Patrick Pauwels

From the Department of Public Health and Primary Care, Biomedical Quality Assurance Research Unit, University of Leuven, Leuven, Belgium (Keppens, Van Royen, Dequeker).

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January 2021

PD-L1 immunohistochemistry in non-small-cell lung cancer: unraveling differences in staining concordance and interpretation.

Authors:

Cleo Keppens Elisabeth Mc Dequeker Patrick Pauwels Ales Ryska Nils 't Hart Jan H von der Thüsen

Virchows Arch 2020 Dec 4. Epub 2020 Dec 4.

Department of Pathology, University Medical Center Rotterdam, Erasmus MC, Rotterdam, The Netherlands.

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December 2020

GSDME and its role in cancer: From behind the scenes to the front of the stage.

Authors:

Elke De Schutter Lieselot Croes Joe Ibrahim Patrick Pauwels Ken Op de Beeck Peter Vandenabeele Guy Van Camp

Int J Cancer 2020 Nov 13. Epub 2020 Nov 13.

Center of Medical Genetics, University of Antwerp and Antwerp University Hospital, Antwerp, Belgium.

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November 2020

Precision Prevention and Cancer Interception: The New Challenges of Liquid Biopsy.

Authors:

Maria Jose Serrano Maria Carmen Garrido-Navas Juan Jose Diaz Mochon Massimo Cristofanilli Ignacio Gil-Bazo Patrick Pauwels Umberto Malapelle Alessandro Russo Jose A Lorente Antonio J Ruiz-Rodriguez Luis G Paz-Ares Eduardo Vilar Luis E Raez Andres F Cardona Christian Rolfo

Cancer Discov 2020 Nov 9;10(11):1635-1644. Epub 2020 Oct 9.

Clinical and Translational Oncology Group, Clínica del Country, Bogotá, Colombia.

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November 2020

Staining Performance of ALK and ROS1 Immunohistochemistry and Influence on Interpretation in Non-Small-Cell Lung Cancer.

Authors:

Cleo Keppens Jan von der Thüsen Patrick Pauwels Ales Ryska Nils 't Hart Ed Schuuring Keith Miller Erik Thunnissen Karen Zwaenepoel Elisabeth M C Dequeker

J Mol Diagn 2020 Dec 2;22(12):1438-1452. Epub 2020 Oct 2.

Biomedical Quality Assurance Research Unit, Department of Public Health and Primary Care, University of Leuven, Leuven, Belgium. Electronic address:

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December 2020

Immunohistochemistry as a screening tool for NTRK gene fusions: results of a first Belgian ring trial.

Authors:

Koen De Winne Laure Sorber Suzan Lambin Vasiliki Siozopoulou Gabriela Beniuga Franceska Dedeurwaerdere Nicky D'Haene Lionel Habran Louis Libbrecht Jacques Van Huysse Birgit Weynand Katrin Wouters Patrick Pauwels Karen Zwaenepoel

Virchows Arch 2020 Sep 11. Epub 2020 Sep 11.

Laboratory of Pathological Anatomy, Antwerp University Hospital (UZA), 2650, Edegem, Belgium.

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September 2020

The immunologic aspects in hormone receptor positive breast cancer.

Authors:

Gizem Oner Sevilay Altintas Zafer Canturk Wiebren Tjalma Christophe Van Berckelaer Glenn Broeckx Karen Zwaenepoel Maria Tholhuijsen Yannick Verhoeven Zwi Berneman Marc Peeters Patrick Pauwels Peter A van Dam

Cancer Treat Res Commun 2020 29;25:100207. Epub 2020 Aug 29.

Multidisciplinary Oncologic Centre Antwerp [(MOCA)], Antwerp University Hospital, Edegem, Belgium; Center for Oncological Research (CORE), University of Antwerp, Wilrijk, Belgium.

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August 2020

Corrigendum to "Challenges and opportunities of cfDNA analysis implementation in clinical practice: Perspective of the International Society of Liquid Biopsy (ISLB)" [Crit. Rev. Oncol. Hematol. 151 (July) (2020) 102978].

Authors:

Christian Rolfo Andrés F Cardona Massimo Cristofanilli Luis Paz-Ares Juan Jose Diaz Mochon Ignacio Duran Luis E Raez Alessandro Russo Jose A Lorente Umberto Malapelle Ignacio Gil-Bazo Eloisa Jantus-Lewintre Patrick Pauwels Tony Mok María José Serrano

Crit Rev Oncol Hematol 2020 Oct 18;154:103058. Epub 2020 Aug 18.

Centre for Genomics and Oncological Research - GENYO, Pfizer, University of Granada, Andalusian Regional Government, Granada, Spain; Bio-Health Research Institute (Instituto de Investigación Biosanitaria ibs. GRANADA), Spain; Complejo Hospitalario Universitario Granada (CHUG), Department of Medical Oncology, University of Granada, Granada, Spain. Electronic address:

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October 2020

Novel combination immunotherapy for pancreatic cancer: potent anti-tumor effects with CD40 agonist and interleukin-15 treatment.

Authors:

Jonas Rm Van Audenaerde Elly Marcq Bianca von Scheidt Ashleigh S Davey Amanda J Oliver Jorrit De Waele Delphine Quatannens Jinthe Van Loenhout Patrick Pauwels Geert Roeyen Filip Lardon Clare Y Slaney Marc Peeters Michael H Kershaw Phillip K Darcy Evelien Ljm Smits

Clin Transl Immunology 2020 15;9(8):e1165. Epub 2020 Aug 15.

Center for Oncological Research (CORE) Integrated Personalized & Precision Oncology Network (IPPON) University of Antwerp Wilrijk Belgium.

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August 2020

International real-world study of DLL3 expression in patients with small cell lung cancer.

Authors:

Federico Rojo Marcelo Corassa Dimitrios Mavroudis Aysim Büge Öz Bonne Biesma Luka Brcic Patrick Pauwels Verena Sailer John Gosney Darko Miljkovic Carlos Hader Meijing Wu Todd Almarez Frédérique Penault-Llorca

Lung Cancer 2020 09 27;147:237-243. Epub 2020 Jul 27.

University Clermont Auvergne, Jean Perrin Center, INSERM, IMoST, 63000 Clermont-Ferrand, France.

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September 2020

Implementation of MALDI Mass Spectrometry Imaging in Cancer Proteomics Research: Applications and Challenges.

Authors:

Eline Berghmans Kurt Boonen Evelyne Maes Inge Mertens Patrick Pauwels Geert Baggerman

J Pers Med 2020 Jun 22;10(2). Epub 2020 Jun 22.

Centre for Proteomics, University of Antwerp, Groenenborgerlaan 171, B-2020 Antwerpen, Belgium.

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June 2020

Clinically Relevant Chemotherapeutics Have the Ability to Induce Immunogenic Cell Death in Non-Small Cell Lung Cancer.

Authors:

Tal Flieswasser Jinthe Van Loenhout Laurie Freire Boullosa Astrid Van den Eynde Jorrit De Waele Jonas Van Audenaerde Filip Lardon Evelien Smits Patrick Pauwels Julie Jacobs

Cells 2020 06 16;9(6). Epub 2020 Jun 16.

Center for Oncological Research (CORE), Integrated Personalized and Precision Oncology Network (IPPON), 2610 Wilrijk, Belgium.

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June 2020

Cetuximab-induced natural killer cell cytotoxicity in head and neck squamous cell carcinoma cell lines: investigation of the role of cetuximab sensitivity and HPV status.

Authors:

Hasan Baysal Ines De Pauw Hannah Zaryouh Jorrit De Waele Marc Peeters Patrick Pauwels Jan Baptist Vermorken Evelien Smits Filip Lardon Julie Jacobs An Wouters

Br J Cancer 2020 Sep 16;123(5):752-761. Epub 2020 Jun 16.

Center for Oncological Research (CORE), University of Antwerp, Antwerp, Belgium.

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September 2020

Challenges and opportunities of cfDNA analysis implementation in clinical practice: Perspective of the International Society of Liquid Biopsy (ISLB).

Authors:

Christian Rolfo Andrés F Cardona Massimo Cristofanilli Luis Paz-Ares Juan Jose Diaz Mochon Ignacio Duran Luis E Raez Alessandro Russo Jose A Lorente Umberto Malapelle Ignacio Gil-Bazo Eloisa Jantus-Lewintre Patrick Pauwels Tony Mok María José Serrano

Crit Rev Oncol Hematol 2020 Jul 5;151:102978. Epub 2020 May 5.

Centre for Genomics and Oncological Research - GENYO, Pfizer, University of Granada, Andalusian Regional Government, Granada, Spain; Bio-Health Research Institute (Instituto de Investigación Biosanitaria ibs. GRANADA), Spain; Complejo Hospitalario Universitario Granada (CHUG), Department of Medical Oncology, University of Granada, Granada, Spain. Electronic address:

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July 2020

Sensitive detection methods are key to identify secondary EGFR c.2369C>T p.(Thr790Met) in non-small cell lung cancer tissue samples.

BMC Cancer 2020 May 1;20(1):366. Epub 2020 May 1.

Department of Pathology, University of Groningen, University Medical Center Groningen (UMCG), Hanzeplein 1, PO Box 30001, 9700, RB, Groningen, the Netherlands.

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May 2020

Mass Spectrometry Imaging Reveals Neutrophil Defensins as Additional Biomarkers for Anti-PD-(L)1 Immunotherapy Response in NSCLC Patients.

Authors:

Eline Berghmans Julie Jacobs Christophe Deben Christophe Hermans Glenn Broeckx Evelien Smits Evelyne Maes Jo Raskin Patrick Pauwels Geert Baggerman

Cancers (Basel) 2020 Apr 2;12(4). Epub 2020 Apr 2.

Centre for Proteomics, University of Antwerp, 2020 Antwerpen, Belgium.

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April 2020

The art of obtaining a high yield of cell-free DNA from urine.

Authors:

Elien Augustus Kaat Van Casteren Laure Sorber Peter van Dam Geert Roeyen Marc Peeters Alex Vorsters An Wouters Jo Raskin Christian Rolfo Karen Zwaenepoel Patrick Pauwels

PLoS One 2020 6;15(4):e0231058. Epub 2020 Apr 6.

Center for Oncological Research Antwerp (CORE), University of Antwerp (UA), Wilrijk, Belgium.

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July 2020

Crizotinib sensitizes the erlotinib resistant HCC827GR5 cell line by influencing lysosomal function.

Authors:

Nele Van Der Steen Kaylee Keller Henk Dekker Letizia Porcelli Richard J Honeywell Johan Van Meerloo René J P Musters Ietje Kathmann Adam E Frampton Daniel S K Liu Rob Ruijtenbeek Christian Rolfo Patrick Pauwels Elisa Giovannetti Godefridus J Peters

J Cell Physiol 2020 Nov 20;235(11):8085-8097. Epub 2020 Jan 20.

Laboratory of Medical Oncology, Amsterdam Universities Medical Centers, VUmc, Amsterdam, The Netherlands.

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November 2020

Clinical Performance of the Idylla MSI Test for a Rapid Assessment of the DNA Microsatellite Status in Human Colorectal Cancer.

Authors:

Karen Zwaenepoel Julie Holmgaard Duelund Koen De Winne Vincent Maes Christine Weyn Suzan Lambin Robina Dendooven Glenn Broeckx Torben Steiniche Patrick Pauwels

J Mol Diagn 2020 03 24;22(3):386-395. Epub 2019 Dec 24.

Laboratory of Pathological Anatomy, Antwerp University Hospital (UZA), Edegem, Belgium; Center for Oncological Research Antwerp (CORE), University of Antwerp, Wilrijk, Belgium.

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March 2020

Specialized Blood Collection Tubes for Liquid Biopsy: Improving the Pre-analytical Conditions.

Authors:

Laure Sorber Karen Zwaenepoel Julie Jacobs Koen De Winne Kaat Van Casteren Elien Augustus Filip Lardon Hans Prenen Marc Peeters Jan Van Meerbeeck Geert Roeyen Christian Rolfo Patrick Pauwels

Mol Diagn Ther 2020 02;24(1):113-124

Center for Oncological Research (CORE) Antwerp, University of Antwerp (UAntwerp), Universiteitsplein 1, 2610, Wilrijk, Belgium.

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February 2020

The Role of c-Met as a Biomarker and Player in Innate and Acquired Resistance in Non-Small-Cell Lung Cancer: Two New Mutations Warrant Further Studies.

Authors:

Nele Van Der Steen Karen Zwaenepoel Giulia Mazzaschi Rosa A Luirink Daan P Geerke Ken Op de Beeck Christophe Hermans Marcello Tiseo Paul Van Schil Filip Lardon Paul Germonpré Christian Rolfo Elisa Giovannetti Godefridus J Peters Patrick Pauwels

Molecules 2019 Dec 4;24(24). Epub 2019 Dec 4.

Center for Oncological Research, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium.

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December 2019

Triple-negative breast cancer-Role of immunology: A systemic review.

Authors:

Gizem Oner Sevilay Altintas Zafer Canturk Wiebren Tjalma Yannick Verhoeven Christophe Van Berckelaer Zwi Berneman Marc Peeters Patrick Pauwels Peter A van Dam

Breast J 2020 05 4;26(5):995-999. Epub 2019 Dec 4.

Multidisciplinary Oncologic Centre Antwerp (MOCA), Antwerp University Hospital, Edegem, Belgium.

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May 2020

Radiosensitization of Non-Small Cell Lung Cancer Cells by the Plk1 Inhibitor Volasertib Is Dependent on the p53 Status.

Authors:

Jolien Van den Bossche Andreas Domen Marc Peeters Christophe Deben Ines De Pauw Julie Jacobs Sven De Bruycker Pol Specenier Patrick Pauwels Jan Baptist Vermorken Filip Lardon An Wouters

Cancers (Basel) 2019 Nov 28;11(12). Epub 2019 Nov 28.

Center for Oncological Research (CORE), University of Antwerp, 2610 Wilrijk, Belgium.

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November 2019

Screening a Broad Range of Solid and Haematological Tumour Types for CD70 Expression Using a Uniform IHC Methodology as Potential Patient Stratification Method.

Authors:

Tal Flieswasser Valérie Camara-Clayette Alina Danu Jacques Bosq Vincent Ribrag Piotr Zabrocki Luc Van Rompaey Hans de Haard Karen Zwaenepoel Evelien Smits Patrick Pauwels Julie Jacobs

Cancers (Basel) 2019 Oct 22;11(10). Epub 2019 Oct 22.

Center for Oncological Research (CORE), University of Antwerp, 2610 Wilrijk, Belgium.

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October 2019

Molecular profiling in lung cancer associated with cystic airspaces.

Authors:

Annemiek Snoeckx Pieter Reyntiens Patrick Pauwels Paul E Van Schil Paul M Parizel Jan P Van Meerbeeck

Acta Clin Belg 2019 Oct 15:1-4. Epub 2019 Oct 15.

Department of Pulmonology and Thoracic Oncology, Antwerp University Hospital and University of Antwerp , Edegem , Belgium.

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October 2019

The potential and controversy of targeting STAT family members in cancer.

Authors:

Yannick Verhoeven Sam Tilborghs Julie Jacobs Jorrit De Waele Delphine Quatannens Christophe Deben Hans Prenen Patrick Pauwels Xuan Bich Trinh An Wouters Evelien L J Smits Filip Lardon Peter A van Dam

Semin Cancer Biol 2020 02 9;60:41-56. Epub 2019 Oct 9.

Multidisciplinary Oncologic Centre Antwerp (MOCA), Antwerp University Hospital, Wilrijkstraat 10, Edegem, B-2650, Belgium; Center for Oncological Research (CORE), University of Antwerp, Universiteitsplein 1, Wilrijk, B-2610, Belgium; Gynaecologic Oncology Unit, Antwerp University Hospital, Wilrijkstraat 10, Edegem, B-2650, Belgium. Electronic address:

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February 2020

Desmoid tumors display a strong immune infiltration at the tumor margins and no PD-L1-driven immune suppression.

Authors:

Vasiliki Siozopoulou Elly Marcq Julie Jacobs Karen Zwaenepoel Christophe Hermans Jantine Brauns Siegrid Pauwels Clément Huysentruyt Martin Lammens Johan Somville Evelien Smits Patrick Pauwels

Cancer Immunol Immunother 2019 Oct 11;68(10):1573-1583. Epub 2019 Sep 11.

Center for Oncological Research, University of Antwerp, Antwerp, Belgium.

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October 2019

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