Patrick O Humbert

Patrick O Humbert

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Patrick O Humbert

Patrick O Humbert

Publications by authors named "Patrick O Humbert"

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Structural analysis of phosphorylation-associated interactions of human MCC with Scribble PDZ domains.

FEBS J 2019 Jul 18. Epub 2019 Jul 18.

Department of Biochemistry & Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1111/febs.15002DOI Listing
July 2019

Crystal structure of the human Scribble PDZ1 domain bound to the PDZ-binding motif of APC.

FEBS Lett 2019 Mar 2;593(5):533-542. Epub 2019 Feb 2.

Department of Biochemistry & Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia.

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http://dx.doi.org/10.1002/1873-3468.13329DOI Listing
March 2019

Regulation of cellular and PCP signalling by the Scribble polarity module.

Semin Cell Dev Biol 2018 09 23;81:33-45. Epub 2017 Nov 23.

Department of Biochemistry & Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria 3086, Australia; Department of Biochemistry & Molecular Biology, University of Melbourne, Melbourne, Victoria 3010, Australia; Department of Pathology, University of Melbourne, Melbourne, Victoria 3010, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.semcdb.2017.11.021DOI Listing
September 2018

The Scribble Cell Polarity Module in the Regulation of Cell Signaling in Tissue Development and Tumorigenesis.

J Mol Biol 2018 Sep 8;430(19):3585-3612. Epub 2018 Feb 8.

Department of Biochemistry and Genetics, La Trobe Institute of Molecular Science, La Trobe University, Melbourne, Victoria, Australia; Department of Biochemistry & Molecular Biology, University of Melbourne, Melbourne, Victoria 3010, Australia; Department of Anatomy & Neurobiology, University of Melbourne, Melbourne, Victoria 3010, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2018.01.011DOI Listing
September 2018

Intermittent hypoxia induces a metastatic phenotype in breast cancer.

Oncogene 2018 08 1;37(31):4214-4225. Epub 2018 May 1.

Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Brisbane, QLD, 4006, Australia.

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http://dx.doi.org/10.1038/s41388-018-0259-3DOI Listing
August 2018

Guk-holder interacts with the Scribbled PDZ1 domain and regulates epithelial development with Scribbled and Discs Large.

J Biol Chem 2018 03 29;293(12):4519-4531. Epub 2018 Jan 29.

From the Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria 3086,

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http://dx.doi.org/10.1074/jbc.M117.817528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868251PMC
March 2018

Structural basis for the differential interaction of Scribble PDZ domains with the guanine nucleotide exchange factor β-PIX.

J Biol Chem 2017 12 23;292(50):20425-20436. Epub 2017 Oct 23.

From the Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria 3086,

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http://dx.doi.org/10.1074/jbc.M117.799452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733582PMC
December 2017

How to expel a bad tenant: Linking cyclin A2, enucleation and cell size.

Cell Cycle 2017 03 19;16(5):397-398. Epub 2017 Jan 19.

a Department of Biochemistry and Genetics , La Trobe Institute for Molecular Science, La Trobe University , Melbourne , Australia.

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http://dx.doi.org/10.1080/15384101.2016.1274586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351922PMC
March 2017

A Phenotypic High-Content Screening Assay to Identify Regulators of Membrane Protein Localization.

Assay Drug Dev Technol 2016 10 23;14(8):478-488. Epub 2016 Sep 23.

1 Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Centre , Victoria, Australia .

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http://dx.doi.org/10.1089/adt.2016.733DOI Listing
October 2016

Calcium Signaling Is Required for Erythroid Enucleation.

PLoS One 2016 5;11(1):e0146201. Epub 2016 Jan 5.

Cell Cycle and Cancer Genetics, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0146201PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701494PMC
June 2016

Lethal giant larvae-1 deficiency enhances the CD8(+) effector T-cell response to antigen challenge in vivo.

Immunol Cell Biol 2016 Mar 22;94(3):306-11. Epub 2015 Sep 22.

Cancer Immunology Laboratory, The Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1038/icb.2015.82DOI Listing
March 2016

Polarity Protein Scrib Facilitates Endothelial Inflammatory Signaling.

Arterioscler Thromb Vasc Biol 2015 Sep 23;35(9):1954-62. Epub 2015 Jul 23.

From the Institute for Cardiovascular Physiology, Goethe University, Frankfurt, Germany (C.K., K.P., R.P.B., C.F., U.R.M.); Walter-Brendel Center of Experimental Medicine, Ludwig-Maximilians University, Munich, Germany (A.R.M.K., M.S.); Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia, and Sir Peter MacCallum Department of Oncology, Department of Pathology, Department of Molecular Biology and Biochemistry, The University of Melbourne, Parkville, Victoria, Australia (P.O.H.); and DZHK (German Centre for Cardiovascular Research), partner sites Rhine-Main and Munich, Germany (C.K., A.R.M.K., K.P., M.S., R.P.B., C.F., U.R.M.).

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http://dx.doi.org/10.1161/ATVBAHA.115.305678DOI Listing
September 2015

Asymmetric cell division during T cell development controls downstream fate.

J Cell Biol 2015 Sep;210(6):933-50

Immune Signalling Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia Centre for Micro-Photonics, Faculty of Science, Engineering, and Technology, Swinburne University of Technology, Hawthorn, Victoria 3122, Australia Department of Pathology, University of Melbourne, Parkville, Victoria 3010, Australia Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria 3010, Australia

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http://dx.doi.org/10.1083/jcb.201502053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576854PMC
September 2015

Mitotic spindle orientation: semaphorin-plexin signaling flags the way.

Dev Cell 2015 May;33(3):243-4

Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1016/j.devcel.2015.04.012DOI Listing
May 2015

The polarity protein Scribble regulates myelination and remyelination in the central nervous system.

PLoS Biol 2015 Mar 25;13(3):e1002107. Epub 2015 Mar 25.

MRC Centre for Regenerative Medicine and MS Society/University of Edinburgh Centre for Translational Research, Scottish Centre for Regenerative Medicine, The University of Edinburgh, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1371/journal.pbio.1002107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373955PMC
March 2015

Muscle stem cell fate is controlled by the cell-polarity protein Scrib.

Cell Rep 2015 Feb 19;10(7):1135-48. Epub 2015 Feb 19.

Kings College London, Randall Division of Cellular and Molecular Biophysics, London SE1 1UL, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S22111247150007
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http://dx.doi.org/10.1016/j.celrep.2015.01.045DOI Listing
February 2015

Dissecting the role of polarity regulators in cancer through the use of mouse models.

Exp Cell Res 2014 Nov 30;328(2):249-57. Epub 2014 Aug 30.

Cell Cycle and Cancer Genetics Laboratory, Research Division, Peter MacCallum Cancer Centre, Locked Bag 1, A׳Beckett Street, Melbourne, VIC 8006, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC, Australia; Departments of Pathology, The University of Melbourne, Parkville, VIC, Australia; Department of Biochemistry and Molecular Biology, The University of Melbourne, Parkville, VIC, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.yexcr.2014.08.036DOI Listing
November 2014

Keratin 76 is required for tight junction function and maintenance of the skin barrier.

PLoS Genet 2014 Oct 23;10(10):e1004706. Epub 2014 Oct 23.

Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Australia; Department of Anatomy and Developmental Biology, Monash University, Melbourne, Australia.

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http://dx.doi.org/10.1371/journal.pgen.1004706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207637PMC
October 2014

Lethal giant larvae 1 tumour suppressor activity is not conserved in models of mammalian T and B cell leukaemia.

PLoS One 2014 27;9(1):e87376. Epub 2014 Jan 27.

Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia ; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia ; Centre for Micro-Photonics, Swinburne University of Technology, Hawthorn, Victoria, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0087376PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903681PMC
September 2014

Scribble modulates the MAPK/Fra1 pathway to disrupt luminal and ductal integrity and suppress tumour formation in the mammary gland.

PLoS Genet 2014 May 22;10(5):e1004323. Epub 2014 May 22.

Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia; Department of Pathology, The University of Melbourne, Parkville, Victoria, Australia; Department of Molecular Biology and Biochemistry, The University of Melbourne, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1371/journal.pgen.1004323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031063PMC
May 2014

Localization, not important in all tumor-suppressing properties: a lesson learnt from scribble.

Cells Tissues Organs 2013 15;198(1):1-11. Epub 2013 Jun 15.

Cell Cycle and Cancer Genetics, Research Division, Peter MacCallum Cancer Centre, Melbourne, Vic. 3002, Australia.

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http://dx.doi.org/10.1159/000348423DOI Listing
February 2014

Scribble regulates an EMT polarity pathway through modulation of MAPK-ERK signaling to mediate junction formation.

J Cell Sci 2013 Sep 26;126(Pt 17):3990-9. Epub 2013 Jun 26.

Cell Cycle and Cancer Genetics, Research Division, Peter MacCallum Cancer Centre, Melbourne, Australia.

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http://dx.doi.org/10.1242/jcs.129387DOI Listing
September 2013

Loss of APKC expression independently predicts tumor recurrence in superficial bladder cancers.

Urol Oncol 2013 Jul 5;31(5):649-55. Epub 2011 May 5.

Department of Surgery, Division of Urology, Royal Melbourne Hospital, University of Melbourne, Parkville, Australia.

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http://dx.doi.org/10.1016/j.urolonc.2011.03.012DOI Listing
July 2013

Increasing intracellular bioavailable copper selectively targets prostate cancer cells.

ACS Chem Biol 2013 Jul 24;8(7):1621-31. Epub 2013 May 24.

Research Division, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia.

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http://dx.doi.org/10.1021/cb400198pDOI Listing
July 2013

An in vivo large-scale chemical screening platform using Drosophila for anti-cancer drug discovery.

Dis Model Mech 2013 Mar 20;6(2):521-9. Epub 2012 Sep 20.

Cell Cycle and Development Laboratory, Peter MacCallum Cancer Centre, 7 St Andrews Place, East Melbourne 3002, Victoria, Australia.

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http://dx.doi.org/10.1242/dmm.009985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597034PMC
March 2013

The Scribble-Dlg-Lgl polarity module in development and cancer: from flies to man.

Essays Biochem 2012 ;53:141-68

Cell Cycle and Cancer Genetics Laboratory, Research Division, Peter MacCallum Cancer Center, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1042/bse0530141DOI Listing
December 2012

SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia.

J Clin Invest 2011 Nov 3;121(11):4257-67. Epub 2011 Oct 3.

Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1172/JCI58509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223862PMC
November 2011

Cell polarity in motion: redefining mammary tissue organization through EMT and cell polarity transitions.

J Mammary Gland Biol Neoplasia 2010 Jun 12;15(2):149-68. Epub 2010 May 12.

Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Center, East Melbourne, VIC 3002, Australia.

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http://dx.doi.org/10.1007/s10911-010-9180-2DOI Listing
June 2010

Tumor suppressor scribble regulates assembly of tight junctions in the intestinal epithelium.

Am J Pathol 2010 Jan 3;176(1):134-45. Epub 2009 Dec 3.

Gastroenterology and Hepatology Division, Department of Medicine, University of Rochester, 601 Elmwood Avenue, Box 646, Rochester, NY 14642, USA.

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http://dx.doi.org/10.2353/ajpath.2010.090220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797876PMC
January 2010

Transcriptional output of the Salvador/warts/hippo pathway is controlled in distinct fashions in Drosophila melanogaster and mammalian cell lines.

Cancer Res 2009 Aug 7;69(15):6033-41. Epub 2009 Jul 7.

Cell Growth and Proliferation Laboratory and Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-4592DOI Listing
August 2009

EKLF/KLF1 controls cell cycle entry via direct regulation of E2f2.

J Biol Chem 2009 Jul 20;284(31):20966-74. Epub 2009 May 20.

Division of Molecular Genetics and Development, Institute for Molecular Bioscience, University of Queensland, Brisbane, 4072, Australia.

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http://dx.doi.org/10.1074/jbc.M109.006346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742862PMC
July 2009

Scribble interacts with beta-catenin to localize synaptic vesicles to synapses.

Mol Biol Cell 2009 Jul 20;20(14):3390-400. Epub 2009 May 20.

Department of Cellular and Physiological Sciences and the Brain Research Centre, University of British Columbia, Vancouver, BC, V6T-1Z3, Canada.

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http://dx.doi.org/10.1091/mbc.e08-12-1172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2710836PMC
July 2009

Vimentin regulates scribble activity by protecting it from proteasomal degradation.

Mol Biol Cell 2009 Jun 22;20(12):2841-55. Epub 2009 Apr 22.

Epithelial Cell Biology Laboratory, Cancer and Developmental Cell Biology Division, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore 138673, Republic of Singapore.

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http://dx.doi.org/10.1091/mbc.e08-02-0199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695792PMC
June 2009

Multiscale modeling of form and function.

Science 2009 Apr;324(5924):208-12

Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1126/science.1170107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527531PMC
April 2009

Polarity regulators and the control of epithelial architecture, cell migration, and tumorigenesis.

Int Rev Cytol 2007 ;262:253-302

Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Center, Melbourne, Australia.

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http://dx.doi.org/10.1016/S0074-7696(07)62006-3DOI Listing
August 2007

The Scribble and Par complexes in polarity and migration: friends or foes?

Trends Cell Biol 2006 Dec 25;16(12):622-30. Epub 2006 Oct 25.

Cell Cycle & Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, Melbourne, VIC 3002, Australia.

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http://dx.doi.org/10.1016/j.tcb.2006.10.005DOI Listing
December 2006

New tricks for old dogs: unexpected roles for cell cycle regulators revealed using animal models.

Curr Opin Cell Biol 2004 Dec;16(6):614-22

Cell cycle and cancer genetics laboratory, Research Division, Peter MacCallum Cancer Centre, East Melbourne, Australia.

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http://dx.doi.org/10.1016/j.ceb.2004.09.001DOI Listing
December 2004

Cell-intrinsic requirement for pRb in erythropoiesis.

Blood 2004 Sep 20;104(5):1324-6. Epub 2004 May 20.

Trescowthick Research Laboratories, Peter MacCallum Cancer Centre, Locked Bag 1, A'Beckett St, Melbourne, Victoria 8006, Australia.

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http://dx.doi.org/10.1182/blood-2004-02-0618DOI Listing
September 2004

All known in vivo functions of the Oct-2 transcription factor require the C-terminal protein domain.

J Immunol 2004 Mar;172(5):2962-9

The Walter and Eliza Hall Institute, Parkville, Victoria, Australia.

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http://dx.doi.org/10.4049/jimmunol.172.5.2962DOI Listing
March 2004

hScrib is a functional homologue of the Drosophila tumour suppressor Scribble.

Oncogene 2003 Dec;22(58):9225-30

Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, St Andrew's Place, East Melbourne, Victoria 3002, Australia.

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http://www.nature.com/articles/1207154
Publisher Site
http://dx.doi.org/10.1038/sj.onc.1207154DOI Listing
December 2003