Patrick J Little

Patrick J Little

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Patrick J Little

Patrick J Little

Publications by authors named "Patrick J Little"

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Sulfamoyl benzamides as novel CB2 cannabinoid receptor ligands.

Bioorg Med Chem Lett 2008 May 7;18(9):2830-5. Epub 2008 Apr 7.

Department of Chemistry, Adolor Corporation, 700 Pennsylvania Drive, Exton, PA, USA.

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http://dx.doi.org/10.1016/j.bmcl.2008.04.006DOI Listing
May 2008

The involvement of the mu-opioid receptor in gastrointestinal pathophysiology: therapeutic opportunities for antagonism at this receptor.

Pharmacol Ther 2008 Jan 16;117(1):162-87. Epub 2007 Oct 16.

Adolor Corporation, 700 Pennsylvania Drive, Exton, PA 19341, USA.

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http://dx.doi.org/10.1016/j.pharmthera.2007.09.007DOI Listing
January 2008

Novel malonamide derivatives as potent kappa opioid receptor agonists.

Bioorg Med Chem Lett 2007 Apr 25;17(7):1951-5. Epub 2007 Jan 25.

Department of Chemistry, Adolor Corporation, 700 Pennsylvania Drive, Exton, PA 19341, USA.

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http://dx.doi.org/10.1016/j.bmcl.2007.01.053DOI Listing
April 2007

Antinociceptive activity of the selective iNOS inhibitor AR-C102222 in rodent models of inflammatory, neuropathic and post-operative pain.

Eur J Pain 2006 Aug 24;10(6):505-12. Epub 2005 Aug 24.

Department of Pharmacology, Adolor Corporation, Exton, PA 19341, USA.

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http://dx.doi.org/10.1016/j.ejpain.2005.07.004DOI Listing
August 2006

Novel phenylamino acetamide derivatives as potent and selective kappa opioid receptor agonists.

Bioorg Med Chem Lett 2006 Feb 2;16(3):645-8. Epub 2005 Nov 2.

Department of Chemistry, Adolor Corporation, 700 Pennsylvania Drive, Exton, PA 19341, USA.

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http://dx.doi.org/10.1016/j.bmcl.2005.10.034DOI Listing
February 2006

Cannabinoid CB2 receptor agonist activity in the hindpaw incision model of postoperative pain.

Eur J Pharmacol 2005 Dec 28;527(1-3):172-4. Epub 2005 Nov 28.

Adolor Corporation, Department of Pharmacology, 700 Pennsylvania Drive, Exton, PA 19341, USA.

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http://dx.doi.org/10.1016/j.ejphar.2005.10.020DOI Listing
December 2005

Pharmacological evaluation of the selective spinal nerve ligation model of neuropathic pain in the rat.

J Neurosci Methods 2005 Jun 18;144(2):175-81. Epub 2004 Dec 18.

Department of Pharmacology, Adolor Corporation, 700 Pennsylvania Drive, Exton, PA 19341, USA.

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http://dx.doi.org/10.1016/j.jneumeth.2004.11.008DOI Listing
June 2005

Azepinone as a conformational constraint in the design of kappa-opioid receptor agonists.

Bioorg Med Chem Lett 2004 Nov;14(22):5693-7

Department of Chemistry, Adolor Corporation, 700 Pennsylvania Drive, Exton, PA 19341, USA.

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http://dx.doi.org/10.1016/j.bmcl.2004.08.041DOI Listing
November 2004