Patrick G Kehoe

Patrick G Kehoe

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Patrick G Kehoe

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Divergence in the activity of the N- and C- catalytic domains of ACE1 - implications for the role of the renin-angiotensin system in Alzheimer's disease.

Acta Neuropathol Commun 2019 Apr 24;7(1):57. Epub 2019 Apr 24.

Dementia Research Group, Translational Health Sciences, Bristol Medical School, University of Bristol, Level 1 Learning and Research, Southmead Hospital, Bristol, BS10 5NB, UK.

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http://dx.doi.org/10.1186/s40478-019-0718-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480511PMC
April 2019

Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.

Authors:
Brian W Kunkle Benjamin Grenier-Boley Rebecca Sims Joshua C Bis Vincent Damotte Adam C Naj Anne Boland Maria Vronskaya Sven J van der Lee Alexandre Amlie-Wolf Céline Bellenguez Aura Frizatti Vincent Chouraki Eden R Martin Kristel Sleegers Nandini Badarinarayan Johanna Jakobsdottir Kara L Hamilton-Nelson Sonia Moreno-Grau Robert Olaso Rachel Raybould Yuning Chen Amanda B Kuzma Mikko Hiltunen Taniesha Morgan Shahzad Ahmad Badri N Vardarajan Jacques Epelbaum Per Hoffmann Merce Boada Gary W Beecham Jean-Guillaume Garnier Denise Harold Annette L Fitzpatrick Otto Valladares Marie-Laure Moutet Amy Gerrish Albert V Smith Liming Qu Delphine Bacq Nicola Denning Xueqiu Jian Yi Zhao Maria Del Zompo Nick C Fox Seung-Hoan Choi Ignacio Mateo Joseph T Hughes Hieab H Adams John Malamon Florentino Sanchez-Garcia Yogen Patel Jennifer A Brody Beth A Dombroski Maria Candida Deniz Naranjo Makrina Daniilidou Gudny Eiriksdottir Shubhabrata Mukherjee David Wallon James Uphill Thor Aspelund Laura B Cantwell Fabienne Garzia Daniela Galimberti Edith Hofer Mariusz Butkiewicz Bertrand Fin Elio Scarpini Chloe Sarnowski Will S Bush Stéphane Meslage Johannes Kornhuber Charles C White Yuenjoo Song Robert C Barber Sebastiaan Engelborghs Sabrina Sordon Dina Voijnovic Perrie M Adams Rik Vandenberghe Manuel Mayhaus L Adrienne Cupples Marilyn S Albert Peter P De Deyn Wei Gu Jayanadra J Himali Duane Beekly Alessio Squassina Annette M Hartmann Adelina Orellana Deborah Blacker Eloy Rodriguez-Rodriguez Simon Lovestone Melissa E Garcia Rachelle S Doody Carmen Munoz-Fernadez Rebecca Sussams Honghuang Lin Thomas J Fairchild Yolanda A Benito Clive Holmes Hata Karamujić-Čomić Matthew P Frosch Hakan Thonberg Wolfgang Maier Gena Roschupkin Bernardino Ghetti Vilmantas Giedraitis Amit Kawalia Shuo Li Ryan M Huebinger Lena Kilander Susanne Moebus Isabel Hernández M Ilyas Kamboh RoseMarie Brundin James Turton Qiong Yang Mindy J Katz Letizia Concari Jenny Lord Alexa S Beiser C Dirk Keene Seppo Helisalmi Iwona Kloszewska Walter A Kukull Anne Maria Koivisto Aoibhinn Lynch Lluís Tarraga Eric B Larson Annakaisa Haapasalo Brian Lawlor Thomas H Mosley Richard B Lipton Vincenzo Solfrizzi Michael Gill W T Longstreth Thomas J Montine Vincenza Frisardi Monica Diez-Fairen Fernando Rivadeneira Ronald C Petersen Vincent Deramecourt Ignacio Alvarez Francesca Salani Antonio Ciaramella Eric Boerwinkle Eric M Reiman Nathalie Fievet Jerome I Rotter Joan S Reisch Olivier Hanon Chiara Cupidi A G Andre Uitterlinden Donald R Royall Carole Dufouil Raffaele Giovanni Maletta Itziar de Rojas Mary Sano Alexis Brice Roberta Cecchetti Peter St George-Hyslop Karen Ritchie Magda Tsolaki Debby W Tsuang Bruno Dubois David Craig Chuang-Kuo Wu Hilkka Soininen Despoina Avramidou Roger L Albin Laura Fratiglioni Antonia Germanou Liana G Apostolova Lina Keller Maria Koutroumani Steven E Arnold Francesco Panza Olymbia Gkatzima Sanjay Asthana Didier Hannequin Patrice Whitehead Craig S Atwood Paolo Caffarra Harald Hampel Inés Quintela Ángel Carracedo Lars Lannfelt David C Rubinsztein Lisa L Barnes Florence Pasquier Lutz Frölich Sandra Barral Bernadette McGuinness Thomas G Beach Janet A Johnston James T Becker Peter Passmore Eileen H Bigio Jonathan M Schott Thomas D Bird Jason D Warren Bradley F Boeve Michelle K Lupton James D Bowen Petra Proitsi Adam Boxer John F Powell James R Burke John S K Kauwe Jeffrey M Burns Michelangelo Mancuso Joseph D Buxbaum Ubaldo Bonuccelli Nigel J Cairns Andrew McQuillin Chuanhai Cao Gill Livingston Chris S Carlson Nicholas J Bass Cynthia M Carlsson John Hardy Regina M Carney Jose Bras Minerva M Carrasquillo Rita Guerreiro Mariet Allen Helena C Chui Elizabeth Fisher Carlo Masullo Elizabeth A Crocco Charles DeCarli Gina Bisceglio Malcolm Dick Li Ma Ranjan Duara Neill R Graff-Radford Denis A Evans Angela Hodges Kelley M Faber Martin Scherer Kenneth B Fallon Matthias Riemenschneider David W Fardo Reinhard Heun Martin R Farlow Heike Kölsch Steven Ferris Markus Leber Tatiana M Foroud Isabella Heuser Douglas R Galasko Ina Giegling Marla Gearing Michael Hüll Daniel H Geschwind John R Gilbert John Morris Robert C Green Kevin Mayo John H Growdon Thomas Feulner Ronald L Hamilton Lindy E Harrell Dmitriy Drichel Lawrence S Honig Thomas D Cushion Matthew J Huentelman Paul Hollingworth Christine M Hulette Bradley T Hyman Rachel Marshall Gail P Jarvik Alun Meggy Erin Abner Georgina E Menzies Lee-Way Jin Ganna Leonenko Luis M Real Gyungah R Jun Clinton T Baldwin Detelina Grozeva Anna Karydas Giancarlo Russo Jeffrey A Kaye Ronald Kim Frank Jessen Neil W Kowall Bruno Vellas Joel H Kramer Emma Vardy Frank M LaFerla Karl-Heinz Jöckel James J Lah Martin Dichgans James B Leverenz David Mann Allan I Levey Stuart Pickering-Brown Andrew P Lieberman Norman Klopp Kathryn L Lunetta H-Erich Wichmann Constantine G Lyketsos Kevin Morgan Daniel C Marson Kristelle Brown Frank Martiniuk Christopher Medway Deborah C Mash Markus M Nöthen Eliezer Masliah Nigel M Hooper Wayne C McCormick Antonio Daniele Susan M McCurry Anthony Bayer Andrew N McDavid John Gallacher Ann C McKee Hendrik van den Bussche Marsel Mesulam Carol Brayne Bruce L Miller Steffi Riedel-Heller Carol A Miller Joshua W Miller Ammar Al-Chalabi John C Morris Christopher E Shaw Amanda J Myers Jens Wiltfang Sid O'Bryant John M Olichney Victoria Alvarez Joseph E Parisi Andrew B Singleton Henry L Paulson John Collinge William R Perry Simon Mead Elaine Peskind David H Cribbs Martin Rossor Aimee Pierce Natalie S Ryan Wayne W Poon Benedetta Nacmias Huntington Potter Sandro Sorbi Joseph F Quinn Eleonora Sacchinelli Ashok Raj Gianfranco Spalletta Murray Raskind Carlo Caltagirone Paola Bossù Maria Donata Orfei Barry Reisberg Robert Clarke Christiane Reitz A David Smith John M Ringman Donald Warden Erik D Roberson Gordon Wilcock Ekaterina Rogaeva Amalia Cecilia Bruni Howard J Rosen Maura Gallo Roger N Rosenberg Yoav Ben-Shlomo Mark A Sager Patrizia Mecocci Andrew J Saykin Pau Pastor Michael L Cuccaro Jeffery M Vance Julie A Schneider Lori S Schneider Susan Slifer William W Seeley Amanda G Smith Joshua A Sonnen Salvatore Spina Robert A Stern Russell H Swerdlow Mitchell Tang Rudolph E Tanzi John Q Trojanowski Juan C Troncoso Vivianna M Van Deerlin Linda J Van Eldik Harry V Vinters Jean Paul Vonsattel Sandra Weintraub Kathleen A Welsh-Bohmer Kirk C Wilhelmsen Jennifer Williamson Thomas S Wingo Randall L Woltjer Clinton B Wright Chang-En Yu Lei Yu Yasaman Saba Alberto Pilotto Maria J Bullido Oliver Peters Paul K Crane David Bennett Paola Bosco Eliecer Coto Virginia Boccardi Phil L De Jager Alberto Lleo Nick Warner Oscar L Lopez Martin Ingelsson Panagiotis Deloukas Carlos Cruchaga Caroline Graff Rhian Gwilliam Myriam Fornage Alison M Goate Pascual Sanchez-Juan Patrick G Kehoe Najaf Amin Nilifur Ertekin-Taner Claudine Berr Stéphanie Debette Seth Love Lenore J Launer Steven G Younkin Jean-Francois Dartigues Chris Corcoran M Arfan Ikram Dennis W Dickson Gael Nicolas Dominique Campion JoAnn Tschanz Helena Schmidt Hakon Hakonarson Jordi Clarimon Ron Munger Reinhold Schmidt Lindsay A Farrer Christine Van Broeckhoven Michael C O'Donovan Anita L DeStefano Lesley Jones Jonathan L Haines Jean-Francois Deleuze Michael J Owen Vilmundur Gudnason Richard Mayeux Valentina Escott-Price Bruce M Psaty Alfredo Ramirez Li-San Wang Agustin Ruiz Cornelia M van Duijn Peter A Holmans Sudha Seshadri Julie Williams Phillippe Amouyel Gerard D Schellenberg Jean-Charles Lambert Margaret A Pericak-Vance

Nat Genet 2019 03 28;51(3):414-430. Epub 2019 Feb 28.

John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.

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http://dx.doi.org/10.1038/s41588-019-0358-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463297PMC
March 2019

Rationale and Design of the Mechanistic Potential of Antihypertensives in Preclinical Alzheimer's (HEART) Trial.

J Alzheimers Dis 2018 ;61(2):815-824

Dementia Research Group, Faculty of Health Sciences, University of Bristol, Learning and Research, Southmead Hospital, Bristol, UK.

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http://dx.doi.org/10.3233/JAD-161198DOI Listing
January 2019

Challenges to and Facilitators of Recruitment to an Alzheimer's Disease Clinical Trial: A Qualitative Interview Study.

J Alzheimers Dis 2019 ;69(4):1067-1075

Bristol Randomised Trials Collaboration, Bristol Trials Centre, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.3233/JAD-190146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6598018PMC
January 2019

Cerebral Aβ and systemic hypertension.

J Cereb Blood Flow Metab 2018 Nov 7;38(11):1993-2005. Epub 2017 Aug 7.

1 School of Clinical Sciences, University of Bristol, Bristol, UK.

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http://journals.sagepub.com/doi/10.1177/0271678X17724930
Publisher Site
http://dx.doi.org/10.1177/0271678X17724930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259324PMC
November 2018

Renin-angiotensin system inhibitors and risk of fractures: a prospective cohort study and meta-analysis of published observational cohort studies.

Eur J Epidemiol 2017 11 27;32(11):947-959. Epub 2017 Jul 27.

Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.

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http://dx.doi.org/10.1007/s10654-017-0285-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684291PMC
November 2017

The Vascular Impairment of Cognition Classification Consensus Study.

Alzheimers Dement 2017 Jun 10;13(6):624-633. Epub 2016 Dec 10.

Dementia Research Group, Faculty of Health Sciences, School of Clinical Sciences, University of Bristol, Southmead Hospital, Bristol, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2016.10.007DOI Listing
June 2017

Metabolomic Profiling of Bile Acids in Clinical and Experimental Samples of Alzheimer's Disease.

Metabolites 2017 Jun 17;7(2). Epub 2017 Jun 17.

Advanced Asset Technology Centre, Institute for Global Food Security, Queen's University Belfast, Belfast BT9 5AG, UK.

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http://dx.doi.org/10.3390/metabo7020028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487999PMC
June 2017

Altered Expression of Human Mitochondrial Branched Chain Aminotransferase in Dementia with Lewy Bodies and Vascular Dementia.

Neurochem Res 2017 Jan 15;42(1):306-319. Epub 2016 Mar 15.

Department of Applied Science, University of the West of England, Coldharbour Lane, Bristol, BS16 1QY, UK.

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http://dx.doi.org/10.1007/s11064-016-1855-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5283609PMC
January 2017

Vascular cognitive impairment neuropathology guidelines (VCING): the contribution of cerebrovascular pathology to cognitive impairment.

Brain 2016 11;139(11):2957-2969

Dementia Research Group, School of Clinical Sciences, Faculty of Health Sciences, University of Bristol, Learning and Research Level 1, Southmead Hospital, Bristol, BS10 5NB, UK.

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http://dx.doi.org/10.1093/brain/aww214DOI Listing
November 2016

Alzheimer's disease-like pathology has transient effects on the brain and blood metabolome.

Neurobiol Aging 2016 Feb 30;38:151-163. Epub 2015 Nov 30.

Advanced Asset Technology Centre, Institute for Global Food Security, Queen's University Belfast, Belfast, Northern Ireland, UK. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2015.11.014DOI Listing
February 2016

Angiotensin-converting enzyme in cerebrospinal fluid and risk of brain atrophy.

J Alzheimers Dis 2015 ;44(1):153-62

Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.3233/JAD-131496DOI Listing
September 2015

Investigation of Aβ phosphorylated at serine 8 (pAβ) in Alzheimer's disease, dementia with Lewy bodies and vascular dementia.

Neuropathol Appl Neurobiol 2015 Jun;41(4):428-44

Dementia Research Group, Institute of Clinical Neurosciences, School of Clinical Sciences, University of Bristol, Level 1 Learning and Research, Southmead Hospital, Bristol, UK.

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http://dx.doi.org/10.1111/nan.12212DOI Listing
June 2015

Is amyloid-β an innocent bystander and marker in Alzheimer's disease? Is the liability of multivalent cation homeostasis and its influence on amyloid-β function the real mechanism?

J Alzheimers Dis 2014 ;42(1):69-85

National Cell Bank, Pasteur Institute of Iran, Tehran, Iran Department of Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Current Address: Department of Pediatrics, Division of Cardiology, School of Medicine, Stanford University, Stanford, CA, USA.

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http://dx.doi.org/10.3233/JAD-140321DOI Listing
May 2015

Blood type gene locus has no influence on ACE association with Alzheimer's disease.

Neurobiol Aging 2015 Apr 22;36(4):1767.e1-1767.e2. Epub 2015 Jan 22.

Human Genetics Group, Translational Cell Sciences, School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham, UK.

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http://dx.doi.org/10.1016/j.neurobiolaging.2015.01.013DOI Listing
April 2015

Aβ degradation or cerebral perfusion? Divergent effects of multifunctional enzymes.

Front Aging Neurosci 2014 11;6:238. Epub 2014 Sep 11.

Dementia Research Group, School of Clinical Sciences, Faculty of Medicine and Dentistry, University of Bristol Bristol, UK.

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http://dx.doi.org/10.3389/fnagi.2014.00238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160973PMC
October 2014

BIN1 is decreased in sporadic but not familial Alzheimer's disease or in aging.

PLoS One 2013 21;8(10):e78806. Epub 2013 Oct 21.

School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0078806PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804620PMC
August 2014

The association of angiotensin-converting enzyme with biomarkers for Alzheimer's disease.

Alzheimers Res Ther 2014 15;6(3):27. Epub 2014 May 15.

Department of Gerontology and Geriatric Medicine, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1186/alzrt257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075229PMC
July 2014

Pathophysiology of white matter perfusion in Alzheimer's disease and vascular dementia.

Brain 2014 May 10;137(Pt 5):1524-32. Epub 2014 Mar 10.

1 Dementia Research Group, Institute of Clinical Neurosciences, School of Clinical Sciences, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1093/brain/awu040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999715PMC
May 2014

Current status of renin-aldosterone angiotensin system-targeting anti-hypertensive drugs as therapeutic options for Alzheimer's disease.

Expert Opin Investig Drugs 2013 Oct 26;22(10):1229-42. Epub 2013 Jun 26.

University of Bristol, Frenchay Hospital, School of Clinical Sciences, John James Laboratories, Dementia Research Group , Bristol, BS16 1LE , UK

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http://dx.doi.org/10.1517/13543784.2013.812631DOI Listing
October 2013

Influence of LRP-1 and apolipoprotein E on amyloid-β uptake and toxicity to cerebrovascular smooth muscle cells.

J Alzheimers Dis 2013 ;33(1):95-110

Dementia Research Group, Institute of Clinical Neurosciences, School of Clinical Sciences, University of Bristol, Frenchay Hospital, Bristol, UK.

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http://dx.doi.org/10.3233/JAD-2012-121336DOI Listing
September 2013

An exploration of the potential mechanisms and translational potential of five medicinal plants for applications in Alzheimer's disease.

Am J Neurodegener Dis 2013 21;2(2):70-88. Epub 2013 Jun 21.

School of Medical Sciences, University of Bristol Bristol, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703121PMC
July 2013

The renin-angiotensin system and antihypertensive drugs in Alzheimer's disease: current standing of the angiotensin hypothesis?

J Alzheimers Dis 2012 ;30 Suppl 2:S251-68

Dementia Research Group, John James Laboratories, Frenchay Hospital, Institute of Clinical Neurosciences, School of Clinical Sciences, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.3233/JAD-2012-111376DOI Listing
December 2012

Calcium channel blockers and Alzheimer's disease: potential relevance in treatment strategies of metabolic syndrome.

J Alzheimers Dis 2012 ;30 Suppl 2:S269-82

Dementia Research Group, John James Laboratories, Frenchay Hospital, Institute of Clinical Neurosciences, School of Clinical Sciences, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.3233/JAD-2012-111664DOI Listing
December 2012

Distribution of the branched chain aminotransferase proteins in the human brain and their role in glutamate regulation.

J Neurochem 2012 Dec 1;123(6):997-1009. Epub 2012 Nov 1.

Faculty of Health and Life Sciences, University of the West of England, Bristol, UK.

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http://dx.doi.org/10.1111/jnc.12044DOI Listing
December 2012

The influence of tumour necrosis factor- α (TNF-α) on amyloid-β (Aβ)-degrading enzymes in vitro.

Int J Mol Epidemiol Genet 2011 30;2(4):409-15. Epub 2011 Nov 30.

Dementia Research Group, School of Clinical Sciences, University of Bristol, John James Building, Frenchay Hospital Bristol, BS16 1LE, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3243456PMC
October 2012

LRP1 expression in cerebral cortex, choroid plexus and meningeal blood vessels: relationship to cerebral amyloid angiopathy and APOE status.

Neurosci Lett 2012 Sep;525(2):123-8

Dementia Research Group, Institute of Clinical Neurosciences, Frenchay Hospital, Bristol, BS16 1LE, UK.

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http://dx.doi.org/10.1016/j.neulet.2012.07.065DOI Listing
September 2012

Endothelin-1 is elevated in Alzheimer's disease and upregulated by amyloid-β.

J Alzheimers Dis 2012 ;29(4):853-61

Dementia ResearchGroup, School of Clinical Sciences, University of Bristol, Frenchay Hospital, Bristol, UK.

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http://dx.doi.org/10.3233/JAD-2012-111760DOI Listing
August 2012

Assessment of activation of the plasma kallikrein-kinin system in frontal and temporal cortex in Alzheimer's disease and vascular dementia.

Neurobiol Aging 2012 Jul 11;33(7):1345-55. Epub 2010 Nov 11.

Dementia Research Group, Institute of Clinical Neurosciences, School of Clinical Sciences, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1016/j.neurobiolaging.2010.09.024DOI Listing
July 2012

The role of variation at AβPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's disease.

J Alzheimers Dis 2012 ;28(2):377-87

MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK.

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http://dx.doi.org/10.3233/JAD-2011-110824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118466PMC
May 2012

Clusterin mRNA and protein in Alzheimer's disease.

J Alzheimers Dis 2012 ;28(2):337-44

Dementia Research Group, Institute of Clinical Neurosciences, University of Bristol, Frenchay Hospital, Bristol, UK.

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http://dx.doi.org/10.3233/JAD-2011-110473DOI Listing
May 2012

Activators and inhibitors of the plasminogen system in Alzheimer's disease.

J Cell Mol Med 2012 Apr;16(4):865-76

Dementia Research Group, Institute of Clinical Neurosciences, Clinical Sciences at North Bristol, Bristol University, Bristol, UK.

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http://dx.doi.org/10.1111/j.1582-4934.2011.01394.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822855PMC
April 2012

Associations of anti-hypertensive treatments with Alzheimer's disease, vascular dementia, and other dementias.

J Alzheimers Dis 2011 ;26(4):699-708

School of Social and Community Medicine, Faculty of Medicine and Dentistry, University of Bristol, Canynge Hall, Bristol, UK.

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http://dx.doi.org/10.3233/JAD-2011-110347DOI Listing
January 2012

Antioxidant and anti-inflammatory effects of Scoparia dulcis L.

J Med Food 2011 Dec 26;14(12):1576-82. Epub 2011 Aug 26.

Laboratories of Biochemistry & Applied Chemistry (Labioca), University of Ouagadougou, Ouagadougou, Burkina Faso.

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http://dx.doi.org/10.1089/jmf.2010.0191DOI Listing
December 2011

Angiotensin-converting enzyme (ACE) genotypes and disability in hospitalized older patients.

Age (Dordr) 2011 Sep 13;33(3):409-19. Epub 2010 Nov 13.

Department of Medical Sciences, Geriatric Unit and Gerontology-Geriatrics Research Laboratory, IRCCS Casa Sollievo della Sofferenza, Padre Pio da Pietrelcina Foundation, San Giovanni Rotondo, Foggia, Italy.

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http://dx.doi.org/10.1007/s11357-010-9192-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168594PMC
September 2011

Tumour necrosis factor-α (TNF-α) and miRNA expression in frontal and temporal neocortex in Alzheimer's disease and the effect of TNF-α on miRNA expression in vitro.

Int J Mol Epidemiol Genet 2011 25;2(2):156-62. Epub 2011 Mar 25.

Dementia Research Group, School of Clinical Sciences, University of Bristol, John James Buildings, Frenchay Hospital Frenchay, Bristol, BS16 1LE, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110390PMC
July 2011

Oxidative balance in Alzheimer's disease: relationship to APOE, Braak tangle stage, and the concentrations of soluble and insoluble amyloid-β.

J Alzheimers Dis 2010 ;22(4):1363-73

Dementia Research Group, Institute of Clinical Neurosciences, Frenchay Hospital, Bristol, UK.

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http://dx.doi.org/10.3233/JAD-2010-101368DOI Listing
May 2011

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.

Authors:
Paul Hollingworth Denise Harold Rebecca Sims Amy Gerrish Jean-Charles Lambert Minerva M Carrasquillo Richard Abraham Marian L Hamshere Jaspreet Singh Pahwa Valentina Moskvina Kimberley Dowzell Nicola Jones Alexandra Stretton Charlene Thomas Alex Richards Dobril Ivanov Caroline Widdowson Jade Chapman Simon Lovestone John Powell Petroula Proitsi Michelle K Lupton Carol Brayne David C Rubinsztein Michael Gill Brian Lawlor Aoibhinn Lynch Kristelle S Brown Peter A Passmore David Craig Bernadette McGuinness Stephen Todd Clive Holmes David Mann A David Smith Helen Beaumont Donald Warden Gordon Wilcock Seth Love Patrick G Kehoe Nigel M Hooper Emma R L C Vardy John Hardy Simon Mead Nick C Fox Martin Rossor John Collinge Wolfgang Maier Frank Jessen Eckart Rüther Britta Schürmann Reiner Heun Heike Kölsch Hendrik van den Bussche Isabella Heuser Johannes Kornhuber Jens Wiltfang Martin Dichgans Lutz Frölich Harald Hampel John Gallacher Michael Hüll Dan Rujescu Ina Giegling Alison M Goate John S K Kauwe Carlos Cruchaga Petra Nowotny John C Morris Kevin Mayo Kristel Sleegers Karolien Bettens Sebastiaan Engelborghs Peter P De Deyn Christine Van Broeckhoven Gill Livingston Nicholas J Bass Hugh Gurling Andrew McQuillin Rhian Gwilliam Panagiotis Deloukas Ammar Al-Chalabi Christopher E Shaw Magda Tsolaki Andrew B Singleton Rita Guerreiro Thomas W Mühleisen Markus M Nöthen Susanne Moebus Karl-Heinz Jöckel Norman Klopp H-Erich Wichmann V Shane Pankratz Sigrid B Sando Jan O Aasly Maria Barcikowska Zbigniew K Wszolek Dennis W Dickson Neill R Graff-Radford Ronald C Petersen Cornelia M van Duijn Monique M B Breteler M Arfan Ikram Anita L DeStefano Annette L Fitzpatrick Oscar Lopez Lenore J Launer Sudha Seshadri Claudine Berr Dominique Campion Jacques Epelbaum Jean-François Dartigues Christophe Tzourio Annick Alpérovitch Mark Lathrop Thomas M Feulner Patricia Friedrich Caterina Riehle Michael Krawczak Stefan Schreiber Manuel Mayhaus S Nicolhaus Stefan Wagenpfeil Stacy Steinberg Hreinn Stefansson Kari Stefansson Jon Snaedal Sigurbjörn Björnsson Palmi V Jonsson Vincent Chouraki Benjamin Genier-Boley Mikko Hiltunen Hilkka Soininen Onofre Combarros Diana Zelenika Marc Delepine Maria J Bullido Florence Pasquier Ignacio Mateo Ana Frank-Garcia Elisa Porcellini Olivier Hanon Eliecer Coto Victoria Alvarez Paolo Bosco Gabriele Siciliano Michelangelo Mancuso Francesco Panza Vincenzo Solfrizzi Benedetta Nacmias Sandro Sorbi Paola Bossù Paola Piccardi Beatrice Arosio Giorgio Annoni Davide Seripa Alberto Pilotto Elio Scarpini Daniela Galimberti Alexis Brice Didier Hannequin Federico Licastro Lesley Jones Peter A Holmans Thorlakur Jonsson Matthias Riemenschneider Kevin Morgan Steven G Younkin Michael J Owen Michael O'Donovan Philippe Amouyel Julie Williams

Nat Genet 2011 May 3;43(5):429-35. Epub 2011 Apr 3.

Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Neurosciences and Mental Health Research Institute, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK.

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http://dx.doi.org/10.1038/ng.803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084173PMC
May 2011

Kallikrein-related peptidase 6 in Alzheimer's disease and vascular dementia.

Brain Res 2010 Dec 21;1363:1-10. Epub 2010 Sep 21.

Dementia Research Group, Institute of Clinical Neurosciences, Clinical Science at North Bristol, University of Bristol, UK.

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http://dx.doi.org/10.1016/j.brainres.2010.09.017DOI Listing
December 2010

Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease.

PLoS One 2010 Nov 15;5(11):e13950. Epub 2010 Nov 15.

Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Cardiff, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0013950PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981526PMC
November 2010

Plasminogen and plasmin in Alzheimer's disease.

Brain Res 2010 Oct 13;1355:7-15. Epub 2010 Aug 13.

Dementia Research Group, Institute of Clinical Neurosciences, Clinical Sciences at North Bristol, Bristol University, Bristol, UK.

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http://dx.doi.org/10.1016/j.brainres.2010.08.025DOI Listing
October 2010

Distribution and expression of picalm in Alzheimer disease.

J Neuropathol Exp Neurol 2010 Oct;69(10):1071-7

Institute of Clinical Neurosciences, University of Bristol, Frenchay Hospital, Bristol, United Kingdom.

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http://dx.doi.org/10.1097/NEN.0b013e3181f52e01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017341PMC
October 2010

Angiotensin receptor blockers associated with decreased incidence and progression of dementia in older men with cardiovascular disease.

Authors:
Patrick G Kehoe

Evid Based Ment Health 2010 Aug;13(3):75

Department of Clinical Science at North Bristol, Institute of Clinical Neurosciences, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1136/ebmh.13.3.75DOI Listing
August 2010

Molecular epidemiology of infectious diseases - expanding horizons for IJMEG.

Int J Mol Epidemiol Genet 2010 Jul 17;1(3):245-7. Epub 2010 Jul 17.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076772PMC
July 2010

Changes with age in the activities of beta-secretase and the Abeta-degrading enzymes neprilysin, insulin-degrading enzyme and angiotensin-converting enzyme.

Brain Pathol 2010 Jul 12;20(4):794-802. Epub 2010 Jan 12.

Dementia Research Group, Institute of Clinical Neurosciences, Clinical Science at North Bristol, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1111/j.1750-3639.2010.00375.xDOI Listing
July 2010

Higher soluble amyloid beta concentration in frontal cortex of young adults than in normal elderly or Alzheimer's disease.

Brain Pathol 2010 Jul 12;20(4):787-93. Epub 2010 Jan 12.

Dementia Research Group, Institute of Clinical Neurosciences, Clinical Science at North Bristol, University of Bristol, UK.

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http://dx.doi.org/10.1111/j.1750-3639.2010.00374.xDOI Listing
July 2010

Oligomeric Abeta in Alzheimer's disease: relationship to plaque and tangle pathology, APOE genotype and cerebral amyloid angiopathy.

Brain Pathol 2010 Mar 16;20(2):468-80. Epub 2009 Jul 16.

Dementia Research Group, Institute of Clinical Neurosciences, Clinical Science at North Bristol, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1111/j.1750-3639.2009.00321.xDOI Listing
March 2010

Angiotensins in Alzheimer's disease - friend or foe?

Trends Neurosci 2009 Dec 30;32(12):619-28. Epub 2009 Sep 30.

Dementia Research Group, Institute of Clinical Neurosciences, Department of Clinical Science at North Bristol, University of Bristol, Frenchay Hospital, Bristol BS16 1LE, UK.

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http://dx.doi.org/10.1016/j.tins.2009.07.006DOI Listing
December 2009

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.

Nat Genet 2009 Oct 6;41(10):1088-93. Epub 2009 Sep 6.

Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK.

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http://dx.doi.org/10.1038/ng.440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845877PMC
October 2009

TNFR-associated factor-2 (TRAF-2) in Alzheimer's disease.

Neurobiol Aging 2009 Jul 11;30(7):1052-60. Epub 2007 Dec 11.

Dementia Research Group, Institute of Clinical Neurosciences, Department of Clinical Sciences at North Bristol, University of Bristol, John James Buildings, Frenchay Hospital, Bristol, United Kingdom.

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http://dx.doi.org/10.1016/j.neurobiolaging.2007.10.014DOI Listing
July 2009

Endothelin-converting enzyme-2 is increased in Alzheimer's disease and up-regulated by Abeta.

Am J Pathol 2009 Jul 18;175(1):262-70. Epub 2009 Jun 18.

Dementia Research Group, Frenchay Hospital, Bristol, United Kingdom.

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http://dx.doi.org/10.2353/ajpath.2009.081054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2708812PMC
July 2009

Angiotensins and Alzheimer's disease: a bench to bedside overview.

Authors:
Patrick G Kehoe

Alzheimers Res Ther 2009 Jul 9;1(1). Epub 2009 Jul 9.

Dementia Research Group, Institute of Clinical Neurosciences, Department of Clinical Science at North Bristol, University of Bristol, Frenchay Hospital, Bristol BS16 1LE, UK.

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http://dx.doi.org/10.1186/alzrt3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719108PMC
July 2009

Evidence that the gene encoding insulin degrading enzyme influences human lifespan.

Hum Mol Genet 2008 Aug 30;17(15):2370-8. Epub 2008 Apr 30.

Department of Medical Epidemiology and Biostatistics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1093/hmg/ddn137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2574758PMC
August 2008

Abeta-degrading enzymes in Alzheimer's disease.

Brain Pathol 2008 Apr;18(2):240-52

Dementia Research Group, University of Bristol Institute of Clinical Neurosciences, Frenchay Hospital, Bristol, UK.

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http://dx.doi.org/10.1111/j.1750-3639.2008.00132.xDOI Listing
April 2008

Protein and gene expression of tumour necrosis factor receptors I and II and their promoter gene polymorphisms in Alzheimer's disease.

Exp Gerontol 2007 Jun 30;42(6):538-44. Epub 2007 Jan 30.

Dementia Research Group, Institute of Clinical Neurosciences, Department of Clinical Sciences at North Bristol, University of Bristol, Frenchay Hospital, Frenchay, Bristol, United Kingdom.

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http://dx.doi.org/10.1016/j.exger.2006.12.001DOI Listing
June 2007

Is inhibition of the renin-angiotensin system a new treatment option for Alzheimer's disease?

Lancet Neurol 2007 Apr;6(4):373-8

Dementia Research Group, Institute of Clinical Neurosciences, Department of Clinical Science at North Bristol, University of Bristol, Frenchay Hospital, Frenchay, Bristol.

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http://dx.doi.org/10.1016/S1474-4422(07)70077-7DOI Listing
April 2007

Neither sequence variation in the IL-10 gene promoter nor presence of IL-10 protein in the cerebral cortex is associated with Alzheimer's disease.

Neurosci Lett 2006 Nov 14;408(2):141-5. Epub 2006 Sep 14.

Dementia Research Group, Institute of Clinical Neurosciences, Department of Clinical Sciences at North Bristol, University of Bristol, John James Buildings, Frenchay Hospital, Frenchay, Bristol, BS16 1LE, United Kingdom.

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http://dx.doi.org/10.1016/j.neulet.2006.08.068DOI Listing
November 2006