Patrik Brundin

Patrik Brundin

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Patrik Brundin

Publications by authors named "Patrik Brundin"

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Parkinson Disease Epidemiology, Pathology, Genetics, and Pathophysiology.

Clin Geriatr Med 2020 Feb 24;36(1):1-12. Epub 2019 Aug 24.

Center for Neurodegenerative Science, Van Andel Institute, 333 Bostwick Avenue Northeast, Grand Rapids, MI 49503-2518, USA.

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http://dx.doi.org/10.1016/j.cger.2019.08.002DOI Listing
February 2020

Endogenous alpha-synuclein monomers, oligomers and resulting pathology: let's talk about the lipids in the room.

NPJ Parkinsons Dis 2019 12;5:23. Epub 2019 Nov 12.

1Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612 USA.

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http://dx.doi.org/10.1038/s41531-019-0095-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851126PMC
November 2019

Parkinson Matters.

J Parkinsons Dis 2018 ;8(4):495-498

Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://www.medra.org/servlet/aliasResolver?alias=iospress&am
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http://dx.doi.org/10.3233/JPD-181374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218141PMC
October 2019

The Times They Are a-Changin': Parkinson's Disease 20 Years from Now.

J Parkinsons Dis 2018;8(s1):S1-S2

Parkinson Center Nijmegen, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.3233/JPD-189002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311357PMC
October 2019

Lots of Movement in Gut and Parkinson's Research.

Trends Endocrinol Metab 2019 Oct 28;30(10):687-689. Epub 2019 Aug 28.

Center for Neurodegenerative Sciences, Van Andel Research Institute, 333 Bostwick Avenue NE, Grand Rapids, MI 49503, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tem.2019.08.001DOI Listing
October 2019

Neural connectivity predicts spreading of alpha-synuclein pathology in fibril-injected mouse models: Involvement of retrograde and anterograde axonal propagation.

Neurobiol Dis 2019 Oct 16;134:104623. Epub 2019 Oct 16.

Weill Cornell Medicine of Cornell University, Department of Radiology, New York, NY 10065, USA; University of California-San Francisco, Department of Biomedical Imaging, USA.

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http://dx.doi.org/10.1016/j.nbd.2019.104623DOI Listing
October 2019

Microglia affect α-synuclein cell-to-cell transfer in a mouse model of Parkinson's disease.

Mol Neurodegener 2019 Aug 16;14(1):34. Epub 2019 Aug 16.

Center for Neurodegenerative Science, Van Andel Research Institute, 333 Bostwick Ave., N.E., Grand Rapids, Michigan, 49503, USA.

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http://dx.doi.org/10.1186/s13024-019-0335-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697982PMC
August 2019

Can infections trigger alpha-synucleinopathies?

Prog Mol Biol Transl Sci 2019 3;168:299-322. Epub 2019 Jul 3.

Center for Neurodegenerative Sciences, Van Andel Research Institute, Grand Rapids, MI, United States. Electronic address:

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http://dx.doi.org/10.1016/bs.pmbts.2019.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857718PMC
July 2019

The Linked Clinical Trials initiative (LCT) for Parkinson's disease.

Eur J Neurosci 2019 Feb 28;49(3):307-315. Epub 2018 Oct 28.

The Cure Parkinson's Trust, London, UK.

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http://dx.doi.org/10.1111/ejn.14175DOI Listing
February 2019

Genetically engineered stem cell-derived neurons can be rendered resistant to alpha-synuclein aggregate pathology.

Eur J Neurosci 2019 Feb 20;49(3):316-319. Epub 2019 Jan 20.

Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, Michigan.

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http://doi.wiley.com/10.1111/ejn.14333
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http://dx.doi.org/10.1111/ejn.14333DOI Listing
February 2019

Revisiting protein aggregation as pathogenic in sporadic Parkinson and Alzheimer diseases.

Neurology 2019 02;92(7):329-337

From the UC Gardner Neuroscience Institute and Gardner Family Center for Parkinson's Disease and Movement Disorders (A.J.E., J.A.V., L.M., A.M.), Department of Neurology, University of Cincinnati, OH; Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic (A.E.L., A.F.), Toronto Western Hospital, University of Toronto; Krembil Research Institute (A.E.L., A.F.), Toronto, Canada; Parkinson's Disease and Movement Disorders Center (D.K.S.), Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA; College of Medicine (K.A.J.), Mayo Clinic, Rochester, MN; Institute of Molecular and Clinical Sciences (F.M.), St George's University of London, UK; Division of Movement Disorders (R.S.), Department of Neurology and Department of Health Science Research, Mayo Clinic College of Medicine, Rochester, MN; Department of Neurology and the Pittsburgh Institute for Neurodegenerative Diseases (J.T.G., F.C.), University of Pittsburgh, PA; Department of Neurology (T.R.Y.), University of Kentucky, Lexington; Parkinson's Disease Research, Education and Clinical Center (C.M.T.), Neurology, San Francisco Veterans Affairs Medical Center; Department of Neurology (C.M.T.), University of California-San Francisco; Department of Neurology & Neurosurgery, Montreal Neurological Institute, and Department of Human Genetics (Z.G.-O.), McGill University, Canada; Parkinson & Other Movement Disorders Center UC San Diego (I.L.), Department of Neurosciences, Altman Clinical Translational Research Institute, La Jolla, CA; VA Puget Sound Health Care System and Department of Neurology (I.F.M., CP.Z.), University of Washington, Seattle; Department of Neurology (I.F.M.), University of Washington School of Medicine, Seattle; Center for Neurodegenerative Science (P.B.), Van Andel Research Institute, Grand Rapids, MI; Center for Neurological Restoration (H.H.F.) and Lou Ruvo Center for Brain Health, Neurological Institute (J.B.L.), Cleveland Clinic, OH; Department of Neurology (D.G.S.), University of Alabama at Birmingham; Consultorio y Laboratorio de Neurogenética (M.A.K.), Centro Universitario de Neurología "José María Ramos Mejía" y División Neurología, Hospital JM Ramos Mejía, Facultad de Medicina, UBA; Programa de Medicina de Precision y Genomica Clinica (M.A.K.), Instituto de Investigaciones en Medicina Traslacional, Facultad de Ciencias Biomédicas, Universidad Austral-CONICET, Buenos Aires, Argentina; Department of Neurology (M.A.S.), Massachusetts General Hospital, Boston; Division of Neuroscience (S.P.S.), Sanofi-Genzyme, Framingham, MA; Michael J. Fox Foundation for Parkinson's Research (T.S.), New York, NY; and College of Sciences (G.P.), University of Texas at San Antonio.

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http://dx.doi.org/10.1212/WNL.0000000000006926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382364PMC
February 2019

Introduction.

Authors:
Brundin Patrik

J Parkinsons Dis 2017 ;7(s1):S1-S2

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http://dx.doi.org/10.3233/JPD-179008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345644PMC
January 2019

Triggers, Facilitators, and Aggravators: Redefining Parkinson's Disease Pathogenesis.

Trends Neurosci 2019 01 17;42(1):4-13. Epub 2018 Oct 17.

Center for Neurodegenerative Science, Van Andel Research Institute, 333 Bostwick Avenue, NE, Grand Rapids, MI 49503, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tins.2018.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6623978PMC
January 2019

Cancer enzyme affects Parkinson's disease.

Science 2018 11;362(6414):521-522

The Cure Parkinson's Trust, 120 Baker Street, London W1U 6TU, UK.

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http://dx.doi.org/10.1126/science.aav3986DOI Listing
November 2018

Prion-like propagation of pathology in Parkinson disease.

Handb Clin Neurol 2018 ;153:321-335

Van Andel Research Institute, Center for Neurodegenerative Science, Grand Rapids, MI, United States. Electronic address:

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http://dx.doi.org/10.1016/B978-0-444-63945-5.00017-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625652PMC
September 2018

The concept of alpha-synuclein as a prion-like protein: ten years after.

Cell Tissue Res 2018 07 26;373(1):161-173. Epub 2018 Feb 26.

Center for Neurodegenerative Science, Van Andel Research Institute, 333 Bostwick Ave. NE, Grand Rapids, MI, 49503, USA.

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http://link.springer.com/10.1007/s00441-018-2814-1
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http://dx.doi.org/10.1007/s00441-018-2814-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541204PMC
July 2018

Fire prevention in the Parkinson's disease brain.

Nat Med 2018 07;24(7):900-902

Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI, USA.

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http://dx.doi.org/10.1038/s41591-018-0109-4DOI Listing
July 2018

Alpha-Synuclein to the Rescue: Immune Cell Recruitment by Alpha-Synuclein during Gastrointestinal Infection.

J Innate Immun 2017 2;9(5):437-440. Epub 2017 Sep 2.

Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI, USA.

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http://dx.doi.org/10.1159/000479653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607025PMC
June 2018

Is the Enzyme ACMSD a Novel Therapeutic Target in Parkinson's Disease?

J Parkinsons Dis 2017 ;7(4):577-587

Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI, USA.

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http://dx.doi.org/10.3233/JPD-171240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676848PMC
June 2018

Targeted Therapies for Parkinson's Disease: From Genetics to the Clinic.

Mov Disord 2018 05 27;33(5):684-696. Epub 2018 Apr 27.

Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI, USA.

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http://dx.doi.org/10.1002/mds.27414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282975PMC
May 2018

Targeting energy metabolism via the mitochondrial pyruvate carrier as a novel approach to attenuate neurodegeneration.

Mol Neurodegener 2018 05 24;13(1):28. Epub 2018 May 24.

Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, 333 Bostwick Ave, Michigan, 49503, USA.

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http://dx.doi.org/10.1186/s13024-018-0260-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968614PMC
May 2018

Is Exenatide a Treatment for Parkinson's Disease?

J Parkinsons Dis 2017 ;7(3):451-458

Sobell Department of Motor Neuroscience, UCL Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.

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http://dx.doi.org/10.3233/JPD-171192DOI Listing
April 2018

The olfactory bulb as the entry site for prion-like propagation in neurodegenerative diseases.

Neurobiol Dis 2018 Jan 20;109(Pt B):226-248. Epub 2016 Dec 20.

Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI 49503, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S09699961163029
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http://dx.doi.org/10.1016/j.nbd.2016.12.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972535PMC
January 2018

Spread of aggregates after olfactory bulb injection of α-synuclein fibrils is associated with early neuronal loss and is reduced long term.

Acta Neuropathol 2018 01 5;135(1):65-83. Epub 2017 Dec 5.

Center for Neurodegenerative Science, Van Andel Research Institute, 333 Bostwick Avenue N.E., Grand Rapids, MI, 49503, USA.

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http://dx.doi.org/10.1007/s00401-017-1792-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756266PMC
January 2018

Recommendations of the Global Multiple System Atrophy Research Roadmap Meeting.

Neurology 2018 01 13;90(2):74-82. Epub 2017 Dec 13.

From Muhammad Ali Parkinson Center (R.R.W.), Barrow Neurological Institute, Phoenix, AZ; Department of Neurology (F.K., G.K.W., W.P., K.S., N.S.), Medical University Innsbruck, Austria; National Institute of Neurological Disorders and Stroke (W.R.G., W.J.K.), NIH, Bethesda, MD; Department of Neurology (P.A.L.), Mayo Clinic, Rochester, MN; Brain and Mind Centre (G.H.), Sydney Medical School, the University of Sydney; UNSW Medicine & Neuroscience Research Australia (G.H.), Sydney; Queen Square Brain Bank (J.H.), UCL Institute of Neurology (N.P.Q.), London, UK; UPS, INSERM, and CHU de Toulouse (O.R.), University de Toulouse; Centre de Référence Maladie Rare contre l'AMS (O.R.), Centre d'Investigation Clinique CIC1436, Départments de Pharmacologie Clinique et de Neurosciences, NeuroToul/COEN Center of Excellence in Neurodegeneration, Toulouse, France; Department of Pathology & Laboratory Medicine (L.M.S.), Perelman School of Medicine, University of Pennsylvania, Philadelphia; Center for Neurosciences (D.E.), The Feinstein Institute for Medical Research, Manhasset, NY; The Multiple System Atrophy (MSA) Coalition, Inc. (P. B., J.B., P.F., L.K., C.L., C.R., S.S.), Charlotte, NC; Cleveland Clinic Lou Ruvo Center for Brain Health (J.L.C.), Las Vegas, NV; Medical Affairs (V.A.), Teva Pharmaceuticals, Frazer, PA; Department of Neurology (G.B.), David Geffen School of Medicine, Brain Research Institute, and Molecular Biology Institute, University of California at Los Angeles; Institute of Neurology (D.J.B.), University of Newcastle upon Tyne, UK; Van Andel Research Institute (P. Brundin), Center for Neurodegenerative Science, Grand Rapids, MI; Center for Neurological Restoration (H.F.), Cleveland Clinic, OH; Defeat MSA (P.F.); MSA Shoe Charity (P.F., C.R.), Saint Clair Shores, MI; Department of Neurology (R.F.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Department of Neurodegenerative Diseases (T.G.), Hertie Institute of Clinical Brain Research, University of Tübingen; German Center for Neurodegenerative Diseases (DZNE) (T.G.), Tübingen, Germany; Lundbeck LLC (A.H.), Deerfield, IL; German Center for Neurodegenerative Diseases (DZNE) (G.U.H.), Munich; Department of Neurology (G.U.H.), Technical University of Munich, Germany; Neurogenomics Division (M.J.H.), The Translational Genomics Research Institute, Phoenix, AZ; Dandrite & Department of Biomedicine (P.H.J.), Aarhus University, Denmark; Quanterix (A.J.), Lexington, MA; Department of Neurology (U.J.K.), Columbia University Medical Center; Department of Neurology (H.K.), New York University School of Medicine, New York; Whitehead Institute for Biomedical Research (V.K.), Cambridge; Ann Romney Center for Neurologic Disease (V.K.), Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston; Harvard Stem Cell Institute (V.K.), Cambridge, MA; Department of Neurology (T.K.), University of Bonn; German Center for Neurodegenerative Diseases (DZNE) (T.K.), Bonn, Germany; Brain and Mind Centre (W.S.K.), Sydney Medical School, University of Sydney, Australia; Department of Neurology (P.L.), Henry Ford Hospital; Department of Neurology (P.L.), Wayne State University School of Medicine, Detroit, MI; Division of Neurosciences (E.M.), National Institute on Aging/NIH, Bethesda, MD; Centre de Référence Maladie Rare AMS (W.M.), Hôpital Pellegrin, CHU de Bordeaux; Université de Bordeaux (W.M.), Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux; Paris Saclay Institute of Neuroscience (R.M.), CNRS, Gif-sur-Yvette, France; Genentech Inc. (S.O.), South San Francisco; Cedars-Sinai Medical Center (S.P.), Los Angeles, CA; Department of Neurology (D.R.), Vanderbilt University Medical Center, Nashville, TN; MSA NJ (C.R.), Howell, NJ; Prothena Biosciences (D.S.), South San Francisco, CA; Division of Neurology (M.S.), Department of Medicine, The Ottawa Hospital, Canada; Department of Neurology (J.D.S.), Massachusetts General Hospital, Harvard Medical School, Boston, MA; Cure MSA Foundation (L.S.), Fremont, CA; Avid Radiopharmaceuticals (A.S.), Philadelphia, PA; Department of Neurological Sciences (G.T.S.), Rush University Medical Center, Chicago, IL; Department of Neurology (S.T.), Graduate School of Medicine, Tokyo University, Tokyo, Japan; and University of Washington (J.Z.), Seattle. W.R.G. is currently affiliated with Janssen Research and Development, Titusville, NJ.

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http://dx.doi.org/10.1212/WNL.0000000000004798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772155PMC
January 2018

Therapeutic approaches to target alpha-synuclein pathology.

Exp Neurol 2017 12 4;298(Pt B):225-235. Epub 2017 Oct 4.

Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI 49503, USA; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA.

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http://dx.doi.org/10.1016/j.expneurol.2017.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541231PMC
December 2017

Prying into the Prion Hypothesis for Parkinson's Disease.

J Neurosci 2017 10;37(41):9808-9818

Paris-Saclay Institute of Neuroscience, Centre National de la Recherche Scientifique, 91190 Gif-sur-Yvette, France

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http://dx.doi.org/10.1523/JNEUROSCI.1788-16.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637113PMC
October 2017

Axonal transport dysfunction in neurodegenerative diseases: the "holy grail" for developing disease modifying therapies?

Neurobiol Dis 2017 09;105:271-272

Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI, USA.

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http://dx.doi.org/10.1016/j.nbd.2017.06.018DOI Listing
September 2017

Novel animal model defines genetic contributions for neuron-to-neuron transfer of α-synuclein.

Sci Rep 2017 08 8;7(1):7506. Epub 2017 Aug 8.

Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, Michigan, USA.

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http://dx.doi.org/10.1038/s41598-017-07383-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548897PMC
August 2017

Solving the conundrum of insoluble protein aggregates.

Lancet Neurol 2017 04 24;16(4):258-259. Epub 2017 Feb 24.

Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI 49503, USA. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(17)30045-5DOI Listing
April 2017

Biomarker-driven phenotyping in Parkinson's disease: A translational missing link in disease-modifying clinical trials.

Mov Disord 2017 03 24;32(3):319-324. Epub 2017 Feb 24.

Morton and Gloria Shulman Movement Disorders Center, Toronto Western Hospital and The Edmond J. Safra Program in PD, Toronto, Ontario, Canada, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/mds.26913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359057PMC
March 2017

Parkinson disease.

Nat Rev Dis Primers 2017 Mar 23;3:17013. Epub 2017 Mar 23.

Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/nrdp.2017.13DOI Listing
March 2017

Oxidative stress in neurodegenerative disease: causation or association?

Oncotarget 2017 Feb;8(7):10777-10778

Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI, USA.

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http://dx.doi.org/10.18632/oncotarget.14650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355220PMC
February 2017

Precision medicine for disease modification in Parkinson disease.

Nat Rev Neurol 2017 Feb 20;13(2):119-126. Epub 2017 Jan 20.

The Morton and Gloria Shulman Movement Disorders Clinic and The Edmond J. Safra Program in Parkinson's Disease, University Health Network, University of Toronto, 399 Bathurst Street, Toronto, Ontario, M5T 2S8, Canada.

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http://dx.doi.org/10.1038/nrneurol.2016.196DOI Listing
February 2017

An Efficient Procedure for Removal and Inactivation of Alpha-Synuclein Assemblies from Laboratory Materials.

J Parkinsons Dis 2016 ;6(1):143-51

Paris-Saclay Institute of Neurosciences, CNRS, Gif-sur-Yvette, France.

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http://dx.doi.org/10.3233/JPD-150691DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927840PMC
January 2017

Are Stem Cell-Based Therapies for Parkinson's Disease Ready for the Clinic in 2016?

J Parkinsons Dis 2016 ;6(1):57-63

Center for Neurodegenerative Science, Van Andel Research Institute, MI, USA.

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http://dx.doi.org/10.3233/JPD-160798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927930PMC
January 2017

Mechanisms for cell-to-cell propagation no longer lag behind.

Mov Disord 2016 12 22;31(12):1798-1799. Epub 2016 Nov 22.

Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, Michigan, USA.

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http://dx.doi.org/10.1002/mds.26879DOI Listing
December 2016

Sorting out release, uptake and processing of alpha-synuclein during prion-like spread of pathology.

J Neurochem 2016 10 10;139 Suppl 1:275-289. Epub 2016 Feb 10.

Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, Michigan, USA.

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http://dx.doi.org/10.1111/jnc.13449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958606PMC
October 2016

How strong is the evidence that Parkinson's disease is a prion disorder?

Curr Opin Neurol 2016 Aug;29(4):459-66

aTranslational Parkinson's Disease Research bPrion Mechanisms in Neurodegenerative Disease cParkinson's Disease: Pathogenesis and Experimental Therapeutics; Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, Michigan dDepartment of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054685PMC
http://dx.doi.org/10.1097/WCO.0000000000000349DOI Listing
August 2016

Identification of Multiple QTLs Linked to Neuropathology in the Engrailed-1 Heterozygous Mouse Model of Parkinson's Disease.

Sci Rep 2016 08 23;6:31701. Epub 2016 Aug 23.

Neurodegeneration and Inflammation Genetics Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, BMC A10, Sölvegatan 17, 221 84 Lund, Sweden.

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http://dx.doi.org/10.1038/srep31701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994027PMC
August 2016

Nilotinib - Differentiating the Hope from the Hype.

J Parkinsons Dis 2016 07;6(3):519-22

Michael J Fox Foundation for Parkinson's Research, New York, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5044778PMC
http://dx.doi.org/10.3233/JPD-160904DOI Listing
July 2016

Enrichment of risk SNPs in regulatory regions implicate diverse tissues in Parkinson's disease etiology.

Sci Rep 2016 07 27;6:30509. Epub 2016 Jul 27.

Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, Michigan, USA.

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http://dx.doi.org/10.1038/srep30509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962314PMC
July 2016

Extensive graft-derived dopaminergic innervation is maintained 24 years after transplantation in the degenerating parkinsonian brain.

Proc Natl Acad Sci U S A 2016 06 2;113(23):6544-9. Epub 2016 May 2.

Neural Plasticity and Repair Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, 221 84 Lund, Sweden;

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http://dx.doi.org/10.1073/pnas.1605245113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988567PMC
June 2016

The Origin, Development and Molecular Diversity of Rodent Olfactory Bulb Glutamatergic Neurons Distinguished by Expression of Transcription Factor NeuroD1.

PLoS One 2015 1;10(6):e0128035. Epub 2015 Jun 1.

Neural Plasticity and Repair Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, BMC A10, 22184, Lund, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0128035PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451148PMC
April 2016

Alpha-synuclein propagation: New insights from animal models.

Mov Disord 2016 Feb 8;31(2):161-8. Epub 2015 Sep 8.

Department of Neurological Sciences, The Graduate College, Rush University, Chicago, Illinois, USA.

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http://dx.doi.org/10.1002/mds.26370DOI Listing
February 2016

Parkinson disease: Laying the foundations for disease-modifying therapies in PD.

Nat Rev Neurol 2015 Oct 25;11(10):553-5. Epub 2015 Aug 25.

The Cure Parkinson's Trust, 120 Baker Street, London W1U 6TU, UK.

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http://www.nature.com/articles/nrneurol.2015.150
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http://dx.doi.org/10.1038/nrneurol.2015.150DOI Listing
October 2015

Basic science breaks through: New therapeutic advances in Parkinson's disease.

Mov Disord 2015 Sep 16;30(11):1521-7. Epub 2015 Jul 16.

Laboratory of Translational Parkinson's Disease Research, Van Andel Research Institute, Grand Rapids, Michigan, USA.

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http://dx.doi.org/10.1002/mds.26332DOI Listing
September 2015

How I examine my patient: the art of neurological examination for Parkinson's disease.

J Parkinsons Dis 2014 ;4(4):563-5

Laboratory of Translational Parkinson's Disease Research, Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI, USA.

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http://dx.doi.org/10.3233/JPD-149006DOI Listing
August 2015

Is exenatide the next big thing in Parkinson's disease?

J Parkinsons Dis 2014 ;4(3):345-7

Laboratory for Translational Parkinson's Disease Research, Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI, USA Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund, Sweden.

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http://dx.doi.org/10.3233/JPD-149001DOI Listing
July 2015

Pre-existing immunity to adeno-associated virus (AAV)2 limits transgene expression following intracerebral AAV2-based gene delivery in a 6-hydroxydopamine model of Parkinson's disease.

J Gene Med 2014 Sep-Oct;16(9-10):300-8

Neuronal Survival Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden.

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http://dx.doi.org/10.1002/jgm.2779DOI Listing
June 2015

A cell culture model for monitoring α-synuclein cell-to-cell transfer.

Neurobiol Dis 2015 May 16;77:266-75. Epub 2014 Jul 16.

Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Sweden; Laboratory for Translational Parkinson's Disease Research, Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2014.07.003DOI Listing
May 2015

Spreading of α-synuclein in the face of axonal transport deficits in Parkinson's disease: a speculative synthesis.

Neurobiol Dis 2015 May 15;77:276-83. Epub 2014 Jul 15.

Laboratory for Translational Parkinson's Disease Research, Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI, USA; Neuronal Survival Unit, Wallenberg Neuroscience Center, Lund University, Lund, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2014.07.002DOI Listing
May 2015

Acceleration of α-synuclein aggregation by exosomes.

J Biol Chem 2015 Jan 25;290(5):2969-82. Epub 2014 Nov 25.

Biochemistry and Structural Biology, and

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http://dx.doi.org/10.1074/jbc.M114.585703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317028PMC
January 2015

The role of Galectin-3 in α-synuclein-induced microglial activation.

Acta Neuropathol Commun 2014 Nov 12;2:156. Epub 2014 Nov 12.

Experimental Neuroinflammation Laboratory, BMC, Lund University, 221 84, Lund, Sweden.

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http://dx.doi.org/10.1186/s40478-014-0156-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236422PMC
November 2014

NGF rescues hippocampal cholinergic neuronal markers, restores neurogenesis, and improves the spatial working memory in a mouse model of Huntington's Disease.

J Huntingtons Dis 2013 ;2(1):69-82

Neuronal Survival Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden Neural Plasticity and Repair Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden.

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http://dx.doi.org/10.3233/JHD-120026DOI Listing
September 2014

Gut feelings about smoking and coffee in Parkinson's disease.

Mov Disord 2014 Jul 21;29(8):976-9. Epub 2014 Apr 21.

CHU Nantes, Department of Neurology, F-44093, France; Inserm, U913, Nantes, F-44093, France.

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http://dx.doi.org/10.1002/mds.25882DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107006PMC
July 2014

Alpha-synuclein transfers from neurons to oligodendrocytes.

Glia 2014 Mar 31;62(3):387-98. Epub 2013 Dec 31.

Neuronal Survival Unit, BMC B11, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund, Sweden.

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http://dx.doi.org/10.1002/glia.22611DOI Listing
March 2014

Lesion of the subiculum reduces the spread of amyloid beta pathology to interconnected brain regions in a mouse model of Alzheimer's disease.

Acta Neuropathol Commun 2014 Feb 11;2:17. Epub 2014 Feb 11.

Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund, Sweden.

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http://dx.doi.org/10.1186/2051-5960-2-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932948PMC
February 2014

Nonsteroidal selective androgen receptor modulators and selective estrogen receptor β agonists moderate cognitive deficits and amyloid-β levels in a mouse model of Alzheimer's disease.

ACS Chem Neurosci 2013 Dec 25;4(12):1537-48. Epub 2013 Sep 25.

Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University , Lund S-22184, Sweden.

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http://dx.doi.org/10.1021/cn400133sDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867967PMC
December 2013

Neuropathology in transplants in Parkinson's disease: implications for disease pathogenesis and the future of cell therapy.

Prog Brain Res 2012 ;200:221-41

Van Andel Research Institute, Center for Neurodegenerative Science, Grand Rapids, MI, USA.

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http://dx.doi.org/10.1016/B978-0-444-59575-1.00010-7DOI Listing
November 2013

Rasagiline ameliorates olfactory deficits in an alpha-synuclein mouse model of Parkinson's disease.

PLoS One 2013 3;8(4):e60691. Epub 2013 Apr 3.

Neuronal Survival Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, BMC B11, Lund University, Lund, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0060691PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616111PMC
October 2013

Transfer of human α-synuclein from the olfactory bulb to interconnected brain regions in mice.

Acta Neuropathol 2013 Oct 8;126(4):555-73. Epub 2013 Aug 8.

Neuronal Survival Unit, BMC B11, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Sölvegatan 19, 221 84, Lund, Sweden,

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http://dx.doi.org/10.1007/s00401-013-1160-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789892PMC
October 2013

Silencing synuclein at the synapse with PLK2.

Proc Natl Acad Sci U S A 2013 Oct 26;110(41):16293-4. Epub 2013 Sep 26.

Department of Chemistry and Biochemistry, Calvin College, Grand Rapids, MI 49546.

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http://dx.doi.org/10.1073/pnas.1315622110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799359PMC
October 2013

What's to like about the prion-like hypothesis for the spreading of aggregated α-synuclein in Parkinson disease?

Prion 2013 Jan-Feb;7(1):92-7. Epub 2013 Jan 1.

Neuronal Survival Unit, Wallenberg Neuroscience Center, Lund University, Lund, Sweden.

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http://dx.doi.org/10.4161/pri.23806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609056PMC
August 2013

A novel α-synuclein-GFP mouse model displays progressive motor impairment, olfactory dysfunction and accumulation of α-synuclein-GFP.

Neurobiol Dis 2013 Aug 30;56:145-55. Epub 2013 Apr 30.

Neural Plasticity and Repair Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, BMC A10, 221 84 Lund, Sweden.

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http://dx.doi.org/10.1016/j.nbd.2013.04.017DOI Listing
August 2013

A new approach to disease-modifying drug trials in Parkinson's disease.

J Clin Invest 2013 Jun;123(6):2364-5

Department of Neurology and Clinical Neurosciences, Cambridge Center for Brain Repair, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1172/JCI69690DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668828PMC
June 2013

Mind the gut: secretion of α-synuclein by enteric neurons.

J Neurochem 2013 May 1;125(4):487-90. Epub 2013 Mar 1.

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http://dx.doi.org/10.1111/jnc.12191DOI Listing
May 2013

α-Synuclein: the long distance runner.

Brain Pathol 2013 May;23(3):350-7

Neuronal Survival Unit, Wallenberg Neuroscience Center, Lund University, Lund, Sweden.

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http://dx.doi.org/10.1111/bpa.12046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674536PMC
May 2013

Inflammation and α-synuclein's prion-like behavior in Parkinson's disease--is there a link?

Mol Neurobiol 2013 Apr 29;47(2):561-74. Epub 2012 Apr 29.

Neuronal Survival Unit, Wallenberg Neuroscience Center, Lund University, BMC B11, 221 84 Lund, Sweden.

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http://dx.doi.org/10.1007/s12035-012-8267-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589652PMC
April 2013

Late onset vascular dysfunction in the R6/1 model of Huntington's disease.

Eur J Pharmacol 2013 Jan 29;698(1-3):345-53. Epub 2012 Oct 29.

Section for Cell and Tissue Biology, Department of Experimental Medical Science, Lund University, BMC D12, Sweden.

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http://dx.doi.org/10.1016/j.ejphar.2012.10.026DOI Listing
January 2013

Parkinson's disease and alpha synuclein: is Parkinson's disease a prion-like disorder?

Mov Disord 2013 Jan;28(1):31-40

Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA.

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http://dx.doi.org/10.1002/mds.25373DOI Listing
January 2013

Alpha-synuclein cell-to-cell transfer and seeding in grafted dopaminergic neurons in vivo.

PLoS One 2012 21;7(6):e39465. Epub 2012 Jun 21.

Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0039465PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380846PMC
December 2012

Can Parkinson's disease pathology be propagated from one neuron to another?

Prog Neurobiol 2012 May 18;97(2):205-19. Epub 2011 Nov 18.

Neuronal Survival Unit, Wallenberg Neuroscience Centre, Lund University, BMC B11, 22184 Lund, Sweden.

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http://dx.doi.org/10.1016/j.pneurobio.2011.11.003DOI Listing
May 2012

Gastrointestinal dysfunction contributes to weight loss in Huntington's disease mice.

Neurobiol Dis 2011 Oct 23;44(1):1-8. Epub 2011 May 23.

Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, BMC A10, Lund, Sweden.

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http://dx.doi.org/10.1016/j.nbd.2011.05.006DOI Listing
October 2011

Can α-synuclein be targeted in novel therapies for Parkinson's disease?

Expert Rev Neurother 2011 Jul;11(7):917-9

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http://dx.doi.org/10.1586/ern.11.73DOI Listing
July 2011

Hsa-miR-34b is a plasma-stable microRNA that is elevated in pre-manifest Huntington's disease.

Hum Mol Genet 2011 Jun 19;20(11):2225-37. Epub 2011 Mar 19.

Department of Experimental Medical Sciences, Wallenberg Neuroscience Center, Lund University, S-221 84 Lund, Sweden.

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http://dx.doi.org/10.1093/hmg/ddr111DOI Listing
June 2011

Caspase signalling controls microglia activation and neurotoxicity.

Nature 2011 Apr 9;472(7343):319-24. Epub 2011 Mar 9.

Department of Oncology-Pathology, Cancer Centrum Karolinska, Karolinska Institutet, 171 76, Stockholm, Sweden.

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http://dx.doi.org/10.1038/nature09788DOI Listing
April 2011