Patrick Lyden

Patrick Lyden

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Patrick Lyden

Patrick Lyden

Publications by authors named "Patrick Lyden"

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Neuron-generated thrombin induces a protective astrocyte response via protease activated receptors.

Glia 2020 02 27;68(2):246-262. Epub 2019 Aug 27.

Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California.

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http://dx.doi.org/10.1002/glia.23714DOI Listing
February 2020

Current Advances in the Use of Therapeutic Hypothermia.

Ther Hypothermia Temp Manag 2020 Jan 14. Epub 2020 Jan 14.

Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California.

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http://dx.doi.org/10.1089/ther.2019.29070.jjlDOI Listing
January 2020

Therapeutic hypothermia and Type II errors: Do not throw out the baby with the ice water.

Brain Circ 2019 Oct-Dec;5(4):203-210. Epub 2019 Dec 27.

Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

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http://dx.doi.org/10.4103/bc.bc_53_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950510PMC
December 2019

Differential effects of hypothermia on neurovascular unit determine protective or toxic results: Toward optimized therapeutic hypothermia.

J Cereb Blood Flow Metab 2019 Sep 21;39(9):1693-1709. Epub 2018 Nov 21.

1 Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

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http://dx.doi.org/10.1177/0271678X18814614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727141PMC
September 2019

Thrombolytic Therapy for Acute Ischemic Stroke.

Authors:
Patrick D Lyden

Stroke 2019 Sep 22;50(9):2597-2603. Epub 2019 Jul 22.

From the Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA.

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http://dx.doi.org/10.1161/STROKEAHA.119.025699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710099PMC
September 2019

Neuroprotection and vasculoprotection using genetically targeted protease-ligands.

Brain Res 2019 Jul 14;1715:13-20. Epub 2019 Mar 14.

Department of Neurology, Cedars Sinai Medical Center, 127 S San Vicente Blvd, Los Angeles, CA 90048, United States. Electronic address:

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http://dx.doi.org/10.1016/j.brainres.2019.03.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6500472PMC
July 2019

Hypothermia in acute ischemic stroke therapy.

Handb Clin Neurol 2018 ;157:823-837

Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, United States. Electronic address:

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http://dx.doi.org/10.1016/B978-0-444-64074-1.00051-3DOI Listing
March 2019

Studies Targeting Stroke and Acute Myocardial Infarction.

Ther Hypothermia Temp Manag 2019 03 7;9(1):8-12. Epub 2019 Jan 7.

4 Center for Intensive Internal Medicine, University Medical Center, Ljubljana, Slovenia.

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http://dx.doi.org/10.1089/ther.2018.29054.mckDOI Listing
March 2019

Differential Expression of Vascular Endothelial Growth Factor-A Isoforms Between Intracranial Atherosclerosis and Moyamoya Disease.

J Stroke Cerebrovasc Dis 2019 Feb 2;28(2):360-368. Epub 2018 Nov 2.

Department of Neurosurgery, Gonzalez Neurovascular Laboratory, Cedars-Sinai Medical Center, Los Angeles, California; Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California. Electronic address:

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6786492PMC
February 2019

Absolute risk and predictors of the growth of acute spontaneous intracerebral haemorrhage: a systematic review and meta-analysis of individual patient data.

Lancet Neurol 2018 10 14;17(10):885-894. Epub 2018 Aug 14.

Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S14744422183025
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http://dx.doi.org/10.1016/S1474-4422(18)30253-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143589PMC
October 2018

Unique Uses of Cooling Strategies.

Ther Hypothermia Temp Manag 2018 09 10;8(3):126-130. Epub 2018 Aug 10.

4 Department of Surgery, Harborview Center for Prehospital Emergency Care , Seattle, Washington.

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http://dx.doi.org/10.1089/ther.2018.29047.pjlDOI Listing
September 2018

Can an anticoagulant reduce brain hemorrhage: Invited comment on "Dabigatran reduces endothelial permeability through inhibition of thrombin-induced cytoskeleton reorganization".

Authors:
Patrick D Lyden

Thromb Res 2018 Jun 12. Epub 2018 Jun 12.

Department of Neurology, 127 S. San Vicente Blvd, Room A6417, Los Angeles, CA 90048, United States. Electronic address:

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http://dx.doi.org/10.1016/j.thromres.2018.06.005DOI Listing
June 2018

Paradoxical cerebrovascular hemodynamic changes with nicardipine.

J Neurosurg 2018 04 21;128(4):1015-1019. Epub 2017 Apr 21.

2Neurology, Cedars-Sinai Medical Center, Los Angeles, California; and.

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http://dx.doi.org/10.3171/2016.11.JNS161992DOI Listing
April 2018

Local to Systemic Use of Hypothermia.

Ther Hypothermia Temp Manag 2018 Mar 23;8(1):4-8. Epub 2018 Jan 23.

4 Departments of Biomedical Engineering and Otolaryngology, University of Miami Miller School of Medicine , Miami, Florida.

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http://dx.doi.org/10.1089/ther.2018.29041.mjkDOI Listing
March 2018

When less is more (brain)-comment on "Rivaroxaban plasma levels in acute ischemic stroke and intracerebral hemorrhage".

Authors:
Patrick D Lyden

Ann Neurol 2018 03 3;83(3):446-448. Epub 2018 Mar 3.

Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA.

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http://doi.wiley.com/10.1002/ana.25163
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http://dx.doi.org/10.1002/ana.25163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867256PMC
March 2018

Cerebral Pulsatility Index Is Elevated in Patients with Elevated Right Atrial Pressure.

J Neuroimaging 2018 01 3;28(1):95-98. Epub 2017 Jul 3.

Departments of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA.

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http://dx.doi.org/10.1111/jon.12456DOI Listing
January 2018

Perspectives on Temperature Management.

Ther Hypothermia Temp Manag 2017 Dec 13;7(4):188-192. Epub 2017 Oct 13.

3 Department of Neurology, Thomas Jefferson University , Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1089/ther.2017.29035.pjlDOI Listing
December 2017

Cerebral microemboli detection for monitoring structural cardiac disease.

Neurol Clin Pract 2017 Oct;7(5):409-412

Department of Neurology (MS), University of California, Irvine; Department of Neurology (SS, MN, M Cavallaro, BR, PL), Cedars-Sinai Medical Center, Los Angeles, CA; Department of Surgery (JL), University of California, San Diego; Children's Heart Institute (JL), Rady Children's Hospital, San Diego, CA; and Benioff Children's Hospital (M Cocalis), University of California, San Francisco.

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http://dx.doi.org/10.1212/CPJ.0000000000000330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874469PMC
October 2017

Optimizing Outcomes for Mechanically Ventilated Patients in an Era of Endovascular Acute Ischemic Stroke Therapy.

J Intensive Care Med 2017 Sep 19;32(8):467-472. Epub 2016 Aug 19.

1 Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

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http://dx.doi.org/10.1177/0885066616663168DOI Listing
September 2017

Meta-Analysis of Pre-Clinical Trials of Therapeutic Hypothermia for Intracerebral Hemorrhage.

Ther Hypothermia Temp Manag 2017 Sep 1;7(3):141-146. Epub 2016 Dec 1.

Department of Neurology, Cedars-Sinai Medical Center , Los Angeles, California.

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http://dx.doi.org/10.1089/ther.2016.0033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612495PMC
September 2017

Brain Transforming Growth Factor-β Resists Hypertension Via Regulating Microglial Activation.

Stroke 2017 09 11;48(9):2557-2564. Epub 2017 Jul 11.

From the School of Life Science and Technology, Tongji University, Shanghai, China (Y.L., T.V.Z., J.F.); The Second Affiliated Hospital of Zhejiang University (P.S.), Institute of Translational Medicine (P.S.), and Department of Physiology (X.Z.S.), Zhejiang University School of Medicine, Hangzhou, China; Department of Neurology (Y.L., L.L., P.L., P.S.) and Department of Biomedical Science (T.V.Z., K.E.B.), Cedars-Sinai Medical Center, Los Angeles, CA; and Pharmacological and Brain Sciences, University of Iowa (A.K.J.).

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http://dx.doi.org/10.1161/STROKEAHA.117.017370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575981PMC
September 2017

Translational Stroke Research: Vision and Opportunities.

Stroke 2017 09 27;48(9):2632-2637. Epub 2017 Jul 27.

From the National Institute of Neurological Disorders and Stroke, National Institutes of Health (F.B., J.I.K., R.A.C., L.B.J., S.J., L.M.M., C.S.M., I.R., W.K.); Department of Neurology, Massachusetts General Hospital, Boston (C.A., E.H.L., L.H.S.); Oregon Health & Science University, Portland (S.A.B., M.P.S.-P.); Department of Neurology and Neurological Surgery, University of Washington, Seattle (K.B.); Department of Neurology and Rehabilitation Medicine, University of Cincinnati, OH (J.P.B.); Department of Neurology, University of California, Los Angeles (S.T.C.); Brain Mind Research Institute, Weill Cornell Medicine, New York, NY (S.C., C.I.); Department of Neurological Sciences, University of Vermont, Burlington (M.J. C.); Brain and Mind Research Institute, University of Ottawa, Ontario (D.C.); Department of Neurology, University of California, Irvine, Orange (S.C.C.); Department of Neurological Surgery, University of California, San Francisco (A.R.F.); Stemetix, Inc, Needham, MA (S.F.); Division of Biomedical Sciences, University of California, Riverside (B.D.F.); Department of Neurology, Brown University, Providence, RI (K.L.F.); Department of Neurology, University of California, San Diego (T.M.H.); Department of Emergency Medicine, Medical University of South Carolina, Charleston (E.C.J.); Department of Neurology, University of Virginia, Charlottesville (K.C.J.); Department of Critical Care Medicine (P.M.K.) and Department of Neurology (L.R.W.), University of Pittsburgh, PA; School of Pharmacy, University of North Carolina, Chapel Hill (H.K.); Cedars-Sinai Medical Center, Los Angeles, CA (P.D.L.); University of Gothenburg, Sweden (C.M.); Department of Neurology, University of Texas Health Science Center, Houston (L.D.M., S.I.S.); Mayo Clinic, Jacksonville, FL (J.F.M.); Department of Neurology, University of Miami Miller School, FL (M.A.P.-P.); Department of Neurosurgery, Stanford University, CA (G.K.S.); Division of Fundamental Neurobiology, Krembil Research Institute, Toronto, ON (M.T.); Department of Neurology, University of Texas, Austin (S.W.); and Department of Neurosurgery and Anesthesiology, Loma Linda University, CA (J.H.Z.).

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http://dx.doi.org/10.1161/STROKEAHA.117.017112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599159PMC
September 2017

Intracerebral Hemorrhagic Expansion Occurs in Patients Using Non-Vitamin K Antagonist Oral Anticoagulants Comparable with Patients Using Warfarin.

J Stroke Cerebrovasc Dis 2017 Aug 21;26(8):1874-1882. Epub 2017 Jun 21.

Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California; Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, California.

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2017.04.025DOI Listing
August 2017

Rethinking Training and Distribution of Vascular Neurology Interventionists in the Era of Thrombectomy.

Stroke 2017 08 13;48(8):2313-2317. Epub 2017 Jul 13.

From the Clinical Innovation and Research Institute Memorial Hermann Hospital - Texas Medical Center, Houston (J.C.G.); Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA (P.L.); and Department of Neurology, Mayo Clinic, Jacksonville, FL (T.B.).

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https://www.ahajournals.org/doi/10.1161/STROKEAHA.116.016416
Publisher Site
http://dx.doi.org/10.1161/STROKEAHA.116.016416DOI Listing
August 2017

Temperature Management in Neurological and Neurosurgical Intensive Care Unit.

Ther Hypothermia Temp Manag 2017 Jun 6;7(2):70-74. Epub 2017 Jun 6.

5 Department of Neurology and Neurocritical Care Unit, Medical University Innsbruck , Innsbruck, Austria .

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http://dx.doi.org/10.1089/ther.2017.29029.pjlDOI Listing
June 2017

Migraine and the Risk of Carotid Artery Dissection in the IPSYS Registry: Are They Related?

Authors:
Patrick D Lyden

JAMA Neurol 2017 05;74(5):503-504

Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California.

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http://dx.doi.org/10.1001/jamaneurol.2016.6008DOI Listing
May 2017

Clinical Studies Targeting Stroke and Ischemic Insults.

Ther Hypothermia Temp Manag 2017 03;7(1):12-15

4 Department of Neurology, Friedrich-Alexander University , Erlangen, Germany .

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http://dx.doi.org/10.1089/ther.2016.29022.jjlDOI Listing
March 2017

In Response.

J Stroke Cerebrovasc Dis 2017 Feb 22;26(2):454. Epub 2016 Nov 22.

Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA.

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2016.10.022DOI Listing
February 2017

Using the National Institutes of Health Stroke Scale: A Cautionary Tale.

Authors:
Patrick Lyden

Stroke 2017 02 11;48(2):513-519. Epub 2017 Jan 11.

From the Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA.

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http://dx.doi.org/10.1161/STROKEAHA.116.015434DOI Listing
February 2017

Clinical Studies Targeting Stroke and Ischemic Insults.

Ther Hypothermia Temp Manag 2017 Jan 20. Epub 2017 Jan 20.

4 Department of Neurology, Friedrich-Alexander University , Erlangen, Germany .

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http://dx.doi.org/10.1089/ther.2016.29022.jjl.revDOI Listing
January 2017

Transcranial Doppler Changes in Patients Treated with Extracorporeal Membrane Oxygenation.

J Stroke Cerebrovasc Dis 2016 Dec 26;25(12):2882-2885. Epub 2016 Aug 26.

Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California.

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2016.07.050DOI Listing
December 2016

Selecting Patients for Intra-Arterial Therapy in the Context of a Clinical Trial for Neuroprotection.

Stroke 2016 12 1;47(12):2979-2985. Epub 2016 Nov 1.

From the Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA (P.L.); ZZ Biotech, LLC, Houston, TX (S.W., H.L., K.P.); Department of Biostatistics, University of Iowa, Iowa City (C.C., S.O.); Neurological Clinical Research Institute, Massachusetts General Hospital, Boston (M.C., S.B.); Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA (M.F.); Department of Neurology, University of Virginia, Charlottesville (E.C.H.); Department of Neurology and Rehabilitation Medicine, University of Cincinnati, OH (P.K.); Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles (J.S.); Department of Neurology, State University of New York Downstate Medical Center, Brooklyn (S.L.); Department of Neurology, University of Kansas Hospital, Kansas City (M.R.); Department of Neurology, University of Pittsburgh Medical School, PA (L.W., A.J.); and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD (E.M., S.W.).

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http://dx.doi.org/10.1161/STROKEAHA.116.013881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5134840PMC
December 2016

Temperature Management in Neurological and Neurosurgical Intensive Care Unit.

Ther Hypothermia Temp Manag 2016 Dec 9;6(4):164-168. Epub 2016 Nov 9.

4 Wellstar Health System, Kennestone Hospital , Marietta, Georgia .

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http://dx.doi.org/10.1089/ther.2016.29020.pjlDOI Listing
December 2016

Results of the ICTuS 2 Trial (Intravascular Cooling in the Treatment of Stroke 2).

Stroke 2016 12 10;47(12):2888-2895. Epub 2016 Nov 10.

From the Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA (P.L.); Department of Neurosciences (T.H., K.R., B.M.) and Sanford Stem Cell Clinical Center (T.R.), University of California, San Diego; Department of Neurology, Memorial Health Care System, Houston, TX (J.G.); Alzheimer's Therapeutic Research Institute, University of Southern California, San Diego (K.E., R.R.); Department of Neurology, University of Texas McGovern Medical School, Houston (S.P.); Department of Neurosciences, Sarasota Memorial Health Care System, FL (M.C.); Department of Neurology, Michigan State University, Kalamazoo (S.H.); Department of Neurology, Columbia University, New York, NY (S.A.); Performance Improvement Patient Safety Department, UC San Diego Health System, CA (J.J.); and Department of Neurology, North Memorial Medical Center, Minneapolis, MN (I.A.).

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http://dx.doi.org/10.1161/STROKEAHA.116.014200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5134910PMC
December 2016

Effects of Alteplase for Acute Stroke on the Distribution of Functional Outcomes: A Pooled Analysis of 9 Trials.

Stroke 2016 09 9;47(9):2373-9. Epub 2016 Aug 9.

From the Institute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom (K.R.L.); Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, United Kingdom (J.E., L.B., C.B.); Statistics Department, Boehringer Ingelheim, Germany (E.B.); Melbourne Brain Centre, The Royal Melbourne Hospital and University of Melbourne, Australia (S.M.D.); Stroke Division, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Australia (G.A.D.); Mobile Stroke Unit and Stroke Research Program, Memorial Hermann Hospital, Houston, TX (J.C.G.); Department of Neurology, Helsinki University Hospital and Clinical Neurosciences, University of Helsinki, Finland (M.K.); Department of Neuroradiology, Technische Universität, Dresden, Germany (R.v.K.); Stanford Stroke Center, Palo Alto, CA (M.G.L.); Discipline of Medicine, Westmead Hospital Clinical School, George Institute for Global Health, University of Sydney, NSW, Australia (R.I.L.); Department of Neurology, Cedars-Sinai, Los Angeles, CA (P.L.); Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, United Kingdom (G.D.M.); Centre for Clinical Brain Sciences, University of Edinburgh, United Kingdom (P.A.G.S., J.M.W., W.N.W.); Department of Neurology and Psychiatry, Sapienza University of Rome, Italy (D.T.); Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan (K.T.); Department of Neurology, University of Heidelberg, Im Neuenheimer Feld, Germany (W.H.); and Department of Biostatistics, UAB School of Public Health, Birmingham, AL (G.H.).

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http://dx.doi.org/10.1161/STROKEAHA.116.013644DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5024752PMC
September 2016

Still cooling after all these years: Meta-analysis of pre-clinical trials of therapeutic hypothermia for acute ischemic stroke.

J Cereb Blood Flow Metab 2016 07 18;36(7):1157-64. Epub 2016 Apr 18.

Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, USA.

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http://dx.doi.org/10.1177/0271678X16645112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929706PMC
July 2016

Novel method for inducing rapid, controllable therapeutic hypothermia in rats using a perivascular implanted closed-loop cooling circuit.

J Neurosci Methods 2016 07 21;267:55-61. Epub 2016 Apr 21.

Department of Neurology, Cedars-Sinai Medical Center, 127 S. San Vicente Blvd, Los Angeles, CA 90048, United States.

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http://dx.doi.org/10.1016/j.jneumeth.2016.04.011DOI Listing
July 2016

Activated protein C promotes neuroprotection: mechanisms and translation to the clinic.

Thromb Res 2016 May;141 Suppl 2:S62-4

Department of Neurosurgery, University of Southern California, Keck School of Medicine, Los Angeles, CA; Department of Neurosurgery, Zilkha Neurogenetic Institute, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA.

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http://dx.doi.org/10.1016/S0049-3848(16)30368-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904825PMC
May 2016

Online Tool to Improve Stratification of Adverse Events in Stroke Clinical Trials.

Stroke 2016 Mar 7;47(3):882-5. Epub 2016 Jan 7.

From the Medical School (K.H.), Institute of Cardiovascular and Medical Sciences (A.H.A.-R, K.R.L., R.L.M.), University of Glasgow, Glasgow, United Kingdom; Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA (P.D.L.); and Department of Statistics, Boehringer Ingelheim, Bieberach, Germany (E.B.).

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http://dx.doi.org/10.1161/STROKEAHA.115.011930DOI Listing
March 2016

Clinical Studies Targeting Stroke and In-Hospital Cardiac Arrest.

Ther Hypothermia Temp Manag 2016 Mar 22;6(1):6-8. Epub 2016 Jan 22.

3 Department of Neurology, Cedars-Sinai Medical Center , Los Angeles, California.

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http://dx.doi.org/10.1089/ther.2016.29008.mjkDOI Listing
March 2016

Current Advances in the Use of Therapeutic Hypothermia.

Ther Hypothermia Temp Manag 2016 Mar 1;6(1):2-5. Epub 2016 Feb 1.

4 Department of Pediatrics, Hennepin County Medical Center , Minneapolis, Minnesota.

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http://dx.doi.org/10.1089/ther.2016.29010.pdlDOI Listing
March 2016

Seizures and Meperidine: Overstated and Underutilized.

Ther Hypothermia Temp Manag 2015 Dec 18;5(4):223-7. Epub 2015 Jun 18.

1 Department of Neurology, Cedars-Sinai Medical Center , Los Angeles, California.

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http://dx.doi.org/10.1089/ther.2015.0013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677539PMC
December 2015

Letter by Lahiri et al Regarding Article, "Endovascular Thrombectomy for Anterior Circulation Stroke: Systematic Review and Meta-Analysis".

Stroke 2015 Dec 3;46(12):e258. Epub 2015 Nov 3.

Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA.

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http://dx.doi.org/10.1161/STROKEAHA.115.011677DOI Listing
December 2015

Troubleshooting the NIHSS: question-and-answer session with one of the designers.

Int J Stroke 2015 Dec;10(8):1284-6

Stroke Center, Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

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http://dx.doi.org/10.1111/ijs.12196DOI Listing
December 2015

Microglia participate in neurogenic regulation of hypertension.

Hypertension 2015 Aug 8;66(2):309-16. Epub 2015 Jun 8.

From the Departments of Biomedical Sciences (X.Z.S., K.H.S., K.E.B.), Neurology (Y.L., L.L., P.L., P.S.), and Pathology and Laboratory Medicine (X.Z.S., K.E.B.), Cedars-Sinai Medical Center, Los Angeles, CA.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.115.05333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498964PMC
August 2015

Type of admission is associated with outcome of spontaneous subarachnoid hemorrhage.

Int J Stroke 2015 Jun 12;10(4):529-33. Epub 2013 Mar 12.

Department of Neurosurgery, Cedars Sinai Medical Center, Los Angeles, CA, USA.

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http://dx.doi.org/10.1111/ijs.12005DOI Listing
June 2015

Why don't more patients receive intravenous rt-PA for acute stroke?

Authors:
Patrick Lyden

Expert Rev Neurother 2015 Jun 4;15(6):571-4. Epub 2015 May 4.

Department of Neurology, Cedars-Sinai Medical Center, 127 S. San Vicente Blvd., AHSP A6417, Los Angeles, CA 90036, USA.

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http://dx.doi.org/10.1586/14737175.2015.1041510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830472PMC
June 2015

Aphasia and Dysarthria in Acute Stroke: Recovery and Functional Outcome.

Int J Stroke 2015 Apr;10(3):400-406

1 Nursing, Midwifery and Allied Health Professions Research Unit, Glasgow Caledonian University, Glasgow, UK.

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http://dx.doi.org/10.1111/ijs.12067DOI Listing
April 2015

Teaching neuroImages: short stature, imperforate anus, and polydactyly: When is a hypothalamic mass an incidentaloma?

Neurology 2015 Apr;84(15):e117

From the Departments of Neurology, Neurosurgery and Imaging, Cedars-Sinai Medical Center, Los Angeles, CA.

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http://dx.doi.org/10.1212/WNL.0000000000001469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408279PMC
April 2015

Thrombolysis in acute stroke--authors' reply.

Lancet 2015 Apr;385(9976):1396

University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1016/S0140-6736(15)60718-8DOI Listing
April 2015

Clinical studies targeting stroke.

Ther Hypothermia Temp Manag 2015 Mar;5(1):4-8

1 Department of Neurology, Cedars-Sinai Medical Center , Los Angeles, California.

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http://dx.doi.org/10.1089/ther.2015.1501DOI Listing
March 2015

Revisiting cerebral postischemic reperfusion injury: new insights in understanding reperfusion failure, hemorrhage, and edema.

Int J Stroke 2015 Feb;10(2):143-52

Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

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http://dx.doi.org/10.1111/ijs.12434DOI Listing
February 2015

Challenges of decision making regarding futility in a randomized trial: the Interventional Management of Stroke III experience.

Stroke 2014 May 3;45(5):1408-14. Epub 2014 Apr 3.

From the Data Coordination Unit, Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC (S.D.Y., R.H.M., L.D.F., R.F.W., Y.Y.P.); Department of Biostatistics, University of Iowa, Iowa City, IA (C.S.C.); Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA (P.D.L.); Department of Neurology, University of Cincinnati Academic Health Center, Cincinnati, OH (J.P.B.); Department of Medicine, Division of Cardiology, Columbia University Medical Center, New York, NY (M.R.D.T); and Department of Radiology, Temple University School of Medicine, Philadelphia, PA (C.A.J.).

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http://stroke.ahajournals.org/cgi/doi/10.1161/STROKEAHA.113.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018452PMC
May 2014

Correlations among impairment, daily activities and thinking operations after stroke.

NeuroRehabilitation 2013 ;33(1):153-60

Rehabilitation Department, Amal Rehabilitation Centre, Tehran, Iran.

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http://dx.doi.org/10.3233/NRE-130940DOI Listing
April 2014

Direct thrombin inhibitor argatroban reduces stroke damage in 2 different models.

Stroke 2014 Mar 28;45(3):896-9. Epub 2014 Jan 28.

From the Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA.

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http://dx.doi.org/10.1161/STROKEAHA.113.004488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995814PMC
March 2014

Representation of people with aphasia in randomized controlled trials of acute stroke interventions.

Int J Stroke 2014 Feb 19;9(2):174-82. Epub 2013 Mar 19.

Nursing, Midwifery and Allied Health Professions Research Unit, Glasgow Caledonian University, Glasgow, UK.

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http://dx.doi.org/10.1111/ijs.12043DOI Listing
February 2014

Endovascular therapeutic hypothermia for acute ischemic stroke: ICTuS 2/3 protocol.

Int J Stroke 2014 Jan 10;9(1):117-25. Epub 2013 Nov 10.

Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

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http://dx.doi.org/10.1111/ijs.12151DOI Listing
January 2014

Activated protein C analog protects from ischemic stroke and extends the therapeutic window of tissue-type plasminogen activator in aged female mice and hypertensive rats.

Stroke 2013 Dec 24;44(12):3529-36. Epub 2013 Oct 24.

From the Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA (Y.W., Z.Z., B.V.Z.); ZZ Biotech Research Laboratory, Rochester, NY (N.C.); Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA (P.S.R., P.D.L.); and Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA (J.H.G.).

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http://dx.doi.org/10.1161/STROKEAHA.113.003350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912991PMC
December 2013

Stroke treatment academic industry roundtable: research priorities in the assessment of neurothrombectomy devices.

Stroke 2013 Dec 5;44(12):3596-601. Epub 2013 Nov 5.

From the Stroke Center and Department of Neurology, David Geffen School of Medicine at the University of California, Los Angeles (J.L.S.); Department of Neurology, University of Pittsburgh Medical Center Stroke Institute, PA (T.G.J.); Department of Neurology, University of California, San Francisco (W.S.S.); and Stroke Center and Department of Neurology, Stanford University School of Medicine, CA (G.W.A.).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142766PMC
December 2013

Mild hypothermia reduces tissue plasminogen activator-related hemorrhage and blood brain barrier disruption after experimental stroke: editorial commentary on tang et Al., 2013.

Authors:
Patrick D Lyden

Ther Hypothermia Temp Manag 2013 Dec 28;3(4):171-2. Epub 2013 Aug 28.

Department of Neurology, Cedars-Sinai Medical Center , Los Angeles, California.

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http://dx.doi.org/10.1089/ther.2013.0014DOI Listing
December 2013

Acute Stroke Imaging Research Roadmap II.

Stroke 2013 Sep 16;44(9):2628-39. Epub 2013 Jul 16.

Department of Radiology, University of Virginia, Charlottesville, VA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040226PMC
September 2013

Preclinical and clinical studies targeting stroke.

Ther Hypothermia Temp Manag 2013 Sep;3(3):114-9

1 Department of Neurology, Cedars-Sinai Medical Center , Los Angeles, California.

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http://dx.doi.org/10.1089/ther.2013.1512DOI Listing
September 2013

Hemorrhagic transformation during thrombolytic therapy and reperfusion: effects of age, blood pressure, and matrix metalloproteinases.

Authors:
Patrick D Lyden

J Stroke Cerebrovasc Dis 2013 May 1;22(4):532-8. Epub 2013 Mar 1.

Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA 90036, USA.

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2013.02.001DOI Listing
May 2013

Thrombolysis in stroke despite contraindications or warnings?

Stroke 2013 Mar 6;44(3):727-33. Epub 2013 Feb 6.

Department of Neurology, University of Duisburg-Essen, Essen, Germany.

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http://dx.doi.org/10.1161/STROKEAHA.112.674622DOI Listing
March 2013

Preclinical and clinical studies targeting therapeutic hypothermia in cerebral ischemia and stroke.

Ther Hypothermia Temp Manag 2013 Mar;3(1):3-6

1 Department of Neurology, Cedars-Sinai Medical Center , Los Angeles, California.

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http://dx.doi.org/10.1089/ther.2013.1500DOI Listing
March 2013

Determinants of Pneumonia Risk During Endovascular Hypothermia.

Ther Hypothermia Temp Manag 2013 Mar;3(1):24-27

Department of Neurology, Cedars-Sinai Medical Center , Los Angeles, California. ; Department of Neurosciences, University of California , San Diego, California.

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http://dx.doi.org/10.1089/ther.2012.0021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3604784PMC
March 2013

Recovery from poststroke visual impairment: evidence from a clinical trials resource.

Neurorehabil Neural Repair 2013 Feb 6;27(2):133-41. Epub 2012 Sep 6.

Glasgow Caledonian University, Glasgow, UK.

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http://dx.doi.org/10.1177/1545968312454683DOI Listing
February 2013

Relationship between temperature, hematoma growth, and functional outcome after intracerebral hemorrhage.

Neurocrit Care 2013 Feb;18(1):45-53

Departments of Neurology and Neurosurgery, Division of Critical Care and Neurotrauma, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://link.springer.com/10.1007/s12028-012-9779-9
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February 2013

PHLPP1 gene deletion protects the brain from ischemic injury.

J Cereb Blood Flow Metab 2013 Feb 17;33(2):196-204. Epub 2012 Oct 17.

Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California, USA.

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http://dx.doi.org/10.1038/jcbfm.2012.150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564187PMC
February 2013

Concurrent middle cerebral artery occlusion and intra-arterial drug infusion via ipsilateral common carotid artery catheter in the rat.

J Neurosci Methods 2013 Feb 20;213(1):63-9. Epub 2012 Dec 20.

Department of Neurology, Cedars-Sinai Medical Center, 8730 Alden Drive, Los Angeles, CA 90048, USA.

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http://dx.doi.org/10.1016/j.jneumeth.2012.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570629PMC
February 2013

The smallest stroke: occlusion of one penetrating vessel leads to infarction and a cognitive deficit.

Nat Neurosci 2013 Jan 16;16(1):55-63. Epub 2012 Dec 16.

Department of Physics, University of California at San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.1038/nn.3278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3952571PMC
January 2013

The effect of transfer and hospital volume in subarachnoid hemorrhage patients.

Neurocrit Care 2012 Dec;17(3):312-23

Department of Neurosurgery, Cedars-Sinai Medical Center, Center for Neurosurgical Outcomes Research, Maxine Dunitz Neurosurgical Institute, 8631 W. Third Street, Suite 800E, Los Angeles, CA 90048, USA.

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http://dx.doi.org/10.1007/s12028-012-9740-yDOI Listing
December 2012

Overview of therapeutic hypothermia.

Curr Treat Options Neurol 2012 Dec;14(6):541-8

Department of Neurology, Cedars-Sinai Medical Center, 8730 Alden Drive, Suite E-240, Los Angeles, CA, 90048, USA.

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http://dx.doi.org/10.1007/s11940-012-0201-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519955PMC
December 2012

Sisyphus and translational stroke research.

Sci Transl Med 2012 Oct;4(156):156ps20

Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

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http://dx.doi.org/10.1126/scitranslmed.3005083DOI Listing
October 2012

Eagle syndrome revisited: cerebrovascular complications.

Ann Vasc Surg 2012 Jul;26(5):729.e1-5

Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

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http://dx.doi.org/10.1016/j.avsg.2011.12.005DOI Listing
July 2012

Determinants of effective cooling during endovascular hypothermia.

Neurocrit Care 2012 Jun;16(3):413-20

Department of Neurology, Cedars-Sinai Medical Center, Thalians E240, 8730 Alden Drive, Los Angeles, CA 90048, USA.

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http://link.springer.com/10.1007/s12028-012-9688-y
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361556PMC
June 2012

In anticipation of International Stroke Trial-3 (IST-3).

Authors:
Patrick D Lyden

Stroke 2012 Jun 3;43(6):1691-4. Epub 2012 May 3.

Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.

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http://dx.doi.org/10.1161/STROKEAHA.112.656876DOI Listing
June 2012

Too old for cold? Editorial commentary on Busch and Søreide, 2011.

Authors:
Patrick D Lyden

Ther Hypothermia Temp Manag 2012 Jun 13;2(2):51-2. Epub 2012 Jul 13.

Department of Neurology, Cedars-Sinai Medical Center , Los Angeles, California.

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https://www.liebertpub.com/doi/10.1089/ther.2012.1510
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http://dx.doi.org/10.1089/ther.2012.1510DOI Listing
June 2012

Stroke: Haemorrhage risk after thrombolysis--the SEDAN score.

Authors:
Patrick D Lyden

Nat Rev Neurol 2012 Apr 17;8(5):246-7. Epub 2012 Apr 17.

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http://www.nature.com/articles/nrneurol.2012.66
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April 2012