Publications by authors named "Patrick M Bossuyt"

100Publications

Sirolimus for the treatment of polyposis of the rectal remnant and ileal pouch in four patients with familial adenomatous polyposis: a pilot study.

BMJ Open Gastroenterol 2020 Dec;7(1)

Department of Gastroenterology and Hepatology, Amsterdam UMC - Location AMC, University of Amsterdam, Cancer Center Amsterdam, Amsterdam, North Holland, The Netherlands

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December 2020

Reporting of test comparisons in diagnostic accuracy studies: A literature review.

Res Synth Methods 2020 Nov 20. Epub 2020 Nov 20.

Department of Epidemiology and Data Science, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

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November 2020

Primary thromboprophylaxis in ambulatory cancer patients with a high Khorana score: a systematic review and meta-analysis.

Blood Adv 2020 Oct;4(20):5215-5225

Department of Vascular Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands; and.

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October 2020

A potential for seamless designs in diagnostic research could be identified.

J Clin Epidemiol 2021 Jan 28;129:51-59. Epub 2020 Sep 28.

Department of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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January 2021

Reply to: "Errors in modeling misrepresent the utility of the enhanced liver fibrosis test in the management of non-alcoholic fatty liver disease".

J Hepatol 2020 Dec 17;73(6):1582-1583. Epub 2020 Sep 17.

Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam UMC, University of Amsterdam, The Netherlands.

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December 2020

Prognostic accuracy of FIB-4, NAFLD fibrosis score, and APRI for NAFLD-related events: a systematic review.

Liver Int 2020 Sep 18. Epub 2020 Sep 18.

Epidemiology and Data Science, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

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September 2020

[Why do observational research if there is already a randomised controlled trial?]

Ned Tijdschr Geneeskd 2020 08 6;164. Epub 2020 Aug 6.

Amsterdam UMC, Afdeling Epidemiologie en Data Science, Amsterdam.

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August 2020

Classifying the diagnosis of study participants in clinical trials: a structured and efficient approach.

Eur Radiol Exp 2020 07 17;4(1):44. Epub 2020 Jul 17.

Department of Internal Medicine, Division of Infectious Diseases, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.

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July 2020

Testing COVID-19 tests faces methodological challenges.

J Clin Epidemiol 2020 10 3;126:172-176. Epub 2020 Jul 3.

Department of Epidemiology & Data Science, Amsterdam Public Health, Amsterdam University Medical Centers, Room J1B-214, PO Box 22660, 1100 DD Amsterdam, The Netherlands. Electronic address:

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October 2020

Endoscopic management of duodenal adenomas in patients with familial adenomatous polyposis.

Gastrointest Endosc 2020 Jun 11. Epub 2020 Jun 11.

Department of Gastroenterology and Hepatology, Cancer Center Amsterdam, Amsterdam Gastroenterology & Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.

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June 2020

Methodologic considerations in randomized clinical trials in reproductive medicine.

Fertil Steril 2020 Jun;113(6):1107-1112

Department of Obstetrics and Gynaecology, Monash University, Clayton, Victoria, Australia. Electronic address:

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June 2020

OPTimal IMAging strategy in patients suspected of non-traumatic pulmonary disease at the emergency department: chest X-ray or ultra-low-dose chest CT (OPTIMACT) trial-statistical analysis plan.

Trials 2020 May 14;21(1):407. Epub 2020 May 14.

Department of Clinical Epidemiology, Biostatics and Bioinformatics, Amsterdam UMC, location AMC, University of Amsterdam, P.O. Box 22660, 1100 DD, Amsterdam, the Netherlands.

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May 2020

Current methods for development of rapid reviews about diagnostic tests: an international survey.

BMC Med Res Methodol 2020 05 13;20(1):115. Epub 2020 May 13.

Clinical Biostatistics Unit, Hospital Universitario Ramón y Cajal, IRYCIS, CIBER of Epidemiology and Public Health, Madrid, Spain.

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May 2020

Reporting guidelines for journal and conference abstracts.

J Clin Epidemiol 2020 Aug 18;124:186-192. Epub 2020 Apr 18.

Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

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August 2020

Addition of an online, validated family history questionnaire to the Dutch FIT-based screening programme did not improve its diagnostic yield.

Br J Cancer 2020 Jun 20;122(12):1865-1871. Epub 2020 Apr 20.

Department of Gastroenterology and Hepatology, Cancer Centre Amsterdam, Amsterdam Gastroenterology and Metabolism, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Amsterdam, Netherlands.

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June 2020

External factors may influence Cochrane reviewers when classifying the risk of bias of original reports.

J Clin Epidemiol 2020 Jul 19;123:1-8. Epub 2020 Mar 19.

Sorbonne Université, Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Pierre Louis d'Epidémiologie et de Santé Publique, AP-HP. Sorbonne Université, Hôpital Pitié Salpêtrière, Département de Santé Publique, Centre de Pharmacoépidémiologie de l'AP-HP (Cephepi), CIC-1422, F75013, Paris, France.

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July 2020

Searching practices and inclusion of unpublished studies in systematic reviews of diagnostic accuracy.

Res Synth Methods 2020 May 5;11(3):343-353. Epub 2020 Feb 5.

Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam University Medical Centres, University of Amsterdam, Amsterdam, the Netherlands.

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May 2020

Diagnostic accuracy of dual-energy computed tomography (DECT) to differentiate uric acid from non-uric acid calculi: systematic review and meta-analysis.

Eur Radiol 2020 May 24;30(5):2791-2801. Epub 2020 Jan 24.

Department of Radiology, Clinical Epidemiology Program, Ottawa Hospital Research Institute, University of Ottawa, Room c159 Ottawa Hospital Civic Campus, 1053 Carling Ave., Ottawa, ON, K1Y 4E9, Canada.

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May 2020

Publication bias in diagnostic imaging: conference abstracts with positive conclusions are more likely to be published.

Eur Radiol 2020 May 17;30(5):2964-2972. Epub 2020 Jan 17.

Department of Radiology, Clinical Epidemiology Program, Ottawa Hospital Research Institute, University of Ottawa, Room c159 Ottawa Hospital Civic Campus, 1053 Carling Ave, Ottawa, ON, K1Y 4E9, Canada.

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May 2020

Targeted test evaluation: a framework for designing diagnostic accuracy studies with clear study hypotheses.

Diagn Progn Res 2019 19;3:22. Epub 2019 Dec 19.

5Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, Amsterdam University Medical Centers, Amsterdam, the Netherlands.

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December 2019

Mapping of reporting guidance for systematic reviews and meta-analyses generated a comprehensive item bank for future reporting guidelines.

J Clin Epidemiol 2020 02 15;118:60-68. Epub 2019 Nov 15.

School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, Canada; Centre for Journalology and Canadian EQUATOR Centre, Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Canada.

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February 2020

Laboratory Measurement's Contribution to the Replication and Application Crisis in Clinical Research.

Clin Chem 2019 12 31;65(12):1479-1480. Epub 2019 Oct 31.

Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam University Medical Centers, Amsterdam the Netherlands.

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December 2019

A Quarter of Participants With Advanced Neoplasia Have Discordant Results From 2-Sample Fecal Immunochemical Tests for Colorectal Cancer Screening.

Clin Gastroenterol Hepatol 2020 Jul 26;18(8):1805-1811.e1. Epub 2019 Sep 26.

Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands. Electronic address:

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July 2020

An analysis reveals differences between pragmatic and explanatory diagnostic accuracy studies.

J Clin Epidemiol 2020 01 24;117:29-35. Epub 2019 Sep 24.

Inserm UMR 1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team, Research Centre for Epidemiology and Biostatistics Sorbonne Paris Cité (CRESS), Paris Descartes University, Paris, France; Department of General Pediatrics and Pediatric Infectious Diseases, Necker - Enfants malades hospital, Assistance Publique - Hôpitaux de Paris, Paris Descartes University, Paris, France.

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January 2020

Effects of Family History on Relative and Absolute Risks for Colorectal Cancer: A Systematic Review and Meta-Analysis.

Clin Gastroenterol Hepatol 2019 12 13;17(13):2657-2667.e9. Epub 2019 Sep 13.

Department of Gastroenterology and Hepatology, Netherlands Cancer Institute, Amsterdam, the Netherlands; Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address:

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December 2019

The harms of early cessation of trials on systematic reviews - Authors' reply.

Lancet Gastroenterol Hepatol 2019 09;4(9):667-668

Department of Surgery, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, Netherlands. Electronic address:

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September 2019

Publication bias may exist among prognostic accuracy studies of middle cerebral artery Doppler ultrasound.

J Clin Epidemiol 2019 12 30;116:1-8. Epub 2019 Jul 30.

Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

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December 2019

A systematic review finds that spin or interpretation bias is abundant in evaluations of ovarian cancer biomarkers.

J Clin Epidemiol 2019 12 19;116:9-17. Epub 2019 Jul 19.

Amsterdam UMC, Department of Clinical Epidemiology, Biostatistics and Bioinformatics, University of Amsterdam, Amsterdam Public Health Research Institute, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

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December 2019

Diagnostic accuracy studies need more informative abstracts.

Eur J Clin Microbiol Infect Dis 2019 Aug;38(8):1383-1385

Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.

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August 2019

Always randomize as late as possible.

Gastric Cancer 2019 11 8;22(6):1308-1309. Epub 2019 Apr 8.

Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

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November 2019

Shortcomings in the evaluation of biomarkers in ovarian cancer: a systematic review.

Clin Chem Lab Med 2019 Dec;58(1):3-10

Amsterdam University Medical Centers, Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.

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December 2019

GRADE guidelines: 22. The GRADE approach for tests and strategies-from test accuracy to patient-important outcomes and recommendations.

J Clin Epidemiol 2019 07 7;111:69-82. Epub 2019 Feb 7.

Department of Health Research Methods, Evidence, and Impact, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S4K1, Canada; Department of Medicine, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S4K1, Canada.

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July 2019

Impact and perceived value of journal reporting guidelines among Radiology authors and reviewers.

Eur Radiol 2019 Aug 29;29(8):3986-3995. Epub 2019 Jan 29.

Beth Israel Deaconess Medical Center, Boston, USA.

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August 2019

The Khorana score for prediction of venous thromboembolism in cancer patients: a systematic review and meta-analysis.

Haematologica 2019 06 3;104(6):1277-1287. Epub 2019 Jan 3.

Amsterdam UMC, University of Amsterdam, Department of Vascular Medicine, Amsterdam Cardiovascular Science, Amsterdam, the Netherlands.

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June 2019

Frequent premature atrial contractions are associated with atrial fibrillation, brain ischaemia, and mortality: a systematic review and meta-analysis.

Europace 2019 May;21(5):698-707

Department of General Practice, Amsterdam UMC, University of Amsterdam, Amsterdam Public Health, Academic Medical Center, Meibergdreef 9, AZ Amsterdam, Netherlands.

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May 2019

Performance of two faecal immunochemical tests for the detection of advanced neoplasia at different positivity thresholds: a cross-sectional study of the Dutch national colorectal cancer screening programme.

Lancet Gastroenterol Hepatol 2019 02 27;4(2):111-118. Epub 2018 Nov 27.

Department of Gastroenterology and Hepatology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands. Electronic address:

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February 2019

Patient-Centered Outcomes Related to Imaging Testing in US Primary Care.

J Am Coll Radiol 2019 Feb 25;16(2):156-163. Epub 2018 Oct 25.

Departments of Family Medicine, University of Washington, Seattle, Washington.

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February 2019

Participant-Related Risk Factors for False-Positive and False-Negative Fecal Immunochemical Tests in Colorectal Cancer Screening: Systematic Review and Meta-Analysis.

Am J Gastroenterol 2018 12 29;113(12):1778-1787. Epub 2018 Aug 29.

Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands. Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, Amsterdam, The Netherlands.

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December 2018

Best practices for MRI systematic reviews and meta-analyses.

J Magn Reson Imaging 2019 Jun 13;49(7):e51-e64. Epub 2018 Aug 13.

University of Ottawa Department of Radiology, Ottawa, ON, Canada.

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June 2019

Practical guide for identifying unmet clinical needs for biomarkers.

EJIFCC 2018 Jul 11;29(2):129-137. Epub 2018 Jul 11.

New South Wales Health Pathology, Department of Clinical Chemistry and Endocrinology, Prince of Wales Hospital and School of Medical Sciences, University of New South Wales, Australia.

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July 2018

[Real-world data are an addition to randomised research].

Ned Tijdschr Geneeskd 2018 Jun 15;162. Epub 2018 Jun 15.

AMC-UvA, afd. Klinische Epidemiologie, Biostatistiek en Bio-informatica, Amsterdam.

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June 2018

Systematic Reviews and Meta-Analyses of Diagnostic Test Accuracy: The PRISMA-DTA Statement.

Radiology 2018 11 17;289(2):313-314. Epub 2018 Jul 17.

From the Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada (R.A.F.); Department of Radiology, University of Ottawa and the Ottawa Hospital, Civic Campus, 1053 Carling Ave, Room C120, Ottawa, ON, Canada K1Y 4E9 (R.A.F., M.D.F.M.); Department of Clinical Epidemiology and Department of Biostatistics and Bioinformatics, Amsterdam Public Health Research Institute, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands (P.M.B.); and Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada (M.D.F.M.).

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November 2018

Screening for child abuse using a checklist and physical examinations in the emergency department led to the detection of more cases.

Acta Paediatr 2019 02 14;108(2):300-313. Epub 2018 Aug 14.

Emma Children's Hospital-Academic Medical Center, Amsterdam, the Netherlands.

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February 2019

Development and evaluating multimarker models for guiding treatment decisions.

BMC Med Inform Decis Mak 2018 06 28;18(1):52. Epub 2018 Jun 28.

Department of Clinical Epidemiology, Biostatistics & Bioinformatics, Academic Medical Centre, Amsterdam, the Netherlands.

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June 2018

Personalized ovarian stimulation for assisted reproductive technology: study design considerations to move from hype to added value for patients.

Fertil Steril 2018 06;109(6):968-979

Global Medical Affairs Fertility, Research and Development, Merck KGaA, Darmstadt, Germany; Research Group Reproductive Medicine, Department of Development and Regeneration, Organ Systems, Group Biomedical Sciences, KU Leuven (University of Leuven), Leuven, Belgium; Department of Obstetrics and Gynecology, Yale University, New Haven, Connecticut. Electronic address:

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June 2018

PRISMA-DTA: An Extension of PRISMA for Reporting of Diagnostic Test Accuracy Systematic Reviews.

Clin Chem 2018 Jun;64(6):985-986

Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, Amsterdam, the Netherlands.

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June 2018

A large proportion of fecal immunochemical test-positive participants in colorectal cancer screening is symptomatic.

United European Gastroenterol J 2018 Apr 24;6(3):471-479. Epub 2017 Sep 24.

Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, the Netherlands.

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April 2018

Prognostic value of cardiovascular parameters in computed tomography pulmonary angiography in patients with acute pulmonary embolism.

Eur Respir J 2018 07 4;52(1). Epub 2018 Jul 4.

Dept of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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July 2018

From the theoretical to the practical: how to evaluate the ethical and scientific justifications of randomized clinical trials.

J Clin Epidemiol 2018 07 26;99:170-171. Epub 2018 Mar 26.

Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

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July 2018

Risk of Oral and Upper Gastrointestinal Cancers in Persons With Positive Results From a Fecal Immunochemical Test in a Colorectal Cancer Screening Program.

Clin Gastroenterol Hepatol 2018 08 7;16(8):1237-1243.e2. Epub 2018 Feb 7.

Cancer Center Amsterdam, Department of Gastroenterology and Hepatology, Academic Medical Centre Amsterdam, Amsterdam, the Netherlands. Electronic address:

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August 2018

Reply.

Gastroenterology 2018 02 17;154(3):763-764. Epub 2018 Jan 17.

Department of Gastroenterology & Hepatology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

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February 2018

Current and Emerging Multianalyte Assays with Algorithmic Analyses-Are Laboratories Ready for Clinical Adoption?

Clin Chem 2018 06 17;64(6):885-891. Epub 2018 Jan 17.

Department of Pathology and Laboratory Medicine, Women and Infants' Hospital of Rhode Island, The Warren Alpert Medical School of Brown, Providence, Rhode Island.

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June 2018

Are Study and Journal Characteristics Reliable Indicators of "Truth" in Imaging Research?

Radiology 2018 04 27;287(1):215-223. Epub 2017 Nov 27.

From the Faculty of Medicine, University of Ottawa, 1053 Carling Ave, Room C120, Ottawa, ON, Canada K1Y 4E9 (R.A.F., T.A.M.); Department of Radiology, University of Ottawa and the Ottawa Hospital, Ottawa, ON, Canada (R.A.F., M.D.F.M., T.A.M.); Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada (M.D.F.M., W.P.); Department of Radiology, Beth Israel Deaconess Medical Center, Harvard University, Boston, Mass (D.L., H.Y.K.); Radiology Editorial Office, Boston, Mass (D.L., H.Y.K.); Department of Radiology, Harvard University, Boston, Mass (J.S.S.); and Clinical Epidemiology and Biostatistics and Bioinformatics, Amsterdam Public Health Research Institute, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands (P.M.B.).

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April 2018

Recommendations for reporting of systematic reviews and meta-analyses of diagnostic test accuracy: a systematic review.

Syst Rev 2017 10 10;6(1):194. Epub 2017 Oct 10.

University of Ottawa Department of Radiology, Clinical Epidemiology Program, Ottawa Hospital Research Institute, Room c159 Ottawa Hospital Civic Campus, 1053 Carling Ave, Ottawa, ON, K1Y 4E9, Canada.

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October 2017

Adrenal Lesions in Patients With (Attenuated) Familial Adenomatous Polyposis and MUTYH-Associated Polyposis.

Dis Colon Rectum 2017 Oct;60(10):1057-1064

1 Department of Gastroenterology and Hepatology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands 2 Department of Radiology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands 3 Department of Endocrinology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands 4 Department of Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands 5 Department of Clinical Genetics, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands 6 Department of Clinical Epidemiology, Biostatistics, and Bioinformatics, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

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October 2017

Screening for Occult Cancer in Patients With Unprovoked Venous Thromboembolism: A Systematic Review and Meta-analysis of Individual Patient Data.

Ann Intern Med 2017 Sep 22;167(6):410-417. Epub 2017 Aug 22.

From Academic Medical Center and Slotervaartziekenhuis, Amsterdam, the Netherlands; Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Université de Bretagne Occidentale, Brest, France; Hospital of Padua, Padua, Italy; Clinica Universidad de Navarra, Pamplona, Spain; Virgen del Rocio Hospital, Seville, Spain; Karolinska Institutet, Stockholm, Sweden; Warsaw Medical University, Warsaw, Poland; Centre Hospitalo-Universitaire Estaing, Clermont-Ferrand, France; University of Utah, Salt Lake City, Utah; University Hospital Leuven, Leuven, Belgium; and University G. D'Annunzio, Chieti-Pescara, Italy.

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September 2017

STARD for Abstracts: essential items for reporting diagnostic accuracy studies in journal or conference abstracts.

BMJ 2017 08 17;358:j3751. Epub 2017 Aug 17.

Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands.

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August 2017

Treatment of multiple test readers in diagnostic accuracy systematic reviews-meta-analyses of imaging studies.

Eur J Radiol 2017 Aug 27;93:59-64. Epub 2017 May 27.

Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. Electronic address:

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August 2017

Reporting of imaging diagnostic accuracy studies with focus on MRI subgroup: Adherence to STARD 2015.

J Magn Reson Imaging 2018 02 22;47(2):523-544. Epub 2017 Jun 22.

Department of Radiology, University of Ottawa Faculty of Medicine, Ottawa, Ontario, Canada.

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February 2018

Facilitating Prospective Registration of Diagnostic Accuracy Studies: A STARD Initiative.

Clin Chem 2017 08 19;63(8):1331-1341. Epub 2017 Jun 19.

Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands.

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August 2017

Overinterpretation of Research Findings: Evidence of "Spin" in Systematic Reviews of Diagnostic Accuracy Studies.

Clin Chem 2017 Aug 12;63(8):1353-1362. Epub 2017 Jun 12.

Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center Amsterdam, the Netherlands.

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August 2017