Patrick Holt

Patrick Holt

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Patrick Holt

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Immunoinflammatory responses to febrile lower respiratory infections in infants display uniquely complex/intense transcriptomic profiles.

J Allergy Clin Immunol 2019 Nov 19;144(5):1411-1413. Epub 2019 Aug 19.

Telethon Kids Institute, The University of Western Australia, Nedlands, Australia; Child Health Research Centre, The University of Queensland, Brisbane, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2019.07.043DOI Listing
November 2019

A method for the generation of large numbers of dendritic cells from CD34+ hematopoietic stem cells from cord blood.

J Immunol Methods 2019 Nov 9:112703. Epub 2019 Nov 9.

Academic Unit of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jim.2019.112703DOI Listing
November 2019

Systems biology and big data in asthma and allergy - recent discoveries and emerging challenges.

Eur Respir J 2019 Oct 16. Epub 2019 Oct 16.

Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1183/13993003.00844-2019DOI Listing
October 2019

Primary prevention of severe lower respiratory illnesses in at-risk infants using the immunomodulator OM-85.

J Allergy Clin Immunol 2019 Sep 8;144(3):870-872.e11. Epub 2019 Jun 8.

Telethon Kids Institute, University of Western Australia, Perth, Australia.

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http://dx.doi.org/10.1016/j.jaci.2019.05.032DOI Listing
September 2019

Risk factors and prognosis of recurrent wheezing in Chinese young children: a prospective cohort study.

Allergy Asthma Clin Immunol 2019 18;15:38. Epub 2019 Jun 18.

1Department of Allergy, Children's Hospital of Capital Institute of Pediatrics, Beijing, China.

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http://dx.doi.org/10.1186/s13223-019-0351-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582479PMC
June 2019

Predicting steroid responsiveness in asthmatic children: Are we there yet?

J Allergy Clin Immunol 2019 Mar 28;143(3):927-928. Epub 2018 Aug 28.

Telethon Kids Institute, Perth, Australia.

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http://dx.doi.org/10.1016/j.jaci.2018.07.035DOI Listing
March 2019

Developmental regulation of type 1 and type 3 interferon production and risk for infant infections and asthma development.

J Allergy Clin Immunol 2019 Mar 12;143(3):1176-1182.e5. Epub 2018 Sep 12.

Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, Md.

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http://dx.doi.org/10.1016/j.jaci.2018.08.035DOI Listing
March 2019

Relationship Between Vitamin D Status From Childhood to Early Adulthood With Body Composition in Young Australian Adults.

J Endocr Soc 2019 Mar 21;3(3):563-576. Epub 2019 Jan 21.

Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia.

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http://dx.doi.org/10.1210/js.2018-00349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382407PMC
March 2019

Basophil counts in PBMC populations during childhood acute wheeze/asthma are associated with future exacerbations.

J Allergy Clin Immunol 2018 11 21;142(5):1639-1641.e5. Epub 2018 Jul 21.

Telethon Kids Institute, University of Western Australia, Subiaco, Australia.

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http://dx.doi.org/10.1016/j.jaci.2018.07.003DOI Listing
November 2018

A marked shift in innate and adaptive immune response in chinese immigrants living in a western environment.

Allergy 2018 10 11;73(10):2092-2094. Epub 2018 Jul 11.

School of Paediatrics and Child Health, University of Western Australia, Perth, WA, Australia.

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http://dx.doi.org/10.1111/all.13531DOI Listing
October 2018

Author Correction: Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis.

Nat Genet 2018 09;50(9):1343

COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1038/s41588-018-0197-6DOI Listing
September 2018

Airway Microbiota Dynamics Uncover a Critical Window for Interplay of Pathogenic Bacteria and Allergy in Childhood Respiratory Disease.

Cell Host Microbe 2018 09;24(3):341-352.e5

Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia; Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK; School of BioSciences, The University of Melbourne, Parkville, VIC 3010, Australia; Telethon Kids Institute, The University of Western Australia, West Perth, WA, Australia; Department of Clinical Pathology, The University of Melbourne, Parkville, VIC 3010, Australia; The Alan Turing Institute, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2018.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291254PMC
September 2018

Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis.

Nat Genet 2018 08 16;50(8):1072-1080. Epub 2018 Jul 16.

COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1038/s41588-018-0157-1DOI Listing
August 2018

Pollution, climate change, and childhood asthma in Australia.

Med J Aust 2018 04;208(7):297-298

Telethon Kids Institute, University of Western Australia, Perth, WA.

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April 2018

Functional differences in airway dendritic cells determine susceptibility to IgE-sensitization.

Immunol Cell Biol 2018 03 2;96(3):316-329. Epub 2018 Feb 2.

Telethon Kids Institute, The University of Western Australia, Subiaco, WA, Australia.

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http://dx.doi.org/10.1111/imcb.12005DOI Listing
March 2018

Streptococcus pneumoniae colonization of the nasopharynx is associated with increased severity during respiratory syncytial virus infection in young children.

Respirology 2018 02 15;23(2):220-227. Epub 2017 Sep 15.

Australian Infectious Diseases Research Centre, The University of Queensland, St Lucia, QLD, Australia.

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http://dx.doi.org/10.1111/resp.13179DOI Listing
February 2018

After asthma: redefining airways diseases.

Lancet 2018 01 11;391(10118):350-400. Epub 2017 Sep 11.

Department of Paediatrics, Imperial College, London, UK; Department of Paediatric Respiratory Medicine, Imperial College, London, UK.

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http://dx.doi.org/10.1016/S0140-6736(17)30879-6DOI Listing
January 2018

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.

Authors:
Florence Demenais Patricia Margaritte-Jeannin Kathleen C Barnes William O C Cookson Janine Altmüller Wei Ang R Graham Barr Terri H Beaty Allan B Becker John Beilby Hans Bisgaard Unnur Steina Bjornsdottir Eugene Bleecker Klaus Bønnelykke Dorret I Boomsma Emmanuelle Bouzigon Christopher E Brightling Myriam Brossard Guy G Brusselle Esteban Burchard Kristin M Burkart Andrew Bush Moira Chan-Yeung Kian Fan Chung Alexessander Couto Alves John A Curtin Adnan Custovic Denise Daley Johan C de Jongste Blanca E Del-Rio-Navarro Kathleen M Donohue Liesbeth Duijts Celeste Eng Johan G Eriksson Martin Farrall Yuliya Fedorova Bjarke Feenstra Manuel A Ferreira Maxim B Freidin Zofia Gajdos Jim Gauderman Ulrike Gehring Frank Geller Jon Genuneit Sina A Gharib Frank Gilliland Raquel Granell Penelope E Graves Daniel F Gudbjartsson Tari Haahtela Susan R Heckbert Dick Heederik Joachim Heinrich Markku Heliövaara John Henderson Blanca E Himes Hiroshi Hirose Joel N Hirschhorn Albert Hofman Patrick Holt Jouke Hottenga Thomas J Hudson Jennie Hui Medea Imboden Vladimir Ivanov Vincent W V Jaddoe Alan James Christer Janson Marjo-Riitta Jarvelin Deborah Jarvis Graham Jones Ingileif Jonsdottir Pekka Jousilahti Michael Kabesch Mika Kähönen David B Kantor Alexandra S Karunas Elza Khusnutdinova Gerard H Koppelman Anita L Kozyrskyj Eskil Kreiner Michiaki Kubo Rajesh Kumar Ashish Kumar Mikko Kuokkanen Lies Lahousse Tarja Laitinen Catherine Laprise Mark Lathrop Susanne Lau Young-Ae Lee Terho Lehtimäki Sébastien Letort Albert M Levin Guo Li Liming Liang Laura R Loehr Stephanie J London Daan W Loth Ani Manichaikul Ingo Marenholz Fernando J Martinez Melanie C Matheson Rasika A Mathias Kenji Matsumoto Hamdi Mbarek Wendy L McArdle Mads Melbye Erik Melén Deborah Meyers Sven Michel Hamida Mohamdi Arthur W Musk Rachel A Myers Maartje A E Nieuwenhuis Emiko Noguchi George T O'Connor Ludmila M Ogorodova Cameron D Palmer Aarno Palotie Julie E Park Craig E Pennell Göran Pershagen Alexey Polonikov Dirkje S Postma Nicole Probst-Hensch Valery P Puzyrev Benjamin A Raby Olli T Raitakari Adaikalavan Ramasamy Stephen S Rich Colin F Robertson Isabelle Romieu Muhammad T Salam Veikko Salomaa Vivi Schlünssen Robert Scott Polina A Selivanova Torben Sigsgaard Angela Simpson Valérie Siroux Lewis J Smith Maria Solodilova Marie Standl Kari Stefansson David P Strachan Bruno H Stricker Atsushi Takahashi Philip J Thompson Gudmar Thorleifsson Unnur Thorsteinsdottir Carla M T Tiesler Dara G Torgerson Tatsuhiko Tsunoda André G Uitterlinden Ralf J P van der Valk Amaury Vaysse Sailaja Vedantam Andrea von Berg Erika von Mutius Judith M Vonk Johannes Waage Nick J Wareham Scott T Weiss Wendy B White Magnus Wickman Elisabeth Widén Gonneke Willemsen L Keoki Williams Inge M Wouters James J Yang Jing Hua Zhao Miriam F Moffatt Carole Ober Dan L Nicolae

Nat Genet 2018 01 22;50(1):42-53. Epub 2017 Dec 22.

Departments of Statistics, Human Genetics and Medicine, Section of Genetic Medicine, University of Chicago, Chicago, IL, USA.

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http://www.nature.com/articles/s41588-017-0014-7
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http://dx.doi.org/10.1038/s41588-017-0014-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901974PMC
January 2018

Diagnostic Evaluation of Upper Extremity Masses and Tumors.

Orthopedics 2017 Sep 22;40(5):e758-e764. Epub 2017 May 22.

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http://dx.doi.org/10.3928/01477447-20170518-02DOI Listing
September 2017

CFTR-dependent defect in alternatively-activated macrophages in cystic fibrosis.

J Cyst Fibros 2017 Jul 17;16(4):475-482. Epub 2017 Apr 17.

Child Health Research Centre, The University of Queensland, Brisbane, Australia.

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http://dx.doi.org/10.1016/j.jcf.2017.03.011DOI Listing
July 2017

Tracking of vitamin D status from childhood to early adulthood and its association with peak bone mass.

Am J Clin Nutr 2017 Jul 7;106(1):276-283. Epub 2017 Jun 7.

Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, Australia; Schools of.

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http://dx.doi.org/10.3945/ajcn.116.150524DOI Listing
July 2017

An exposome perspective: Early-life events and immune development in a changing world.

J Allergy Clin Immunol 2017 Jul;140(1):24-40

Children's Health and Environment Program, Child Health Research Centre, University of Queensland, Brisbane, Australia.

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http://dx.doi.org/10.1016/j.jaci.2017.05.015DOI Listing
July 2017

Mannitol challenge testing for asthma in a community cohort of young adults.

Respirology 2017 05 5;22(4):678-683. Epub 2016 Dec 5.

Telethon Kids Institute, Perth, Perth, Western Australia, Australia.

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http://dx.doi.org/10.1111/resp.12955DOI Listing
May 2017

Vitamin D over the first decade and susceptibility to childhood allergy and asthma.

J Allergy Clin Immunol 2017 02 7;139(2):472-481.e9. Epub 2016 Oct 7.

Telethon Kids Institute, University of Western Australia, Perth, Australia; University of Queensland, Brisbane, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2016.07.032DOI Listing
February 2017

Severe winter asthma exacerbations can be prevented by omalizumab, but there is no carryover effect.

J Allergy Clin Immunol 2017 02 13;139(2):703-705.e4. Epub 2016 Sep 13.

Telethon Kids Institute, Perth, Australia.

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http://dx.doi.org/10.1016/j.jaci.2016.07.035DOI Listing
February 2017

Rapid recruitment of CD14(+) monocytes in experimentally induced allergic rhinitis in human subjects.

J Allergy Clin Immunol 2016 06 4;137(6):1872-1881.e12. Epub 2016 Feb 4.

Department of Pathology and Centre for Immune Regulation (CIR), Oslo University Hospital-Rikshospitalet and University of Oslo, Oslo, Norway. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2015.11.025DOI Listing
June 2016

Distinguishing benign from pathologic TH2 immunity in atopic children.

J Allergy Clin Immunol 2016 Feb 27;137(2):379-87. Epub 2015 Oct 27.

Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair, University of Manchester and University Hospital of South Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2015.08.044DOI Listing
February 2016

Differential gene network analysis for the identification of asthma-associated therapeutic targets in allergen-specific T-helper memory responses.

BMC Med Genomics 2016 Feb 27;9. Epub 2016 Feb 27.

Telethon Kids Institute, The University of Western Australia, Crawley, Australia.

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http://dx.doi.org/10.1186/s12920-016-0171-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769846PMC
February 2016

Environmental Microbial Exposure and Protection against Asthma.

N Engl J Med 2015 Dec;373(26):2576-8

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http://dx.doi.org/10.1056/NEJMcibr1511291DOI Listing
December 2015

Phenotypic, functional, and plasticity features of classical and alternatively activated human macrophages.

Am J Respir Cell Mol Biol 2015 Nov;53(5):676-88

1 Queensland Children's Medical Research Institute, Royal Children's Hospital, Brisbane, The University of Queensland, Brisbane, Queensland, Australia; and.

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http://dx.doi.org/10.1165/rcmb.2015-0012OCDOI Listing
November 2015

Meta-analysis identifies seven susceptibility loci involved in the atopic march.

Nat Commun 2015 Nov 6;6:8804. Epub 2015 Nov 6.

Max-Delbrück-Center (MDC) for Molecular Medicine, Berlin, Germany.

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http://dx.doi.org/10.1038/ncomms9804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667629PMC
November 2015

Persistent and compartmentalised disruption of dendritic cell subpopulations in the lung following influenza A virus infection.

PLoS One 2014 14;9(11):e111520. Epub 2014 Nov 14.

Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, Perth, W.A., Australia; School of Veterinary and Life Sciences, Murdoch University, Perth, W.A., Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0111520PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232261PMC
July 2015

The mechanism or mechanisms driving atopic asthma initiation: The infant respiratory microbiome moves to center stage.

Authors:
Patrick G Holt

J Allergy Clin Immunol 2015 Jul;136(1):15-22

Telethon Kids Institute, University of Western Australia, Perth, Australia; Queensland Children's Medical Research Institute, University of Queensland, Brisbane, Australia. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00916749150071
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http://dx.doi.org/10.1016/j.jaci.2015.05.011DOI Listing
July 2015

The infant nasopharyngeal microbiome impacts severity of lower respiratory infection and risk of asthma development.

Cell Host Microbe 2015 May 9;17(5):704-15. Epub 2015 Apr 9.

Medical Systems Biology, Department of Pathology and Department of Microbiology & Immunology, The University of Melbourne, Parkville, VIC 3010, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2015.03.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433433PMC
May 2015

Evidence for the contribution of non-covalent steroid interactions between DNA and topoisomerase in the genotoxicity of steroids.

Drug Chem Toxicol 2015 Apr 30;38(2):212-9. Epub 2014 Jun 30.

RDS Consulting Services , 3335 Grand Falls Blvd, Maineville, OH , United States and.

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http://dx.doi.org/10.3109/01480545.2014.928725DOI Listing
April 2015

Genome-wide association study identifies peanut allergy-specific loci and evidence of epigenetic mediation in US children.

Nat Commun 2015 Feb 24;6:6304. Epub 2015 Feb 24.

1] Department of Population, Family and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, 615 North Wolfe Street, E4132, Baltimore, Maryland 21205, USA [2] Division of General Pediatrics and Adolescent Medicine, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.

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http://dx.doi.org/10.1038/ncomms7304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340086PMC
February 2015

Anti-infective proteins in breast milk and asthma-associated phenotypes during early childhood.

Pediatr Allergy Immunol 2014 Oct;25(6):544-51

School of Public Health, Curtin University, Perth, WA, Australia.

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http://doi.wiley.com/10.1111/pai.12265
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http://dx.doi.org/10.1111/pai.12265DOI Listing
October 2014

Elucidation of pathways driving asthma pathogenesis: development of a systems-level analytic strategy.

Front Immunol 2014 23;5:447. Epub 2014 Sep 23.

Medical Systems Biology, Department of Pathology, The University of Melbourne , Parkville, VIC , Australia ; Telethon Kids Institute, The University of Western Australia , West Perth, WA , Australia ; Medical Systems Biology, Department of Microbiology and Immunology, The University of Melbourne , Parkville, VIC , Australia.

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http://dx.doi.org/10.3389/fimmu.2014.00447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172064PMC
October 2014

Prenatal adverse life events increase the risk for atopic diseases in children, which is enhanced in the absence of a maternal atopic predisposition.

J Allergy Clin Immunol 2014 Jul 21;134(1):160-9. Epub 2014 Mar 21.

Department of Obstetrics and Fetal Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2014.01.033DOI Listing
July 2014

Low serum 25-hydroxyvitamin D concentrations associate with non-alcoholic fatty liver disease in adolescents independent of adiposity.

J Gastroenterol Hepatol 2014 Jun;29(6):1215-22

Telethon Institute for Child Health Research, The University of Western Australia, Perth, Western Australia, Australia.

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http://dx.doi.org/10.1111/jgh.12541DOI Listing
June 2014

Antibody and cell-mediated immunity to pertussis 4 years after monovalent acellular pertussis vaccine at birth.

Pediatr Infect Dis J 2014 May;33(5):511-7

From the *National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases, The Children's Hospital at Westmead and the University of Sydney, New South Wales; †The Children's Hospital, Westmead, Sydney; ‡The University of Sydney, New South Wales, Australia; §Discipline of Paediatrics, School of Paediatrics and Reproductive Health and the Robinson Institute, The University of Adelaide; ¶Vaccinology and Immunology Research Trials Unit, Women's and Children's Hospital, Women's and Children's Health Network, South Australia; ‖Telethon Institute for Child Health Research and Centre for Child Health Research, Faculty of Medicine and Dentistry, The University of Western Australia, Perth; and **Queensland Children's Medical Research Institute, University of Queensland, Brisbane, Queensland, Australia.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/INF.0000000000000246DOI Listing
May 2014

Persistent effects of maternal smoking during pregnancy on lung function and asthma in adolescents.

Am J Respir Crit Care Med 2014 Feb;189(4):401-7

1 Division of Cell Biology and.

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http://dx.doi.org/10.1164/rccm.201302-0323OCDOI Listing
February 2014

Defective respiratory tract immune surveillance in asthma: a primary causal factor in disease onset and progression.

Chest 2014 Feb;145(2):370-378

Telethon Institute for Child Health Research and Centre for Child Health Research, The University of Western Australia, Perth, WA; QCMRI-Queensland Children's Medical Research Institute and University of Queensland, Brisbane, QLD, Australia.

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http://dx.doi.org/10.1378/chest.13-1341DOI Listing
February 2014

Prevention--what is the most promising approach?

Authors:
Patrick G Holt

Pediatr Allergy Immunol 2014 Feb;25(1):12-4

Telethon Institute for Child Health Research, The University of Western Australia, West Perth, WA, Australia; Queensland Children's Medical Research Institute, University of Queensland, Brisbane, Qld, Australia.

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http://dx.doi.org/10.1111/pai.12194DOI Listing
February 2014

Prophylactic use of sublingual allergen immunotherapy in high-risk children: a pilot study.

J Allergy Clin Immunol 2013 Oct 12;132(4):991-3.e1. Epub 2013 Jun 12.

Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, Perth, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2013.04.049DOI Listing
October 2013

Prediction of noncovalent Drug/DNA interaction using computational docking models: studies with over 1350 launched drugs.

Environ Mol Mutagen 2013 Oct 26;54(8):668-81. Epub 2013 Jul 26.

3335 Grand Falls Blvd, Maineville, Ohio.

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http://dx.doi.org/10.1002/em.21796DOI Listing
October 2013

Maternal vitamin D levels and the autism phenotype among offspring.

J Autism Dev Disord 2013 Jul;43(7):1495-504

Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, 100 Roberts Road, Subiaco, West Perth, WA, 6008, Australia.

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http://dx.doi.org/10.1007/s10803-012-1676-8DOI Listing
July 2013

Th2 Cytokine Levels Distort the Association of IL-10 and IFN-γ with Allergic Phenotypes.

ISRN Allergy 2011 28;2011:405813. Epub 2011 Dec 28.

School of Paediatrics and Child Health, Faculty of Medicine, Dentistry and Health Sciences, The University of Western Australia, GPO Box D184, Perth, WA 6840, Australia ; Telethon Institute for Child Health Research and UWA Centre for Child Health Research, Faculty of Medicine, Dentistry and Health Sciences, The University of Western Australia, GPO Box D184, Perth, WA 6840, Australia.

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http://dx.doi.org/10.5402/2011/405813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658504PMC
June 2013

Airway epithelial cells condition dendritic cells to express multiple immune surveillance genes.

PLoS One 2012 11;7(9):e44941. Epub 2012 Sep 11.

Telethon Institute for Child Health Research, and Centre for Child Health Research, The University of Western Australia, Perth, Western Australia, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0044941PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439377PMC
March 2013

Not all G-quadruplexes are created equally: an investigation of the structural polymorphism of the c-Myc G-quadruplex-forming sequence and its interaction with the porphyrin TMPyP4.

Org Biomol Chem 2012 Dec 29;10(47):9393-404. Epub 2012 Oct 29.

Department of Biochemistry and Molecular Biology, School of Medicine, University of Louisville, HSC-A Building, Room 616, Louisville, Kentucky 40292, USA.

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http://dx.doi.org/10.1039/c2ob26504dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501587PMC
December 2012

Neonatal antigen-presenting cells are functionally more quiescent in children born under traditional compared with modern environmental conditions.

J Allergy Clin Immunol 2012 Nov 19;130(5):1167-1174.e10. Epub 2012 Jul 19.

Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Australia.

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http://linkinghub.elsevier.com/retrieve/pii/S009167491200952
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http://dx.doi.org/10.1016/j.jaci.2012.06.005DOI Listing
November 2012

A novel role for interleukin-1 receptor signaling in the developmental regulation of immune responses to endotoxin.

Pediatr Allergy Immunol 2012 Sep 22;23(6):567-72. Epub 2012 Mar 22.

School of Paediatrics and Child Health, University of Western Australia, Perth, Western Australia, Australia.

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http://dx.doi.org/10.1111/j.1399-3038.2012.01287.xDOI Listing
September 2012

Sensitizing and Th2 adjuvant activity of cysteine protease allergens.

Int Arch Allergy Immunol 2012 3;158(4):347-58. Epub 2012 Apr 3.

Centre for Child Health Research, University of Western Australia, Subiaco, W.A., Australia.

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https://www.karger.com/Article/FullText/334280
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http://dx.doi.org/10.1159/000334280DOI Listing
September 2012

Hospitalisation for bronchiolitis in infants is more common after elective caesarean delivery.

Arch Dis Child 2012 May 28;97(5):410-4. Epub 2011 Oct 28.

Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Australia.

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http://dx.doi.org/10.1136/archdischild-2011-300607DOI Listing
May 2012

Viral infections and atopy in asthma pathogenesis: new rationales for asthma prevention and treatment.

Nat Med 2012 May 4;18(5):726-35. Epub 2012 May 4.

Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Perth, Australia.

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http://dx.doi.org/10.1038/nm.2768DOI Listing
May 2012

Antibacterial antibody responses associated with the development of asthma in house dust mite-sensitised and non-sensitised children.

Thorax 2012 Apr 21;67(4):321-7. Epub 2011 Nov 21.

Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, 100 Roberts Road, Subiaco, WA 6008, Australia.

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April 2012

Virus infection and allergy in the development of asthma: what is the connection?

Curr Opin Allergy Clin Immunol 2012 Apr;12(2):151-7

Telethon Institute for Child Health Research, and Centre for Child Health Research, The University of Western Australia, Perth, Australia.

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http://dx.doi.org/10.1097/ACI.0b013e3283520166DOI Listing
April 2012

Comparison of neonatal T regulatory cell function in Papua New Guinean and Australian newborns.

Pediatr Allergy Immunol 2012 Mar 23;23(2):173-80. Epub 2011 Dec 23.

Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Australia.

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http://dx.doi.org/10.1111/j.1399-3038.2011.01242.xDOI Listing
March 2012

Maternal serum vitamin D levels during pregnancy and offspring neurocognitive development.

Pediatrics 2012 Mar 13;129(3):485-93. Epub 2012 Feb 13.

Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Subiaco, Australia.

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http://dx.doi.org/10.1542/peds.2011-2644DOI Listing
March 2012

A genomics-based approach to assessment of vaccine safety and immunogenicity in children.

Vaccine 2012 Feb 9;30(10):1865-74. Epub 2012 Jan 9.

Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Perth, Australia.

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February 2012

Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis.

Authors:
Lavinia Paternoster Marie Standl Chih-Mei Chen Adaikalavan Ramasamy Klaus Bønnelykke Liesbeth Duijts Manuel A Ferreira Alexessander Couto Alves Jacob P Thyssen Eva Albrecht Hansjörg Baurecht Bjarke Feenstra Patrick M A Sleiman Pirro Hysi Nicole M Warrington Ivan Curjuric Ronny Myhre John A Curtin Maria M Groen-Blokhuis Marjan Kerkhof Annika Sääf Andre Franke David Ellinghaus Regina Fölster-Holst Emmanouil Dermitzakis Stephen B Montgomery Holger Prokisch Katharina Heim Anna-Liisa Hartikainen Anneli Pouta Juha Pekkanen Alexandra I F Blakemore Jessica L Buxton Marika Kaakinen David L Duffy Pamela A Madden Andrew C Heath Grant W Montgomery Philip J Thompson Melanie C Matheson Peter Le Souëf Beate St Pourcain George Davey Smith John Henderson John P Kemp Nicholas J Timpson Panos Deloukas Susan M Ring H-Erich Wichmann Martina Müller-Nurasyid Natalija Novak Norman Klopp Elke Rodríguez Wendy McArdle Allan Linneberg Torkil Menné Ellen A Nohr Albert Hofman André G Uitterlinden Cornélia M van Duijn Fernando Rivadeneira Johan C de Jongste Ralf J P van der Valk Matthias Wjst Rain Jogi Frank Geller Heather A Boyd Jeffrey C Murray Cecilia Kim Frank Mentch Michael March Massimo Mangino Tim D Spector Veronique Bataille Craig E Pennell Patrick G Holt Peter Sly Carla M T Tiesler Elisabeth Thiering Thomas Illig Medea Imboden Wenche Nystad Angela Simpson Jouke-Jan Hottenga Dirkje Postma Gerard H Koppelman Henriette A Smit Cilla Söderhäll Bo Chawes Eskil Kreiner-Møller Hans Bisgaard Erik Melén Dorret I Boomsma Adnan Custovic Bo Jacobsson Nicole M Probst-Hensch Lyle J Palmer Daniel Glass Hakon Hakonarson Mads Melbye Deborah L Jarvis Vincent W V Jaddoe Christian Gieger David P Strachan Nicholas G Martin Marjo-Riitta Jarvelin Joachim Heinrich David M Evans Stephan Weidinger

Nat Genet 2011 Dec 25;44(2):187-92. Epub 2011 Dec 25.

Medical Research Council Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272375PMC
December 2011

Restricted aeroallergen access to airway mucosal dendritic cells in vivo limits allergen-specific CD4+ T cell proliferation during the induction of inhalation tolerance.

J Immunol 2011 Nov 19;187(9):4561-70. Epub 2011 Sep 19.

Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, Nedlands, Western Australia, Australia.

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http://dx.doi.org/10.4049/jimmunol.1004189DOI Listing
November 2011

Polymorphism and resolution of oncogene promoter quadruplex-forming sequences.

Org Biomol Chem 2011 Oct 21;9(22):7633-7. Epub 2011 Sep 21.

Department of Medicine, University of Louisville, Louisville, KY 40202, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962748PMC
October 2011

T regulatory cells in childhood asthma.

Trends Immunol 2011 Sep 27;32(9):420-7. Epub 2011 Jul 27.

Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Perth, Australia.

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September 2011

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.

Authors:
María Soler Artigas Daan W Loth Louise V Wain Sina A Gharib Ma'en Obeidat Wenbo Tang Guangju Zhai Jing Hua Zhao Albert Vernon Smith Jennifer E Huffman Eva Albrecht Catherine M Jackson David M Evans Gemma Cadby Myriam Fornage Ani Manichaikul Lorna M Lopez Toby Johnson Melinda C Aldrich Thor Aspelund Inês Barroso Harry Campbell Patricia A Cassano David J Couper Gudny Eiriksdottir Nora Franceschini Melissa Garcia Christian Gieger Gauti Kjartan Gislason Ivica Grkovic Christopher J Hammond Dana B Hancock Tamara B Harris Adaikalavan Ramasamy Susan R Heckbert Markku Heliövaara Georg Homuth Pirro G Hysi Alan L James Stipan Jankovic Bonnie R Joubert Stefan Karrasch Norman Klopp Beate Koch Stephen B Kritchevsky Lenore J Launer Yongmei Liu Laura R Loehr Kurt Lohman Ruth J F Loos Thomas Lumley Khalid A Al Balushi Wei Q Ang R Graham Barr John Beilby John D Blakey Mladen Boban Vesna Boraska Jonas Brisman John R Britton Guy G Brusselle Cyrus Cooper Ivan Curjuric Santosh Dahgam Ian J Deary Shah Ebrahim Mark Eijgelsheim Clyde Francks Darya Gaysina Raquel Granell Xiangjun Gu John L Hankinson Rebecca Hardy Sarah E Harris John Henderson Amanda Henry Aroon D Hingorani Albert Hofman Patrick G Holt Jennie Hui Michael L Hunter Medea Imboden Karen A Jameson Shona M Kerr Ivana Kolcic Florian Kronenberg Jason Z Liu Jonathan Marchini Tricia McKeever Andrew D Morris Anna-Carin Olin David J Porteous Dirkje S Postma Stephen S Rich Susan M Ring Fernando Rivadeneira Thierry Rochat Avan Aihie Sayer Ian Sayers Peter D Sly George Davey Smith Akshay Sood John M Starr André G Uitterlinden Judith M Vonk S Goya Wannamethee Peter H Whincup Cisca Wijmenga O Dale Williams Andrew Wong Massimo Mangino Kristin D Marciante Wendy L McArdle Bernd Meibohm Alanna C Morrison Kari E North Ernst Omenaas Lyle J Palmer Kirsi H Pietiläinen Isabelle Pin Ozren Pola Sbreve Ek Anneli Pouta Bruce M Psaty Anna-Liisa Hartikainen Taina Rantanen Samuli Ripatti Jerome I Rotter Igor Rudan Alicja R Rudnicka Holger Schulz So-Youn Shin Tim D Spector Ida Surakka Veronique Vitart Henry Völzke Nicholas J Wareham Nicole M Warrington H-Erich Wichmann Sarah H Wild Jemma B Wilk Matthias Wjst Alan F Wright Lina Zgaga Tatijana Zemunik Craig E Pennell Fredrik Nyberg Diana Kuh John W Holloway H Marike Boezen Debbie A Lawlor Richard W Morris Nicole Probst-Hensch Jaakko Kaprio James F Wilson Caroline Hayward Mika Kähönen Joachim Heinrich Arthur W Musk Deborah L Jarvis Sven Gläser Marjo-Riitta Järvelin Bruno H Ch Stricker Paul Elliott George T O'Connor David P Strachan Stephanie J London Ian P Hall Vilmundur Gudnason Martin D Tobin

Nat Genet 2011 Sep 25;43(11):1082-90. Epub 2011 Sep 25.

Department of Health Sciences, University of Leicester, Leicester, UK.

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September 2011

Risk factors for bronchial hyperresponsiveness in teenagers differ with sex and atopic status.

J Allergy Clin Immunol 2011 Aug 17;128(2):301-307.e1. Epub 2011 Apr 17.

Division of Clinical Sciences, Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Australia.

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August 2011

Gene polymorphisms, breast-feeding, and development of food sensitization in early childhood.

J Allergy Clin Immunol 2011 Aug;128(2):374-81.e2

Mary Ann and J. Milburn Smith Child Health Research Program, Department of Pediatrics, Northwestern University Feinberg School of Medicine and Children's Memorial Hospital and Children's Memorial Research Center, Chicago, IL 60614, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149737PMC
August 2011

Allergen-specific IgG antibody levels modify the relationship between allergen-specific IgE and wheezing in childhood.

J Allergy Clin Immunol 2011 Jun 13;127(6):1480-5. Epub 2011 Apr 13.

University of Manchester, Manchester Academic Health Science Centre, NIHR Translational Research Facility in Respiratory Medicine, University Hospital of South Manchester NHS Foundation Trust, Manchester, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4781815PMC
June 2011

Interaction between adaptive and innate immune pathways in the pathogenesis of atopic asthma: operation of a lung/bone marrow axis.

Chest 2011 May;139(5):1165-1171

Queensland Children's Medical Research Institute and University of Queensland, Brisbane, QLD, Australia.

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May 2011

Role of innate immunity in the development of allergy and asthma.

Curr Opin Allergy Clin Immunol 2011 Apr;11(2):127-31

Queensland Children's Medical Research Institute, University of Queensland, Brisbane, Queensland, Australia.

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April 2011

A Discovery Funnel for Nucleic Acid Binding Drug Candidates.

Drug Dev Res 2011 Mar;72(2):178-186

James Graham Brown Cancer Center, University of Louisville, 505 S. Hancock St., Louisville, KY 40202, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090163PMC
March 2011

Epithelial-dendritic cell interactions in allergic disorders.

Curr Opin Immunol 2010 Dec 23;22(6):789-94. Epub 2010 Nov 23.

Telethon Institute for Child Health Research, and Centre for Child Health Research, The University of Western Australia, Perth, Western Australia, Australia.

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http://dx.doi.org/10.1016/j.coi.2010.10.019DOI Listing
December 2010

The hygiene hypothesis revisited: role of materno-fetal interactions.

Curr Allergy Asthma Rep 2010 Nov;10(6):444-52

Institute of Life Science, Swansea University, Wales, UK.

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http://dx.doi.org/10.1007/s11882-010-0148-5DOI Listing
November 2010

Lung homing T-cell generation is dependent on strength and timing of antigen delivery to lymph nodes.

Immunol Cell Biol 2010 Aug 2;88(6):658-66. Epub 2010 Mar 2.

Telethon Institute for Child Health Research and Centre for Child Health Research, School of Paediatrics and Child Health, University of Western Australia, Perth, Western Australia, Australia.

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http://dx.doi.org/10.1038/icb.2010.18DOI Listing
August 2010

Do early-life viral infections cause asthma?

J Allergy Clin Immunol 2010 Jun 20;125(6):1202-5. Epub 2010 Mar 20.

Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, Perth, Australia.

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June 2010

Interactions between innate and adaptive immunity in asthma pathogenesis: new perspectives from studies on acute exacerbations.

J Allergy Clin Immunol 2010 May 15;125(5):963-72; quiz 973-4. Epub 2010 Apr 15.

Telethon Institute for Child Health Research and the Centre for Child Health Research, Faculty of Medicine and Dentistry, University of Western Australia, Perth, Australia.

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May 2010

Th2-polarisation of cellular immune memory to neonatal pertussis vaccination.

Vaccine 2010 Mar 20;28(14):2648-52. Epub 2010 Jan 20.

Telethon Institute for Child Health Research, and Centre for Child Health Research, Faculty of Medicine and Dentistry, The University of Western Australia, Perth, Australia.

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March 2010

Toward improved prediction of risk for atopy and asthma among preschoolers: a prospective cohort study.

J Allergy Clin Immunol 2010 Mar;125(3):653-9, 659.e1-659.e7

Division of Cell Biology, Telethon Institute for Child Health Research and the Centre for Child Health Research, Faculty of Medicine and Dentistry, the University of Western Australia, Perth, Australia.

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March 2010