2017.56DOI Listing
July 2017

Expanding antigen-specific regulatory networks to treat autoimmunity.

Nature 2016 Feb 17;530(7591):434-40. Epub 2016 Feb 17.

Julia McFarlane Diabetes Research Centre (JMDRC), and Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases and Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada.

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http://dx.doi.org/10.1038/nature16962DOI Listing
February 2016

Nanoparticle-based autoimmune disease therapy.

Clin Immunol 2015 Sep 19;160(1):3-13. Epub 2015 Feb 19.

Institut D'Investigacions Biomediques August Pi i Sunyer, Barcelona 08036, Spain; Julia McFarlane Diabetes Research Centre (JMDRC) and Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases and Hotchkiss Brain Institute, Cummings School of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2015.02.003DOI Listing
September 2015

The cross-priming capacity and direct presentation potential of an autoantigen are separable and inversely related properties.

J Immunol 2014 Oct 27;193(7):3296-307. Epub 2014 Aug 27.

Julia McFarlane Diabetes Research Centre, Snyder Institute for Chronic Diseases, Faculty of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada; Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, Faculty of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada; Institut D'Investigacions Biomèdiques August Pi i Sunyer, Barcelona 08036, Spain

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http://dx.doi.org/10.4049/jimmunol.1401001DOI Listing
October 2014

Dendritic cell-dependent in vivo generation of autoregulatory T cells by antidiabetogenic MHC class II.

J Immunol 2013 Jul 5;191(1):70-82. Epub 2013 Jun 5.

Department of Microbiology, Immunology and Infectious Diseases and Julia McFarlane Diabetes Research Centre, Snyder Institute for Chronic Diseases, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.4049/jimmunol.1300168DOI Listing
July 2013

IL-2 promotes the function of memory-like autoregulatory CD8+ T cells but suppresses their development via FoxP3+ Treg cells.

Eur J Immunol 2013 Feb 15;43(2):394-403. Epub 2013 Jan 15.

Julia McFarlane Diabetes Research Centre and Departments of Microbiology, Snyder Institute for Chronic Diseases, the University of Calgary, Calgary, AB, Canada.

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http://dx.doi.org/10.1002/eji.201242845DOI Listing
February 2013

Antidiabetogenic MHC class II promotes the differentiation of MHC-promiscuous autoreactive T cells into FOXP3+ regulatory T cells.

Proc Natl Acad Sci U S A 2013 Feb 11;110(9):3471-6. Epub 2013 Feb 11.

Department of Microbiology, Immunology and Infectious Diseases, Julia McFarlane Diabetes Research Centre, Snyder Institute for Chronic Diseases, Faculty of Medicine, University of Calgary, Calgary, AB, Canada T2N 4N1.

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http://www.pnas.org/content/110/9/3471.full.pdf
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http://www.pnas.org/lookup/doi/10.1073/pnas.1211391110
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http://dx.doi.org/10.1073/pnas.1211391110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3587200PMC
February 2013

Reversal of autoimmunity by boosting memory-like autoregulatory T cells.

Immunity 2010 Apr 8;32(4):568-80. Epub 2010 Apr 8.

Julia McFarlane Diabetes Research Centre, Department of Microbiology and Infectious Diseases, The University of Calgary, 3330 Hospital Drive N.W., Calgary, AB T2N 4N1, Canada.

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http://dx.doi.org/10.1016/j.immuni.2010.03.015DOI Listing
April 2010

The proline-rich sequence of CD3epsilon as an amplifier of low-avidity TCR signaling.

J Immunol 2008 Jul;181(1):243-55

Julia McFarlane Diabetes Research Centre and Department of Microbiology, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2665931PMC
http://dx.doi.org/10.4049/jimmunol.181.1.243DOI Listing
July 2008

Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity.

Nat Genet 2007 Mar 4;39(3):329-37. Epub 2007 Feb 4.

Julia McFarlane Diabetes Research Centre (JMDRC) and Department of Microbiology and Infectious Diseases, Institute of Inflammation, Infection and Immunity, Faculty of Medicine, The University of Calgary, Calgary, Alberta T2N 4N1, Canada.

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http://dx.doi.org/10.1038/ng1958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2886969PMC
March 2007

To 'B' regulated: B cells as members of the regulatory workforce.

Trends Immunol 2006 Jan 21;27(1):7-10. Epub 2005 Nov 21.

Julia McFarlane Diabetes Research Centre, Faculty of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada.

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http://dx.doi.org/10.1016/j.it.2005.11.003DOI Listing
January 2006

Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice.

Nat Immunol 2006 Jan 27;7(1):83-92. Epub 2005 Nov 27.

Diabetes Center, Department of Medicine, University of California, San Francisco 94143, USA.

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http://dx.doi.org/10.1038/ni1289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057888PMC
January 2006

Developmental control of CD8 T cell-avidity maturation in autoimmune diabetes.

J Clin Invest 2005 Jul 2;115(7):1879-87. Epub 2005 Jun 2.

Department of Microbiology and Infectious Diseases, Julia McFarlane Diabetes Research Centre, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1172/JCI24219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1142112PMC
July 2005

Prevention of diabetes by manipulation of anti-IGRP autoimmunity: high efficiency of a low-affinity peptide.

Nat Med 2005 Jun 22;11(6):645-52. Epub 2005 May 22.

Julia McFarlane Diabetes Research Centre, University of Calgary, Faculty of Medicine, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1.

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http://dx.doi.org/10.1038/nm1250DOI Listing
June 2005

Cross-priming of diabetogenic T cells dissociated from CTL-induced shedding of beta cell autoantigens.

J Immunol 2003 Dec;171(12):6900-9

Julia McFarlane Diabetes Research Centre and Department of Microbiology and Infectious Diseases, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.4049/jimmunol.171.12.6900DOI Listing
December 2003

CD40 ligation releases immature dendritic cells from the control of regulatory CD4+CD25+ T cells.

Immunity 2003 Dec;19(6):877-89

Julia McFarlane Diabetes Research Centre, University of Calgary, Faculty of Medicine, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1.

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http://dx.doi.org/10.1016/s1074-7613(03)00327-3DOI Listing
December 2003

RAG-dependent peripheral T cell receptor diversification in CD8+ T lymphocytes.

Proc Natl Acad Sci U S A 2002 Nov 13;99(24):15566-71. Epub 2002 Nov 13.

Department of Microbiology and Infectious Diseases, and Julia McFarlane Diabetes Research Centre, Faculty of Medicine, Health Sciences Centre, University of Calgary, 3330 Hospital Drive N.W., AB, Canada T2N 4N1.

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http://www.pnas.org/content/99/24/15566.full.pdf
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http://www.pnas.org/cgi/doi/10.1073/pnas.242321099
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http://dx.doi.org/10.1073/pnas.242321099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC137757PMC
November 2002

CD154-dependent priming of diabetogenic CD4(+) T cells dissociated from activation of antigen-presenting cells.

Immunity 2002 May;16(5):719-32

Department of Microbiology and Infectious Diseases and Julia McFarlane Diabetes Research Center, The University of Calgary, Faculty of Medicine, 3330 Hospital Drive N.W., Calgary, Alberta, Canada T2N 4N1.

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http://dx.doi.org/10.1016/s1074-7613(02)00315-1DOI Listing
May 2002

T-cell tolerance by dendritic cells and macrophages as a mechanism for the major histocompatibility complex-linked resistance to autoimmune diabetes.

Diabetes 2002 Feb;51(2):325-38

Department of Microbiology and Infectious Diseases, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.2337/diabetes.51.2.325DOI Listing
February 2002