Patricia Steeg

Patricia Steeg

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Patricia Steeg

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Metastasis Suppressors NME1 and NME2 Promote Dynamin 2 Oligomerization and Regulate Tumor Cell Endocytosis, Motility, and Metastasis.

Cancer Res 2019 Sep 16;79(18):4689-4702. Epub 2019 Jul 16.

Women's Malignancies Branch, Center for Cancer Research, NCI, Bethesda, Maryland.

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http://dx.doi.org/10.1158/0008-5472.CAN-19-0492DOI Listing
September 2019

Antibody-drug conjugates for cancer.

Lancet 2019 08;394(10200):793-804

Molecular Pharmacology Section, Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(19)31774-XDOI Listing
August 2019

Estradiol induces BDNF/TrkB signaling in triple-negative breast cancer to promote brain metastases.

Oncogene 2019 06 22;38(24):4685-4699. Epub 2019 Feb 22.

Department of Pathology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.

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http://dx.doi.org/10.1038/s41388-019-0756-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6565485PMC
June 2019

Brain metastases.

Nat Rev Dis Primers 2019 01 17;5(1). Epub 2019 Jan 17.

Department of Neurosurgery, University of California-Davis, School of Medicine, Sacramento, CA, USA.

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http://www.nature.com/articles/s41572-018-0055-y
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http://dx.doi.org/10.1038/s41572-018-0055-yDOI Listing
January 2019

Metastasis suppressors: functional pathways.

Lab Invest 2018 02 2;98(2):198-210. Epub 2017 Oct 2.

Women's Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.

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http://dx.doi.org/10.1038/labinvest.2017.104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545599PMC
February 2018

The relationship of NM23 (NME) metastasis suppressor histidine phosphorylation to its nucleoside diphosphate kinase, histidine protein kinase and motility suppression activities.

Oncotarget 2018 Feb 31;9(12):10185-10202. Epub 2017 Dec 31.

Women's Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.

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http://dx.doi.org/10.18632/oncotarget.23796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828198PMC
February 2018

Therapeutics for Brain Metastases, v3.

Clin Cancer Res 2016 Dec 10;22(24):5953-5955. Epub 2016 Oct 10.

Women's Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-2035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545573PMC
December 2016

Vinorelbine Delivery and Efficacy in the MDA-MB-231BR Preclinical Model of Brain Metastases of Breast Cancer.

Pharm Res 2016 12 19;33(12):2904-2919. Epub 2016 Aug 19.

Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, 1300 South Coulter Drive, Amarillo, Texas, 79106, USA.

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http://dx.doi.org/10.1007/s11095-016-2012-3DOI Listing
December 2016

FMN2 Makes Perinuclear Actin to Protect Nuclei during Confined Migration and Promote Metastasis.

Cell 2016 Dec 10;167(6):1571-1585.e18. Epub 2016 Nov 10.

Cell Biology and Physiology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.10.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135586PMC
December 2016

Targeting metastasis.

Authors:
Patricia S Steeg

Nat Rev Cancer 2016 Apr;16(4):201-18

Women's Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/nrc.2016.25DOI Listing
April 2016

Analysis of radiation therapy in a model of triple-negative breast cancer brain metastasis.

Clin Exp Metastasis 2015 Oct 30;32(7):717-27. Epub 2015 Aug 30.

Women's Malignancies Branch, Center for Cancer Research, National Cancer Institute, NIH, Bldg 37, Rm. 1126, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1007/s10585-015-9739-9DOI Listing
October 2015

Capecitabine and lapatinib uptake in surgically resected brain metastases from metastatic breast cancer patients: a prospective study.

Neuro Oncol 2015 Feb 11;17(2):289-95. Epub 2014 Jul 11.

Memorial Sloan-Kettering Cancer Center, New York, New York (A.M., C.G.M., A.S., V.T., A.D.S.); Cleveland Clinic, Cleveland, Ohio (D.M.P., R.J.W.); Texas Tech University Health Sciences Center, Amarillo, Texas (H.R.T., R.S., R.B., P.R.L., Q.R.S.); Center for Cancer Research National Cancer Institute, Bethesda, Maryland (P.S.S.).

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http://dx.doi.org/10.1093/neuonc/nou141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288517PMC
February 2015

Progress on Nme (NDP kinase/Nm23/Awd) gene family-related functions derived from animal model systems: studies on development, cardiovascular disease, and cancer metastasis exemplified.

Naunyn Schmiedebergs Arch Pharmacol 2015 Feb 15;388(2):109-17. Epub 2015 Jan 15.

Department of Medicine, Boston University School of Medicine, Boston, MA, 02118, USA,

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http://dx.doi.org/10.1007/s00210-014-1079-9DOI Listing
February 2015

Meaningful prevention of breast cancer metastasis: candidate therapeutics, preclinical validation, and clinical trial concerns.

J Mol Med (Berl) 2015 Jan 22;93(1):13-29. Epub 2014 Nov 22.

Women's Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, 20892, USA,

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http://link.springer.com/10.1007/s00109-014-1226-2
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http://dx.doi.org/10.1007/s00109-014-1226-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545582PMC
January 2015

A phase II study of medroxyprogesterone acetate in patients with hormone receptor negative metastatic breast cancer: translational breast cancer research consortium trial 007.

Breast Cancer Res Treat 2014 Nov 26;148(1):99-106. Epub 2014 Sep 26.

Indiana University Melvin and Bren Simon Cancer Center, 535 Barnhill Drive, RT 473, Indianapolis, IN, 46202, USA,

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http://link.springer.com/10.1007/s10549-014-3131-3
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http://dx.doi.org/10.1007/s10549-014-3131-3DOI Listing
November 2014

Identification and validation of genes with expression patterns inverse to multiple metastasis suppressor genes in breast cancer cell lines.

Clin Exp Metastasis 2014 Oct 3;31(7):771-86. Epub 2014 Aug 3.

Women's Malignancies Branch, Center for Cancer Research, National Cancer Institute, Building 37/Room 1126, 37 Convent Drive, Bethesda, MD, 20892, USA,

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http://dx.doi.org/10.1007/s10585-014-9667-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948753PMC
October 2014

DNA double-strand break repair genes and oxidative damage in brain metastasis of breast cancer.

J Natl Cancer Inst 2014 Jul 19;106(7). Epub 2014 Jun 19.

Affiliations of authors: Women's Malignancies Branch (SW, LE, TR, DP, BG, NMF, PSS), DNA Replication Group, Laboratory of Molecular Pharmacology (MIA, HF), and Tumor Biology Section, Radiation Biology Branch (JBM), Center for Cancer Research, National Cancer Institute, Bethesda, MD; Department of Oncology, Military Institute of Medicine, Warsaw, Poland (RD); Laboratory Animal Sciences Program, Frederick National Laboratory, Frederick MD (YQ); Departments of Pathology and Laboratory Medicine (SB), and Departments of Medicine (GS, YG-P), Indiana University School of Medicine, Indianapolis, IN; Department of Pathology (WB), and Department of Oncology and Radiotherapy (ES-Z, JJ), Medical University of Gdańsk, Gdańsk, Poland; Department of Neurosurgery, Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland (TM); Department of Neurosurgery and Children's Neurosurgery Clinic, Medical University of Lublin, Lublin, Poland (TT); Department of Neurosurgery, Interior Affairs Hospital, Olsztyn, Poland (WO); Department of Clinical Oncology, Białystok Oncology Center, Białystok, Poland (BC-A); Present addresses: Teach for America, Baltimore, MD (LE); National Heart, Lung, and Blood Institute, Bethesda, MD (DP); Cancer Biology Program (NMF), and Department of Oncology (GS), Stanford University, Stanford, CA.

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http://dx.doi.org/10.1093/jnci/dju145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073622PMC
July 2014

Inhibition of type I insulin-like growth factor receptor signaling attenuates the development of breast cancer brain metastasis.

PLoS One 2013 5;8(9):e73406. Epub 2013 Sep 5.

Department of Molecular and Cellular Oncology, the University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America ; Cancer Biology Program, the University of Texas Graduate School of Biomedical Sciences at Houston, Houston, Texas, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0073406PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764163PMC
June 2014

Profound prevention of experimental brain metastases of breast cancer by temozolomide in an MGMT-dependent manner.

Clin Cancer Res 2014 May 14;20(10):2727-39. Epub 2014 Mar 14.

Authors' Affiliations: Women's Malignancies Branch; Laboratory of Pathology, Center for Cancer Research; Biostatistics and Data Management Section, NCI, NIH, Bethesda; Laboratory Animal Sciences Program, SAIC-Frederick, NCI, NIH, Frederick, Maryland; Department of Oncology, Military Institute of Medicine, Warsaw; Departments of Pathomorphology, and Oncology and Radiotherapy, Medical University; Regional Cancer Center, Gdańsk, Poland; and Klinik fur Neurochirurgie UKSH Campus Kiel, Kiel, Germany

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http://clincancerres.aacrjournals.org/content/20/10/2727.ful
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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-13-2588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100541PMC
May 2014

CNS metastases in breast cancer: old challenge, new frontiers.

Clin Cancer Res 2013 Dec;19(23):6404-18

Authors' Affiliations: Dana-Farber Cancer Institute, Boston, Massachusetts; Medical Oncology Branch, Center for Cancer Research, National Cancer Institute; Women's Cancers Section, Laboratory of Molecular Pharmacology; and Biostatistics and Data Management Section, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-0790DOI Listing
December 2013

Paclitaxel-hyaluronic nanoconjugates prolong overall survival in a preclinical brain metastases of breast cancer model.

Mol Cancer Ther 2013 Nov 3;12(11):2389-99. Epub 2013 Sep 3.

Corresponding Author: Paul R. Lockman, Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, 1406 S. Coulter Dr., Amarillo, TX, 79106-1712;

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http://dx.doi.org/10.1158/1535-7163.MCT-13-0132DOI Listing
November 2013

Breast cancer metastasis: issues for the personalization of its prevention and treatment.

Am J Pathol 2013 Oct 26;183(4):1084-1095. Epub 2013 Jul 26.

Women's Cancers Section, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.

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http://linkinghub.elsevier.com/retrieve/pii/S000294401300460
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http://dx.doi.org/10.1016/j.ajpath.2013.06.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791679PMC
October 2013

Nm23-h1 binds to gelsolin and inactivates its actin-severing capacity to promote tumor cell motility and metastasis.

Cancer Res 2013 Oct 12;73(19):5949-62. Epub 2013 Aug 12.

Authors' Affiliations: Women's Cancers Section, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda; and Laboratory of Proteomics and Analytical Technologies, Science Applications International Corporation-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-0368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825031PMC
October 2013

SRC family kinases as novel therapeutic targets to treat breast cancer brain metastases.

Cancer Res 2013 Sep 1;73(18):5764-74. Epub 2013 Aug 1.

Authors' Affiliations: Departments of Molecular and Cellular Oncology, Neurosurgery, and Pathology, The University of Texas MD Anderson Cancer Center; Cancer Biology Program, Graduate School of Biomedical Sciences-Houston, Houston, Texas; Women's Cancers Section, Laboratory of Molecular Pharmacology, National Cancer Institute, Bethesda, Maryland; and Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-1803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781592PMC
September 2013

Roadblocks to translational advances on metastasis research.

Nat Med 2013 Sep;19(9):1104-9

1] Department of General and Visceral Surgery, Comprehensive Cancer Center and BIOSS Centre for Biological Signalling Studies, University of Freiburg Medical Center, Freiburg, Germany. [2].

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http://dx.doi.org/10.1038/nm.3327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972758PMC
September 2013

Pazopanib inhibits the activation of PDGFRβ-expressing astrocytes in the brain metastatic microenvironment of breast cancer cells.

Am J Pathol 2013 Jun 12;182(6):2368-79. Epub 2013 Apr 12.

Women's Cancers Section, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1016/j.ajpath.2013.02.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668025PMC
June 2013

A rapid ultra HPLC-MS/MS method for the quantitation and pharmacokinetic analysis of 3-deazaneplanocin A in mice.

J Chromatogr B Analyt Technol Biomed Life Sci 2013 May 9;927:142-6. Epub 2013 Jan 9.

Clinical Pharmacology Program, Office of the Clinical Director, National Cancer Institute, Bethesda, MD, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S15700232130002
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http://dx.doi.org/10.1016/j.jchromb.2013.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640617PMC
May 2013

Dipyridamole prevents triple-negative breast-cancer progression.

Clin Exp Metastasis 2013 Jan 4;30(1):47-68. Epub 2012 Jul 4.

Centro di Ingegneria Genetica Biotecnologie Avanzate, Via Gaetano Salvatore 486, 80145 Naples, Italy.

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http://dx.doi.org/10.1007/s10585-012-9506-0DOI Listing
January 2013

Insights into the biology and prevention of tumor metastasis provided by the Nm23 metastasis suppressor gene.

Cancer Metastasis Rev 2012 Dec;31(3-4):593-603

Women's Cancers Section, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, 37 Convent Drive, Room 1122, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1007/s10555-012-9374-8DOI Listing
December 2012

The role of MMP-1 in breast cancer growth and metastasis to the brain in a xenograft model.

BMC Cancer 2012 Dec 7;12:583. Epub 2012 Dec 7.

Department of Cancer Biology, The University of Texas, MD, Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1186/1471-2407-12-583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526403PMC
December 2012

TPI-287, a new taxane family member, reduces the brain metastatic colonization of breast cancer cells.

Mol Cancer Ther 2012 Sep 23;11(9):1959-67. Epub 2012 May 23.

Women's Cancers Section, Laboratory of Molecular Pharmacology, National Cancer Institute, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-12-0061DOI Listing
September 2012

Effect of inhibition of the lysophosphatidic acid receptor 1 on metastasis and metastatic dormancy in breast cancer.

J Natl Cancer Inst 2012 Sep 21;104(17):1306-19. Epub 2012 Aug 21.

The Women's Cancers Section, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1093/jnci/djs319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3611817PMC
September 2012

Perspective: The right trials.

Authors:
Patricia S Steeg

Nature 2012 May 30;485(7400):S58-9. Epub 2012 May 30.

Women's Cancers Section, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1038/485S58aDOI Listing
May 2012

The B-Raf status of tumor cells may be a significant determinant of both antitumor and anti-angiogenic effects of pazopanib in xenograft tumor models.

PLoS One 2011 5;6(10):e25625. Epub 2011 Oct 5.

Women's Cancers Section, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0025625PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187787PMC
February 2012

Protein-protein interactions: a mechanism regulating the anti-metastatic properties of Nm23-H1.

Naunyn Schmiedebergs Arch Pharmacol 2011 Oct 29;384(4-5):351-62. Epub 2011 Jun 29.

Women's Cancers Section, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1007/s00210-011-0646-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545597PMC
October 2011

Caveolin-1 upregulation mediates suppression of primary breast tumor growth and brain metastases by stat3 inhibition.

Cancer Res 2011 Jul 27;71(14):4932-43. Epub 2011 May 27.

Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-4249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170798PMC
July 2011

Brain metastases as preventive and therapeutic targets.

Nat Rev Cancer 2011 May 7;11(5):352-63. Epub 2011 Apr 7.

National Cancer Institute, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1038/nrc3053DOI Listing
May 2011

Pazopanib reveals a role for tumor cell B-Raf in the prevention of HER2+ breast cancer brain metastasis.

Clin Cancer Res 2011 Jan 16;17(1):142-53. Epub 2010 Nov 16.

Women's Cancers Section, Laboratory of Molecular Pharmacology, Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-1603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059742PMC
January 2011

Translational research in brain metastasis is identifying molecular pathways that may lead to the development of new therapeutic strategies.

Eur J Cancer 2010 May 19;46(7):1204-10. Epub 2010 Mar 19.

Women's Cancers Section, Laboratory of Molecular Pharmacology, National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.ejca.2010.02.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858326PMC
May 2010

The Nm23-H1 metastasis suppressor as a translational target.

Eur J Cancer 2010 May 19;46(7):1278-82. Epub 2010 Mar 19.

Women's Cancers Section, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, 37 Convent Drive, Room 1122, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.ejca.2010.02.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858387PMC
May 2010

Cancer metastasis as a therapeutic target.

Eur J Cancer 2010 May 20;46(7):1177-80. Epub 2010 Mar 20.

Universitätsmedizin Mannheim, University of Heidelberg, Ludolf-Krehl-Str. 13-17, D-68167 Mannheim, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S09598049100016
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http://dx.doi.org/10.1016/j.ejca.2010.02.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545591PMC
May 2010

Upregulation of neutrophil gelatinase-associated lipocalin by ErbB2 through nuclear factor-kappaB activation.

Cancer Res 2009 Dec;69(24):9163-8

Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-2483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2794902PMC
December 2009

Clinical-translational strategies for the elevation of Nm23-H1 metastasis suppressor gene expression.

Mol Cell Biochem 2009 Sep 23;329(1-2):115-20. Epub 2009 Apr 23.

Women's Cancers Section, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.

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http://dx.doi.org/10.1007/s11010-009-0116-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501675PMC
September 2009

Altered gene and protein expression by Nm23-H1 in metastasis suppression.

Mol Cell Biochem 2009 Sep 5;329(1-2):141-8. Epub 2009 May 5.

Women's Cancers Section, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, 37 Convent Drive, Room 1122, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1007/s11010-009-0124-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514412PMC
September 2009

Breast cancer metastasis: challenges and opportunities.

Cancer Res 2009 Jun 26;69(12):4951-3. Epub 2009 May 26.

Department of Molecular and Cellular Oncology, University of Texas, M. D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-0099DOI Listing
June 2009

Reactive glia are recruited by highly proliferative brain metastases of breast cancer and promote tumor cell colonization.

Clin Exp Metastasis 2008 23;25(7):799-810. Epub 2008 Jul 23.

Women's Cancers Section, Laboratory of Molecular Pharmacology, National Cancer Institute, Building 37, Room 1126, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1007/s10585-008-9193-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679391PMC
December 2008

Molecular basis for the critical role of suppressor of cytokine signaling-1 in melanoma brain metastasis.

Cancer Res 2008 Dec;68(23):9634-42

Department of Neurosurgery, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-08-1429DOI Listing
December 2008

The role of metastasis suppressor genes in metastatic dormancy.

APMIS 2008 Jul-Aug;116(7-8):586-601

Women's Cancers Section, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1111/j.1600-0463.2008.01213.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508681PMC
November 2008

Effect of lapatinib on the outgrowth of metastatic breast cancer cells to the brain.

J Natl Cancer Inst 2008 Aug 29;100(15):1092-103. Epub 2008 Jul 29.

Women's Cancers Section, Laboratory of Molecular Pharmacology, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building 37, Room 1122, MSC 4254, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1093/jnci/djn216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575427PMC
August 2008

Clinical-translational approaches to the Nm23-H1 metastasis suppressor.

Clin Cancer Res 2008 Aug;14(16):5006-12

Women's Cancers Section, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, 37 Convent Drive, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-08-0238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730725PMC
August 2008

Nm23-H1 homologs suppress tumor cell motility and anchorage independent growth.

Clin Exp Metastasis 2008 5;25(2):131-8. Epub 2007 Dec 5.

Women's Cancers Section, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NCI/NIH, 37 Convent Dr., Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1007/s10585-007-9128-0DOI Listing
June 2008

Heterogeneity of drug target expression among metastatic lesions: lessons from a breast cancer autopsy program.

Authors:
Patricia S Steeg

Clin Cancer Res 2008 Jun;14(12):3643-5

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-08-1135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2692037PMC
June 2008

Metastasis: a therapeutic target for cancer.

Nat Clin Pract Oncol 2008 Apr 5;5(4):206-19. Epub 2008 Feb 5.

Women's Cancers Section, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1038/ncponc1066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709494PMC
April 2008

Quantitative protein network monitoring in response to DNA damage.

J Proteome Res 2008 Feb;7(2):803-8

Molecular Therapeutics Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1021/pr0702971DOI Listing
February 2008

Alterations in Gemin5 expression contribute to alternative mRNA splicing patterns and tumor cell motility.

Cancer Res 2008 Feb;68(3):639-44

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-2632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678556PMC
February 2008

In vitro and in vivo radiosensitization induced by the DNA methylating agent temozolomide.

Clin Cancer Res 2008 Feb;14(3):931-8

Radiation Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-07-1856DOI Listing
February 2008

Nm23-H1 suppresses metastasis by inhibiting expression of the lysophosphatidic acid receptor EDG2.

Cancer Res 2007 Dec;67(24):11751-9

Women's Cancers Section, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-3175DOI Listing
December 2007

Cancer: micromanagement of metastasis.

Authors:
Patricia S Steeg

Nature 2007 Oct;449(7163):671-3

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http://dx.doi.org/10.1038/449671aDOI Listing
October 2007

Nm23-H1 suppresses tumor cell motility by down-regulating the lysophosphatidic acid receptor EDG2.

Cancer Res 2007 Aug;67(15):7238-46

Women's Cancer Section, Laboratory of Molecular Pharmacology, National Cancer Institute/NIH, 37 Convent Drive, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-0962DOI Listing
August 2007

Brain metastases of breast cancer.

Breast Dis 2006-2007;26:139-47

Women's Cancers Section, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.

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http://dx.doi.org/10.3233/bd-2007-26112DOI Listing
July 2007

Quantitative assessment of the p53-Mdm2 feedback loop using protein lysate microarrays.

Cancer Res 2007 Jul;67(13):6247-52

Molecular Therapeutics Program, National Cancer Institute, NIH, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-0342DOI Listing
July 2007

The biology of metastasis to a sanctuary site.

Clin Cancer Res 2007 Mar;13(6):1656-62

Women's Cancers Section, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-06-2659DOI Listing
March 2007

Combined breast ductal lavage and ductal endoscopy for the evaluation of the high-risk breast: a feasibility study.

J Surg Oncol 2006 Dec;94(7):555-64

Surgery Branch, The Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1002/jso.20650DOI Listing
December 2006

Tumor metastasis: mechanistic insights and clinical challenges.

Authors:
Patricia S Steeg

Nat Med 2006 Aug;12(8):895-904

Women's Cancers Section, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute Building 37, Room 1122, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/nm1469DOI Listing
August 2006

Translational approaches using metastasis suppressor genes.

J Bioenerg Biomembr 2006 Aug;38(3-4):151-61

Women's Cancers Section, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Building 37, Room 1122, NIH, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1007/s10863-006-9039-9DOI Listing
August 2006