Publications by authors named "Patrick C Seed"

59Publications

Optimization of a non-canonical anti-infective: Interrogation of the target binding pocket for a small molecule inhibitor of polysaccharide capsule expression.

Antimicrob Agents Chemother 2020 Oct 19. Epub 2020 Oct 19.

Department of Pediatrics, Duke University School of Medicine, Durham, NC.

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http://dx.doi.org/10.1128/AAC.01208-20DOI Listing
October 2020

Long-term stability of microbiome diversity and composition in fecal samples stored in eNAT medium.

Microbiologyopen 2020 07 10;9(7):e1046. Epub 2020 May 10.

Division of Pediatric Infectious Diseases, Duke University, Durham, NC, USA.

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http://dx.doi.org/10.1002/mbo3.1046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349174PMC
July 2020

Update on Associated Risk Factors, Diagnosis, and Management of Recurrent Urinary Tract Infections in Children.

J Pediatric Infect Dis Soc 2019 May;8(2):152-159

Division of Infectious Diseases, Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina.

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http://dx.doi.org/10.1093/jpids/piy065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510945PMC
May 2019

Utility of Autopsy among Pediatric Allogeneic Hematopoietic Stem Cell Transplant Recipients: One Last Chance to Learn?

Biol Blood Marrow Transplant 2018 09 9;24(9):1861-1865. Epub 2018 Jun 9.

Division of Pediatric Blood and Marrow Transplant, Duke University Medical Center, Durham, North Carolina.

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http://dx.doi.org/10.1016/j.bbmt.2018.05.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163060PMC
September 2018

Early-life skin microbiota in hospitalized preterm and full-term infants.

Microbiome 2018 05 31;6(1):98. Epub 2018 May 31.

Department of Pediatrics, Northwestern University, 310 E. Superior, Morton 4-685, Chicago, IL, 60611, USA.

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http://dx.doi.org/10.1186/s40168-018-0486-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984431PMC
May 2018

Predominant bacteria and patterns of antibiotic susceptibility in urinary tract infection in children with spina bifida.

J Pediatr Urol 2018 10 20;14(5):444.e1-444.e8. Epub 2018 Apr 20.

The University of North Carolina at Chapel Hill School of Medicine, Department of Urology, Chapel Hill, NC, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S14775131183016
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http://dx.doi.org/10.1016/j.jpurol.2018.03.017DOI Listing
October 2018

Copper Influences the Antibacterial Outcomes of a β-Lactamase-Activated Prochelator against Drug-Resistant Bacteria.

ACS Infect Dis 2018 06 26;4(6):1019-1029. Epub 2018 Mar 26.

Department of Chemistry , Duke University , 124 Science Drive , Durham , North Carolina 27708 , United States.

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http://dx.doi.org/10.1021/acsinfecdis.8b00037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6252259PMC
June 2018

The Nasopharyngeal Microbiota of Children With Respiratory Infections in Botswana.

Pediatr Infect Dis J 2017 Sep;36(9):e211-e218

From the *Botswana-UPenn Partnership, Gaborone, Botswana; †Division of Pediatric Infectious Diseases, Duke University Medical Center, Durham, North Carolina; ‡Department of Medicine, McMaster University, §Department of Pathology and Molecular Medicine, McMaster University, ¶St. Joseph's Healthcare, and ‖Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada; **Global Health Center, and ††Division of Pediatric Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; ‡‡Department of Pathology and Laboratory Medicine, BC Children's Hospital, Vancouver, British Columbia, Canada; §§University of Botswana School of Medicine, Gaborone, Botswana; ¶¶Department of Molecular Genetics and Microbiology, Center for the Genomics of Microbial Systems, Duke University Medical Center, Durham, North Carolina; and ‖‖Divisions of Hospital Medicine and Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

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http://dx.doi.org/10.1097/INF.0000000000001607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555803PMC
September 2017

Enteral High Fat-Polyunsaturated Fatty Acid Blend Alters the Pathogen Composition of the Intestinal Microbiome in Premature Infants with an Enterostomy.

J Pediatr 2017 02 15;181:93-101.e6. Epub 2016 Nov 15.

Department of Pediatrics, Duke University Medical Center, Durham, NC; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC.

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http://dx.doi.org/10.1016/j.jpeds.2016.10.053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5274578PMC
February 2017

Do Bacteria in the Gut Set the Stage for Who Gets Viral Bronchiolitis and Its Severity?

Authors:
Patrick C Seed

Pediatrics 2016 07;138(1)

Department of Pediatrics, Molecular Genetics & Microbiology, and Surgery, Duke University School of Medicine, Durham, North Carolina

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http://dx.doi.org/10.1542/peds.2016-1377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4925090PMC
July 2016

Early-Life Intranasal Colonization with Nontypeable Haemophilus influenzae Exacerbates Juvenile Airway Disease in Mice.

Infect Immun 2016 07 23;84(7):2022-2030. Epub 2016 Jun 23.

Duke University School of Medicine, Department of Pediatrics, Durham, North Carolina, USA.

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http://dx.doi.org/10.1128/IAI.01539-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936370PMC
July 2016

Genetic and Molecular Basis of Kingella kingae Encapsulation.

Infect Immun 2016 06 24;84(6):1775-1784. Epub 2016 May 24.

Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA

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http://dx.doi.org/10.1128/IAI.00128-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907139PMC
June 2016

Inflammatory Response of Human Gestational Membranes to Ureaplasma parvum Using a Novel Dual-Chamber Tissue Explant System.

Biol Reprod 2016 05 23;94(5):119. Epub 2016 Mar 23.

Department of Obstetrics and Gynecology, Duke University, Durham, North Carolina Department of Pediatrics, Duke University, Durham, North Carolina

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http://dx.doi.org/10.1095/biolreprod.115.137596DOI Listing
May 2016

Threading the Needle: Small-Molecule Targeting of a Xenobiotic Receptor to Ablate Escherichia coli Polysaccharide Capsule Expression Without Altering Antibiotic Resistance.

J Infect Dis 2016 Apr 15;213(8):1330-9. Epub 2015 Dec 15.

Department of Pediatrics Department of Molecular Genetics and Microbiology Center for Microbial Pathogenesis, Duke University School of Medicine, Durham, North Carolina.

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https://academic.oup.com/jid/article-lookup/doi/10.1093/infd
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http://dx.doi.org/10.1093/infdis/jiv584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4799666PMC
April 2016

Efficacy of Fluoroquinolone/Probiotic Combination Therapy for Recurrent Urinary Tract Infection in Children: A Retrospective Analysis.

Clin Ther 2015 Sep 29;37(9):2143-7. Epub 2015 Jul 29.

Division of Urologic Surgery and the Departments of; Pediatrics; Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina. Electronic address:

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http://dx.doi.org/10.1016/j.clinthera.2015.06.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915914PMC
September 2015

Association between positive urine cultures and necrotizing enterocolitis in a large cohort of hospitalized infants.

Early Hum Dev 2015 Oct 27;91(10):583-6. Epub 2015 Jul 27.

Department of Pediatrics, Duke University School of Medicine, Durham, NC, United States; Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03783782150015
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http://dx.doi.org/10.1016/j.earlhumdev.2015.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575648PMC
October 2015

Urinary tract infections in the infant.

Clin Perinatol 2015 Mar 24;42(1):17-28, vii. Epub 2014 Dec 24.

Division of Infectious Diseases, Department of Pediatrics, Duke University School of Medicine, DUMC 3499, Durham, NC 27710, USA. Electronic address:

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http://dx.doi.org/10.1016/j.clp.2014.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511626PMC
March 2015

The human mycobiome.

Authors:
Patrick C Seed

Cold Spring Harb Perspect Med 2014 Nov 10;5(5):a019810. Epub 2014 Nov 10.

Departments of Pediatrics, Molecular Genetics and Microbiology, and Surgery, Duke University School of Medicine, Durham, North Carolina 27710.

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http://dx.doi.org/10.1101/cshperspect.a019810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448585PMC
November 2014

Lifting the mask: identification of new small molecule inhibitors of uropathogenic Escherichia coli group 2 capsule biogenesis.

PLoS One 2014 1;9(7):e96054. Epub 2014 Jul 1.

Department. of Pediatrics, Duke University School of Medicine, Durham, North Carolina, United States of America; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, United States of America; Center for Microbial Pathogenesis, Duke University School of Medicine, Durham, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0096054PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077706PMC
October 2015

Bacteria localization and chorion thinning among preterm premature rupture of membranes.

PLoS One 2014 8;9(1):e83338. Epub 2014 Jan 8.

Division Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Duke University Medical Center, Duke University, Durham, North Carolina, United States of America.

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http://dukespace.lib.duke.edu/dspace/bitstream/handle/10161/
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http://dx.plos.org/10.1371/journal.pone.0083338
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0083338PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3885429PMC
September 2014

A review of the source and function of microbiota in breast milk.

Semin Reprod Med 2014 Jan 3;32(1):68-73. Epub 2014 Jan 3.

Department of Pediatrics, Division of Infectious Diseases, Duke University, Durham, North Carolina.

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http://dx.doi.org/10.1055/s-0033-1361824DOI Listing
January 2014

Inflammatory response to Escherichia coli urinary tract infection in the neurogenic bladder of the spinal cord injured host.

J Urol 2014 May 14;191(5):1454-61. Epub 2013 Dec 14.

Division of Urologic Surgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina; Department of Pediatrics, Duke University Medical Center, Durham, North Carolina; Department of Molecular Genetics and Microbiology and Center for Microbial Pathogenesis, Duke University Medical Center, Durham, North Carolina; Duke University Medical Center, Durham, North Carolina.

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http://dx.doi.org/10.1016/j.juro.2013.12.013DOI Listing
May 2014

The type 1 pili regulator gene fimX and pathogenicity island PAI-X as molecular markers of uropathogenic Escherichia coli.

Microbiology (Reading) 2013 Aug 6;159(Pt 8):1606-1617. Epub 2013 Jun 6.

Department of Pediatrics, Duke University School of Medicine, Durham, NC 27710, USA.

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http://dx.doi.org/10.1099/mic.0.066472-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749053PMC
August 2013

Anger management: bacteria soothe the savage host.

Authors:
Patrick C Seed

J Clin Invest 2013 Jun;123(6):2348-9

Department of Pediatrics-Infectious Diseases, Duke University School of Medicine, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1172/JCI69647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668819PMC
June 2013

How to make it in the urinary tract: a tutorial by Escherichia coli.

PLoS Pathog 2012 4;8(10):e1002907. Epub 2012 Oct 4.

Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1002907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464229PMC
April 2013

Coming of AGE: facile generation of attenuated vaccine strains through heterologous gene expression.

Virulence 2012 Jan-Feb;3(1):12-4. Epub 2012 Jan 1.

Department of Pediatrics, Duke University, Durham, NC, USA.

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http://dx.doi.org/10.4161/viru.3.1.19087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3337149PMC
September 2012

Epigenetic regulation of the nitrosative stress response and intracellular macrophage survival by extraintestinal pathogenic Escherichia coli.

Mol Microbiol 2012 Mar 30;83(5):908-25. Epub 2012 Jan 30.

Department of Molecular Genetics and Microbiology Center for Microbial Pathogenesis Department of Pediatrics, Duke University School of Medicine, Durham, NC 27710, USA.

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http://doi.wiley.com/10.1111/j.1365-2958.2012.07977.x
Publisher Site
http://dx.doi.org/10.1111/j.1365-2958.2012.07977.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809820PMC
March 2012

Population dynamics and niche distribution of uropathogenic Escherichia coli during acute and chronic urinary tract infection.

Infect Immun 2011 Oct 1;79(10):4250-9. Epub 2011 Aug 1.

Department of Pediatrics, Molecular Genetics, and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA.

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http://dx.doi.org/10.1128/IAI.05339-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187256PMC
October 2011

Urinary tract infection drives genome instability in uropathogenic Escherichia coli and necessitates translesion synthesis DNA polymerase IV for virulence.

Virulence 2011 May-Jun;2(3):222-32. Epub 2011 May 1.

Department of Pediatrics, Center for Microbial Pathogenesis, Duke University, Durham, NC, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265773PMC
http://dx.doi.org/10.4161/viru.2.3.16143DOI Listing
October 2011

Revisiting the Escherichia coli polysaccharide capsule as a virulence factor during urinary tract infection: contribution to intracellular biofilm development.

Virulence 2010 Jul-Aug;1(4):333-7

Department of Pediatrics, Center for Microbial Pathogenesis, Duke University, Durham, NC, USA.

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http://dx.doi.org/10.4161/viru.1.4.12388DOI Listing
April 2011

High-throughput identification of chemical inhibitors of E. coli Group 2 capsule biogenesis as anti-virulence agents.

PLoS One 2010 Jul 19;5(7):e11642. Epub 2010 Jul 19.

Department of Pediatrics, Center for Microbial Pathogenesis, Duke University, Durham, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0011642PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906519PMC
July 2010

Procession to pediatric bacteremia and sepsis: covert operations and failures in diplomacy.

Pediatrics 2010 Jul 21;126(1):137-50. Epub 2010 Jun 21.

Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.

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http://dx.doi.org/10.1542/peds.2009-3169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142627PMC
July 2010

LeuX tRNA-dependent and -independent mechanisms of Escherichia coli pathogenesis in acute cystitis.

Mol Microbiol 2008 Jan 25;67(1):116-28. Epub 2007 Nov 25.

Department of Molecular Microbiology and Microbial Pathogenesis, Washington University School of Medicine, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1111/j.1365-2958.2007.06025.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675907PMC
January 2008

Predictive value of cerebrospinal fluid parameters in neonates with intraventricular drainage devices.

J Neurosurg 2007 Sep;107(3 Suppl):209-12

Department of Pediatrics, Duke University, Durham, North Carolina, USA.

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http://dx.doi.org/10.3171/PED-07/09/209DOI Listing
September 2007

Development of intracellular bacterial communities of uropathogenic Escherichia coli depends on type 1 pili.

Cell Microbiol 2007 Sep 8;9(9):2230-41. Epub 2007 May 8.

Department of Molecular Microbiology, Box 8230, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, MO 63110, USA.

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http://doi.wiley.com/10.1111/j.1462-5822.2007.00952.x
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http://dx.doi.org/10.1111/j.1462-5822.2007.00952.xDOI Listing
September 2007

Tick-borne relapsing fever polymerase chain reaction of tick-borne relapsing fever caused by Borrelia hermsii.

Pediatr Infect Dis J 2007 Mar;26(3):267-9

Department of Pathology and Immunology, Washington University School of Medicine, One Children's Place, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1097/01.inf.0000254392.99545.69DOI Listing
March 2007

Filamentation by Escherichia coli subverts innate defenses during urinary tract infection.

Proc Natl Acad Sci U S A 2006 Dec 15;103(52):19884-9. Epub 2006 Dec 15.

Department of Molecular Microbiology and Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1073/pnas.0606329104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1750882PMC
December 2006

Uropathogenic Escherichia coli flagella aid in efficient urinary tract colonization.

Infect Immun 2005 Nov;73(11):7657-68

Department of Molecular Microbiology, Box 8230, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1128/IAI.73.11.7657-7668.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1273872PMC
November 2005

Blueprinting the regulatory response of Escherichia coli to the urinary tract.

Trends Microbiol 2005 Jun;13(6):246-8

Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, 63110, USA.

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http://dx.doi.org/10.1016/j.tim.2005.03.014DOI Listing
June 2005