Patrick Y Wen

Patrick Y Wen

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Patrick Y Wen

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Utility of claims data for delineation of intracranial treatment among patients with brain metastases.

Neuro Oncol 2020 Jul 21. Epub 2020 Jul 21.

Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1093/neuonc/noaa175DOI Listing
July 2020

Neurologic Complications of Cranial Radiation Therapy and Strategies to Prevent or Reduce Radiation Toxicity.

Curr Neurol Neurosci Rep 2020 Jun 29;20(8):34. Epub 2020 Jun 29.

Center for Neuro-Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1007/s11910-020-01051-5DOI Listing
June 2020

Prediction of Outcomes with a Computational Biology Model in Newly Diagnosed Glioblastoma Patients Treated with Radiation Therapy and Temozolomide.

Int J Radiat Oncol Biol Phys 2020 May 14. Epub 2020 May 14.

Department of Radiation Oncology, Dana-Farber/Brigham and Women's Cancer Center, Harvard Medical School, Boston, MA. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2020.05.010DOI Listing
May 2020

Novel Therapies for Glioblastoma.

Curr Neurol Neurosci Rep 2020 May 22;20(7):19. Epub 2020 May 22.

Brain and Spine Tumor Center, Laura and Isaac Perlmutter Cancer Center at NYU Langone Health, 240 E. 38th Street, 19th floor, New York, NY, 10019, USA.

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http://dx.doi.org/10.1007/s11910-020-01042-6DOI Listing
May 2020

Fertility preservation outcomes in women with gliomas: a retrospective case-control study.

J Neurooncol 2020 Apr 14;147(2):371-376. Epub 2020 Feb 14.

Department of Obstetrics, Gynecology, and Reproductive Biology, Center for Infertility and Reproductive Surgery, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1007/s11060-020-03429-4DOI Listing
April 2020

Mechanisms and therapeutic implications of hypermutation in gliomas.

Nature 2020 04 15;580(7804):517-523. Epub 2020 Apr 15.

Department of Oncologic Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41586-020-2209-9DOI Listing
April 2020

Imaging of Central Nervous System Tumors Based on the 2016 World Health Organization Classification.

Neurol Clin 2020 02 7;38(1):95-113. Epub 2019 Nov 7.

Department of Radiology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ncl.2019.08.004DOI Listing
February 2020

Glioma progression through synaptic activity.

Nat Rev Neurol 2020 Jan;16(1):6-7

Center for Neuro-Oncology, Dana Farber Cancer Institute, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41582-019-0290-1DOI Listing
January 2020

A Phase Ib/II, open-label, multicenter study of INC280 (capmatinib) alone and in combination with buparlisib (BKM120) in adult patients with recurrent glioblastoma.

J Neurooncol 2020 Jan 27;146(1):79-89. Epub 2019 Nov 27.

Clinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), and Neurology Clinic and National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s11060-019-03337-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938467PMC
January 2020

Provider-reported challenges and barriers to referring patients to neuro-oncology clinical trials: a report from the Society for Neuro-Oncology member survey.

Neurooncol Pract 2020 Jan 10;7(1):38-51. Epub 2019 Sep 10.

Neuro-Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1093/nop/npz038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104882PMC
January 2020

Medical management of meningiomas.

Handb Clin Neurol 2020 ;170:291-302

Center for Neuro-Oncology, Dana-Farber Cancer Institute, Boston, MA, United States; Division of Neuro-Oncology, Department of Neurology, Brigham and Women's Hospital, Boston, MA, United States. Electronic address:

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http://dx.doi.org/10.1016/B978-0-12-822198-3.00048-3DOI Listing
January 2020

Tie2-FGFR1 Interaction Induces Adaptive PI3K Inhibitor Resistance by Upregulating Aurora A/PLK1/CDK1 Signaling in Glioblastoma.

Cancer Res 2019 10 15;79(19):5088-5101. Epub 2019 Aug 15.

Brain Tumor Center, Departments of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/0008-5472.CAN-19-0325DOI Listing
October 2019

Design and Evaluation of an External Control Arm Using Prior Clinical Trials and Real-World Data.

Clin Cancer Res 2019 08 7;25(16):4993-5001. Epub 2019 Jun 7.

Dana-Farber Program in Regulatory Science, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-19-0820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697596PMC
August 2019

Thrombotic Complications in Gliomas.

Semin Thromb Hemost 2019 Jun 30;45(4):326-333. Epub 2019 Apr 30.

Center for Neuro-Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1055/s-0039-1687892DOI Listing
June 2019

Local control after brain-directed radiation in patients with cystic versus solid brain metastases.

J Neurooncol 2019 Apr 4;142(2):355-363. Epub 2019 Feb 4.

Department of Radiation Oncology, Dana-Farber/Brigham and Women's Cancer Center, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1007/s11060-019-03106-1DOI Listing
April 2019

Use of the Response Assessment in Neuro-Oncology (RANO) criteria in clinical trials and clinical practice.

CNS Oncol 2019 03 26;8(1):CNS28. Epub 2019 Feb 26.

Department of Medical Oncology, Center for Neuro-Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.

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http://dx.doi.org/10.2217/cns-2018-0007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499019PMC
March 2019

The lomustine crisis: awareness and impact of the 1500% price hike.

Neuro Oncol 2019 01;21(1):1-3

Center for Neuro-Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1093/neuonc/noy189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303421PMC
January 2019

Imaging and diagnostic advances for intracranial meningiomas.

Neuro Oncol 2019 01;21(Suppl 1):i44-i61

Center for Skull Base and Pituitary Surgery, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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https://academic.oup.com/neuro-oncology/article/21/Supplemen
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http://dx.doi.org/10.1093/neuonc/noy143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347083PMC
January 2019

Voxel-Wise Analysis of Fluoroethyltyrosine PET and MRI in the Assessment of Recurrent Glioblastoma During Antiangiogenic Therapy.

AJR Am J Roentgenol 2018 12 17;211(6):1342-1347. Epub 2018 Oct 17.

1 Department of Radiology, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115.

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https://www.ajronline.org/doi/10.2214/AJR.18.19988
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http://dx.doi.org/10.2214/AJR.18.19988DOI Listing
December 2018

PD-1 inhibition has only limited clinical benefit in patients with recurrent high-grade glioma.

Neurology 2018 10 31;91(14):e1355-e1359. Epub 2018 Aug 31.

From the Laura and Isaac Perlmutter Cancer Center (S.C.K.), Brain Tumor Center, NYU Langone Medical Center, New York; Dana-Farber Cancer Institute (L.P.C., D.H., M.R., L.N., E.Q.L., D.A.R., P.Y.W.), Center for Neuro-Oncology; and Department of Radiology (R.H., P.U.), Brigham and Women's Hospital, Boston, MA.

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http://dx.doi.org/10.1212/WNL.0000000000006283DOI Listing
October 2018

The FDA NIH Biomarkers, EndpointS, and other Tools (BEST) resource in neuro-oncology.

Neuro Oncol 2018 08;20(9):1162-1172

Department of Radiation Oncology, Dana-Farber/Brigham and Women's Cancer Center, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1093/neuonc/nox242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071649PMC
August 2018

Antiangiogenic Therapy of High-Grade Gliomas.

Prog Neurol Surg 2018 25;31:180-199. Epub 2018 Jan 25.

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http://dx.doi.org/10.1159/000467379DOI Listing
August 2018

Trial designs for chemotherapy-induced peripheral neuropathy prevention: ACTTION recommendations.

Neurology 2018 08 27;91(9):403-413. Epub 2018 Jul 27.

From the University of Rochester (J.S.G., M.P.M., R.H.D.), NY; MetroHealth Medical Center (J.B.), Case Western Reserve University, Cleveland, OH; University of Milano-Bicocca (G.C.), Monza, Italy; MD Anderson Cancer Center (P.M.D.), Houston, TX; Milkin Institute School of Public Health (S.E.), George Washington University, Washington, DC; Division of Oncology Products (L.H.), US Food and Drug Administration, Silver Spring; National Institutes of Health (A.O.), Bethesda, MD; Virginia Commonwealth University (A.G.S.), Richmond; Mundipharma R&D Limited (D.D.-P.), Cambridge, UK; Université Laval (L.R.G.), Québec, Canada; Washington University (S.H.), St. Louis, MO; Regenacy Pharmaceuticals (M.J.), Boston; Analgesic Solutions (N.P.K.), Natick; Tufts University (N.P.K.), Boston, MA; Mayo Clinic (C.L.), Rochester, MN; Dana-Farber/Brigham and Women's Cancer Center (P.R., P.Y.W.) and Beth Israel Deaconess Medical Center (R.F.), Harvard Medical School, Boston, MA; University of Michigan (E.M.L.S.), Ann Arbor; and University of Washington (D.C.T.), Seattle.

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http://dx.doi.org/10.1212/WNL.0000000000006083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133627PMC
August 2018

The Interface Between Neurology and Oncology.

Neurol Clin 2018 08 13;36(3):xiii-xiv. Epub 2018 Jun 13.

Center for Neuro-Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, D2, Boston, MA 02215, USA; Division of Cancer Neurology, Department of Neurology, Brigham and Women's Hospital, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ncl.2018.05.001DOI Listing
August 2018

Is it time to reconsider the role of irinotecan for the treatment of high-grade gliomas?

Neuro Oncol 2018 07;20(8):1144

Center for Neuro-Oncology, Dana Farber Cancer Institute, and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1093/neuonc/noy092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280142PMC
July 2018

Toward methylation-based classification of central nervous system tumors.

Neuro Oncol 2018 04;20(5):579-581

Department of Pathology and Center for Cancer Research, Massachusetts General Hospital, Broad Institute of Harvard and MIT, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1093/neuonc/noy023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892157PMC
April 2018

Pharmacodynamics of mutant-IDH1 inhibitors in glioma patients probed by in vivo 3D MRS imaging of 2-hydroxyglutarate.

Nat Commun 2018 04 16;9(1):1474. Epub 2018 Apr 16.

Department of Neurology, Massachusetts General Hospital, Stephen E. and Catherine Pappas Center for Neuro-Oncology, Division of Hematology/Oncology, Harvard Medical School, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1038/s41467-018-03905-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902553PMC
April 2018

Quo Vadis-Do Immunotherapies Have a Role in Glioblastoma?

Curr Treat Options Neurol 2018 Apr 18;20(5):14. Epub 2018 Apr 18.

Center for Neuro-Oncology, Dana-Farber Cancer Institute, 450 Brookline Ave, Boston, MA, 02215, USA.

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http://dx.doi.org/10.1007/s11940-018-0499-0DOI Listing
April 2018

Evidence and context of use for contrast enhancement as a surrogate of disease burden and treatment response in malignant glioma.

Neuro Oncol 2018 03;20(4):457-471

UCLA Neuro-Oncology Program, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, California.

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https://academic.oup.com/neuro-oncology/article/20/4/457/448
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http://dx.doi.org/10.1093/neuonc/nox193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909663PMC
March 2018

Working plan for the use of patient-reported outcome measures in adults with brain tumours: a Response Assessment in Neuro-Oncology (RANO) initiative.

Lancet Oncol 2018 03;19(3):e173-e180

Department of Neurology, Leiden University Medical Center, Leiden, Netherlands; Department of Neurology, Haaglanden Medical Center, The Hague, Netherlands. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(18)30004-4DOI Listing
March 2018

Imaging in neuro-oncology.

Ther Adv Neurol Disord 2018 28;11:1756286418759865. Epub 2018 Feb 28.

Department of Radiology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02445, USA.

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http://dx.doi.org/10.1177/1756286418759865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833173PMC
February 2018

Imaging Criteria in Neuro-oncology.

Semin Neurol 2018 02 16;38(1):24-31. Epub 2018 Mar 16.

Department of Neurology and Neurooncology, University Medical Center, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1627468
Publisher Site
http://dx.doi.org/10.1055/s-0038-1627468DOI Listing
February 2018

Phase II study of cabozantinib in patients with progressive glioblastoma: subset analysis of patients naive to antiangiogenic therapy.

Neuro Oncol 2018 01;20(2):249-258

Center for Neuro-Oncology, Dana-Farber/Brigham & Women's Cancer Center, Boston, Massachusetts (P.Y.W, J.D.); The University of Texas MD Anderson Cancer Center, Houston, Texas (J.dG.); University of California, San Francisco, Helen Diller Cancer Center Building, San Francisco, California (M.D.P.); Duke University, Durham, North Carolina (D.A.R., A.D.); Neuro-Oncology Center, University of Virginia Health System, Charlottesville, Virginia (D.S.); University of Washington, Department of Neurology, Fred Hutchinson Cancer Research Center, Seattle, Washington (M.C.); Henry Ford Health System, Detroit, Michigan (T.M.); Exelixis, South San Francisco, California (J.H., J.P., R.W.); The Ronald Reagan UCLA Medical Center, Los Angeles, California (T.F.C.).

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http://dx.doi.org/10.1093/neuonc/nox154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777496PMC
January 2018

Phase II study of cabozantinib in patients with progressive glioblastoma: subset analysis of patients with prior antiangiogenic therapy.

Neuro Oncol 2018 01;20(2):259-267

The Ronald Reagan UCLA Medical Center, Los Angeles, California (T.F.C.); Center for Neuro-Oncology, Dana-Farber/Brigham & Women's Cancer Center, Boston, Massachusetts (P.Y.W., J.D.); The University of Texas MD Anderson Cancer Center, Houston, Texas (J.dG.); University of California San Francisco, San Francisco, California (M.D.P.); Duke University, Durham, North Carolina (D.A.R., A.D.); Neuro-Oncology Center, University of Virginia Health System, Charlottesville, Virginia (D.S.); University of Washington, Department of Neurology, Fred Hutchinson Cancer Research Center, Seattle, Washington (M.C.); Henry Ford Health System, Detroit, Michigan (T.M.); Exelixis, South San Francisco, California (J.P., J.H., R.W.).

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http://dx.doi.org/10.1093/neuonc/nox151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777491PMC
January 2018

Dabrafenib and Trametinib Treatment in Patients With Locally Advanced or Metastatic BRAF V600-Mutant Anaplastic Thyroid Cancer.

J Clin Oncol 2018 01 26;36(1):7-13. Epub 2017 Oct 26.

Vivek Subbiah and Maria E. Cabanillas, The University of Texas MD Anderson Cancer Center, Houston, TX; Robert J. Kreitman, National Institutes of Health, Bethesda, MD; Zev A. Wainberg, University of California Los Angeles, Los Angeles, CA; Jae Yong Cho, Yonsei University College of Medicine Gangnam Severance Hospital; Bhumsuk Keam, Seoul National University Hospital, Seoul, Republic of Korea; Jan H.M. Schellens, Netherlands Cancer Institute, Amsterdam; Jan H.M. Schellens, Utrecht Institute for Pharmaceutical Sciences, Utrecht, the Netherlands; Jean Charles Soria, Institut Gustave Roussy, University of Paris-Sud, and University of Paris-Saclay, Villejuif, France; Patrick Y. Wen, Dana-Farber Cancer Institute, Boston, MA; Christoph Zielinski, Comprehensive Cancer Center, Medical University Vienna; Vienna, Austria; and Gladys Urbanowitz, Bijoyesh Mookerjee, Dazhe Wang, and Fatima Rangwala, Novartis Oncology, East Hanover, NJ.

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http://dx.doi.org/10.1200/JCO.2017.73.6785DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791845PMC
January 2018

Meeting Update-Society for Neuro-Oncology 2017 Annual Meeting.

Neuro Oncol 2018 01;20(2):156-159

Center for Neuro-Oncology, Dana Farber/Brigham and Women's Cancer Center and Division of Neurology, Brigham and Women's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1093/neuonc/nox239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777479PMC
January 2018

The siren song of bevacizumab: swan song or clarion call?

Neuro Oncol 2018 01;20(2):147-148

Center for Neuro-Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1093/neuonc/nox244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777485PMC
January 2018

2016 World Health Organization Classification of Central Nervous System Tumors.

Continuum (Minneap Minn) 2017 12;23(6, Neuro-oncology):1531-1547

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http://dx.doi.org/10.1212/CON.0000000000000536DOI Listing
December 2017

Transition: Message from the Editor-in-Chief.

Authors:
Patrick Y Wen

Neuro Oncol 2017 11;19(12):1567

Harvard Medical School, Director, Center for Neuro-Oncology, Dana-Farber/Brigham and Women's Cancer Center.

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http://dx.doi.org/10.1093/neuonc/nox201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716062PMC
November 2017

A phase 2 study of the first imipridone ONC201, a selective DRD2 antagonist for oncology, administered every three weeks in recurrent glioblastoma.

Oncotarget 2017 Oct 12;8(45):79298-79304. Epub 2017 May 12.

Stephen E. and Catherine Pappas Center for Neuro-Oncology, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.18632/oncotarget.17837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668041PMC
October 2017