Patrick T Gunning

Patrick T Gunning

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Patrick T Gunning

Patrick T Gunning

Publications by authors named "Patrick T Gunning"

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Direct Targeting Options for STAT3 and STAT5 in Cancer.

Cancers (Basel) 2019 Dec 3;11(12). Epub 2019 Dec 3.

Institute of Animal Breeding and Genetics, University of Veterinary Medicine, 1210 Vienna, Austria.

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http://dx.doi.org/10.3390/cancers11121930DOI Listing
December 2019

Structural Implications of STAT3 and STAT5 SH2 Domain Mutations.

Cancers (Basel) 2019 Nov 8;11(11). Epub 2019 Nov 8.

Centre for Medicinal Chemistry, University of Toronto at Mississauga, Mississauga, ON L5L 1C6, Canada.

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http://dx.doi.org/10.3390/cancers11111757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895964PMC
November 2019

Effect of caveolin-1 on Stat3-ptyr705 levels in breast and lung carcinoma cells.

Biochem Cell Biol 2019 10 15;97(5):638-646. Epub 2019 Apr 15.

Department of Biomedical and Molecular Sciences, Pathology and Molecular Medicine, and Queen's University Cancer Research Institute, Queen's University, Kingston, ON K7L 3N6, Canada.

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http://dx.doi.org/10.1139/bcb-2018-0367DOI Listing
October 2019

PI3k and Stat3: Oncogenes that are Required for Gap Junctional, Intercellular Communication.

Cancers (Basel) 2019 Feb 1;11(2). Epub 2019 Feb 1.

Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON K7L 3N6, Canada.

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http://dx.doi.org/10.3390/cancers11020167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406562PMC
February 2019

A functional in vitro assay for screening inhibitors of STAT5B phosphorylation.

J Pharm Biomed Anal 2019 Jan 18;162:60-65. Epub 2018 Aug 18.

Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Rd N., Mississauga, Ontario L5L 1C6, Canada; Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 3H6, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jpba.2018.08.036DOI Listing
January 2019

Regulating the Master Regulator: Controlling Ubiquitination by Thinking Outside the Active Site.

J Med Chem 2018 01 28;61(2):405-421. Epub 2017 Feb 28.

Department of Chemistry, University of Toronto , Toronto, ON M5S 3H6, Canada.

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http://dx.doi.org/10.1021/acs.jmedchem.6b01346DOI Listing
January 2018

Emerging therapeutic targets in myeloproliferative neoplasms and peripheral T-cell leukemia and lymphomas.

Expert Opin Ther Targets 2018 01 24;22(1):45-57. Epub 2017 Nov 24.

a Institute of Animal Breeding and Genetics , University of Veterinary Medicine Vienna , Vienna , Austria.

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http://dx.doi.org/10.1080/14728222.2018.1406924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743003PMC
January 2018

ProxyPhos sensors for the detection of negatively charged membranes.

Analyst 2017 Nov;142(23):4511-4521

Department of Chemistry and Department of Chemical & Physical Sciences, University of Toronto, Mississauga, 3359 Mississauga Road North, Mississauga, Ontario, Canada L5L 1C6.

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http://dx.doi.org/10.1039/c7an00568gDOI Listing
November 2017

High-throughput thermofluor-based assays for inhibitor screening of STAT SH2 domains.

J Pharm Biomed Anal 2017 Sep 1;143:159-167. Epub 2017 May 1.

Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Rd N., Mississauga, Ontario L5L 1C6, Canada; Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 3H6, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jpba.2017.04.052DOI Listing
September 2017

Strategies for over-expression and purification of recombinant full length STAT5B in Escherichia coli.

Protein Expr Purif 2017 01 31;129:1-8. Epub 2016 Aug 31.

Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Rd N., Mississauga, Ontario L5L 1C6, Canada; Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 3H6, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.pep.2016.08.017DOI Listing
January 2017

A selective inhibitor of the UFM1-activating enzyme, UBA5.

Bioorg Med Chem Lett 2016 09 8;26(18):4542-4547. Epub 2015 Oct 8.

Department of Chemistry, University of Toronto, Toronto, ON M5S 3H6, Canada; Department of Chemical and Physical Sciences, University of Toronto at Mississauga, Mississauga, ON L5L 1C6, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2015.10.015DOI Listing
September 2016

A STAT inhibitor patent review: progress since 2011.

Expert Opin Ther Pat 2015 22;25(12):1397-421. Epub 2015 Sep 22.

a University of Toronto Mississauga, Department of Chemical and Physical Sciences , 3359 Mississauga Road North, Mississauga, Ontario L5L 1C6, Canada +1 90 55 69 45 88 ; +1 90 55 69 49 29 ;

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http://www.tandfonline.com/doi/full/10.1517/13543776.2015.10
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http://dx.doi.org/10.1517/13543776.2015.1086749DOI Listing
July 2016

Applying Small Molecule Signal Transducer and Activator of Transcription-3 (STAT3) Protein Inhibitors as Pancreatic Cancer Therapeutics.

Mol Cancer Ther 2016 05 12;15(5):794-805. Epub 2016 Feb 12.

Department of Pediatrics, Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana. Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana.

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http://dx.doi.org/10.1158/1535-7163.MCT-15-0003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873422PMC
May 2016

Understanding Protein-Protein Interactions: Essential Players in (Patho)physiology (Part 1).

Chembiochem 2016 Apr 30;17(8):644-5. Epub 2016 Mar 30.

Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, M5S 3H6, Canada.

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http://dx.doi.org/10.1002/cbic.201600166DOI Listing
April 2016

Understanding Protein-Protein Interactions: Essential Players in (Patho)physiology (Part 2).

ChemMedChem 2016 Apr 9;11(8):732-3. Epub 2016 Apr 9.

Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON, M5S 3H6, Canada.

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http://dx.doi.org/10.1002/cmdc.201600158DOI Listing
April 2016

A tool for the selective sequestration of ATP and PPi to aid in-solution phosphopeptide detection assays.

Analyst 2016 Feb 8;141(3):820-2. Epub 2015 Dec 8.

Department of Chemistry and Department of Chemical and Physical Sciences, University of Toronto, Mississauga, 3359 Mississauga Road North, Mississauga, Ontario, CanadaL5L1C6.

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http://dx.doi.org/10.1039/c5an01414jDOI Listing
February 2016

Identification of Bidentate Salicylic Acid Inhibitors of PTP1B.

ACS Med Chem Lett 2015 Sep 22;6(9):982-6. Epub 2015 Jul 22.

Department of Chemical and Physical Sciences, University of Toronto Mississauga , Mississauga, ON L5L 1C6, Canada.

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http://dx.doi.org/10.1021/acsmedchemlett.5b00171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569880PMC
September 2015

Selective detection of tyrosine-containing proximally phosphorylated motifs using an antenna-free Tb³⁺ luminescent sensor.

Chem Commun (Camb) 2015 Apr;51(30):6675-7

University of Toronto Mississauga, 3359 Mississauga Road North, Mississauga, Ontario, L5L 1C6 Canada.

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http://dx.doi.org/10.1039/c5cc00679aDOI Listing
April 2015

Changes in signal transducer and activator of transcription 3 (STAT3) dynamics induced by complexation with pharmacological inhibitors of Src homology 2 (SH2) domain dimerization.

J Biol Chem 2014 Nov 6;289(47):32538-47. Epub 2014 Oct 6.

From the Center for Research in Mass Spectrometry, Department of Chemistry, York University, Toronto, Ontario M3J 1P3, Canada and

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http://dx.doi.org/10.1074/jbc.M114.595454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239608PMC
November 2014

Nanomolar-Potency Small Molecule Inhibitor of STAT5 Protein.

ACS Med Chem Lett 2014 Nov 19;5(11):1202-1206. Epub 2014 Sep 19.

Department of Chemistry, University of Toronto Mississauga , Mississauga, Ontario L5L 1C6, Canada.

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http://dx.doi.org/10.1021/ml500165rDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234445PMC
November 2014

An excimer-based, turn-on fluorescent sensor for the selective detection of diphosphorylated proteins in aqueous solution and polyacrylamide gels.

J Am Chem Soc 2014 Jan 14;136(4):1234-7. Epub 2014 Jan 14.

Department of Chemistry and Department of Chemical and Physical Sciences, University of Toronto, Mississauga , 3359 Mississauga Road North, Mississauga, Ontario, Canada L5L1C6.

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http://dx.doi.org/10.1021/ja411492kDOI Listing
January 2014

Targeting the ubiquitin E1 as a novel anti-cancer strategy.

Curr Pharm Des 2013 ;19(18):3201-9

The Princess Margaret Hospital, The Ontario Cancer Institute, Toronto, ON, M5G 2M9 Canada.

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http://dx.doi.org/10.2174/1381612811319180004DOI Listing
October 2013

Extolling the benefits of molecular therapeutic lipidation.

Mol Biosyst 2013 Sep;9(9):2179-88

Department of Chemical and Physical Sciences, University of Toronto Mississauga, Mississauga, Canada.

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http://dx.doi.org/10.1039/c3mb70147fDOI Listing
September 2013

A 2,6,9-hetero-trisubstituted purine inhibitor exhibits potent biological effects against multiple myeloma cells.

Bioorg Med Chem 2013 Sep 9;21(17):5618-28. Epub 2013 May 9.

Department of Chemistry, University of Toronto, 3359 Mississauga Road North, Mississauga, ON, L5L 1C6, Canada.

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http://dx.doi.org/10.1016/j.bmc.2013.04.080DOI Listing
September 2013

Progress towards the development of SH2 domain inhibitors.

Chem Soc Rev 2013 Apr 11;42(8):3337-70. Epub 2013 Feb 11.

Department of Chemical and Physical Sciences, University of Toronto, 3359 Mississauga Road North, Mississauga, Ontario L5L 1C6, Canada.

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http://dx.doi.org/10.1039/c3cs35449kDOI Listing
April 2013

Exploring a new frontier in cancer treatment: targeting the ubiquitin and ubiquitin-like activating enzymes.

J Med Chem 2013 Mar 1;56(6):2165-77. Epub 2013 Mar 1.

Department of Chemical and Physical Sciences, University of Toronto Mississauga , 3359 Mississauga Road North, Mississauga, Ontario L5L 1C6, Canada.

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http://dx.doi.org/10.1021/jm301420bDOI Listing
March 2013

Phosphopeptide selective coordination complexes as promising SRC homology 2 domain mimetics.

Inorg Chem 2012 Aug 11;51(15):8284-91. Epub 2012 Jul 11.

Department of Chemical and Physical Sciences, University of Toronto, 3359 Mississauga Road North, Mississauga, Ontario L5L 1C6, Canada.

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http://dx.doi.org/10.1021/ic3008393DOI Listing
August 2012

Progress towards direct inhibitors of Stat5 protein.

Horm Mol Biol Clin Investig 2012 Jun;10(2):281-6

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http://dx.doi.org/10.1515/hmbci-2012-0009DOI Listing
June 2012

Small molecule STAT5-SH2 domain inhibitors exhibit potent antileukemia activity.

J Med Chem 2012 Feb 13;55(3):1047-55. Epub 2012 Jan 13.

Department of Chemistry, University of Toronto, 3359 Mississauga Road North, Mississauga, ON, L5L 1C6, Canada.

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http://dx.doi.org/10.1021/jm200720nDOI Listing
February 2012

Identification of a non-phosphorylated, cell permeable, small molecule ligand for the Stat3 SH2 domain.

Bioorg Med Chem Lett 2011 Sep 30;21(18):5605-9. Epub 2011 Jun 30.

Department of Chemistry, University of Toronto Mississauga, 3359 Mississauga Road, Mississauga, ON, Canada L5L 1C6.

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http://dx.doi.org/10.1016/j.bmcl.2011.06.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530782PMC
September 2011

Identification of NAE Inhibitors Exhibiting Potent Activity in Leukemia Cells: Exploring the Structural Determinants of NAE Specificity.

ACS Med Chem Lett 2011 Aug 16;2(8):577-82. Epub 2011 May 16.

Department of Chemistry, University of Toronto Mississauga , 3359 Mississauga Road North, Mississauga, ON, L5L1C6, Canada.

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http://dx.doi.org/10.1021/ml2000615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018054PMC
August 2011

Artificially induced protein-membrane anchorage with cholesterol-based recognition agents as a new therapeutic concept.

Angew Chem Int Ed Engl 2011 Jul;50(28):6248-53

Department of Chemical and Physical Sciences, University of Toronto Mississauga, Mississauga, ON L5L 1C6, Canada.

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http://dx.doi.org/10.1002/anie.201102486DOI Listing
July 2011

Inhibiting aberrant Stat3 function with molecular therapeutics: a progress report.

Anticancer Drugs 2011 Feb;22(2):115-27

Department of Chemistry, University of Toronto, Mississauga, Canada.

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http://dx.doi.org/10.1097/CAD.0b013e328341185bDOI Listing
February 2011

Signal transducer and activator of transcription 3 inhibitors: a patent review.

Expert Opin Ther Pat 2011 Jan 29;21(1):65-83. Epub 2010 Nov 29.

University of Toronto, Mississauga, Department of Chemistry, Mississauga, ON L5 L 1C6, Canada.

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http://www.tandfonline.com/doi/full/10.1517/13543776.2011.53
Publisher Site
http://dx.doi.org/10.1517/13543776.2011.539205DOI Listing
January 2011

A novel small-molecule disrupts Stat3 SH2 domain-phosphotyrosine interactions and Stat3-dependent tumor processes.

Biochem Pharmacol 2010 May 11;79(10):1398-409. Epub 2010 Jan 11.

University of Central Florida College of Medicine, Orlando, 32827, USA.

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http://dx.doi.org/10.1016/j.bcp.2010.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188443PMC
May 2010

Molecular disruption of oncogenic signal transducer and activator of transcription 3 (STAT3) protein.

Biochem Cell Biol 2009 Dec;87(6):825-33

Department of Chemistry, 3359 Mississauga Road North, South Building, Rm 4046, University of Toronto, Mississauga, ON L5L 1C6.

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http://dx.doi.org/10.1139/o09-044DOI Listing
December 2009

Novel asymmetrically functionalized bis-dipicolylamine metal complexes: peripheral decoration of a potent anion recognition scaffold.

Org Biomol Chem 2009 Dec 12;7(24):5074-7. Epub 2009 Oct 12.

Department of Chemistry, University of Toronto, 3359 Mississauga Road North, Mississauga, ON, CanadaL5L 1C6.

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http://xlink.rsc.org/?DOI=b917692f
Publisher Site
http://dx.doi.org/10.1039/b917692fDOI Listing
December 2009

A photostable, pH-invariant fluorescein derivative for single-molecule microscopy.

J Fluoresc 2009 Sep 21;19(5):915-20. Epub 2009 May 21.

Department of Physics, Institute for Optical Sciences, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1007/s10895-009-0492-9DOI Listing
September 2009

Molecular approaches towards the inhibition of the signal transducer and activator of transcription 3 (Stat3) protein.

ChemMedChem 2008 Aug;3(8):1159-68

Department of Chemistry, University of Toronto, Mississauga, Ontario L5L 1C6, Canada.

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http://dx.doi.org/10.1002/cmdc.200800123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2603136PMC
August 2008

An oxazole-based small-molecule Stat3 inhibitor modulates Stat3 stability and processing and induces antitumor cell effects.

ACS Chem Biol 2007 Dec;2(12):787-98

BioMolecular Science Center, Department of Molecular Biology and Microbiology, University of Central Florida College of Medicine, Orlando, Florida 32826, USA.

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http://dx.doi.org/10.1021/cb7001973DOI Listing
December 2007

Positive ion pair cooperativity exhibited for the binding of phosphate under physiological conditions.

Org Biomol Chem 2005 Nov 27;3(21):3877-9. Epub 2005 Sep 27.

University of Glasgow, Joseph Black Building, Dept. of Chemistry, Glasgow, UKG12 8QQ.

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http://xlink.rsc.org/?DOI=b510262f
Publisher Site
http://dx.doi.org/10.1039/b510262fDOI Listing
November 2005