Patrick Tan

Patrick Tan

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Patrick Tan

Publications by authors named "Patrick Tan"

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DNA epigenetic signature predictive of benefit from neoadjuvant chemotherapy in oesophageal adenocarcinoma: results from the MRC OE02 trial.

Eur J Cancer 2019 Dec 23;123:48-57. Epub 2019 Oct 23.

Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore; Cancer Science Institute of Singapore, National University of Singapore, Singapore; Biomedical Research Council, Agency for Science, Technology and Research, Singapore; SingHealth/Duke-NUS Institute of Precision Medicine, National Heart Centre Singapore, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2019.09.016DOI Listing
December 2019

KRAS status is related to histological phenotype in gastric cancer: results from a large multicentre study.

Gastric Cancer 2019 11 20;22(6):1193-1203. Epub 2019 May 20.

Department of Pathology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center+, P. Debyelaan 25, 6229 HX, Maastricht, The Netherlands.

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http://dx.doi.org/10.1007/s10120-019-00972-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6811379PMC
November 2019

Correction to: KRAS status is related to histological phenotype in gastric cancer: results from a large multicentre study.

Gastric Cancer 2019 Nov;22(6):1204-1205

Department of Pathology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center+, P. Debyelaan 25, 6229 HX, Maastricht, The Netherlands.

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http://dx.doi.org/10.1007/s10120-019-00975-3DOI Listing
November 2019

Dissection of gastric cancer heterogeneity for precision oncology.

Cancer Sci 2019 Nov 25;110(11):3405-3414. Epub 2019 Sep 25.

Cancer Science Institute of Singapore, National University of Singapore, Singapore.

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http://dx.doi.org/10.1111/cas.14191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825006PMC
November 2019

Large-Scale Whole-Genome Sequencing of Three Diverse Asian Populations in Singapore.

Cell 2019 Oct;179(3):736-749.e15

Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China; Computational and Systems Biology, Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore 138672, Singapore. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674193107
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http://dx.doi.org/10.1016/j.cell.2019.09.019DOI Listing
October 2019

A Pan-cancer Transcriptome Analysis Reveals Pervasive Regulation through Alternative Promoters.

Cell 2019 Sep;178(6):1465-1477.e17

Computational and Systems Biology, Genome Institute of Singapore, Singapore 138672, Singapore; Cellular and Molecular Research, National Cancer Centre, Singapore 169610, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.08.018DOI Listing
September 2019

A STAT3-based gene signature stratifies glioma patients for targeted therapy.

Nat Commun 2019 08 9;10(1):3601. Epub 2019 Aug 9.

Neuro-Oncology Research Laboratory, Department of Research, National Neuroscience Institute, Singapore, Singapore.

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http://dx.doi.org/10.1038/s41467-019-11614-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689009PMC
August 2019

Toll-like receptor 2 regulates metabolic reprogramming in gastric cancer via superoxide dismutase 2.

Int J Cancer 2019 06 7;144(12):3056-3069. Epub 2019 Jan 7.

Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.32060
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http://dx.doi.org/10.1002/ijc.32060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590666PMC
June 2019

Biological heterogeneity and versatility of cancer-associated fibroblasts in the tumor microenvironment.

Oncogene 2019 06 28;38(25):4887-4901. Epub 2019 Feb 28.

Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan.

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http://dx.doi.org/10.1038/s41388-019-0765-yDOI Listing
June 2019

Long-term outcomes of surgical management of rectal prolapse.

ANZ J Surg 2019 Jun 13;89(6):E231-E235. Epub 2019 May 13.

Colorectal Division, Department of General Surgery, St John of God Subiaco Hospital, Perth, Western Australia, Australia.

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http://dx.doi.org/10.1111/ans.15264DOI Listing
June 2019

The Integrator Complex Prevents Dedifferentiation of Intermediate Neural Progenitors back into Neural Stem Cells.

Cell Rep 2019 Apr;27(4):987-996.e3

Neuroscience & Behavioral Disorders Programme, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore; NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, 28 Medical Drive, Singapore 117456, Singapore; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.03.089DOI Listing
April 2019

A rare case of acute presentation of trocar site hernia from robot-assisted laparoscopic partial nephrectomy.

J Robot Surg 2019 Feb 15;13(1):159-162. Epub 2018 Feb 15.

Department of General Surgery, St John of God Subiaco Hospital, 12 Salvado Road, Subiaco, WA, 6008, Australia.

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http://dx.doi.org/10.1007/s11701-018-0787-4DOI Listing
February 2019

KRAS Mutation in Gastric Cancer and Prognostication Associated with Microsatellite Instability Status.

Pathol Oncol Res 2019 Jan 8;25(1):333-340. Epub 2017 Nov 8.

General Surgery and Surgical Oncology Department, University of Siena, viale Bracci 16, 53-100, Siena, Italy.

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http://dx.doi.org/10.1007/s12253-017-0348-6DOI Listing
January 2019

Transcriptional analysis of immune genes in Epstein-Barr virus-associated gastric cancer and association with clinical outcomes.

Gastric Cancer 2018 11 18;21(6):1064-1070. Epub 2018 Jun 18.

Cancer and Stem Cell Biology Program, Duke-NUS Medical School, 8 College Road, Singapore, 169857, Singapore.

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http://link.springer.com/10.1007/s10120-018-0851-9
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http://dx.doi.org/10.1007/s10120-018-0851-9DOI Listing
November 2018

Anal squamous cell carcinoma: are we improving outcomes?

ANZ J Surg 2018 10 29;88(10):1013-1016. Epub 2018 Aug 29.

Colorectal Surgical Unit, St John of God Subiaco Hospital, Perth, Western Australia, Australia.

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http://doi.wiley.com/10.1111/ans.14745
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http://dx.doi.org/10.1111/ans.14745DOI Listing
October 2018

Overexpression of CXCR7 Is a Novel Prognostic Indicator in Gastric Cancer.

Dig Surg 2017 10;34(4):312-318. Epub 2016 Dec 10.

Department of Surgery, Kyushu University Beppu Hospital, Beppu, Japan.

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http://dx.doi.org/10.1159/000452977DOI Listing
April 2018

Mutation hotspots at CTCF binding sites coupled to chromosomal instability in gastrointestinal cancers.

Nat Commun 2018 04 18;9(1):1520. Epub 2018 Apr 18.

Computational and Systems Biology, Agency for Science Technology and Research, Genome Institute of Singapore, 60 Biopolis Street, Singapore, 138672, Singapore.

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http://dx.doi.org/10.1038/s41467-018-03828-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906695PMC
April 2018

Clinical Utility of a STAT3-Regulated miRNA-200 Family Signature with Prognostic Potential in Early Gastric Cancer.

Clin Cancer Res 2018 03 12;24(6):1459-1472. Epub 2018 Jan 12.

Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, Australia.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-2485DOI Listing
March 2018

Genomic predictors of chemotherapy efficacy in advanced or recurrent gastric cancer in the GC0301/TOP002 phase III clinical trial.

Cancer Lett 2018 01 20;412:208-215. Epub 2017 Oct 20.

Department of Surgery, Tsuboi Cancer Center Hospital, Koriyama, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2017.10.011DOI Listing
January 2018

Genomic and Epigenomic Profiling of High-Risk Intestinal Metaplasia Reveals Molecular Determinants of Progression to Gastric Cancer.

Cancer Cell 2018 01 28;33(1):137-150.e5. Epub 2017 Dec 28.

Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore 169857, Singapore; Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore; Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, Singapore 138672, Singapore; SingHealth/Duke-NUS Institute of Precision Medicine, National Heart Centre Singapore, Singapore 169856, Singapore; Cellular and Molecular Research, National Cancer Centre, Singapore 169610, Singapore; Singapore Gastric Cancer Consortium, Singapore 119074, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.11.018DOI Listing
January 2018

Genomic Analyses and Precision Oncology in Gastroesophageal Cancer: Forwards or Backwards?

Cancer Discov 2018 01;8(1):14-16

Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.

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http://dx.doi.org/10.1158/2159-8290.CD-17-1295DOI Listing
January 2018

Ethical frameworks for obtaining informed consent in tumour profiling: an evidence-based case for Singapore.

Hum Genomics 2017 Dec 8;11(1):31. Epub 2017 Dec 8.

SingHealth Duke-NUS Institute of Precision Medicine, Singapore, Singapore.

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http://dx.doi.org/10.1186/s40246-017-0127-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723075PMC
December 2017

Erratum: An intrinsic mechanism controls reactivation of neural stem cells by spindle matrix proteins.

Nat Commun 2017 10 31;8(1):1298. Epub 2017 Oct 31.

Neuroscience and Behavioural Disorders Program, Duke-NUS Medical School, 8 College Road, Singapore, 169857, Singapore.

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http://dx.doi.org/10.1038/s41467-017-01017-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663954PMC
October 2017

A formalin-fixed paraffin-embedded (FFPE)-based prognostic signature to predict metastasis in clinically low risk stage I/II microsatellite stable colorectal cancer.

Cancer Lett 2017 09 15;403:13-20. Epub 2017 Jun 15.

Department of Colorectal Surgery, Singapore General Hospital, 169856, Singapore; SingHealth Duke-NUS Surgery Academic Clinical Programme, Office of Clinical, Academic and Faculty Affairs, Duke-NUS Medical School, National University of Singapore, Singapore; Saw Swee Hock School of Public Health, National University of Singapore, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2017.05.031DOI Listing
September 2017

Genomics of worms, with an emphasis on Opisthorchis viverrini - opportunities for fundamental discovery and biomedical outcomes.

Parasitol Int 2017 Aug 12;66(4):341-345. Epub 2016 Jan 12.

Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria 3010, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.parint.2016.01.005DOI Listing
August 2017

How to stomach an epigenetic insult: the gastric cancer epigenome.

Nat Rev Gastroenterol Hepatol 2017 Aug 17;14(8):467-478. Epub 2017 May 17.

Cancer and Stem Cell Biology Programme, Duke-NUS Medical School, 8 College Road, 169857 Singapore.

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http://dx.doi.org/10.1038/nrgastro.2017.53DOI Listing
August 2017

Mitochondrial genomic comparison of Clonorchis sinensis from South Korea with other isolates of this species.

Infect Genet Evol 2017 07 22;51:160-166. Epub 2017 Feb 22.

Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.meegid.2017.02.015DOI Listing
July 2017

An intrinsic mechanism controls reactivation of neural stem cells by spindle matrix proteins.

Nat Commun 2017 07 25;8(1):122. Epub 2017 Jul 25.

Neuroscience & Behavioural Disorders Program, Duke-NUS Medical School, 8 College Road, Singapore, 169857, Singapore.

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http://dx.doi.org/10.1038/s41467-017-00172-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526931PMC
July 2017

Molecular subtypes in cancers of the gastrointestinal tract.

Nat Rev Gastroenterol Hepatol 2017 Jun 12;14(6):333-342. Epub 2017 Apr 12.

Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/nrgastro.2017.33DOI Listing
June 2017

Prognostic RNAs in oesophageal squamous cell carcinoma: small is beautiful.

Gut 2017 02 15;66(2):210-211. Epub 2016 Sep 15.

Division of Cancer Research, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.

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http://dx.doi.org/10.1136/gutjnl-2016-312585DOI Listing
February 2017

ADAR-Mediated RNA Editing Predicts Progression and Prognosis of Gastric Cancer.

Gastroenterology 2016 10 1;151(4):637-650.e10. Epub 2016 Jul 1.

Cancer Science Institute of Singapore, National University of Singapore, Singapore; Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2016.06.043DOI Listing
October 2016

Epigenomic Consequences of Coding and Noncoding Driver Mutations.

Trends Cancer 2016 10 30;2(10):585-605. Epub 2016 Sep 30.

Cancer and Stem Cell Biology Program, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore; National Cancer Centre, 11 Hospital Drive, Singapore 169610, Singapore; Cancer Science Institute of Singapore, National University of Singapore, 14 Medical Drive, #12-01, Singapore 117599, Singapore; SingHealth/Duke-NUS Precision Medicine Institute, Singapore 168752, Singapore; Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673. Electronic address:

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http://dx.doi.org/10.1016/j.trecan.2016.09.002DOI Listing
October 2016

Technical Validation of a Next-Generation Sequencing Assay for Detecting Actionable Mutations in Patients with Gastrointestinal Cancer.

J Mol Diagn 2016 05 9;18(3):416-424. Epub 2016 Mar 9.

Genome Institute of Singapore, Singapore; Cancer & Stem Cell Biology Program, Duke-National University of Singapore Graduate Medical School, Singapore; Cancer Science Institute Singapore, National University of Singapore, Singapore; Division of Cellular and Molecular Research, National Cancer Centre Singapore, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2016.01.006DOI Listing
May 2016

Melanoma associated antigen (MAGE)-A3 promotes cell proliferation and chemotherapeutic drug resistance in gastric cancer.

Cell Oncol (Dordr) 2016 Apr 11;39(2):175-86. Epub 2016 Feb 11.

Department of Haematology-Oncology, National University Hospital, Level 7, NUHS Tower Block, 1E, Kent Ridge Road, Singapore, 119228, Singapore.

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http://dx.doi.org/10.1007/s13402-015-0261-5DOI Listing
April 2016

Translating gastric cancer genomics into targeted therapies.

Crit Rev Oncol Hematol 2016 Apr 18;100:141-6. Epub 2016 Feb 18.

Cancer Science Institute of Singapore, National University of Singapore, Singapore; Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, Singapore; Cancer Therapeutics and Stratified Oncology, Genomic Institute of Singapore, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.critrevonc.2016.02.007DOI Listing
April 2016

Pipeline for the identification and classification of ion channels in parasitic flatworms.

Parasit Vectors 2016 Mar 16;9:155. Epub 2016 Mar 16.

Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria, 3010, Australia.

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http://dx.doi.org/10.1186/s13071-016-1428-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794918PMC
March 2016

Defining the Molecular Alterations of Ampullary Carcinoma.

Cancer Cell 2016 Feb;29(2):135-6

Laboratory of Cancer Epigenome, National Cancer Centre Singapore, 11 Hospital Drive, Singapore 169610, Singapore; Division of Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, 8 College Road, Singapore 169857, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.01.011DOI Listing
February 2016

NanoString expression profiling identifies candidate biomarkers of RAD001 response in metastatic gastric cancer.

ESMO Open 2016 17;1(1):e000009. Epub 2016 Feb 17.

Cancer and Stem Cell Biology Program, Duke-NUS Medical School; Genome Institute of Singapore, Biopolis, Singapore; Cancer Science Institute of Singapore, National University of Singapore, Singapore.

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http://dx.doi.org/10.1136/esmoopen-2015-000009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070203PMC
February 2016

Defining the Schistosoma haematobium kinome enables the prediction of essential kinases as anti-schistosome drug targets.

Sci Rep 2015 Dec 4;5:17759. Epub 2015 Dec 4.

Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1038/srep17759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669435PMC
December 2015