Publications by authors named "Patrizia Minetti"

21Publications

Development of Potent Inhibitors of Fatty Acid Amide Hydrolase Useful for the Treatment of Neuropathic Pain.

Authors:
Margherita Brindisi Giuseppe Borrelli Simone Brogi Alessandro Grillo Samuele Maramai Marco Paolino Mascia Benedusi Alessandra Pecorelli Giuseppe Valacchi Lorenzo Di Cesare Mannelli Carla Ghelardini Marco Allarà Alessia Ligresti Patrizia Minetti Giuseppe Campiani Vincenzo di Marzo Stefania Butini Sandra Gemma

ChemMedChem 2018 10 30;13(19):2090-2103. Epub 2018 Aug 30.

European Research Centre for Drug Discovery and Development (NatSynDrugs), Department of Biotechnology, Chemistry, and Pharmacy (DoE 2018-2020), University of Siena, Via Aldo Moro 2, 53100, Siena, Italy.

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October 2018

Potent, Metabolically Stable 2-Alkyl-8-(2H-1,2,3-triazol-2-yl)-9H-adenines as Adenosine A2A Receptor Ligands.

Authors:
Silvia Pace Giandomenico Brogin Maria Antonietta Stasi Teresa Riccioni Franco Borsini Francesca Capocasa Francesco Manera Carlo Tallarico Pietro Grossi Federica Vacondio Michele Bassi Francesca Bartoccini Simone Lucarini Giovanni Piersanti Giorgio Tarzia Walter Cabri Patrizia Minetti

ChemMedChem 2015 Jul 7;10(7):1149-52. Epub 2015 May 7.

Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. Via Pontina Km 30, 400, 00040 Pomezia (Italy).

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July 2015

Animal models of Parkinson׳s disease: Effects of two adenosine A2A receptor antagonists ST4206 and ST3932, metabolites of 2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine (ST1535).

Authors:
Maria Antonietta Stasi Patrizia Minetti Katia Lombardo Teresa Riccioni Antonio Caprioli Mario Vertechy Stefano Di Serio Silvia Pace Franco Borsini

Eur J Pharmacol 2015 Aug 30;761:353-61. Epub 2015 Apr 30.

Research & Development Area, Sigma-tau, Italy.

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August 2015

Towards the development of 5-HT₇ ligands combining serotonin-like and arylpiperazine moieties.

Authors:
Gilberto Spadoni Annalida Bedini Silvia Bartolucci Daniele Pala Marco Mor Teresa Riccioni Franco Borsini Walter Cabri Diana Celona Mauro Marzi Giorgio Tarzia Silvia Rivara Patrizia Minetti

Eur J Med Chem 2014 Jun 13;80:8-35. Epub 2014 Apr 13.

Sigma-Tau Industrie Farmaceutiche Riunite S.p.A., Via Pontina Km 30,400, I-00040 Pomezia, Italy. Electronic address:

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June 2014

Synthesis and biological evaluation of metabolites of 2-n-butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine (ST1535), a potent antagonist of the A2A adenosine receptor for the treatment of Parkinson's disease.

Authors:
Giovanni Piersanti Francesca Bartoccini Simone Lucarini Walter Cabri Maria Antonietta Stasi Teresa Riccioni Franco Borsini Giorgio Tarzia Patrizia Minetti

J Med Chem 2013 Jul 24;56(13):5456-63. Epub 2013 Jun 24.

Dipartimento di Scienze Biomolecolari, Università degli Studi di Urbino , Piazza Rinascimento 6, I-61029 Urbino (PU), Italy.

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July 2013

Synthesis of (E)-8-(3-chlorostyryl)caffeine analogues leading to 9-deazaxanthine derivatives as dual A(2A) antagonists/MAO-B inhibitors.

Authors:
Silvia Rivara Giovanni Piersanti Francesca Bartoccini Giuseppe Diamantini Daniele Pala Teresa Riccioni Maria Antonietta Stasi Walter Cabri Franco Borsini Marco Mor Giorgio Tarzia Patrizia Minetti

J Med Chem 2013 Feb 16;56(3):1247-61. Epub 2013 Jan 16.

Dipartimento di Farmacia, Università degli Studi di Parma, Viale G.P. Usberti 27 A, I-43124 Parma, Italy.

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February 2013

Identification of a novel arylpiperazine scaffold for fatty acid amide hydrolase inhibition with improved drug disposition properties.

Authors:
Stefania Butini Sandra Gemma Margherita Brindisi Samuele Maramai Patrizia Minetti Diana Celona Raffaella Napolitano Franco Borsini Walter Cabri Filomena Fezza Lucio Merlini Sabrina Dallavalle Giuseppe Campiani Mauro Maccarrone

Bioorg Med Chem Lett 2013 Jan 22;23(2):492-5. Epub 2012 Nov 22.

European Research Centre for Drug Discovery and Development (NatSynDrugs), Università degli Studi di Siena, Via Aldo Moro, 53100 Siena, Italy.

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January 2013

Divergent synthesis of novel 9-deazaxanthine derivatives via late-stage cross-coupling reactions.

Authors:
Francesca Bartoccini Giovanni Piersanti Marco Mor Giorgio Tarzia Patrizia Minetti Walter Cabri

Org Biomol Chem 2012 Nov;10(44):8860-7

Department of Biomolecular Sciences, University of Urbino, Piazza Rinascimento 6, 61029 Urbino (PU), Italy.

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November 2012

Design, synthesis, and structure-activity relationship of N-arylnaphthylamine derivatives as amyloid aggregation inhibitors.

Authors:
Roberto Di Santo Roberta Costi Giuliana Cuzzucoli Crucitti Luca Pescatori Federica Rosi Luigi Scipione Diana Celona Mario Vertechy Orlando Ghirardi Paola Piovesan Mauro Marzi Silvio Caccia Giovanna Guiso Fabrizio Giorgi Patrizia Minetti

J Med Chem 2012 Oct 1;55(19):8538-48. Epub 2012 Oct 1.

Dipartimento di Chimica e Tecnologie del Farmaco, Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza Università di Roma, P.le A. Moro 5, I-00185 Roma, Italy.

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October 2012

Discovery of potent inhibitors of human and mouse fatty acid amide hydrolases.

Authors:
Stefania Butini Margherita Brindisi Sandra Gemma Patrizia Minetti Walter Cabri Grazia Gallo Silvia Vincenti Emanuela Talamonti Franco Borsini Antonio Caprioli Maria Antonietta Stasi Stefano Di Serio Sindu Ros Giuseppe Borrelli Samuele Maramai Filomena Fezza Giuseppe Campiani Mauro Maccarrone

J Med Chem 2012 Aug 26;55(15):6898-915. Epub 2012 Jul 26.

European Research Centre for Drug Discovery and Development (NatSynDrugs), Università degli Studi di Siena , Via Aldo Moro 2, 53100 Siena, Italy.

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August 2012

ST1936 stimulates cAMP, Ca2+, ERK1/2 and Fyn kinase through a full activation of cloned human 5-HT6 receptors.

Authors:
Teresa Riccioni Fabio Bordi Patrizia Minetti Gilberto Spadoni Hyung-Mun Yun Bo-Hye Im Giorgio Tarzia Hyewhon Rhim Franco Borsini

Eur J Pharmacol 2011 Jul 28;661(1-3):8-14. Epub 2011 Apr 28.

Sigma-tau Industrie Farmaceutiche Riunite S.p.A., Pomezia, Italy.

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July 2011

Direct B-alkyl Suzuki-Miyaura cross-coupling of 2-halopurines. Practical synthesis of ST1535, a potent adenosine A2A receptor antagonist.

Authors:
Francesca Bartoccini Walter Cabri Diana Celona Patrizia Minetti Giovanni Piersanti Giorgio Tarzia

J Org Chem 2010 Aug;75(15):5398-401

Department of Drug and Health Sciences, University of Urbino Carlo Bo, P.zza Rinascimento 6, 61029 Urbino (PU), Italy.

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August 2010

A new group of oxime carbamates as reversible inhibitors of fatty acid amide hydrolase.

Authors:
Sonia Gattinoni Chiara De Simone Sabrina Dallavalle Filomena Fezza Raffaella Nannei Natalia Battista Patrizia Minetti Gianandrea Quattrociocchi Antonio Caprioli Franco Borsini Walter Cabri Sergio Penco Lucio Merlini Mauro Maccarrone

Bioorg Med Chem Lett 2010 Aug 15;20(15):4406-11. Epub 2010 Jun 15.

DISMA, Università degli Studi di Milano, Via Celoria 2, 20133 Milano, Italy.

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August 2010

Enol carbamates as inhibitors of fatty acid amide hydrolase (FAAH) endowed with high selectivity for FAAH over the other targets of the endocannabinoid system.

Authors:
Sonia Gattinoni Chiara De Simone Sabrina Dallavalle Filomena Fezza Raffaella Nannei Daniele Amadio Patrizia Minetti Gianandrea Quattrociocchi Antonio Caprioli Franco Borsini Walter Cabri Sergio Penco Lucio Merlini Mauro Maccarrone

ChemMedChem 2010 Mar;5(3):357-60

DISMA, Università degli Studi di Milano, Via Celoria 2, 20133 Milano, Italy.

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March 2010

Synthesis of benzo[1,2-d;3,4-d']diimidazole and 1H-pyrazolo[4,3-b]pyridine as putative A2A receptor antagonists.

Authors:
Giovanni Piersanti Luca Giorgi Francesca Bartoccini Giorgio Tarzia Patrizia Minetti Grazia Gallo Fabrizio Giorgi Massimo Castorina Orlando Ghirardi Paolo Carminati

Org Biomol Chem 2007 Aug;5(16):2567-71

Institute of Medicinal Chemistry, University of Urbino "Carlo Bo", Piazza del Rinascimento 6, 61029 Urbino PU, Italy.

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August 2007

ST2472: a new potential antipsychotic with very low liability to induce side-effects.

Authors:
Maria A Stasi Stefano Di Serio Mario Vertechy Antonio Schiavone Orlando Ghirardi Patrizia Minetti Giuseppe Campiani Franco Borsini Paolo Carminati

Int J Neuropsychopharmacol 2008 May 10;11(3):309-19. Epub 2007 Oct 10.

Sigma-Tau Industrie Farmaceutiche Riunite S.p.A., Pomezia, Rome, Italy.

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May 2008

ST 1535: a preferential A2A adenosine receptor antagonist.

Authors:
Maria Antonietta Stasi Franco Borsini Katia Varani Fabrizio Vincenzi Maria Assunta Di Cesare Patrizia Minetti Orlando Ghirardi Paolo Carminati

Int J Neuropsychopharmacol 2006 Oct 23;9(5):575-84. Epub 2005 Nov 23.

Sigma-Tau Industrie Farmaceutiche Riunite S.p.A., Pomezia (Rome), Italy.

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October 2006

2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization.

Authors:
Patrizia Minetti Maria Ornella Tinti Paolo Carminati Massimo Castorina Maria Assunta Di Cesare Stefano Di Serio Grazia Gallo Orlando Ghirardi Fabrizio Giorgi Luca Giorgi Giovanni Piersanti Francesca Bartoccini Giorgio Tarzia

J Med Chem 2005 Nov;48(22):6887-96

Istituto di Chimica Farmaceutica, Università degli Studi di Urbino Carlo Bo, Piazza del Rinascimento 6, 61029 Urbino (PU), Italy.

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November 2005

Novel atypical antipsychotic agents: rational design, an efficient palladium-catalyzed route, and pharmacological studies.

Authors:
Giuseppe Campiani Stefania Butini Caterina Fattorusso Francesco Trotta Sandra Gemma Bruno Catalanotti Vito Nacci Isabella Fiorini Alfredo Cagnotto Ilario Mereghetti Tiziana Mennini Patrizia Minetti M Assunta Di Cesare M Antonietta Stasi Stefano Di Serio Orlando Ghirardi Ornella Tinti Paolo Carminati

J Med Chem 2005 Mar;48(6):1705-8

Dipartimento Farmaco Chimico Tecnologico, Via Aldo Moro, and European Research Centre for Drug Discovery and Development, Università di Siena, 53100 Siena, Italy.

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March 2005

Pyrrolo[1,3]benzothiazepine-based serotonin and dopamine receptor antagonists. Molecular modeling, further structure-activity relationship studies, and identification of novel atypical antipsychotic agents.

Authors:
Giuseppe Campiani Stefania Butini Caterina Fattorusso Bruno Catalanotti Sandra Gemma Vito Nacci Elena Morelli Alfredo Cagnotto Ilario Mereghetti Tiziana Mennini Miriana Carli Patrizia Minetti M Assunta Di Cesare Domenico Mastroianni Nazzareno Scafetta Bruno Galletti M Antonietta Stasi Massimo Castorina Licia Pacifici Mario Vertechy Stefano Di Serio Orlando Ghirardi Ornella Tinti Paolo Carminati

J Med Chem 2004 Jan;47(1):143-57

Dipartimento Farmaco Chimico Tecnologico, Via Aldo Moro and European Research Centre for Drug Discovery and Development, Universitá degli Studi di Siena, 53100 Siena, Italy.

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January 2004