Publications by authors named "Patrycja Gazinska"

32Publications

RIPK1-mediated immunogenic cell death promotes anti-tumour immunity against soft-tissue sarcoma.

Authors:
Henry G Smith Kunzah Jamal Jasbani Hs Dayal Tencho Tenev Joan Kyula-Currie Naomi Guppy Patrycja Gazinska Victoria Roulstone Gianmaria Liccardi Emma Davies Ioannis Roxanis Alan A Melcher Andrew J Hayes Gareth J Inman Kevin J Harrington Pascal Meier

EMBO Mol Med 2020 06 18;12(6):e10979. Epub 2020 May 18.

The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.

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June 2020

An innate-like Vδ1 γδ T cell compartment in the human breast is associated with remission in triple-negative breast cancer.

Authors:
Yin Wu Fernanda Kyle-Cezar Richard T Woolf Cristina Naceur-Lombardelli Julie Owen Dhruva Biswas Anna Lorenc Pierre Vantourout Patrycja Gazinska Anita Grigoriadis Andrew Tutt Adrian Hayday

Sci Transl Med 2019 10;11(513)

Peter Gorer Department of Immunobiology, School of Immunology & Microbial Sciences, King's College London, London SE1 9RT, UK.

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October 2019

Anti-Folate Receptor Alpha-Directed Antibody Therapies Restrict the Growth of Triple-negative Breast Cancer.

Authors:
Anthony Cheung James Opzoomer Kristina M Ilieva Patrycja Gazinska Ricarda M Hoffmann Hasan Mirza Rebecca Marlow Erika Francesch-Domenech Matthew Fittall Diana Dominguez Rodriguez Angela Clifford Luned Badder Nirmesh Patel Silvia Mele Giulia Pellizzari Heather J Bax Silvia Crescioli Gyula Petranyi Daniel Larcombe-Young Debra H Josephs Silvana Canevari Mariangela Figini Sarah Pinder Frank O Nestle Cheryl Gillett James F Spicer Anita Grigoriadis Andrew N J Tutt Sophia N Karagiannis

Clin Cancer Res 2018 10 1;24(20):5098-5111. Epub 2018 Aug 1.

Breast Cancer Now Research Unit, School of Cancer & Pharmaceutical Sciences, King's College London, Guy's Cancer Centre, London, United Kingdom.

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October 2018

Carboplatin in BRCA1/2-mutated and triple-negative breast cancer BRCAness subgroups: the TNT Trial.

Authors:
Andrew Tutt Holly Tovey Maggie Chon U Cheang Sarah Kernaghan Lucy Kilburn Patrycja Gazinska Julie Owen Jacinta Abraham Sophie Barrett Peter Barrett-Lee Robert Brown Stephen Chan Mitchell Dowsett James M Flanagan Lisa Fox Anita Grigoriadis Alexander Gutin Catherine Harper-Wynne Matthew Q Hatton Katherine A Hoadley Jyoti Parikh Peter Parker Charles M Perou Rebecca Roylance Vandna Shah Adam Shaw Ian E Smith Kirsten M Timms Andrew M Wardley Gregory Wilson Cheryl Gillett Jerry S Lanchbury Alan Ashworth Nazneen Rahman Mark Harries Paul Ellis Sarah E Pinder Judith M Bliss

Nat Med 2018 05 30;24(5):628-637. Epub 2018 Apr 30.

Clinical Trials and Statistics Unit, The Institute of Cancer Research, London, UK.

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May 2018

E-Cadherin/ROS1 Inhibitor Synthetic Lethality in Breast Cancer.

Authors:
Ilirjana Bajrami Rebecca Marlow Marieke van de Ven Rachel Brough Helen N Pemberton Jessica Frankum Feifei Song Rumana Rafiq Asha Konde Dragomir B Krastev Malini Menon James Campbell Aditi Gulati Rahul Kumar Stephen J Pettitt Mark D Gurden Marta Llorca Cardenosa Irene Chong Patrycja Gazinska Fredrik Wallberg Elinor J Sawyer Lesley-Ann Martin Mitch Dowsett Spiros Linardopoulos Rachael Natrajan Colm J Ryan Patrick W B Derksen Jos Jonkers Andrew N J Tutt Alan Ashworth Christopher J Lord

Cancer Discov 2018 04;8(4):498-515

The Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom.

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April 2018

Clinically compliant spatial and temporal imaging of chimeric antigen receptor T-cells.

Authors:
Nia Emami-Shahri Julie Foster Roxana Kashani Patrycja Gazinska Celia Cook Jane Sosabowski John Maher Sophie Papa

Nat Commun 2018 03 14;9(1):1081. Epub 2018 Mar 14.

ImmunoEngineering Group, King's College London, Division of Cancer Studies, 3rd Floor Bermondsey Wing, King's Health Partners Integrated Cancer Centre, Great Maze Pond, Guy's Hospital, London, SE1 9RT, UK.

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March 2018

Integrated genomics and functional validation identifies malignant cell specific dependencies in triple negative breast cancer.

Authors:
Nirmesh Patel Daniel Weekes Konstantinos Drosopoulos Patrycja Gazinska Elodie Noel Mamun Rashid Hasan Mirza Jelmar Quist Fara Brasó-Maristany Sumi Mathew Riccardo Ferro Ana Mendes Pereira Cynthia Prince Farzana Noor Erika Francesch-Domenech Rebecca Marlow Emanuele de Rinaldis Anita Grigoriadis Spiros Linardopoulos Pierfrancesco Marra Andrew N J Tutt

Nat Commun 2018 03 13;9(1):1044. Epub 2018 Mar 13.

Breast Cancer Now Research Unit, King's College London, London, SE1 9RT, UK.

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March 2018

Histological scoring of immune and stromal features in breast and axillary lymph nodes is prognostic for distant metastasis in lymph node-positive breast cancers.

Authors:
Anita Grigoriadis Patrycja Gazinska Trupti Pai Sheeba Irhsad Yin Wu Rosemary Millis Kalnisha Naidoo Julie Owen Cheryl E Gillett Andrew Tutt Anthonius Cc Coolen Sarah E Pinder

J Pathol Clin Res 2018 Jan 8;4(1):39-54. Epub 2018 Jan 8.

School of Cancer and Pharmaceutical SciencesCRUK King's Health Partners Centre, King's College London, Innovation Hub, Cancer Centre at Guy's Hospital, Great Maze PondLondonUK.

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January 2018

Genomic Evolution of Breast Cancer Metastasis and Relapse.

Authors:
Lucy R Yates Stian Knappskog David Wedge James H R Farmery Santiago Gonzalez Inigo Martincorena Ludmil B Alexandrov Peter Van Loo Hans Kristian Haugland Peer Kaare Lilleng Gunes Gundem Moritz Gerstung Elli Pappaemmanuil Patrycja Gazinska Shriram G Bhosle David Jones Keiran Raine Laura Mudie Calli Latimer Elinor Sawyer Christine Desmedt Christos Sotiriou Michael R Stratton Anieta M Sieuwerts Andy G Lynch John W Martens Andrea L Richardson Andrew Tutt Per Eystein Lønning Peter J Campbell

Cancer Cell 2017 08;32(2):169-184.e7

Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK. Electronic address:

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August 2017

Erratum: PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer.

Authors:
Fara Brasó-Maristany Simone Filosto Steven Catchpole Rebecca Marlow Jelmar Quist Erika Francesch-Domenech Darren A Plumb Leila Zakka Patrycja Gazinska Gianmaria Liccardi Pascal Meier Albert Gris-Oliver Maggie Chon U Cheang Anna Perdrix-Rosell Manar Shafat Elodie Noël Nirmesh Patel Kristen McEachern Maurizio Scaltriti Pau Castel Farzana Noor Richard Buus Sumi Mathew Johnathan Watkins Violeta Serra Pierfrancesco Marra Anita Grigoriadis Andrew N Tutt

Nat Med 2017 06;23(6):788

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June 2017

Erratum: PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer.

Authors:
Fara Brasó-Maristany Simone Filosto Steven Catchpole Rebecca Marlow Jelmar Quist Erika Francesch-Domenech Darren A Plumb Leila Zakka Patrycja Gazinska Gianmaria Liccardi Pascal Meier Albert Gris-Oliver Maggie Chon U Cheang Anna Perdrix-Rosell Manar Shafat Elodie Noël Nirmesh Patel Kristen McEachern Maurizio Scaltriti Pau Castel Farzana Noor Richard Buus Sumi Mathew Johnathan Watkins Violeta Serra Pierfrancesco Marra Anita Grigoriadis Andrew N Tutt

Nat Med 2017 Apr;23(4):526

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April 2017

Automated Classification of Breast Cancer Stroma Maturity From Histological Images.

Authors:
Sara Reis Patrycja Gazinska John H Hipwell Thomy Mertzanidou Kalnisha Naidoo Norman Williams Sarah Pinder David J Hawkes

IEEE Trans Biomed Eng 2017 10 7;64(10):2344-2352. Epub 2017 Feb 7.

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October 2017

Anti-Folate Receptor-α IgE but not IgG Recruits Macrophages to Attack Tumors via TNFα/MCP-1 Signaling.

Authors:
Debra H Josephs Heather J Bax Tihomir Dodev Mirella Georgouli Mano Nakamura Giulia Pellizzari Louise Saul Panagiotis Karagiannis Anthony Cheung Cecilia Herraiz Kristina M Ilieva Isabel Correa Matthew Fittall Silvia Crescioli Patrycja Gazinska Natalie Woodman Silvia Mele Giulia Chiaruttini Amy E Gilbert Alexander Koers Marguerite Bracher Christopher Selkirk Heike Lentfer Claire Barton Elliott Lever Gareth Muirhead Sophia Tsoka Silvana Canevari Mariangela Figini Ana Montes Noel Downes David Dombrowicz Christopher J Corrigan Andrew J Beavil Frank O Nestle Paul S Jones Hannah J Gould Victoria Sanz-Moreno Philip J Blower James F Spicer Sophia N Karagiannis

Cancer Res 2017 03 17;77(5):1127-1141. Epub 2017 Jan 17.

St. John's Institute of Dermatology, Division of Genetics and Molecular Medicine, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom.

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March 2017

RORγt Innate Lymphoid Cells Promote Lymph Node Metastasis of Breast Cancers.

Authors:
Sheeba Irshad Fabian Flores-Borja Katherine Lawler James Monypenny Rachel Evans Victoria Male Peter Gordon Anthony Cheung Patrycja Gazinska Farzana Noor Felix Wong Anita Grigoriadis Gilbert O Fruhwirth Paul R Barber Natalie Woodman Dominic Patel Manuel Rodriguez-Justo Julie Owen Stewart G Martin Sarah E Pinder Cheryl E Gillett Simon P Poland Simon Ameer-Beg Frank McCaughan Leo M Carlin Uzma Hasan David R Withers Peter Lane Borivoj Vojnovic Sergio A Quezada Paul Ellis Andrew N J Tutt Tony Ng

Cancer Res 2017 03 12;77(5):1083-1096. Epub 2017 Jan 12.

Breast Cancer Now (BCN) Research Unit, King's College London, London, United Kingdom.

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March 2017

Splicing imbalances in basal-like breast cancer underpin perturbation of cell surface and oncogenic pathways and are associated with patients' survival.

Authors:
Filipe Gracio Brian Burford Patrycja Gazinska Anca Mera Aisyah Mohd Noor Pierfrancesco Marra Cheryl Gillett Anita Grigoriadis Sarah Pinder Andrew Tutt Emanuele de Rinaldis

Sci Rep 2017 01 6;7:40177. Epub 2017 Jan 6.

Guy's and St Thomas' NHS Foundation Trust and King's College London NIHR Biomedical Research Centre - Translational Bioinformatics Platform, Guy's Hospital, London, UK.

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January 2017

Microstructural models for diffusion MRI in breast cancer and surrounding stroma: an ex vivo study.

Authors:
Colleen Bailey Bernard Siow Eleftheria Panagiotaki John H Hipwell Thomy Mertzanidou Julie Owen Patrycja Gazinska Sarah E Pinder Daniel C Alexander David J Hawkes

NMR Biomed 2017 Feb 21;30(2). Epub 2016 Dec 21.

University College London, Centre for Medical Image Computing, London, UK.

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February 2017

PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer.

Authors:
Fara Brasó-Maristany Simone Filosto Steven Catchpole Rebecca Marlow Jelmar Quist Erika Francesch-Domenech Darren A Plumb Leila Zakka Patrycja Gazinska Gianmaria Liccardi Pascal Meier Albert Gris-Oliver Maggie Chon U Cheang Anna Perdrix-Rosell Manar Shafat Elodie Noël Nirmesh Patel Kristen McEachern Maurizio Scaltriti Pau Castel Farzana Noor Richard Buus Sumi Mathew Johnathan Watkins Violeta Serra Pierfrancesco Marra Anita Grigoriadis Andrew N Tutt

Nat Med 2016 11 24;22(11):1303-1313. Epub 2016 Oct 24.

Breast Cancer Now Research Unit, Division of Cancer Studies, Faculty of Life Sciences and Medicine, King's College London, Guy's Hospital, London, UK.

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November 2016

Vessel co-option mediates resistance to anti-angiogenic therapy in liver metastases.

Authors:
Sophia Frentzas Eve Simoneau Victoria L Bridgeman Peter B Vermeulen Shane Foo Eleftherios Kostaras Mark Nathan Andrew Wotherspoon Zu-Hua Gao Yu Shi Gert Van den Eynden Frances Daley Clare Peckitt Xianming Tan Ayat Salman Anthoula Lazaris Patrycja Gazinska Tracy J Berg Zak Eltahir Laila Ritsma Jacco Van Rheenen Alla Khashper Gina Brown Hanna Nystrom Malin Sund Steven Van Laere Evelyne Loyer Luc Dirix David Cunningham Peter Metrakos Andrew R Reynolds

Nat Med 2016 11 17;22(11):1294-1302. Epub 2016 Oct 17.

Tumour Biology Team, The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.

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November 2016

Phase II Randomized Preoperative Window-of-Opportunity Study of the PI3K Inhibitor Pictilisib Plus Anastrozole Compared With Anastrozole Alone in Patients With Estrogen Receptor-Positive Breast Cancer.

Authors:
Peter Schmid Sarah E Pinder Duncan Wheatley Jane Macaskill Charles Zammit Jennifer Hu Robert Price Nigel Bundred Sirwan Hadad Alice Shia Shah-Jalal Sarker Louise Lim Patrycja Gazinska Natalie Woodman Darren Korbie Matt Trau Paul Mainwaring Steven Gendreau Mark R Lackner Mika Derynck Timothy R Wilson Hannah Butler Gemma Earl Peter Parker Arnie Purushotham Alastair Thompson

J Clin Oncol 2016 06 14;34(17):1987-94. Epub 2016 Mar 14.

Peter Schmid, Alice Shia, Shah-Jalal Sarker, and Louise Lim, Queen Mary University London; Sarah E. Pinder, Patrycja Gazinska, Natalie Woodman, Peter Parker, and Arnie Purushotham, Kings College London; Robert Price, Kings College Hospital; Jennifer Hu, Barts Health National Health Service (NHS) Trust, London; Duncan Wheatley, Royal Cornwall Hospital, Truro; Jane Macaskill, Ninewells Hospital Dundee, Dundee; Charles Zammit, Hannah Butler, and Gemma Earl, Brighton & Sussex University Hospitals NHS Trust, Brighton; Nigel Bundred, University Hospital of South Manchester, Manchester; Sirwan Hadad, Royal Hallamshire Sheffield, Sheffield; Darren Korbie and Matt Trau, Australian Institute for Bioengineering and Nanotechnology, and Matt Trau, University of Queensland; Paul Mainwaring, Mater Research Centre; Brisbane, Australia; Steven Gendreau, Mark R. Lackner, Mika Derynck, and Timothy R. Wilson, Genentech, South San Francisco, CA; and Alastair Thompson, MD Anderson Cancer Centre, Houston, TX.

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June 2016

c-Met PET Imaging Detects Early-Stage Locoregional Recurrence of Basal-Like Breast Cancer.

Authors:
Appitha Arulappu Mark Battle Michel Eisenblaetter Graeme McRobbie Imtiaz Khan James Monypenny Gregory Weitsman Myria Galazi Susan Hoppmann Patrycja Gazinska Wulan Wulaningsih Grethe Tang Dalsgaard Sven Macholl Tony Ng

J Nucl Med 2016 05 3;57(5):765-70. Epub 2015 Dec 3.

Richard Dimbleby Department of Cancer Research, Kings College London, London, United Kingdom Breast Cancer NOW Unit, King's College London School of Medicine, London, United Kingdom UCL Cancer Institute, University College London, London, United Kingdom

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May 2016