Publications

Hepatocyte-derived macrophage migration inhibitory factor mediates alcohol-induced liver injury in mice and patients.
J Hepatol 2017 Nov 22;67(5):1018-1025. Epub 2017 Jun 22.
Center for Liver Disease Research, Department of Pathobiology, Cleveland Clinic, Spain; Department of Molecular Medicine, Case Western Reserve University, USA. Electronic address:

A small population of liver endothelial cells undergoes endothelial-to-mesenchymal transition in response to chronic liver injury.
Am J Physiol Gastrointest Liver Physiol 2017 Nov 10;313(5):G492-G504. Epub 2017 Aug 10.
Biochemistry and Molecular Genetics Department, Hospital Clínic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Barcelona, Spain;



Mesenchymal stromal cells for immunomodulatory cell therapy in liver transplantation: One step at a time.
J Hepatol 2017 Jul 21;67(1):7-9. Epub 2017 Apr 21.
Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Liver Unit, Hospital Clínic, University of Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Spain. Electronic address:



LPS-TLR4 Pathway Mediates Ductular Cell Expansion in Alcoholic Hepatitis.
Sci Rep 2016 Oct 18;6:35610. Epub 2016 Oct 18.
Division of Gastroenterology and Hepatology, Departments of Medicine and Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Integrative microRNA profiling in alcoholic hepatitis reveals a role for microRNA-182 in liver injury and inflammation.
Gut 2016 Sep 10;65(9):1535-45. Epub 2016 May 10.
Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Spain.

Kinase analysis in alcoholic hepatitis identifies p90RSK as a potential mediator of liver fibrogenesis.
Gut 2016 May 4;65(5):840-51. Epub 2015 Feb 4.
Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CIBER de Enfermedades Hepáticas y Digestivas (CIBERehd), Facultat de Medicina, Universitat de Barcelona, Barcelona, Catalonia, Spain Division of Gastroenterology and Hepatology, Departments of Medicine and Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Systemic inflammatory response and serum lipopolysaccharide levels predict multiple organ failure and death in alcoholic hepatitis.
Hepatology 2015 Sep 13;62(3):762-72. Epub 2015 Apr 13.
Institut d'Investigacions Biomèdiques August-Pi-Sunyer, University of Barcelona, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Barcelona, Spain.

Gas6/Axl pathway is activated in chronic liver disease and its targeting reduces fibrosis via hepatic stellate cell inactivation.
J Hepatol 2015 Sep 20;63(3):670-8. Epub 2015 Apr 20.
Liver Unit, Hospital Clinic, IDIBAPS-CIBEK, CIBEREHD, Barcelona, Catalonia, Spain; Department of Cell Death and Proliferation, IIBB-CSIC, Barcelona, Catalonia, Spain. Electronic address:


Integrative miRNA and Gene Expression Profiling Analysis of Human Quiescent Hepatic Stellate Cells.
Sci Rep 2015 Jun 22;5:11549. Epub 2015 Jun 22.
1] Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain [2] Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Spain [3] Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Spain.

VSL#3 probiotic treatment decreases bacterial translocation in rats with carbon tetrachloride-induced cirrhosis.
Liver Int 2015 Mar 12;35(3):735-45. Epub 2014 May 12.
Department of Gastroenterology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Institut d'Investigacions Biomèdiques (IIB) Sant Pau, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain; Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), Spain.

CCL20 mediates lipopolysaccharide induced liver injury and is a potential driver of inflammation and fibrosis in alcoholic hepatitis.
Gut 2014 Nov 10;63(11):1782-92. Epub 2014 Jan 10.
Liver Unit, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Faculty of Medicine University of Barcelona, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Spain.

The biliary epithelium gives rise to liver progenitor cells.
Hepatology 2014 Oct 21;60(4):1367-77. Epub 2014 Aug 21.
Liver Unit, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Spain.

Human and experimental evidence supporting a role for osteopontin in alcoholic hepatitis.
Hepatology 2013 Nov 19;58(5):1742-56. Epub 2013 Aug 19.
Liver Unit, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CIBER de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Catalonia, Spain.

Transcriptome analysis identifies TNF superfamily receptors as potential therapeutic targets in alcoholic hepatitis.
Gut 2013 Mar 25;62(3):452-60. Epub 2012 May 25.
Liver Unit, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centre Esther Koplowitz, CIBER de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Spain.

Liver progenitor cell markers correlate with liver damage and predict short-term mortality in patients with alcoholic hepatitis.
Hepatology 2012 Jun 23;55(6):1931-41. Epub 2012 Apr 23.
Liver Unit, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Barcelona, Spain.



Human embryonic and rat adult stem cells with primitive endoderm-like phenotype can be fated to definitive endoderm, and finally hepatocyte-like cells.
PLoS One 2010 Aug 11;5(8):e12101. Epub 2010 Aug 11.
Interdepartmental Stem Cell Institute Leuven, Catholic University Leuven, and Hepatology Department, University Hospitals Leuven, Leuven, Belgium.

Reduction of advanced liver fibrosis by short-term targeted delivery of an angiotensin receptor blocker to hepatic stellate cells in rats.
Hepatology 2010 Mar;51(3):942-52
Liver Unit, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi I Sunyer, Centro de investigación biomédica en red de enfermedades hepáticas y digestivas, University of Barcelona, Barcelona, Catalonia, Spain.


Hepatocarcinoma cells stimulate the growth, migration and expression of pro-angiogenic genes in human hepatic stellate cells.
Liver Int 2010 Jan 19;30(1):31-41. Epub 2009 Nov 19.
Liver Unit, Institut Clínic de Malalties Digestives i Metabòliques, Hospital Clinic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Catalonia, Spain.

Effects of losartan on hepatic expression of nonphagocytic NADPH oxidase and fibrogenic genes in patients with chronic hepatitis C.
Am J Physiol Gastrointest Liver Physiol 2009 Oct 23;297(4):G726-34. Epub 2009 Jul 23.
Liver Unit, Institut Clínic de Malalties Digestives i Metabòliques, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica En Red de Enfermedades Hepáticas y Digestivas, University of Barcelona, Catalonia, Spain.

Atorvastatin attenuates angiotensin II-induced inflammatory actions in the liver.
Am J Physiol Gastrointest Liver Physiol 2009 Feb 4;296(2):G147-56. Epub 2008 Dec 4.
Institut de Malalties Digestives i Metabòliques, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica Esther Koplowitz, Barcelona, Catalonia, Spain.

Bradykinin attenuates hepatocellular damage and fibrosis in rats with chronic liver injury.
Gastroenterology 2007 Dec 26;133(6):2019-28. Epub 2007 Sep 26.
Liver Unit, Institut Clínic de Malalties Digestives i Metabòliques, Barcelona, Catalonia, Spain.

Resistin as an intrahepatic cytokine: overexpression during chronic injury and induction of proinflammatory actions in hepatic stellate cells.
Am J Pathol 2006 Dec;169(6):2042-53
Dipartimento di Medicina Interna, University of Florence, Viale Morgagni, 85, I-50134 Florence, Italy, and the Liver Unit, Hospital Clinic, Institut d'Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain.

Human hepatic stellate cells show features of antigen-presenting cells and stimulate lymphocyte proliferation.
Hepatology 2003 Oct;38(4):919-29
Laboratory of Immunology, Hospital Clínic, University of Barcelona School of Medicine, Institut d'Investigacios Biomèdiques August Pi-Sunyer (IDIBAPS), Villaroel 170, 08036 Barcelona, Catalonia, Spain.

Activated human hepatic stellate cells express the renin-angiotensin system and synthesize angiotensin II.
Gastroenterology 2003 Jul;125(1):117-25
Department of Medicine, Hospital Clínic, Institut d'Investigacions Biomédiques August Pi y Sunyer, University of Brescia School of Medicine, Barcelona, Catalonia, Spain.


Gene expression profiling and secretome analysis differentiate adult-derived human liver stem/progenitor cells and human hepatic stellate cells.
PLoS One 2014 21;9(1):e86137. Epub 2014 Jan 21.
Université Catholique de Louvain, Institut de Recherche Expérimentale et Clinique (IREC), Laboratory of Pediatric Hepatology and Cell Therapy, Brussels, Belgium.

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