Publications by authors named "Patrick Mathieu"

100Publications

Oxyphospholipids in Cardiovascular Calcification.

Arterioscler Thromb Vasc Biol 2020 Nov 24:ATVBAHA120313790. Epub 2020 Nov 24.

Department of Surgery, Laboratory of Cardiovascular Pathobiology, Quebec Heart and Lung Institute/Research Center, Laval University, Quebec, Canada. (A.C., V.B.-B., M.-C.B., P.M.).

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http://dx.doi.org/10.1161/ATVBAHA.120.313790DOI Listing
November 2020

Association of Bioprosthetic Aortic Valve Leaflet Calcification on Hemodynamic and Clinical Outcomes.

J Am Coll Cardiol 2020 Oct;76(15):1737-1748

Institut Universitaire de Cardiologie et de Pneumologie de Québec (Quebec Heart & Lung Institute), Université Laval, Québec City, Québec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2020.08.034DOI Listing
October 2020

Phenome-wide analyses establish a specific association between aortic valve PALMD expression and calcific aortic valve stenosis.

Commun Biol 2020 Aug 28;3(1):477. Epub 2020 Aug 28.

Institut Universitaire de Cardiologie et de Pneumologie de Québec-Université Laval, Quebec City, QC, G1V 0A6, Canada.

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http://dx.doi.org/10.1038/s42003-020-01210-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455695PMC
August 2020

Visceral adiposity and liver fat as mediators of the association between cardiorespiratory fitness and plasma glucose-insulin homeostasis.

Am J Physiol Endocrinol Metab 2020 Sep 27;319(3):E548-E556. Epub 2020 Jul 27.

Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval, Québec City, Québec, Canada.

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http://dx.doi.org/10.1152/ajpendo.00251.2020DOI Listing
September 2020

Warning AlarmIn Diabetes Mellitus: A Balancing Act Between Inflammation and Redox Signaling in Vascular Mineralization.

Arterioscler Thromb Vasc Biol 2020 08 22;40(8):1804-1807. Epub 2020 Jul 22.

Laboratory of Cardiovascular Pathobiology, Quebec Heart and Lung Institute/Research Center, Department of Surgery, Laval University, Canada.

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http://dx.doi.org/10.1161/ATVBAHA.120.314733DOI Listing
August 2020

Acute and Chronic Impact of Biliopancreatic Diversion with Duodenal Switch Surgery on Plasma Lipoprotein(a) Levels in Patients with Severe Obesity.

Obes Surg 2020 Oct 14;30(10):3714-3720. Epub 2020 Jul 14.

Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Y-3601, Pavillon Marguerite D'Youville, 2725 chemin Ste-Foy, Québec, QC, G1V 4G5, Canada.

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http://dx.doi.org/10.1007/s11695-020-04450-2DOI Listing
October 2020

Dietary sucrose induces metabolic inflammation and atherosclerotic cardiovascular diseases more than dietary fat in LDLrApoB mice.

Atherosclerosis 2020 07 24;304:9-21. Epub 2020 May 24.

Quebec Heart and Lung Institute, Department of Medicine, Faculty of Medicine, Laval University, Quebec City, Quebec, Canada; Institute of Nutraceuticals and Functional Foods, Laval University, Quebec City, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2020.05.002DOI Listing
July 2020

Age, Sex, and Valve Phenotype Differences in Fibro-Calcific Remodeling of Calcified Aortic Valve.

J Am Heart Assoc 2020 May 8;9(10):e015610. Epub 2020 May 8.

Institut Universitaire de Cardiologie et de Pneumologie de Québec/Québec Heart and Lung Institute Université Laval Québec City Québec Canada.

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http://dx.doi.org/10.1161/JAHA.119.015610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660864PMC
May 2020

Single-cell expression and Mendelian randomization analyses identify blood genes associated with lifespan and chronic diseases.

Commun Biol 2020 May 1;3(1):206. Epub 2020 May 1.

Laboratory of Cardiovascular Pathobiology, Department of Surgery, Quebec Heart and Lung Institute/Research Center, Laval University, Quebec, QC, Canada.

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http://dx.doi.org/10.1038/s42003-020-0937-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195437PMC
May 2020

A Mendelian randomization study of IL6 signaling in cardiovascular diseases, immune-related disorders and longevity.

NPJ Genom Med 2019 20;4:23. Epub 2019 Sep 20.

1Laboratory of Cardiovascular Pathobiology, Quebec Heart and Lung Institute/Research Center, Department of Surgery, Laval University, Quebec, Canada.

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http://dx.doi.org/10.1038/s41525-019-0097-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754413PMC
September 2019

Enhancer-mediated enrichment of interacting JMJD3-DDX21 to ENPP2 locus prevents R-loop formation and promotes transcription.

Nucleic Acids Res 2019 09;47(16):8424-8438

Laboratory of Cardiovascular Pathobiology, Quebec Heart and Lung Institute/Research Center, Department of Surgery, Laval University, Quebec G1V-4G5, Canada.

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http://dx.doi.org/10.1093/nar/gkz560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895255PMC
September 2019

UCP1 expression-associated gene signatures of human epicardial adipose tissue.

JCI Insight 2019 04 18;4(8). Epub 2019 Apr 18.

Department of Medicine, Faculty of Medicine, Université Laval, Québec, Québec, Canada.

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https://insight.jci.org/articles/view/123618
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http://dx.doi.org/10.1172/jci.insight.123618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538324PMC
April 2019

Autotaxin and Lipoprotein Metabolism in Calcific Aortic Valve Disease.

Front Cardiovasc Med 2019 1;6:18. Epub 2019 Mar 1.

Laboratory of Cardiovascular Pathobiology, Department of Surgery, Research Center, Quebec Heart and Lung Institute, Laval University, Quebec, QC, Canada.

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http://dx.doi.org/10.3389/fcvm.2019.00018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405425PMC
March 2019

PALMD as a novel target for calcific aortic valve stenosis.

Curr Opin Cardiol 2019 03;34(2):105-111

Institut Universitaire de Cardiologie et de Pneumologie de Québec.

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http://dx.doi.org/10.1097/HCO.0000000000000605DOI Listing
March 2019

Activated platelets promote an osteogenic programme and the progression of calcific aortic valve stenosis.

Eur Heart J 2019 05;40(17):1362-1373

Laboratory of Cardiovascular Pathobiology, Department of Surgery, Quebec Heart and Lung Institute/Research Center, Laval University, 2725 chemin Ste-Foy, Quebec, Canada.

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http://dx.doi.org/10.1093/eurheartj/ehy696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492053PMC
May 2019

Rate, Timing, Correlates, and Outcomes of Hemodynamic Valve Deterioration After Bioprosthetic Surgical Aortic Valve Replacement.

Circulation 2018 09;138(10):971-985

Institut Universitaire de Cardiologie et de Pneumologie de Québec/Québec Heart and Lung Institute, Laval University, Canada (E.S., H.M., F.D., P.V., S.M., D.K., R.P., N.C., J.R.-C., P.M., M.-A.C., P.P.).

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.118.0
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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.035150DOI Listing
September 2018

Life's simple 7 and calcific aortic valve stenosis incidence in apparently healthy men and women.

Int J Cardiol 2018 Oct 24;269:226-228. Epub 2018 Jul 24.

Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Canada; Department of Medicine, Faculty of Medicine, Université Laval, Québec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2018.07.107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481556PMC
October 2018

Hemodynamic Deterioration of Surgically Implanted Bioprosthetic Aortic Valves.

J Am Coll Cardiol 2018 07 9;72(3):241-251. Epub 2018 Jul 9.

Institut Universitaire de Cardiologie et de Pneumologie de Québec/Québec Heart & Lung Institute, Laval University, Quebec City, Québec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2018.04.064DOI Listing
July 2018

Soluble CD14 is associated with the structural failure of bioprostheses.

Clin Chim Acta 2018 Oct 30;485:173-177. Epub 2018 Jun 30.

Laboratory of Cardiovascular Pathobiology, Quebec Heart and Lung Institute/Research Center, Department of Surgery, Laval University, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cca.2018.06.045DOI Listing
October 2018

GATA6 Regulates Aortic Valve Remodeling, and Its Haploinsufficiency Leads to Right-Left Type Bicuspid Aortic Valve.

Circulation 2018 09;138(10):1025-1038

Department of Biochemistry, Microbiology, and Immunology, Molecular Genetics and Cardiac Regeneration Laboratory, University of Ottawa, Ontario, Canada (L.G., H.K., R.H., M.T., M.N.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.029506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151169PMC
September 2018

Synthesis and biological evaluation of novel quinazoline-4-piperidinesulfamide derivatives as inhibitors of NPP1.

Eur J Med Chem 2018 Mar 2;147:130-149. Epub 2018 Feb 2.

PROTEO, CCVC, Département de chimie, Université Laval, Québec, QC G1V 0A6, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2018.01.094DOI Listing
March 2018

Functional characterization of the Ucp1-associated oxidative phenotype of human epicardial adipose tissue.

Sci Rep 2017 Nov 14;7(1):15566. Epub 2017 Nov 14.

Institut universitaire de cardiologie et de pneumologie de Québec (IUCPQ), 2725 Chemin Sainte-Foy, Québec, G1V 4G5, Canada.

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http://dx.doi.org/10.1038/s41598-017-15501-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686183PMC
November 2017

Do Oxidized Lipoproteins Cause Atherosclerotic Cardiovascular Diseases?

Can J Cardiol 2017 12 6;33(12):1513-1516. Epub 2017 Oct 6.

Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Québec City, Québec, Canada; Department of Surgery, Faculty of Medicine, Université Laval, Québec City, Québec, Canada.

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http://dx.doi.org/10.1016/j.cjca.2017.09.016DOI Listing
December 2017

B-Type Natriuretic Peptide and High-Sensitivity Cardiac Troponin for Risk Stratification in Low-Flow, Low-Gradient Aortic Stenosis: A Substudy of the TOPAS Study.

JACC Cardiovasc Imaging 2018 07 5;11(7):939-947. Epub 2017 Oct 5.

Institut Universitaire de Cardiologie et de Pneumologie de Québec/Québec Heart & Lung Institute, Laval University, Québec, Québec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jcmg.2017.06.018DOI Listing
July 2018

Pathobiology of Lp(a) in calcific aortic valve disease.

Expert Rev Cardiovasc Ther 2017 Oct 24;15(10):797-807. Epub 2017 Aug 24.

d Robarts Research Institute , London , ON , Canada.

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http://dx.doi.org/10.1080/14779072.2017.1367286DOI Listing
October 2017

Characterization of the structure, dynamics and allosteric pathways of human NPP1 in its free form and substrate-bound complex from molecular modeling.

Mol Biosyst 2017 May;13(6):1058-1069

Department of Chemistry, Faculty of Science and Engineering, Université Laval, Québec (Québec), Canada.

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http://dx.doi.org/10.1039/c7mb00095bDOI Listing
May 2017

OxLDL-derived lysophosphatidic acid promotes the progression of aortic valve stenosis through a LPAR1-RhoA-NF-κB pathway.

Cardiovasc Res 2017 Sep;113(11):1351-1363

Laboratory of Cardiovascular Pathobiology, Institut Universitaire de Cardiologie et de Pneumologie de Québec/Quebec Heart and Lung Institute, Research Center, Department of Surgery, Laval University, 2725 Chemin Ste-Foy, Quebec, Quebec G1V-4G5, Canada.

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http://dx.doi.org/10.1093/cvr/cvx089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852522PMC
September 2017

CAVD: civilization aortic valve disease.

Eur Heart J 2017 07;38(28):2198-2200

Department of Medicine, Laval University, Quebec, Canada.

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http://dx.doi.org/10.1093/eurheartj/ehx219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837646PMC
July 2017

Impact of a 1-year lifestyle modification program on plasma lipoprotein and PCSK9 concentrations in patients with coronary artery disease.

J Clin Lipidol 2016 Nov - Dec;10(6):1353-1361. Epub 2016 Sep 2.

Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Quebec City, Québec, Canada; Department of medicine, Faculty of Medicine, Université Laval, Quebec City, Québec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jacl.2016.08.014DOI Listing
October 2017

Synthesis of novel substituted pyrimidine derivatives bearing a sulfamide group and their in vitro cancer growth inhibition activity.

Bioorg Med Chem Lett 2017 01 19;27(2):299-302. Epub 2016 Nov 19.

PROTEO, Département de chimie, Université Laval, Québec, QC G1V 0A6, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2016.11.052DOI Listing
January 2017

Sex-Related Discordance Between Aortic Valve Calcification and Hemodynamic Severity of Aortic Stenosis: Is Valvular Fibrosis the Explanation?

Circ Res 2017 Feb 22;120(4):681-691. Epub 2016 Nov 22.

From the Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Québec, Canada.

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http://dx.doi.org/10.1161/CIRCRESAHA.116.309306DOI Listing
February 2017

Altered DNA Methylation of Long Noncoding RNA H19 in Calcific Aortic Valve Disease Promotes Mineralization by Silencing NOTCH1.

Circulation 2016 Dec 27;134(23):1848-1862. Epub 2016 Oct 27.

From Laboratory of Cardiovascular Pathobiology, Quebec Heart and Lung Institute/Research Center, Department of Surgery (F.H., M.-C.B, N.G., S.A., G.M., R.B., M.J.N., P.M.), Department of Molecular Medicine (J.T.M., S.G.-O., Y.B.), and Department of Medicine (P.P.), Laval University, Quebec, QC, Canada; Department of Biochemistry, Université de Sherbrooke, Sherbrooke, QC, Canada (S.-P.G., L.B.); and ECOGENE-21 and Lipid Clinic, Chicoutimi Hospital, Saguenay, QC, Canada (S.-P.G., L.B.).

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http://circ.ahajournals.org/content/early/2016/10/26/CIRCULA
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http://circ.ahajournals.org/content/circulationaha/134/23/18
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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.023116DOI Listing
December 2016

Effect of age and aortic valve anatomy on calcification and haemodynamic severity of aortic stenosis.

Heart 2017 01 8;103(1):32-39. Epub 2016 Aug 8.

Institut Universitaire de Cardiologie et de Pneumologie de Québec/Quebec Heart & Lung Institute, Laval University, Quebec City, Quebec, Canada.

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http://dx.doi.org/10.1136/heartjnl-2016-309665DOI Listing
January 2017

RNA expression profile of calcified bicuspid, tricuspid, and normal human aortic valves by RNA sequencing.

Physiol Genomics 2016 10 5;48(10):749-761. Epub 2016 Aug 5.

Centre de recherche Institut universitaire de cardiologie et de pneumologie de Québec, Laval University, Quebec, Canada; Department of Molecular Medicine, Laval University, Quebec, Canada

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http://dx.doi.org/10.1152/physiolgenomics.00041.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195654PMC
October 2016

Association between plasma lipoprotein levels and bioprosthetic valve structural degeneration.

Heart 2016 12 4;102(23):1915-1921. Epub 2016 Jul 4.

Laboratory of Cardiovascular Pathobiology, Department of Surgery, Quebec Heart and Lung Institute/Research Center, Laval University, Quebec, Quebec, Canada.

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http://dx.doi.org/10.1136/heartjnl-2016-309541DOI Listing
December 2016

Calcific aortic stenosis.

Nat Rev Dis Primers 2016 03 3;2:16006. Epub 2016 Mar 3.

Québec Heart and Lung Institute, Department of Medicine, Laval University, 2725 Chemin Sainte-Foy, Québec City, Québec G1V 4G5, Canada.

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http://dx.doi.org/10.1038/nrdp.2016.6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127286PMC
March 2016

Pathophysiology and management of multivalvular disease.

Nat Rev Cardiol 2016 07 28;13(7):429-40. Epub 2016 Apr 28.

Quebec Heart &Lung Institute, Department of Medicine, Laval University, Chemin Sainte-Foy, Quebec City, QC, G1V 4G5, Canada.

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http://dx.doi.org/10.1038/nrcardio.2016.57DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129845PMC
July 2016

Quantification of Treatment Effect Modification on Both an Additive and Multiplicative Scale.

PLoS One 2016 5;11(4):e0153010. Epub 2016 Apr 5.

Hospices Civils de Lyon, Service de Biostatistiques, Lyon, F-69003, France, Université de Lyon, Lyon, F-69000, France, Université Lyon I, Villeurbanne, F-69100, France, CNRS, UMR5558, Laboratoire de Biométrie et Biologie Evolutive, Equipe Biostatistiques Santé, Villeurbanne, F-69100, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0153010PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821587PMC
August 2016

Epigenetic and genetic variations at the TNNT1 gene locus are associated with HDL-C levels and coronary artery disease.

Epigenomics 2016 Mar 7;8(3):359-71. Epub 2016 Mar 7.

Department of Biochemistry, Université de Sherbrooke, Sherbrooke, QC J1K 2R1, Canada.

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http://dx.doi.org/10.2217/epi.15.120DOI Listing
March 2016

Systolic hypertension and progression of aortic valve calcification in patients with aortic stenosis: results from the PROGRESSA study.

Eur Heart J Cardiovasc Imaging 2017 Jan 18;18(1):70-78. Epub 2016 Feb 18.

Institut Universitaire de Cardiologie et de Pneumologie de Québec/Québec Heart and Lung Institute, Laval University, 2725 Chemin Sainte-Foy, Québec city, Québec, Canada G1V-4G5

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http://dx.doi.org/10.1093/ehjci/jew013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217738PMC
January 2017

Circulating Lp-PLA2 is associated with high valvuloarterial impedance and low arterial compliance in patients with aortic valve bioprostheses.

Clin Chim Acta 2016 Apr 18;455:20-5. Epub 2016 Jan 18.

Laboratoire d'Études Moléculaires des Valvulopathies (LEMV), Groupe de Recherche en Valvulopathies (GRV), Quebec Heart and Lung Institute/Research Center, Department of Surgery, Laval University, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cca.2016.01.014DOI Listing
April 2016

Identification of Gender-Specific Genetic Variants in Patients With Bicuspid Aortic Valve.

Am J Cardiol 2016 Feb 19;117(3):420-6. Epub 2015 Nov 19.

Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (CRIUCPQ), Quebec City, Quebec, Canada; Department of Molecular Medicine, Laval University, Quebec City, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.amjcard.2015.10.058DOI Listing
February 2016

Calcium Signaling Pathway Genes RUNX2 and CACNA1C Are Associated With Calcific Aortic Valve Disease.

Circ Cardiovasc Genet 2015 Dec 9;8(6):812-22. Epub 2015 Nov 9.

From the Centre de recherche Institut universitaire de cardiologie et de pneumologie de Québec, Quebec, Canada (S.G.-O., M.L., J.T.-M., E.L.-C., N.G., P.M., P.P., Y.B.); Departments of Molecular Medicine (A.D., Y.B.), Surgery (P.M.), and Medicine (P.P.), Laval University, Quebec, Canada; Cardiology Department, AP-HP, Bichat Hospital, Paris, France (D.M.-Z.); INSERM U698, Paris, France (D.M.-Z.); Département de Génétique, Hôpital Bichat, 75018 Paris, France (C.B.); Centre de Recherche du CHUQ, Quebec, Canada (A.D.); Montreal Heart Institute, Department of Medicine (M.-P.D., J.-C.T.), Université de Montréal, Montreal, Canada (B.J.A.); Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA (S.C.B.); and Department of Genetics, Harvard Medical School, Boston, MA (J.G.S.).

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http://dx.doi.org/10.1161/CIRCGENETICS.115.001145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4934886PMC
December 2015

The Underestimated Belly Factor: Waist Circumference Is Linked to Significant Morbidity Following Isolated Coronary Artery Bypass Grafting.

Can J Cardiol 2016 Mar 7;32(3):327-35. Epub 2015 Jul 7.

Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Ste-Foy, Québec, Canada; Faculty of Pharmacy, Université Laval, Ste-Foy, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cjca.2015.06.031DOI Listing
March 2016

Oxidized Phospholipids, Lipoprotein(a), and Progression of Calcific Aortic Valve Stenosis.

J Am Coll Cardiol 2015 Sep;66(11):1236-1246

Division of Cardiovascular Diseases, Department of Medicine, University of California San Diego, La Jolla, California. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2015.07.020DOI Listing
September 2015

Relationship Between Insulin-Like Growth Factor Binding Protein-2 and Left Ventricular Stroke Volume in Patients With Aortic Stenosis.

Can J Cardiol 2015 Dec 30;31(12):1447-54. Epub 2015 Apr 30.

Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Québec, Québec, Canada; Faculty of Pharmacy, Université Laval, Québec, Québec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cjca.2015.04.024DOI Listing
December 2015

Autotaxin Derived From Lipoprotein(a) and Valve Interstitial Cells Promotes Inflammation and Mineralization of the Aortic Valve.

Circulation 2015 Aug 29;132(8):677-90. Epub 2015 Jul 29.

From Laboratoire d'Études Moléculaires des Valvulopathies (LEMV), Groupe de Recherche en Valvulopathies (GRV), Quebec Heart and Lung Institute/Research Center, Department of Surgery (R.B., A.M., M.J.N., M.-C.B., J.-L.L., M.-H.L., F.H., P.M.), Department of Medicine (A.D., P.P., B.J.A., A.M.), Department of Pathology (C.C., S.T., S.P.), and Department of Molecular Medicine (Y.B.), Laval University, Québec, Canada; and Department of Chemistry and Biochemistry, University of Windsor, Ontario, Canada (C.A.S., R.R., M.L.K.).

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http://circ.ahajournals.org/content/early/2015/07/29/CIRCULA
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http://circ.ahajournals.org/lookup/doi/10.1161/CIRCULATIONAH
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http://dx.doi.org/10.1161/CIRCULATIONAHA.115.016757DOI Listing
August 2015

Innate and Adaptive Immunity in Calcific Aortic Valve Disease.

J Immunol Res 2015 3;2015:851945. Epub 2015 May 3.

Laboratoire d'Études Moléculaires des Valvulopathies (LEMV), Groupe de Recherche en Valvulopathies (GRV), Quebec Heart and Lung Institute/Research Center, Department of Surgery, Laval University, QC, Canada ; Institut de Cardiologie et de Pneumologie de Québec, 2725 Chemin Sainte-Foy, Québec, QC, Canada G1V 4G5.

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http://www.hindawi.com/journals/jir/2015/851945/
Publisher Site
http://dx.doi.org/10.1155/2015/851945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433691PMC
March 2016

Quinazoline-4-piperidine sulfamides are specific inhibitors of human NPP1 and prevent pathological mineralization of valve interstitial cells.

Br J Pharmacol 2015 Aug 8;172(16):4189-99. Epub 2015 Jul 8.

Laboratoire d'Études Moléculaires des Valvulopathies (LEMV), Groupe de Recherche en Valvulopathies (GRV), Quebec Heart and Lung Institute/Research Center, Department of Surgery, Université Laval, QC, Canada.

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http://dx.doi.org/10.1111/bph.13204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4543622PMC
August 2015

Carbonic anhydrase XII in valve interstitial cells promotes the regression of calcific aortic valve stenosis.

J Mol Cell Cardiol 2015 May 11;82:104-15. Epub 2015 Mar 11.

Laboratoire d'Études Moléculaires des Valvulopathies (LEMV), Groupe de Recherche en Valvulopathies (GRV), Quebec Heart and Lung Institute/Research Center, Department of Surgery, Laval University, Québec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2015.03.002DOI Listing
May 2015

A study in familial hypercholesterolemia suggests reduced methylomic plasticity in men with coronary artery disease.

Epigenomics 2015 ;7(1):17-34

Department of Biochemistry, Université de Sherbrooke, University-Affiliated Chicoutimi Hospital, 305 rue St-Vallier, Saguenay, Québec G7H 5H6, Canada.

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http://dx.doi.org/10.2217/epi.14.64DOI Listing
September 2015

Impact of classic and paradoxical low flow on survival after aortic valve replacement for severe aortic stenosis.

J Am Coll Cardiol 2015 Feb;65(7):645-53

Institut Universitaire de Cardiologie et de Pneumologie de Québec/Québec Heart and Lung Institute, Laval University, Québec City, Québec, Canada.

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http://dx.doi.org/10.1016/j.jacc.2014.11.047DOI Listing
February 2015

Adenosine derived from ecto-nucleotidases in calcific aortic valve disease promotes mineralization through A2a adenosine receptor.

Cardiovasc Res 2015 Apr 2;106(1):109-20. Epub 2015 Feb 2.

Laboratoire d'Études Moléculaires des Valvulopathies (LEMV), Groupe de Recherche en Valvulopathies (GRV), Quebec Heart and Lung Institute/Research Center, Department of Surgery, Laval University, 2725 Chemin Ste-Foy, Quebec, Canada G1V-4G5

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http://dx.doi.org/10.1093/cvr/cvv027DOI Listing
April 2015

Determinants of aortic bioprosthetic valve calcification assessed by multidetector CT.

Heart 2015 Mar 24;101(6):472-7. Epub 2015 Jan 24.

Institut Universitaire de Cardiologie et de Pneumologie de Québec/Québec Heart & Lung Institute, Laval University, Québec, Canada.

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http://heart.bmj.com/cgi/doi/10.1136/heartjnl-2014-306445
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March 2015

Impact of plasma Lp-PLA2 activity on the progression of aortic stenosis: the PROGRESSA study.

JACC Cardiovasc Imaging 2015 Jan 1;8(1):26-33. Epub 2014 Nov 1.

Institut Universitaire de Cardiologie et de Pneumologie de Québec/Québec Heart and Lung Institute, Laval University, Québec City, Québec, Canada. Electronic address:

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http://imaging.onlinejacc.org/data/Journals/JCMG/931902/0901
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http://dx.doi.org/10.1016/j.jcmg.2014.09.016DOI Listing
January 2015

Valve tissue characterization by magnetic resonance imaging in calcific aortic valve disease.

Can J Cardiol 2014 Dec 7;30(12):1676-83. Epub 2014 Oct 7.

Département Multidisciplinaire De Cardiologie, Institut Universitaire de Cardiologie et de pneumologie de Québec, and Faculté de Médecine de l'Université Laval, Québec, Québec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cjca.2014.09.036DOI Listing
December 2014

Ectopic visceral fat: a clinical and molecular perspective on the cardiometabolic risk.

Rev Endocr Metab Disord 2014 Dec;15(4):289-98

Institut de Cardiologie et de Pneumologie de Québec/Quebec Heart and Lung Institute, 2725 Chemin Ste-Foy, Québec, QC, G1V-4G5, Canada,

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http://dx.doi.org/10.1007/s11154-014-9299-3DOI Listing
December 2014

Supported core-shell nanobiosensors for quantitative fluorescence imaging of extracellular pH.

Chem Commun (Camb) 2014 Nov;50(89):13746-9

Département de chimie, Faculté de Sciences et Génie, Université Laval, Québec (QC), Canada G1V 0A6.

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http://dx.doi.org/10.1039/c4cc06075jDOI Listing
November 2014

Early development of calcific aortic valve disease and left ventricular hypertrophy in a mouse model of combined dyslipidemia and type 2 diabetes mellitus.

Arterioscler Thromb Vasc Biol 2014 Oct 14;34(10):2283-91. Epub 2014 Aug 14.

From the Heart and Lung Institute, Laval University, Sainte-Foy, Québec, Canada (K.L.Q., R.B., D.L., M.-A.L., D.E.H., M.-C.B., D.F., X.P.F., R.K.A., P.P., Y.D., P.M., A.M.); and Department of Biology, York University, Toronto, Ontario, Canada (X.P.F., G.S.).

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http://dx.doi.org/10.1161/ATVBAHA.114.304205DOI Listing
October 2014

Parathyroid hormone is associated with the LV mass after aortic valve replacement.

Heart 2014 Dec 5;100(23):1859-64. Epub 2014 Aug 5.

Laboratoire d'Études Moléculaires des Valvulopathies (LEMV), Department of Surgery, Groupe de Recherche en Valvulopathies (GRV), Quebec Heart and Lung Institute/Research Center, Laval University, Quebec, Canada.

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http://dx.doi.org/10.1136/heartjnl-2014-305837DOI Listing
December 2014

Acetylsalicylic acid, aging and coronary artery disease are associated with ABCA1 DNA methylation in men.

Clin Epigenetics 2014 29;6(1):14. Epub 2014 Jul 29.

Department of Biochemistry, Faculté de médecine et des sciences de la santé, de l'Université de Sherbrooke, 3001 12e Avenue Nord, Sherbrooke, Québec J1H 5 N4, Canada ; ECOGENE-21 and Lipid Clinic, Chicoutimi Hospital, 305 rue St-Vallier, Saguenay, Québec G7H5H6, Canada.

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http://dx.doi.org/10.1186/1868-7083-6-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120725PMC
August 2014

Basic mechanisms of calcific aortic valve disease.

Can J Cardiol 2014 Sep 27;30(9):982-93. Epub 2014 Mar 27.

Laboratoire d'Études Moléculaires des Valvulopathies (LEMV), Groupe de Recherche en Valvulopathies (GRV), Québec Heart and Lung Institute/Research Center, Department of Surgery, Laval University, Québec, Québec, Canada.

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http://dx.doi.org/10.1016/j.cjca.2014.03.029DOI Listing
September 2014

Circulating levels of matrix gla protein and progression of aortic stenosis: a substudy of the Aortic Stenosis Progression Observation: Measuring Effects of rosuvastatin (ASTRONOMER) trial.

Can J Cardiol 2014 Sep 24;30(9):1088-95. Epub 2014 Mar 24.

Institut Universitaire de Cardiologie et de Pneumologie de Québec, Québec Heart and Lung Institute, Laval University, Québec City, Québec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cjca.2014.03.025DOI Listing
September 2014

Visceral adiposity and left ventricular mass and function in patients with aortic stenosis: the PROGRESSA study.

Can J Cardiol 2014 Sep 19;30(9):1080-7. Epub 2014 Feb 19.

Institut Universitaire de Cardiologie et de Pneumologie de Québec/Québec Heart and Lung Institute, Laval University, Québec City, Québec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cjca.2014.02.007DOI Listing
September 2014

Bicuspid aortic valve: identifying knowledge gaps and rising to the challenge from the International Bicuspid Aortic Valve Consortium (BAVCon).

Circulation 2014 Jun;129(25):2691-704

From the Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN (H.I.M., N.A., M.E.-S.); Division of Medical Genetics; Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, TX (S.K.P., D.M.M.); Department of Cardiothoracic Sciences, Second University of Naples, Naples, Italy (A.D.C.); Department of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, United Kingdom (M.M.B.); Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Québec, Canada (P.M., Y.B., P.P.); Cardiologia SUN, Monaldi Hospital, Naples, Italy (G.L.); Cardiology Division, "Cava de' Tirreni and Amalfi Coast" Hospital, Heart Department, University of Salerno, Italy (E.B.); Children's Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, WI (D.W.B.); University Hospital of Liège, GIGA Cardiovascular Sciences, CHU Sart Tilman, Liège, Belgium (P.L.); Heart Center and Thoracic Aortic Center, Massachusetts General Hospital, Boston, MA (E.M.I.); Division of Cardiac Surgery and Corrigan Minehan Heart Center, Massachusetts General Hospital, Boston, MA (T.M.S.); Servei de Cardiologia, Hospital Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain (A.E.); and Dept of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (S.C.B.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.113.007851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145814PMC
June 2014

Molecular biology of calcific aortic valve disease: towards new pharmacological therapies.

Expert Rev Cardiovasc Ther 2014 Jul 24;12(7):851-62. Epub 2014 May 24.

Department of Surgery, Laboratoire d'Études Moléculaires des Valvulopathies (LEMV), Groupe de Recherche en Valvulopathies (GRV), Quebec Heart and Lung Institute/Research Center, Laval University, Quebec, Canada.

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http://dx.doi.org/10.1586/14779072.2014.923756DOI Listing
July 2014

Paradoxical low-flow, low-gradient aortic stenosis despite preserved left ventricular ejection fraction: new insights from weights of operatively excised aortic valves.

Eur Heart J 2014 Oct 21;35(38):2655-62. Epub 2014 Apr 21.

Department of Cardiology, Institut Universitaire de Cardiologie et de Pneumologie de Québec/Québec Heart & Lung Institute, Laval University, 2725 Chemin Sainte-Foy, Québec, Canada G1V-4G5

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http://dx.doi.org/10.1093/eurheartj/ehu152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187204PMC
October 2014

P2Y2 receptor represses IL-6 expression by valve interstitial cells through Akt: implication for calcific aortic valve disease.

J Mol Cell Cardiol 2014 Jul 11;72:146-56. Epub 2014 Mar 11.

Laboratoire d'Études Moléculaires des Valvulopathies (LEMV), Groupe de Recherche en Valvulopathies (GRV), Quebec Heart and Lung Institute/Research Center, Department of Surgery, Laval University, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2014.02.014DOI Listing
July 2014

The genetic and metabolic determinants of cardiovascular complications in type 2 diabetes: recent insights from animal models and clinical investigations.

Can J Diabetes 2013 Oct;37(5):351-8

Centre de recherche de l'Institut Universitaire de Cardiologie et Pneumologie de Québec, Pavillon Marguerite d'Youville, Ste-Foy, Canada; Institute of Nutrition and Functional Foods, 2440, boul. Hochelaga, Québec City, Québec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jcjd.2013.08.262DOI Listing
October 2013

Mechanical strain induces the production of spheroid mineralized microparticles in the aortic valve through a RhoA/ROCK-dependent mechanism.

J Mol Cell Cardiol 2014 Feb 22;67:49-59. Epub 2013 Dec 22.

Laboratoire d'Études Moléculaires des Valvulopathies (LEMV), Groupe de Recherche en Valvulopathies (GRV), Quebec Heart and Lung Institute/Research Center, Department of Surgery, Laval University, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2013.12.009DOI Listing
February 2014

Evaluation of links between high-density lipoprotein genetics, functionality, and aortic valve stenosis risk in humans.

Arterioscler Thromb Vasc Biol 2014 Feb 12;34(2):457-62. Epub 2013 Dec 12.

From the Montreal Heart Institute, Montreal, Canada (B.J.A., M.-P.D., M.R.B., A.B.d.O.M., V.L., A.-E.K., D.R., É.R., J.-C.T.); Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Canada (B.J.A., M.-P.D., M.R.B., A.B.d.O.M., É.R., J.-C.T.); Beaulieu-Saucier Université de Montréal Pharmacogenomics Centre, Montreal, Canada (M.-P.D., J.-C.T.); Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Québec (S.G.-O., P.M., P.P., Y.B.) and Department of Molecular Medicine (Y.B.), Laval University, Québec, Canada; Cardiology Department, AP-HP, Bichat Hospital, Paris, France (D.M.-Z.); and INSERM U698, University Paris 7, Paris, France (D.M.-Z.).

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http://dx.doi.org/10.1161/ATVBAHA.113.302730DOI Listing
February 2014

Lp-PLA2 is associated with structural valve degeneration of bioprostheses.

Eur J Clin Invest 2014 Feb 28;44(2):136-45. Epub 2013 Nov 28.

Laboratoire d'Études Moléculaires des Valvulopathies (LEMV), Groupe de Recherche en Valvulopathies (GRV), Department of Surgery, Quebec Heart and Lung Institute/Research Center, Laval University, Quebec, QC, Canada.

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http://dx.doi.org/10.1111/eci.12199DOI Listing
February 2014

Elevated expression of lipoprotein-associated phospholipase A2 in calcific aortic valve disease: implications for valve mineralization.

J Am Coll Cardiol 2014 Feb 23;63(5):460-9. Epub 2013 Oct 23.

Laboratoire d'Études Moléculaires des Valvulopathies, Groupe de Recherche en Valvulopathies, Quebec Heart and Lung Institute/Research Center, Department of Surgery, Laval University, Quebec City, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2013.05.105DOI Listing
February 2014