Patrick M Nolan

Patrick M Nolan

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Patrick M Nolan

Patrick M Nolan

Publications by authors named "Patrick M Nolan"

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The guanine nucleotide exchange factor, Spata13, influences social behaviour and nocturnal activity.

Mamm Genome 2019 04 24;30(3-4):54-62. Epub 2019 Apr 24.

MRC Harwell Institute, Harwell Campus, Didcot, Oxfordshire, OX11 0RD, UK.

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http://dx.doi.org/10.1007/s00335-019-09800-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491400PMC
April 2019

Assessing mouse behaviour throughout the light/dark cycle using automated in-cage analysis tools.

J Neurosci Methods 2018 04 26;300:37-47. Epub 2017 Apr 26.

Mammalian Genetics Unit, MRC Harwell Institute, Harwell Science Campus, Oxfordshire, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jneumeth.2017.04.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909039PMC
April 2018

The after-hours circadian mutant has reduced phenotypic plasticity in behaviors at multiple timescales and in sleep homeostasis.

Sci Rep 2017 12 19;7(1):17765. Epub 2017 Dec 19.

Department of Neuroscience and Brain Technologies - Genetics and Epigenetics of Behaviour - Istituto Italiano di Tecnologia, via Morego, 30, 16163, Genova, Italy.

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http://dx.doi.org/10.1038/s41598-017-18130-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736711PMC
December 2017

Meta-analysis of transcriptomic datasets identifies genes enriched in the mammalian circadian pacemaker.

Nucleic Acids Res 2017 Sep;45(17):9860-9873

Sleep and Circadian Neuroscience Institute (SCNi), Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OX1 3RE, UK.

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http://dx.doi.org/10.1093/nar/gkx714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737434PMC
September 2017

Phenotyping first-generation genome editing mutants: a new standard?

Mamm Genome 2017 08 29;28(7-8):377-382. Epub 2017 Jul 29.

Mammalian Genetics Unit, MRC Harwell Institute, Harwell Science Campus, Didcot, Oxfordshire, UK.

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http://link.springer.com/10.1007/s00335-017-9711-x
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http://dx.doi.org/10.1007/s00335-017-9711-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569115PMC
August 2017

Reciprocal interactions between circadian clocks and aging.

Mamm Genome 2016 08 2;27(7-8):332-40. Epub 2016 May 2.

Sleep and Circadian Neuroscience Institute (SCNi), Nuffield Department of Clinical Neurosciences, Oxford Molecular Pathology Institute, Sir William Dunn School of Pathology, South Parks Road, Oxfordshire, OX1 3RE, UK.

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http://dx.doi.org/10.1007/s00335-016-9639-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935744PMC
August 2016

The Zfhx3-Mediated Axis Regulates Sleep and Interval Timing in Mice.

Cell Rep 2016 07 30;16(3):615-21. Epub 2016 Jun 30.

Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, via Morego, 30, 16163 Genova, Italy. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247163075
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http://dx.doi.org/10.1016/j.celrep.2016.06.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991551PMC
July 2016

Loss-of-Function Mutations in FRRS1L Lead to an Epileptic-Dyskinetic Encephalopathy.

Am J Hum Genet 2016 06 26;98(6):1249-1255. Epub 2016 May 26.

Children's Health Research Center, Sanford Research, Sioux Falls, SD 57104, USA; Department of Child Health, University of Arizona College of Medicine, Phoenix, AZ 85004, USA; Neurogenetics Research Program, Barrow Neurological Institute, Phoenix Children's Hospital, Phoenix, AZ 85016, USA; Program in Neuroscience, Arizona State University, Tempe, AZ 85287, USA; Pediatric Movement Disorders Center, Barrow Neurological Institute, Phoenix Children's Hospital, Phoenix, AZ 85016, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2016.04.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908178PMC
June 2016

Melanopsin Regulates Both Sleep-Promoting and Arousal-Promoting Responses to Light.

PLoS Biol 2016 06 8;14(6):e1002482. Epub 2016 Jun 8.

Sleep and Circadian Neuroscience Institute (SCNi), Nuffield Department of Clinical Neurosciences, Oxford Molecular Pathology Institute, Dunn School of Pathology, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1371/journal.pbio.1002482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898879PMC
June 2016

Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics.

Authors:
Martin Hrabě de Angelis George Nicholson Mohammed Selloum Jacqui White Hugh Morgan Ramiro Ramirez-Solis Tania Sorg Sara Wells Helmut Fuchs Martin Fray David J Adams Niels C Adams Thure Adler Antonio Aguilar-Pimentel Dalila Ali-Hadji Gregory Amann Philippe André Sarah Atkins Aurelie Auburtin Abdel Ayadi Julien Becker Lore Becker Elodie Bedu Raffi Bekeredjian Marie-Christine Birling Andrew Blake Joanna Bottomley Mike Bowl Véronique Brault Dirk H Busch James N Bussell Julia Calzada-Wack Heather Cater Marie-France Champy Philippe Charles Claire Chevalier Francesco Chiani Gemma F Codner Roy Combe Roger Cox Emilie Dalloneau André Dierich Armida Di Fenza Brendan Doe Arnaud Duchon Oliver Eickelberg Chris T Esapa Lahcen El Fertak Tanja Feigel Irina Emelyanova Jeanne Estabel Jack Favor Ann Flenniken Alessia Gambadoro Lilian Garrett Hilary Gates Anna-Karin Gerdin George Gkoutos Simon Greenaway Lisa Glasl Patrice Goetz Isabelle Goncalves Da Cruz Alexander Götz Jochen Graw Alain Guimond Wolfgang Hans Geoff Hicks Sabine M Hölter Heinz Höfler John M Hancock Robert Hoehndorf Tertius Hough Richard Houghton Anja Hurt Boris Ivandic Hughes Jacobs Sylvie Jacquot Nora Jones Natasha A Karp Hugo A Katus Sharon Kitchen Tanja Klein-Rodewald Martin Klingenspor Thomas Klopstock Valerie Lalanne Sophie Leblanc Christoph Lengger Elise le Marchand Tonia Ludwig Aline Lux Colin McKerlie Holger Maier Jean-Louis Mandel Susan Marschall Manuel Mark David G Melvin Hamid Meziane Kateryna Micklich Christophe Mittelhauser Laurent Monassier David Moulaert Stéphanie Muller Beatrix Naton Frauke Neff Patrick M Nolan Lauryl Mj Nutter Markus Ollert Guillaume Pavlovic Natalia S Pellegata Emilie Peter Benoit Petit-Demoulière Amanda Pickard Christine Podrini Paul Potter Laurent Pouilly Oliver Puk David Richardson Stephane Rousseau Leticia Quintanilla-Fend Mohamed M Quwailid Ildiko Racz Birgit Rathkolb Fabrice Riet Janet Rossant Michel Roux Jan Rozman Ed Ryder Jennifer Salisbury Luis Santos Karl-Heinz Schäble Evelyn Schiller Anja Schrewe Holger Schulz Ralf Steinkamp Michelle Simon Michelle Stewart Claudia Stöger Tobias Stöger Minxuan Sun David Sunter Lydia Teboul Isabelle Tilly Glauco P Tocchini-Valentini Monica Tost Irina Treise Laurent Vasseur Emilie Velot Daniela Vogt-Weisenhorn Christelle Wagner Alison Walling Bruno Weber Olivia Wendling Henrik Westerberg Monja Willershäuser Eckhard Wolf Anne Wolter Joe Wood Wolfgang Wurst Ali Önder Yildirim Ramona Zeh Andreas Zimmer Annemarie Zimprich Chris Holmes Karen P Steel Yann Herault Valérie Gailus-Durner Ann-Marie Mallon Steve Dm Brown

Nat Genet 2015 Sep 27;47(9):969-978. Epub 2015 Jul 27.

MRC Harwell, Medical Research Council, Harwell, UK.

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http://dx.doi.org/10.1038/ng.3360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564951PMC
September 2015

A twin and molecular genetics study of sleep paralysis and associated factors.

J Sleep Res 2015 Aug 9;24(4):438-46. Epub 2015 Feb 9.

Department of Psychology, Goldsmiths, University of London, London, UK.

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http://dx.doi.org/10.1111/jsr.12282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4950339PMC
August 2015

Replication of Genome-Wide Association Studies (GWAS) loci for sleep in the British G1219 cohort.

Am J Med Genet B Neuropsychiatr Genet 2013 Jul;162B(5):431-8

Mammalian Genetics Unit, MRC Harwell, Oxfordshire, UK.

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http://doi.wiley.com/10.1002/ajmg.b.32106
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http://dx.doi.org/10.1002/ajmg.b.32106DOI Listing
July 2013

Generation of mouse mutants as tools in dissecting the molecular clock.

Prog Brain Res 2012 ;199:247-265

Neurobehavioural Genetics, MRC Harwell, Harwell Science and Innovation Campus, Oxfordshire, United Kingdom. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/B97804445942730
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http://dx.doi.org/10.1016/B978-0-444-59427-3.00015-0DOI Listing
January 2013

Assessment of Circadian and Light-Entrainable Parameters in Mice Using Wheel-Running Activity.

Curr Protoc Mouse Biol 2011 Sep 1;1(3):369-81. Epub 2011 Sep 1.

Neurobehavioural Genetics, MRC Harwell, Harwell Science and Innovation Campus, Oxfordshire, United Kingdom.

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http://dx.doi.org/10.1002/9780470942390.mo110123DOI Listing
September 2011

Stringent requirement of a proper level of canonical WNT signalling activity for head formation in mouse embryo.

Development 2011 Feb 12;138(4):667-76. Epub 2011 Jan 12.

Embryology Unit, Children's Medical Research Institute, University of Sydney, 214 Hawkesbury Road, Westmead, Sydney, NSW 2145, Australia.

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http://dx.doi.org/10.1242/dev.052803DOI Listing
February 2011

Overexpression of Fto leads to increased food intake and results in obesity.

Nat Genet 2010 Dec 14;42(12):1086-92. Epub 2010 Nov 14.

MRC Harwell, Metabolism and Inflammation, Harwell Science and Innovation Campus, Harwell, UK.

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http://dx.doi.org/10.1038/ng.713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018646PMC
December 2010

A point mutation in TRPC3 causes abnormal Purkinje cell development and cerebellar ataxia in moonwalker mice.

Proc Natl Acad Sci U S A 2009 Apr 7;106(16):6706-11. Epub 2009 Apr 7.

Medical Research Council Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0810599106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2666615PMC
April 2009

Clocks go forward: progress in the molecular genetic analysis of rhythmic behaviour.

Mamm Genome 2009 Feb 15;20(2):67-70. Epub 2009 Jan 15.

MRC Harwell, Mammalian Genetics Unit, Harwell Science and Innovation Campus, Oxfordshire, OX11 0RD, UK.

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http://link.springer.com/10.1007/s00335-008-9166-1
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http://dx.doi.org/10.1007/s00335-008-9166-1DOI Listing
February 2009

When clocks go bad: neurobehavioural consequences of disrupted circadian timing.

PLoS Genet 2008 May 30;4(5):e1000040. Epub 2008 May 30.

Neurobehavioural Genetics Group, Medical Research Council Mammalian Genetics Unit, Harwell, Oxfordshire, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1000040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2295261PMC
May 2008

Defining the cause of skewed X-chromosome inactivation in X-linked mental retardation by use of a mouse model.

Am J Hum Genet 2007 Jun 25;80(6):1138-49. Epub 2007 Apr 25.

MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK.

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http://dx.doi.org/10.1086/518369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1867101PMC
June 2007

SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins.

Science 2007 May 26;316(5826):900-4. Epub 2007 Apr 26.

Department of Pathology, NYU Cancer Institute, New York University School of Medicine, 550 First Avenue, MSB 599, New York, NY 10016, USA.

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http://dx.doi.org/10.1126/science.1141194DOI Listing
May 2007

Gene-environment interactions differentially affect mouse strain behavioral parameters.

Mamm Genome 2006 Nov 7;17(11):1113-20. Epub 2006 Nov 7.

MRC Mammalian Genetics Unit, Harwell, Didcot, Oxfordshire, OX11 0RD, UK.

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http://dx.doi.org/10.1007/s00335-006-0075-xDOI Listing
November 2006

A comparison of physiological and behavioural parameters in C57BL/6J mice undergoing food or water restriction regimes.

Behav Brain Res 2006 Oct 25;173(1):22-9. Epub 2006 Jul 25.

MRC Mammalian Genetics Unit, Harwell, Didcot, Oxfordshire OX11 0RD, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S016643280600297
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http://dx.doi.org/10.1016/j.bbr.2006.05.031DOI Listing
October 2006

The role of mutagenesis in defining genes in behaviour.

Eur J Hum Genet 2006 Jun;14(6):651-9

MRC Mammalian Genetics Unit, Harwell, Didcot, Oxfordshire OX11 0RD, UK.

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http://dx.doi.org/10.1038/sj.ejhg.5201545DOI Listing
June 2006

Mutations in gasdermin 3 cause aberrant differentiation of the hair follicle and sebaceous gland.

J Invest Dermatol 2005 Mar;124(3):615-21

School of Life Sciences, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1111/j.0022-202X.2005.23623.xDOI Listing
March 2005

N-ethyl-N-nitrosourea mouse mutants in the dissection of behavioural and psychiatric disorders.

Eur J Pharmacol 2003 Nov;480(1-3):205-17

MRC Mammalian Genetics Unit, Harwell, Didcot, OX11 0RD, Oxfordshire, UK.

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http://dx.doi.org/10.1016/j.ejphar.2003.08.107DOI Listing
November 2003

A mutation in Af4 is predicted to cause cerebellar ataxia and cataracts in the robotic mouse.

J Neurosci 2003 Mar;23(5):1631-7

Medical Research Council Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6741966PMC
March 2003

Mutations in Rab3a alter circadian period and homeostatic response to sleep loss in the mouse.

Nat Genet 2002 Oct 16;32(2):290-5. Epub 2002 Sep 16.

Center for Neurobiology of Behavior of the Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1038/ng991DOI Listing
October 2002

ENU mutagenesis in the mouse: application to human genetic disease.

Brief Funct Genomic Proteomic 2002 Oct;1(3):278-89

Neurobehavioural Genetics Group, Medical Research Council Mammalian Genetics Unit, Harwell, Didcot, UK.

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http://dx.doi.org/10.1093/bfgp/1.3.278DOI Listing
October 2002

Novel ENU-induced eye mutations in the mouse: models for human eye disease.

Hum Mol Genet 2002 Apr;11(7):755-67

Comparative and Developmental Genetics Section, MRC Human Genetics Unit, Edinburgh EH4 2XU, UK.

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http://dx.doi.org/10.1093/hmg/11.7.755DOI Listing
April 2002

Running endurance abnormality in mdx mice.

Muscle Nerve 2002 Feb;25(2):207-11

Division of Neurology, Department of Medicine, Showa University, Fujigaoka Hospital, 1-30, Fujigaoka, Aobaku, Yokohamashi 227-0043, Japan.

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http://dx.doi.org/10.1002/mus.10023DOI Listing
February 2002