Patrick B Ryan

Patrick B Ryan

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PheValuator: Development and evaluation of a phenotype algorithm evaluator.

J Biomed Inform 2019 Sep 29;97:103258. Epub 2019 Jul 29.

Janssen Research & Development, 920 Route 202, Raritan, NJ 08869, USA; OHDSI Collaborators, Observational Health Data Sciences and Informatics (OHDSI), 622 West 168th Street, PH-20, New York, NY 10032, USA; Columbia University, 622 West 168th Street, PH20, New York, NY 10032, USA.

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http://dx.doi.org/10.1016/j.jbi.2019.103258DOI Listing
September 2019

Supplementing claims data analysis using self-reported data to develop a probabilistic phenotype model for current smoking status.

J Biomed Inform 2019 Sep 3;97:103264. Epub 2019 Aug 3.

Janssen Research and Development, Titusville, NJ, USA.

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http://dx.doi.org/10.1016/j.jbi.2019.103264DOI Listing
September 2019

A plea to stop using the case-control design in retrospective database studies.

Stat Med 2019 Sep 22;38(22):4199-4208. Epub 2019 Aug 22.

Observational Health Data Sciences and Informatics, New York, New York.

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http://dx.doi.org/10.1002/sim.8215DOI Listing
September 2019

Comment on "How pharmacoepidemiology networks can manage distributed analyses to improve replicability and transparency and minimize bias".

Pharmacoepidemiol Drug Saf 2019 Jul 8;28(7):1032-1033. Epub 2019 May 8.

Observational Health Data Sciences and Informatics, New York, NY.

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http://dx.doi.org/10.1002/pds.4798DOI Listing
July 2019

Identifying the DEAD: Development and Validation of a Patient-Level Model to Predict Death Status in Population-Level Claims Data.

Drug Saf 2019 May 3. Epub 2019 May 3.

Janssen Research and Development, 1125 Trenton Harbourton Rd, Titusville, NJ, 08560, USA.

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http://dx.doi.org/10.1007/s40264-019-00827-0DOI Listing
May 2019

Criteria2Query: a natural language interface to clinical databases for cohort definition.

J Am Med Inform Assoc 2019 Apr;26(4):294-305

Department of Biomedical Informatics, Columbia University, New York, New York, USA.

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http://dx.doi.org/10.1093/jamia/ocy178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402359PMC
April 2019

Effect of vocabulary mapping for conditions on phenotype cohorts.

J Am Med Inform Assoc 2018 12;25(12):1618-1625

Department of Biomedical Informatics, Columbia University, New York, New York, USA.

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https://academic.oup.com/jamia/advance-article/doi/10.1093/j
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http://dx.doi.org/10.1093/jamia/ocy124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289550PMC
December 2018

Improving reproducibility by using high-throughput observational studies with empirical calibration.

Philos Trans A Math Phys Eng Sci 2018 Sep;376(2128)

Observational Health Data Sciences and Informatics (OHDSI), New York, NY 10032, USA.

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http://rsta.royalsocietypublishing.org/lookup/doi/10.1098/rs
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http://dx.doi.org/10.1098/rsta.2017.0356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107542PMC
September 2018

The Impact of Censoring Drug Switching in Medication Adherence Measures of Chronic Single Ingredient Oral Drugs.

Stud Health Technol Inform 2017 ;245:1200-1204

Janssen Research & Development, Titusville, NJ, USA.

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June 2018

The representativeness of eligible patients in type 2 diabetes trials: a case study using GIST 2.0.

J Am Med Inform Assoc 2017 Sep 13. Epub 2017 Sep 13.

Department of Biomedical Informatics, Columbia University, New York, NY, USA.

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https://academic.oup.com/jamia/article/25/3/239/4157244
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http://dx.doi.org/10.1093/jamia/ocx091DOI Listing
September 2017

A Comparison of Data Quality Assessment Checks in Six Data Sharing Networks.

EGEMS (Wash DC) 2017 Jun 12;5(1). Epub 2017 Jun 12.

Department of Pediatrics, University of Colorado Denver Anschutz Medical Campus.

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http://dx.doi.org/10.5334/egems.223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5982846PMC
June 2017

Atypical Antipsychotics and the Risk of Falls and Fractures Among Older Adults: An Emulation Analysis and an Evaluation of Additional Confounding Control Strategies.

J Clin Psychopharmacol 2017 Apr;37(2):162-168

From Global Research & Development Epidemiology, Janssen Research & Development, LLC, Titusville, NJ.

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http://dx.doi.org/10.1097/JCP.0000000000000647DOI Listing
April 2017

Atypical Antipsychotics and the Risks of Acute Kidney Injury and Related Outcomes Among Older Adults: A Replication Analysis and an Evaluation of Adapted Confounding Control Strategies.

Drugs Aging 2017 03;34(3):211-219

Janssen Research & Development, LLC, Global Research and Development Epidemiology, 1125 Trenton Harbourton Road, Rm K30205, Titusville, NJ, 08560, USA.

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http://link.springer.com/10.1007/s40266-016-0430-x
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http://dx.doi.org/10.1007/s40266-016-0430-xDOI Listing
March 2017

Correlating eligibility criteria generalizability and adverse events using Big Data for patients and clinical trials.

Ann N Y Acad Sci 2017 01 6;1387(1):34-43. Epub 2016 Sep 6.

Department of Biomedical Informatics, Columbia University, New York, New York.

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http://dx.doi.org/10.1111/nyas.13195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5266625PMC
January 2017

Detecting adverse drug reactions following long-term exposure in longitudinal observational data: The exposure-adjusted self-controlled case series.

Stat Methods Med Res 2016 12 31;25(6):2577-2592. Epub 2014 Mar 31.

Observational Medical Outcomes Partnership, Foundation for the National Institutes of Health, Bethesda, USA.

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http://dx.doi.org/10.1177/0962280214527531DOI Listing
December 2016

GIST 2.0: A scalable multi-trait metric for quantifying population representativeness of individual clinical studies.

J Biomed Inform 2016 10 4;63:325-336. Epub 2016 Sep 4.

Department of Biomedical Informatics, Columbia University, New York, NY 10032, United States. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5077682PMC
http://dx.doi.org/10.1016/j.jbi.2016.09.003DOI Listing
October 2016

Robust empirical calibration of p-values using observational data.

Stat Med 2016 09;35(22):3883-8

Department of Biomathematics and Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA, U.S.A.

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http://dx.doi.org/10.1002/sim.6977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108459PMC
September 2016

Hierarchical Models for Multiple, Rare Outcomes Using Massive Observational Healthcare Databases.

Stat Anal Data Min 2016 Aug 17;9(4):260-268. Epub 2016 Jul 17.

Department of Biomathematics, David Geffen School of Medicine at UCLA, Los Angeles, California, U.S.A.

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http://dx.doi.org/10.1002/sam.11324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423675PMC
August 2016

Characterizing treatment pathways at scale using the OHDSI network.

Proc Natl Acad Sci U S A 2016 07 6;113(27):7329-36. Epub 2016 Jun 6.

Observational Health Data Sciences and Informatics, New York, NY 10032; Department of Statistics, Columbia University, New York, NY 10027.

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http://dx.doi.org/10.1073/pnas.1510502113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941483PMC
July 2016

A curated and standardized adverse drug event resource to accelerate drug safety research.

Sci Data 2016 05 10;3:160026. Epub 2016 May 10.

Center for Biomedical Informatics Research, Stanford University, Stanford, California 94305, USA.

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http://dx.doi.org/10.1038/sdata.2016.26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872271PMC
May 2016

Seasonality in acute liver injury? Findings in two health care claims databases.

Drug Healthc Patient Saf 2016 31;8:39-48. Epub 2016 Mar 31.

Epidemiology, Janssen Research and Development, LLC, Titusville, NJ, USA.

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http://dx.doi.org/10.2147/DHPS.S95399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824282PMC
April 2016

A Method to Combine Signals from Spontaneous Reporting Systems and Observational Healthcare Data to Detect Adverse Drug Reactions.

Drug Saf 2015 Oct;38(10):895-908

Department of Biomedical Informatics, Columbia University Medical Center, 622 W. 168th Street, Presbyterian Building 20th Floor, New York, NY, 10032, USA.

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http://dx.doi.org/10.1007/s40264-015-0314-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579260PMC
October 2015

Switching from risperidone long-acting injectable to paliperidone long-acting injectable or oral antipsychotics: analysis of a Medicaid claims database.

Int Clin Psychopharmacol 2015 May;30(3):151-7

aJanssen Research & Development, LLC bJanssen Scientific Affairs, LLC, Titusville, New Jersey, USA.

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http://dx.doi.org/10.1097/YIC.0000000000000068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383368PMC
May 2015

The impact of standardizing the definition of visits on the consistency of multi-database observational health research.

BMC Med Res Methodol 2015 Mar 8;15:13. Epub 2015 Mar 8.

Janssen Research & Development, 920 Route 202, Raritan, NJ, 08869, USA.

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http://dx.doi.org/10.1186/s12874-015-0001-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369827PMC
March 2015

Authors' reply to Hennessy and Leonard's comment on "Desideratum for evidence-based epidemiology".

Drug Saf 2015 Jan;38(1):105-7

Siemens Medical Solutions, Malvern, PA, USA,

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http://dx.doi.org/10.1007/s40264-014-0254-8DOI Listing
January 2015

Interpreting observational studies: why empirical calibration is needed to correct p-values.

Stat Med 2014 Jan 30;33(2):209-18. Epub 2013 Jul 30.

Department of Medical Informatics, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands; Observational Medical Outcomes Partnership, Foundation for the National Institutes of Health, Bethesda, MD, U.S.A.

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http://dx.doi.org/10.1002/sim.5925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285234PMC
January 2014

Discussion: An estimate of the science-wise false discovery rate and application to the top medical literature.

Biostatistics 2014 Jan 25;15(1):36-9; discussion 39-45. Epub 2013 Sep 25.

Observational Medical Outcomes Partnership, Foundation for the National Institutes of Health, Bethesda, MD 20814, USAJanssen Research and Development LLC, Titusville, NJ 08560, USA.

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http://dx.doi.org/10.1093/biostatistics/kxt037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3862211PMC
January 2014

Multiple self-controlled case series for large-scale longitudinal observational databases.

Biometrics 2013 Dec 11;69(4):893-902. Epub 2013 Oct 11.

Department of Statistics, Columbia University, New York, New York, U.S.A.

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http://dx.doi.org/10.1111/biom.12078DOI Listing
December 2013

Comparison of the risks of opioid abuse or dependence between tapentadol and oxycodone: results from a cohort study.

J Pain 2013 Oct 10;14(10):1227-41. Epub 2013 Jul 10.

Janssen Pharmaceutical Research & Development, LLC, Titusville, New Jersey. Electronic address:

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http://dx.doi.org/10.1016/j.jpain.2013.05.010DOI Listing
October 2013

Desideratum for evidence based epidemiology.

Drug Saf 2013 Oct;36 Suppl 1:S5-14

Siemens Health Services, Malvern, PA, USA,

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http://dx.doi.org/10.1007/s40264-013-0102-2DOI Listing
October 2013

Defining a reference set to support methodological research in drug safety.

Drug Saf 2013 Oct;36 Suppl 1:S33-47

Janssen Research and Development LLC, 1125 Trenton-Harbourton Road, Room K30205, PO Box 200, Titusville, NJ, 08560, USA,

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http://link.springer.com/content/pdf/10.1007%2Fs40264-013-00
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http://link.springer.com/10.1007/s40264-013-0097-8
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http://dx.doi.org/10.1007/s40264-013-0097-8DOI Listing
October 2013

Managing data quality for a drug safety surveillance system.

Drug Saf 2013 Oct;36 Suppl 1:S49-58

College of Pharmacy, University of Florida, Gainesville, FL, USA,

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http://dx.doi.org/10.1007/s40264-013-0098-7DOI Listing
October 2013

Empirical performance of the case-control method: lessons for developing a risk identification and analysis system.

Drug Saf 2013 Oct;36 Suppl 1:S73-82

Department of Statistics, Columbia University, 1255 Amsterdam Avenue, New York, NY, 10027, USA,

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http://link.springer.com/10.1007/s40264-013-0105-z
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http://dx.doi.org/10.1007/s40264-013-0105-zDOI Listing
October 2013

Empirical performance of the self-controlled case series design: lessons for developing a risk identification and analysis system.

Drug Saf 2013 Oct;36 Suppl 1:S83-93

Department of Biomathematics, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA, USA,

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http://dx.doi.org/10.1007/s40264-013-0100-4DOI Listing
October 2013

Empirical performance of a self-controlled cohort method: lessons for developing a risk identification and analysis system.

Drug Saf 2013 Oct;36 Suppl 1:S95-106

Janssen Research and Development LLC, 1125 Trenton-Harbourton Road, Room K30205, PO Box 200, Titusville, NJ, 08560, USA,

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http://dx.doi.org/10.1007/s40264-013-0101-3DOI Listing
October 2013

Empirical performance of the calibrated self-controlled cohort analysis within temporal pattern discovery: lessons for developing a risk identification and analysis system.

Drug Saf 2013 Oct;36 Suppl 1:S107-21

Uppsala Monitoring Centre, WHO Collaborating Centre for International Drug Monitoring, Uppsala, Sweden,

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http://dx.doi.org/10.1007/s40264-013-0095-xDOI Listing
October 2013

Evaluation of disproportionality safety signaling applied to healthcare databases.

Drug Saf 2013 Oct;36 Suppl 1:S123-32

Oracle Health Sciences, Burlington, Massachusetts, USA,

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http://dx.doi.org/10.1007/s40264-013-0106-yDOI Listing
October 2013

Empirical performance of LGPS and LEOPARD: lessons for developing a risk identification and analysis system.

Drug Saf 2013 Oct;36 Suppl 1:S133-42

Department of Medical Informatics, Erasmus University Medical Center Rotterdam, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands,

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http://dx.doi.org/10.1007/s40264-013-0107-xDOI Listing
October 2013

A comparison of the empirical performance of methods for a risk identification system.

Drug Saf 2013 Oct;36 Suppl 1:S143-58

Janssen Research and Development LLC, 1125 Trenton-Harbourton Road, Room K30205, PO Box 200, Titusville, NJ, 08560, USA,

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http://dx.doi.org/10.1007/s40264-013-0108-9DOI Listing
October 2013

Evaluating performance of risk identification methods through a large-scale simulation of observational data.

Drug Saf 2013 Oct;36 Suppl 1:S171-80

Janssen Research and Development LLC, 1125 Trenton-Harbourton Road, Room K30205, PO Box 200, Titusville, NJ, 08560, USA,

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http://dx.doi.org/10.1007/s40264-013-0110-2DOI Listing
October 2013

Alternative outcome definitions and their effect on the performance of methods for observational outcome studies.

Drug Saf 2013 Oct;36 Suppl 1:S181-93

AstraZeneca PLC, 35 Gatehouse Drive, Waltham, MA, 02451, USA,

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http://dx.doi.org/10.1007/s40264-013-0111-1DOI Listing
October 2013

The impact of drug and outcome prevalence on the feasibility and performance of analytical methods for a risk identification and analysis system.

Drug Saf 2013 Oct;36 Suppl 1:S195-204

AstraZeneca PLC, 35 Gatehouse Drive, Waltham, MA, 02451, USA,

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http://dx.doi.org/10.1007/s40264-013-0112-0DOI Listing
October 2013

Evaluating the impact of database heterogeneity on observational study results.

Am J Epidemiol 2013 Aug 5;178(4):645-51. Epub 2013 May 5.

Department of Statistics, Columbia University, 1255 Amsterdam Avenue, New York, NY 10027, USA.

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http://dx.doi.org/10.1093/aje/kwt010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736754PMC
August 2013

Assessment of case definitions for identifying acute liver injury in large observational databases.

Drug Saf 2013 Aug;36(8):651-61

UNC Eshelman School of Pharmacy, Division of Pharmaceutical Policy and Outcomes, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1007/s40264-013-0060-8DOI Listing
August 2013

Does design matter? Systematic evaluation of the impact of analytical choices on effect estimates in observational studies.

Ther Adv Drug Saf 2013 Apr;4(2):53-62

Observational Medical Outcomes Partnership, Foundation for the National Institutes of Health, Bethesda, MD and Department of Medical Informatics, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1177/2042098613477445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110833PMC
April 2013

Applying standardized drug terminologies to observational healthcare databases: a case study on opioid exposure.

Health Serv Outcomes Res Methodol 2013 Mar 27;13(1):58-67. Epub 2012 Oct 27.

Janssen Pharmaceutical Research & Development, L.L.C. 920 Route 202, Raritan, NJ 08869 USA.

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http://link.springer.com/10.1007/s10742-012-0102-1
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http://dx.doi.org/10.1007/s10742-012-0102-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566397PMC
March 2013

Design and validation of a data simulation model for longitudinal healthcare data.

AMIA Annu Symp Proc 2011 22;2011:1176-85. Epub 2011 Oct 22.

United BioSource Corporation, Harrisburg, PA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3243118PMC
February 2013

Empirical assessment of methods for risk identification in healthcare data: results from the experiments of the Observational Medical Outcomes Partnership.

Stat Med 2012 Dec 27;31(30):4401-15. Epub 2012 Sep 27.

Johnson & Johnson Pharmaceutical Research and Development LLC, Titusville, NJ 08560, USA.

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http://doi.wiley.com/10.1002/sim.5620
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http://dx.doi.org/10.1002/sim.5620DOI Listing
December 2012

Evaluation of alternative standardized terminologies for medical conditions within a network of observational healthcare databases.

J Biomed Inform 2012 Aug 7;45(4):689-96. Epub 2012 Jun 7.

Observational Medical Outcomes Partnership, Foundation for the National Institutes of Health, 9650 Rockville Pike, Bethesda, MD 20814, USA.

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http://dx.doi.org/10.1016/j.jbi.2012.05.002DOI Listing
August 2012

Validation of a common data model for active safety surveillance research.

J Am Med Inform Assoc 2012 Jan-Feb;19(1):54-60. Epub 2011 Oct 28.

Regenstrief Institute, Indiana University, School of Medicine, Indianapolis, Indiana, USA.

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http://dx.doi.org/10.1136/amiajnl-2011-000376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3240764PMC
March 2012

Design considerations in an active medical product safety monitoring system.

Pharmacoepidemiol Drug Saf 2012 Jan;21 Suppl 1:32-40

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02120, USA.

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http://dx.doi.org/10.1002/pds.2316DOI Listing
January 2012

Patterns in nursing home medication errors: disproportionality analysis as a novel method to identify quality improvement opportunities.

Pharmacoepidemiol Drug Saf 2010 Oct;19(10):1087-94

Division of Pharmaceutical Outcomes and Policy, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599-7573, USA.

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http://dx.doi.org/10.1002/pds.2024DOI Listing
October 2010