Patricia N Holden

Patricia N Holden

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Patricia N Holden

Patricia N Holden

Publications by authors named "Patricia N Holden"

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21Publications

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Azithromycin Pharmacodynamics against Persistent Haemophilus influenzae in Chronic Obstructive Pulmonary Disease.

Antimicrob Agents Chemother 2018 02 25;62(2). Epub 2018 Jan 25.

Division of Infectious Diseases, University at Buffalo, the State University of New York, Buffalo, New York, USA

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http://dx.doi.org/10.1128/AAC.01995-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786777PMC
February 2018

Pharmacodynamics of dose-escalated 'front-loading' polymyxin B regimens against polymyxin-resistant mcr-1-harbouring Escherichia coli.

J Antimicrob Chemother 2017 08;72(8):2297-2303

Laboratory for Antimicrobial Pharmacodynamics, University at Buffalo, School of Pharmacy and Pharmaceutical Sciences, Buffalo, NY, USA.

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http://dx.doi.org/10.1093/jac/dkx121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890756PMC
August 2017

Defining the Active Fraction of Daptomycin against Methicillin-Resistant Staphylococcus aureus (MRSA) Using a Pharmacokinetic and Pharmacodynamic Approach.

PLoS One 2016 10;11(6):e0156131. Epub 2016 Jun 10.

Laboratory for Antimicrobial Pharmacodynamics, School of Pharmacy and Pharmaceutical Sciences Buffalo, Buffalo, NY, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0156131PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902307PMC
July 2017

Polymyxin Combinations Combat Harboring and : Preparation for a Postantibiotic Era.

mBio 2017 07 25;8(4). Epub 2017 Jul 25.

Laboratory for Antimicrobial Dynamics, NYS Center of Excellence in Bioinformatics and Life Sciences, Buffalo, New York, USA

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http://dx.doi.org/10.1128/mBio.00540-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527306PMC
July 2017

Influence of and on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.

Antimicrob Agents Chemother 2017 04 24;61(4). Epub 2017 Mar 24.

Laboratory for Antimicrobial Pharmacodynamics, University at Buffalo School of Pharmacy and Pharmaceutical Sciences, Buffalo, New York, USA

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http://aac.asm.org/lookup/doi/10.1128/AAC.00096-16
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http://dx.doi.org/10.1128/AAC.00096-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5365695PMC
April 2017

New Polymyxin B Dosing Strategies To Fortify Old Allies in the War against KPC-2-Producing Klebsiella pneumoniae.

Antimicrob Agents Chemother 2017 04 24;61(4). Epub 2017 Mar 24.

Laboratory for Antimicrobial Dynamics, NYS Center of Excellence in Bioinformatics & Life Sciences, Buffalo, New York, USA

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http://dx.doi.org/10.1128/AAC.02023-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5365650PMC
April 2017

In vitro pharmacodynamic evaluation of ceftolozane/tazobactam against β-lactamase-producing Escherichia coli in a hollow-fibre infection model.

Int J Antimicrob Agents 2017 Jan 1;49(1):25-30. Epub 2016 Sep 1.

Laboratory for Antimicrobial Dynamics, NYS Center of Excellence in Bioinformatics & Life Sciences, Buffalo, NY, USA; School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ijantimicag.2016.07.015DOI Listing
January 2017

Polymyxin B in combination with doripenem against heteroresistant Acinetobacter baumannii: pharmacodynamics of new dosing strategies.

J Antimicrob Chemother 2016 11 3;71(11):3148-3156. Epub 2016 Aug 3.

Laboratory for Antimicrobial Pharmacodynamics, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, USA

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http://dx.doi.org/10.1093/jac/dkw293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079300PMC
November 2016

Combinatorial pharmacodynamics of polymyxin B and tigecycline against heteroresistant Acinetobacter baumannii.

Int J Antimicrob Agents 2016 Sep 12;48(3):331-6. Epub 2016 Jul 12.

Laboratory for Antimicrobial Pharmacodynamics, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, SUNY, Buffalo, NY, USA; The New York State Center of Excellence in Bioinformatics & Life Sciences, University at Buffalo, SUNY, Buffalo, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ijantimicag.2016.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5256686PMC
September 2016

Paradoxical Effect of Polymyxin B: High Drug Exposure Amplifies Resistance in Acinetobacter baumannii.

Antimicrob Agents Chemother 2016 07 20;60(7):3913-20. Epub 2016 Jun 20.

Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.

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http://dx.doi.org/10.1128/AAC.02831-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914656PMC
July 2016

Effect of Fluoroquinolones and Macrolides on Eradication and Resistance of Haemophilus influenzae in Chronic Obstructive Pulmonary Disease.

Antimicrob Agents Chemother 2016 07 20;60(7):4151-8. Epub 2016 Jun 20.

Division of Infectious Diseases and Clinical and Translational Research Center, University at Buffalo, the State University of New York, Buffalo, New York, USA Department of Microbiology and Immunology University at Buffalo, the State University of New York, Buffalo, New York, USA

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http://dx.doi.org/10.1128/AAC.00301-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914697PMC
July 2016

Optimization of Polymyxin B in Combination with Doripenem To Combat Mutator Pseudomonas aeruginosa.

Antimicrob Agents Chemother 2016 05 22;60(5):2870-80. Epub 2016 Apr 22.

Laboratory for Antimicrobial Pharmacodynamics, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, New York, USA The New York State Center of Excellence in Bioinformatics and Life Sciences, University at Buffalo, State University of New York, Buffalo, New York, USA

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http://dx.doi.org/10.1128/AAC.02377-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862466PMC
May 2016

Combinatorial Pharmacodynamics of Ceftolozane-Tazobactam against Genotypically Defined β-Lactamase-Producing Escherichia coli: Insights into the Pharmacokinetics/Pharmacodynamics of β-Lactam-β-Lactamase Inhibitor Combinations.

Antimicrob Agents Chemother 2016 Apr 25;60(4):1967-73. Epub 2016 Mar 25.

Laboratory for Antimicrobial Pharmacodynamics, New York State Center of Excellence in Bioinformatics & Life Sciences, University at Buffalo, Buffalo, New York, USA School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, New York, USA

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http://dx.doi.org/10.1128/AAC.02635-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808171PMC
April 2016

Emergence of polymyxin B resistance influences pathogenicity in Pseudomonas aeruginosa mutators.

Antimicrob Agents Chemother 2015 Jul 27;59(7):4343-6. Epub 2015 Apr 27.

Laboratory for Antimicrobial Pharmacodynamics, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, SUNY, Buffalo, New York, USA The New York State Center of Excellence in Bioinformatics Life Sciences, University at Buffalo, State University of New York, Buffalo, New York, USA

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http://dx.doi.org/10.1128/AAC.04629-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468730PMC
July 2015

Colistin and doripenem combinations against Pseudomonas aeruginosa: profiling the time course of synergistic killing and prevention of resistance.

J Antimicrob Chemother 2015 May 23;70(5):1434-42. Epub 2015 Feb 23.

Laboratory for Antimicrobial and Bacterial Dynamics, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA The New York State Center of Excellence in Bioinformatics & Life Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA

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http://jac.oxfordjournals.org/content/early/2015/02/23/jac.d
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http://www.jac.oxfordjournals.org/lookup/doi/10.1093/jac/dku
Publisher Site
http://dx.doi.org/10.1093/jac/dku567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4398476PMC
May 2015

Evolution of Staphylococcus aureus under vancomycin selective pressure: the role of the small-colony variant phenotype.

Antimicrob Agents Chemother 2015 Feb 1;59(2):1347-51. Epub 2014 Dec 1.

Laboratory for Antimicrobial Pharmacodynamics, NYS Center of Excellence in Bioinformatics & Life Sciences, University at Buffalo, Buffalo, New York, USA School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, New York, USA

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http://aac.asm.org/content/59/2/1347.full.pdf
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http://aac.asm.org/content/early/2014/11/25/AAC.04508-14.ful
Web Search
http://aac.asm.org/lookup/doi/10.1128/AAC.04508-14
Publisher Site
http://dx.doi.org/10.1128/AAC.04508-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335873PMC
February 2015

Front-loaded linezolid regimens result in increased killing and suppression of the accessory gene regulator system of Staphylococcus aureus.

Antimicrob Agents Chemother 2012 Jul 23;56(7):3712-9. Epub 2012 Apr 23.

Laboratory for Antimicrobial Pharmacodynamics, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, New York, USA.

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http://aac.asm.org/lookup/doi/10.1128/AAC.05453-11
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http://dx.doi.org/10.1128/AAC.05453-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3393439PMC
July 2012

Microbiological effects of prior vancomycin use in patients with methicillin-resistant Staphylococcus aureus bacteraemia.

J Antimicrob Chemother 2008 Jan 27;61(1):85-90. Epub 2007 Nov 27.

University of the Pacific School of Pharmacy and VA San Diego Healthcare System, San Diego, CA 92161, USA.

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http://dx.doi.org/10.1093/jac/dkm445DOI Listing
January 2008