Patrick L J M Zeeuwen

Patrick L J M Zeeuwen

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Patrick L J M Zeeuwen

Patrick L J M Zeeuwen

Publications by authors named "Patrick L J M Zeeuwen"

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62Publications

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Targeting the Cutaneous Microbiota in Atopic Dermatitis by Coal Tar via AHR-Dependent Induction of Antimicrobial Peptides.

J Invest Dermatol 2019 Jul 22. Epub 2019 Jul 22.

Department of Dermatology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2019.06.142DOI Listing
July 2019

STAT1 gain-of-function compromises skin host defense in the context of IFN-γ signaling.

J Allergy Clin Immunol 2019 Apr 18;143(4):1626-1629.e5. Epub 2018 Dec 18.

Department of Internal Medicine, Radboud University Medical Center, Radboud Center for Infectious Diseases, Nijmegen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2018.11.033DOI Listing
April 2019

The skin barrier: Epidermis vs environment.

Exp Dermatol 2018 08;27(8):805-806

Department of Dermatology, Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Nijmegen Medical Center (Radboudumc), Nijmegen, The Netherlands.

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http://doi.wiley.com/10.1111/exd.13731
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http://dx.doi.org/10.1111/exd.13731DOI Listing
August 2018

The Effects of Human Beta-Defensins on Skin Cells in vitro.

Dermatology 2017 8;233(2-3):155-163. Epub 2017 Jul 8.

Department of Dermatology, Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Centre (Radboudumc), Nijmegen, The Netherlands.

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http://dx.doi.org/10.1159/000477346DOI Listing
July 2018

3D skin models for 3R research: The potential of 3D reconstructed skin models to study skin barrier function.

Exp Dermatol 2018 05 6;27(5):501-511. Epub 2018 Apr 6.

Department of Dermatology, Radboud university medical center (Radboudumc), Radboud Institute for Molecular Life Sciences (RIMLS), Nijmegen, The Netherlands.

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http://dx.doi.org/10.1111/exd.13531DOI Listing
May 2018

Cathepsin B as a potential cystatin M/E target in the mouse hair follicle.

FASEB J 2017 10 8;31(10):4286-4294. Epub 2017 Jun 8.

Department of Dermatology, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands;

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http://dx.doi.org/10.1096/fj.201700267RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5602906PMC
October 2017

Immortalized N/TERT keratinocytes as an alternative cell source in 3D human epidermal models.

Sci Rep 2017 09 19;7(1):11838. Epub 2017 Sep 19.

Department of Dermatology, Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center (Radboudumc), PO BOX 9101, 6500 HB, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1038/s41598-017-12041-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605545PMC
September 2017

Epidermal equivalents of filaggrin null keratinocytes do not show impaired skin barrier function.

J Allergy Clin Immunol 2017 06 11;139(6):1979-1981.e13. Epub 2016 Oct 11.

Department of Dermatology, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2016.09.016DOI Listing
June 2017

Reply to Meisel et al.

J Invest Dermatol 2017 04 22;137(4):961-962. Epub 2016 Nov 22.

NIZO Food Research B.V., Ede, The Netherlands.

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http://dx.doi.org/10.1016/j.jid.2016.11.013DOI Listing
April 2017

An In vitro Model for Bacterial Growth on Human Stratum Corneum.

Acta Derm Venereol 2016 Nov;96(7):873-879

Department of Dermatology, Radboud university medical center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.2340/00015555-2401DOI Listing
November 2016

Myeloid lineage-restricted somatic mosaicism of NLRP3 mutations in patients with variant Schnitzler syndrome.

J Allergy Clin Immunol 2015 Feb 16;135(2):561-4. Epub 2014 Sep 16.

Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands; Radboud Institute for Molecular Life Sciences (RIMLS), Nijmegen, The Netherlands; Nijmegen Center for Immunodeficiency and Autoinflammation, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.jaci.2014.07.050DOI Listing
February 2015

Genotype-phenotype correlations in a prospective cohort study of paediatric plaque psoriasis: lack of correlation between HLA-C*06 and family history of psoriasis.

Acta Derm Venereol 2014 Nov;94(6):667-71

Department of Dermatology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.2340/00015555-1810DOI Listing
November 2014

Absent in Melanoma 2 is predominantly present in primary melanoma and primary squamous cell carcinoma, but largely absent in metastases of both tumors.

J Am Acad Dermatol 2014 Nov 15;71(5):1012-5. Epub 2014 Oct 15.

Department of Dermatology, Radboud University Medical Center, Nijmegen, The Netherlands; Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.jaad.2014.06.012DOI Listing
November 2014

Analysis of protein-protein interaction between late cornified envelope proteins and corneodesmosin.

Exp Dermatol 2014 Oct;23(10):769-71

Department of Dermatology, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1111/exd.12524DOI Listing
October 2014

Combination of pantothenamides with vanin inhibitors as a novel antibiotic strategy against gram-positive bacteria.

Antimicrob Agents Chemother 2013 Oct 22;57(10):4794-800. Epub 2013 Jul 22.

Department of Dermatology and Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1128/AAC.00603-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811400PMC
October 2013

Microbiome and skin diseases.

Curr Opin Allergy Clin Immunol 2013 Oct;13(5):514-20

Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1097/ACI.0b013e328364ebebDOI Listing
October 2013

Coal tar induces AHR-dependent skin barrier repair in atopic dermatitis.

J Clin Invest 2013 Feb 25;123(2):917-27. Epub 2013 Jan 25.

Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, P.O. Box 9101, Nijmegen 6500 HB, The Netherlands.

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http://dx.doi.org/10.1172/JCI65642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561798PMC
February 2013

Genetics of psoriasis: evidence for epistatic interaction between skin barrier abnormalities and immune deviation.

J Invest Dermatol 2012 Oct;132(10):2320-2331

Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands. Electronic address:

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http://linkinghub.elsevier.com/retrieve/pii/S0022202X1535472
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http://dx.doi.org/10.1038/jid.2012.167DOI Listing
October 2012

Pattern recognition receptors in infectious skin diseases.

Microbes Infect 2012 Sep 31;14(11):881-93. Epub 2012 Mar 31.

Department of Dermatology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB, The Netherlands.

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http://dx.doi.org/10.1016/j.micinf.2012.03.004DOI Listing
September 2012

Rho kinase inhibitor Y-27632 prolongs the life span of adult human keratinocytes, enhances skin equivalent development, and facilitates lentiviral transduction.

Tissue Eng Part A 2012 Sep 5;18(17-18):1827-36. Epub 2012 Jun 5.

Department of Dermatology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1089/ten.TEA.2011.0616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432898PMC
September 2012

Pattern recognition receptors in immune disorders affecting the skin.

J Innate Immun 2012 6;4(3):225-40. Epub 2012 Mar 6.

Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1159/000335900DOI Listing
August 2012

Construction of a microstructured collagen membrane mimicking the papillary dermis architecture and guiding keratinocyte morphology and gene expression.

Macromol Biosci 2012 May 13;12(5):675-91. Epub 2012 Mar 13.

Department of Biochemistry 280, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1002/mabi.201100443DOI Listing
May 2012

A comprehensive analysis of pattern recognition receptors in normal and inflamed human epidermis: upregulation of dectin-1 in psoriasis.

J Invest Dermatol 2010 Nov 15;130(11):2611-20. Epub 2010 Jul 15.

Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1038/jid.2010.196DOI Listing
November 2010

A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.

Nat Genet 2010 Nov 17;42(11):985-90. Epub 2010 Oct 17.

Wellcome Trust Centre for Human Genetics, Oxford, UK.

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http://dx.doi.org/10.1038/ng.694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749730PMC
November 2010

The cystatin M/E-cathepsin L balance is essential for tissue homeostasis in epidermis, hair follicles, and cornea.

FASEB J 2010 Oct 21;24(10):3744-55. Epub 2010 May 21.

Department of Dermatology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://www.fasebj.org/doi/10.1096/fj.10-155879
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http://dx.doi.org/10.1096/fj.10-155879DOI Listing
October 2010

Expression of the vanin gene family in normal and inflamed human skin: induction by proinflammatory cytokines.

J Invest Dermatol 2009 Sep 26;129(9):2167-74. Epub 2009 Mar 26.

Department of Dermatology and Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1038/jid.2009.67DOI Listing
September 2009

The biology of cystatin M/E and its cognate target proteases.

J Invest Dermatol 2009 Jun 5;129(6):1327-38. Epub 2009 Mar 5.

Department of Dermatology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S0022202X1534355
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http://dx.doi.org/10.1038/jid.2009.40DOI Listing
June 2009

Colocalization of cystatin M/E and its target proteases suggests a role in terminal differentiation of human hair follicle and nail.

J Invest Dermatol 2009 May 13;129(5):1232-42. Epub 2008 Nov 13.

Department of Dermatology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S0022202X1534309
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http://dx.doi.org/10.1038/jid.2008.353DOI Listing
May 2009

Genetically programmed differences in epidermal host defense between psoriasis and atopic dermatitis patients.

PLoS One 2008 Jun 4;3(6):e2301. Epub 2008 Jun 4.

Laboratory of Skin Biology and Experimental Dermatology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0002301PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409155PMC
June 2008

Colocalization of cystatin M/E and cathepsin V in lamellar granules and corneodesmosomes suggests a functional role in epidermal differentiation.

J Invest Dermatol 2007 Jan 27;127(1):120-8. Epub 2006 Jul 27.

Department of Dermatology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S0022202X1533103
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http://dx.doi.org/10.1038/sj.jid.5700480DOI Listing
January 2007

Host defense effector molecules in mucosal secretions.

FEMS Immunol Med Microbiol 2005 Aug 9;45(2):151-8. Epub 2005 Apr 9.

Department of Pulmonology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.femsim.2005.03.004DOI Listing
August 2005

Phenotypical and functional differences in germinative subpopulations derived from normal and psoriatic epidermis.

J Invest Dermatol 2005 Feb;124(2):373-83

Department of Dermatology, University Medical Centre Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S0022202X1532154
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http://dx.doi.org/10.1111/j.0022-202X.2004.23612.xDOI Listing
February 2005

Epidermal differentiation: the role of proteases and their inhibitors.

Eur J Cell Biol 2004 Dec;83(11-12):761-73

Laboratory of Skin Biology and Experimental Dermatology, Nijmegen Center for Molecular Life Sciences, University Medical Center Nijmegen, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1078/0171-9335-00388DOI Listing
December 2004

Evidence that unrestricted legumain activity is involved in disturbed epidermal cornification in cystatin M/E deficient mice.

Hum Mol Genet 2004 May 25;13(10):1069-79. Epub 2004 Mar 25.

Department of Dermatology, Nijmegen Center for Molecular Life Sciences, University Medical Center Nijmegen, The Netherlands.

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http://dx.doi.org/10.1093/hmg/ddh115DOI Listing
May 2004

The human cystatin M/E gene (CST6): exclusion candidate gene for harlequin ichthyosis.

J Invest Dermatol 2003 Jul;121(1):65-8

Department of Dermatology, University Medical Center Nijmegen, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1046/j.1523-1747.2003.12312.xDOI Listing
July 2003

A null mutation in the cystatin M/E gene of ichq mice causes juvenile lethality and defects in epidermal cornification.

Hum Mol Genet 2002 Nov;11(23):2867-75

Department of Dermatology, University Medical Center Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1093/hmg/11.23.2867DOI Listing
November 2002

A partial transcriptome of human epidermis.

Genomics 2002 May;79(5):671-8

Neurozintuigen Laboratory, Academic Medical Center, 1100 D Amsterdam, The Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S088875430296756
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http://dx.doi.org/10.1006/geno.2002.6756DOI Listing
May 2002