Pau Sancho-Bru

Pau Sancho-Bru

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Pau Sancho-Bru

Pau Sancho-Bru

Publications by authors named "Pau Sancho-Bru"

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54Publications

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TLR7-let7 signaling contributes to ethanol-induced hepatic inflammatory response in mice and in alcoholic hepatitis.

Alcohol Clin Exp Res 2018 Aug 13. Epub 2018 Aug 13.

Bowles Center For Alcohol Studies, University of North, Carolina Medical School, University of North Carolina at Chapel Hill, Chapel Hill, NC, U.S.A.

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August 2018

Generation of Hepatic Stellate Cells from Human Pluripotent Stem Cells Enables In Vitro Modeling of Liver Fibrosis.

Cell Stem Cell 2018 Jul 28;23(1):101-113.e7. Epub 2018 Jun 28.

Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Spain. Electronic address:

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July 2018

Expression of microRNA-155 in inflammatory cells modulates liver injury.

Hepatology 2018 Feb 8. Epub 2018 Feb 8.

Laboratory of Liver Cell Plasticity and Tissue Repair, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS).

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February 2018

Alcohol dysregulates miR-148a in hepatocytes through FoxO1, facilitating pyroptosis via TXNIP overexpression.

Gut 2018 Feb 23. Epub 2018 Feb 23.

College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea.

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February 2018

Hepatocyte-derived macrophage migration inhibitory factor mediates alcohol-induced liver injury in mice and patients.

J Hepatol 2017 Nov 22;67(5):1018-1025. Epub 2017 Jun 22.

Center for Liver Disease Research, Department of Pathobiology, Cleveland Clinic, Spain; Department of Molecular Medicine, Case Western Reserve University, USA. Electronic address:

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November 2017

A small population of liver endothelial cells undergoes endothelial-to-mesenchymal transition in response to chronic liver injury.

Am J Physiol Gastrointest Liver Physiol 2017 Nov 10;313(5):G492-G504. Epub 2017 Aug 10.

Biochemistry and Molecular Genetics Department, Hospital Clínic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Barcelona, Spain;

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November 2017

Mesenchymal stromal cells for immunomodulatory cell therapy in liver transplantation: One step at a time.

J Hepatol 2017 Jul 21;67(1):7-9. Epub 2017 Apr 21.

Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Liver Unit, Hospital Clínic, University of Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Spain. Electronic address:

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July 2017

Integrative microRNA profiling in alcoholic hepatitis reveals a role for microRNA-182 in liver injury and inflammation.

Gut 2016 09 10;65(9):1535-45. Epub 2016 May 10.

Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Spain.

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September 2016

Targeting the renin-angiotensin system in liver fibrosis.

Hepatol Int 2016 Sep 31;10(5):730-2. Epub 2016 May 31.

Liver Unit, Hospital Clinic of Barcelona, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Centro de Investigaciones en Red Hepaticas y Digestivas (CIBEReHD), Barcelona, Spain.

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September 2016

Kinase analysis in alcoholic hepatitis identifies p90RSK as a potential mediator of liver fibrogenesis.

Gut 2016 May 4;65(5):840-51. Epub 2015 Feb 4.

Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CIBER de Enfermedades Hepáticas y Digestivas (CIBERehd), Facultat de Medicina, Universitat de Barcelona, Barcelona, Catalonia, Spain Division of Gastroenterology and Hepatology, Departments of Medicine and Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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May 2016

Assessment of Liver Fibrotic Insults In Vitro.

Methods Mol Biol 2015 ;1250:391-401

Laboratory of Liver Fibrosis, Institut d'Investigacions Biomèdiques, August Pi i Sunyer (IDIBAPS), Rossello 149-153, Barcelona, 08036, Spain.

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May 2016

Stem cell-derived hepatocytes: A novel model for hepatitis E virus replication.

J Hepatol 2016 Mar 25;64(3):565-73. Epub 2015 Nov 25.

Stem Cell Institute, University of Leuven (KU Leuven), Leuven, Belgium.

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March 2016

Systemic inflammatory response and serum lipopolysaccharide levels predict multiple organ failure and death in alcoholic hepatitis.

Hepatology 2015 Sep 13;62(3):762-72. Epub 2015 Apr 13.

Institut d'Investigacions Biomèdiques August-Pi-Sunyer, University of Barcelona, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Barcelona, Spain.

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September 2015

Gas6/Axl pathway is activated in chronic liver disease and its targeting reduces fibrosis via hepatic stellate cell inactivation.

J Hepatol 2015 Sep 20;63(3):670-8. Epub 2015 Apr 20.

Liver Unit, Hospital Clinic, IDIBAPS-CIBEK, CIBEREHD, Barcelona, Catalonia, Spain; Department of Cell Death and Proliferation, IIBB-CSIC, Barcelona, Catalonia, Spain. Electronic address:

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September 2015

In vitro reversion of activated primary human hepatic stellate cells.

Fibrogenesis Tissue Repair 2015 6;8:14. Epub 2015 Aug 6.

Liver Cell Biology Lab, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, 1090 Brussels, Belgium.

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August 2015

Integrative miRNA and Gene Expression Profiling Analysis of Human Quiescent Hepatic Stellate Cells.

Sci Rep 2015 Jun 22;5:11549. Epub 2015 Jun 22.

1] Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain [2] Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Spain [3] Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Spain.

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June 2015

VSL#3 probiotic treatment decreases bacterial translocation in rats with carbon tetrachloride-induced cirrhosis.

Liver Int 2015 Mar 12;35(3):735-45. Epub 2014 May 12.

Department of Gastroenterology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Institut d'Investigacions Biomèdiques (IIB) Sant Pau, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain; Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), Spain.

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March 2015

CCL2: a link between hepatic inflammation, fibrosis and angiogenesis?

Gut 2014 Dec 2;63(12):1834-5. Epub 2014 Apr 2.

Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Spain.

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December 2014

CCL20 mediates lipopolysaccharide induced liver injury and is a potential driver of inflammation and fibrosis in alcoholic hepatitis.

Gut 2014 Nov 10;63(11):1782-92. Epub 2014 Jan 10.

Liver Unit, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Faculty of Medicine University of Barcelona, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Spain.

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November 2014

The biliary epithelium gives rise to liver progenitor cells.

Hepatology 2014 Oct 21;60(4):1367-77. Epub 2014 Aug 21.

Liver Unit, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Spain.

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October 2014

Gene expression profiling and secretome analysis differentiate adult-derived human liver stem/progenitor cells and human hepatic stellate cells.

PLoS One 2014 21;9(1):e86137. Epub 2014 Jan 21.

Université Catholique de Louvain, Institut de Recherche Expérimentale et Clinique (IREC), Laboratory of Pediatric Hepatology and Cell Therapy, Brussels, Belgium.

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September 2014

Human and experimental evidence supporting a role for osteopontin in alcoholic hepatitis.

Hepatology 2013 Nov 19;58(5):1742-56. Epub 2013 Aug 19.

Liver Unit, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CIBER de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Catalonia, Spain.

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November 2013

Transcriptome analysis identifies TNF superfamily receptors as potential therapeutic targets in alcoholic hepatitis.

Gut 2013 Mar 25;62(3):452-60. Epub 2012 May 25.

Liver Unit, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centre Esther Koplowitz, CIBER de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Spain.

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March 2013

Liver progenitor cell markers correlate with liver damage and predict short-term mortality in patients with alcoholic hepatitis.

Hepatology 2012 Jun 23;55(6):1931-41. Epub 2012 Apr 23.

Liver Unit, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Barcelona, Spain.

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June 2012

[Therapeutic possibilities of stem cells in the treatment of liver diseases].

Authors:
Pau Sancho-Bru

Gastroenterol Hepatol 2011 Dec 2;34(10):701-10. Epub 2011 Jun 2.

Unidad de Hepatología, Hospital Clínic de Barcelona, Centro de Investigación Biológica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, España.

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December 2011

Directed differentiation of murine-induced pluripotent stem cells to functional hepatocyte-like cells.

J Hepatol 2011 Jan 6;54(1):98-107. Epub 2010 Sep 6.

Interdepartmental Stem Cell Institute Leuven, Catholic University Leuven, Belgium.

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January 2011

Differentiation of rat multipotent adult progenitor cells to functional hepatocyte-like cells by mimicking embryonic liver development.

Nat Protoc 2010 Jul 24;5(7):1324-36. Epub 2010 Jun 24.

Interdepartmental Stem Cell Institute Leuven, Catholic University Leuven, Leuven, Belgium.

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July 2010

Reduction of advanced liver fibrosis by short-term targeted delivery of an angiotensin receptor blocker to hepatic stellate cells in rats.

Hepatology 2010 Mar;51(3):942-52

Liver Unit, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi I Sunyer, Centro de investigación biomédica en red de enfermedades hepáticas y digestivas, University of Barcelona, Barcelona, Catalonia, Spain.

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March 2010

Hepatocarcinoma cells stimulate the growth, migration and expression of pro-angiogenic genes in human hepatic stellate cells.

Liver Int 2010 Jan 19;30(1):31-41. Epub 2009 Nov 19.

Liver Unit, Institut Clínic de Malalties Digestives i Metabòliques, Hospital Clinic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Catalonia, Spain.

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January 2010

Effects of losartan on hepatic expression of nonphagocytic NADPH oxidase and fibrogenic genes in patients with chronic hepatitis C.

Am J Physiol Gastrointest Liver Physiol 2009 Oct 23;297(4):G726-34. Epub 2009 Jul 23.

Liver Unit, Institut Clínic de Malalties Digestives i Metabòliques, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica En Red de Enfermedades Hepáticas y Digestivas, University of Barcelona, Catalonia, Spain.

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October 2009

Atorvastatin attenuates angiotensin II-induced inflammatory actions in the liver.

Am J Physiol Gastrointest Liver Physiol 2009 Feb 4;296(2):G147-56. Epub 2008 Dec 4.

Institut de Malalties Digestives i Metabòliques, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica Esther Koplowitz, Barcelona, Catalonia, Spain.

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February 2009

Bradykinin attenuates hepatocellular damage and fibrosis in rats with chronic liver injury.

Gastroenterology 2007 Dec 26;133(6):2019-28. Epub 2007 Sep 26.

Liver Unit, Institut Clínic de Malalties Digestives i Metabòliques, Barcelona, Catalonia, Spain.

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December 2007

Up-regulation of myocardial L-type Ca2+ channel in chronic alcoholic subjects without cardiomyopathy.

Alcohol Clin Exp Res 2007 Jul 4;31(7):1099-105. Epub 2007 May 4.

Department of Internal Medicine, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain.

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July 2007

Hepatic expression of candidate genes in patients with alcoholic hepatitis: correlation with disease severity.

Gastroenterology 2007 Feb 20;132(2):687-97. Epub 2006 Dec 20.

Liver Unit, Institut Clínic de Malalties Digestives i Metabòliques, Barcelona, Catalonia, Spain.

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February 2007

Resistin as an intrahepatic cytokine: overexpression during chronic injury and induction of proinflammatory actions in hepatic stellate cells.

Am J Pathol 2006 Dec;169(6):2042-53

Dipartimento di Medicina Interna, University of Florence, Viale Morgagni, 85, I-50134 Florence, Italy, and the Liver Unit, Hospital Clinic, Institut d'Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain.

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December 2006

Norepinephrine induces calcium spikes and proinflammatory actions in human hepatic stellate cells.

Am J Physiol Gastrointest Liver Physiol 2006 Nov 15;291(5):G877-84. Epub 2006 Jun 15.

Liver Unit, Institut Clínic de Malalties Digestives i Metabòliques, Hospital Clínic, Villarroel 170, Barcelona, Spain.

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November 2006

Liver fibrogenesis: a new role for the renin-angiotensin system.

Antioxid Redox Signal 2005 Sep-Oct;7(9-10):1346-55

Institut de Malalties Digestives i Metabòliques, Hospital Clinic, IDIBAPS, Barcelona, Catalonia, Spain.

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January 2006

Genomic and functional characterization of stellate cells isolated from human cirrhotic livers.

J Hepatol 2005 Aug;43(2):272-82

Liver Unit, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Catalonia, Spain.

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August 2005

Human hepatic stellate cells show features of antigen-presenting cells and stimulate lymphocyte proliferation.

Hepatology 2003 Oct;38(4):919-29

Laboratory of Immunology, Hospital Clínic, University of Barcelona School of Medicine, Institut d'Investigacios Biomèdiques August Pi-Sunyer (IDIBAPS), Villaroel 170, 08036 Barcelona, Catalonia, Spain.

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October 2003

Activated human hepatic stellate cells express the renin-angiotensin system and synthesize angiotensin II.

Gastroenterology 2003 Jul;125(1):117-25

Department of Medicine, Hospital Clínic, Institut d'Investigacions Biomédiques August Pi y Sunyer, University of Brescia School of Medicine, Barcelona, Catalonia, Spain.

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July 2003