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Publications Authored by Pau Castel | PubFacts
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PI3K Inhibition Activates SGK1 via a Feedback Loop to Promote Chromatin-Based Regulation of ER-Dependent Gene Expression.

Cell Rep 2019 Apr;27(1):294-306.e5

Human Oncology and Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 20, New York, NY 10065, USA; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Research & Development Oncology, AstraZeneca Pharmaceuticals, Gaithersburg, MD 20878, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247193029
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http://dx.doi.org/10.1016/j.celrep.2019.02.111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503687PMC
April 2019

RIT1 oncoproteins escape LZTR1-mediated proteolysis.

Science 2019 03;363(6432):1226-1230

Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA.

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http://dx.doi.org/10.1126/science.aav1444DOI Listing
March 2019

The emerging role of serum/glucocorticoid-regulated kinases in cancer.

Cell Cycle 2017 01 16;16(1):5-6. Epub 2016 Sep 16.

a Human Oncology & Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center , New York , NY , USA.

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http://dx.doi.org/10.1080/15384101.2016.1232071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5270517PMC
January 2017

Therapeutic Benefit of Selective Inhibition of p110α PI3-Kinase in Pancreatic Neuroendocrine Tumors.

Clin Cancer Res 2016 Dec 25;22(23):5805-5817. Epub 2016 May 25.

Vascular Signaling Laboratory, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-3051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338478PMC
December 2016

The hVps34-SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumour growth.

EMBO J 2016 09 1;35(17):1902-22. Epub 2016 Aug 1.

MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences University of Dundee, Dundee, UK

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http://dx.doi.org/10.15252/embj.201693929DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007552PMC
September 2016

PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition.

Cancer Cell 2016 08 21;30(2):229-242. Epub 2016 Jul 21.

Human Oncology & Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 20, New York, NY 10065, USA; Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 20, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982440PMC
August 2016

Rationale-based therapeutic combinations with PI3K inhibitors in cancer treatment.

Mol Cell Oncol 2014 Jul-Sep;1(3):e963447. Epub 2014 Oct 29.

Human Oncology & Pathogenesis Program (HOPP); Memorial Sloan Kettering Cancer Center ; New York, NY USA.

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http://dx.doi.org/10.4161/23723548.2014.963447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904898PMC
June 2016

Somatic PIK3CA mutations as a driver of sporadic venous malformations.

Sci Transl Med 2016 Mar;8(332):332ra42

Human Oncology and Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1126/scitranslmed.aaf1164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962922PMC
March 2016

The tumor suppressor PTEN and the PDK1 kinase regulate formation of the columnar neural epithelium.

Elife 2016 Jan 26;5:e12034. Epub 2016 Jan 26.

Developmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States.

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http://dx.doi.org/10.7554/eLife.12034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4739759PMC
January 2016

PI3K inhibition results in enhanced estrogen receptor function and dependence in hormone receptor-positive breast cancer.

Sci Transl Med 2015 Apr;7(283):283ra51

Human Oncology and Pathogenesis Program and Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 20, New York, NY 10065, USA. Breast Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Weill Cornell Medical College, New York, NY 10065, USA.

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http://dx.doi.org/10.1126/scitranslmed.aaa4442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433148PMC
April 2015