Patricia L Brubaker

Patricia L Brubaker

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Patricia L Brubaker

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Analysis of Western diet, palmitate and BMAL1 regulation of neuropeptide Y expression in the murine hypothalamus and BMAL1 knockout cell models.

Mol Cell Endocrinol 2020 May 27;507:110773. Epub 2020 Feb 27.

Department of Physiology, University of Toronto, Toronto, ON, Canada; Department of Medicine, University of Toronto, Toronto, ON, Canada; Department of Obstetrics and Gynaecology, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2020.110773DOI Listing
May 2020

GLP-2, EGF, and the Intestinal Epithelial IGF-1 Receptor Interactions in the Regulation of Crypt Cell Proliferation.

Endocrinology 2020 Apr;161(4)

Department of Physiology, University of Toronto, Toronto, ON M5S 1A8, Canada.

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http://dx.doi.org/10.1210/endocr/bqaa040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098877PMC
April 2020

The roles of glucagon-like peptide-2 and the intestinal epithelial insulin-like growth factor-1 receptor in regulating microvillus length.

Sci Rep 2019 Sep 10;9(1):13010. Epub 2019 Sep 10.

Department of Physiology Rm 3366 Medical Sciences Building, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada.

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http://dx.doi.org/10.1038/s41598-019-49510-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737075PMC
September 2019

Insulin-like growth factor-binding protein-4 inhibits epithelial growth and proliferation in the rodent intestine.

Am J Physiol Gastrointest Liver Physiol 2018 08 6;315(2):G206-G219. Epub 2018 Apr 6.

Department of Physiology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1152/ajpgi.00349.2017DOI Listing
August 2018

Linking the Gut Microbiome to Metabolism Through Endocrine Hormones.

Endocrinology 2018 08;159(8):2978-2979

Department of Physiology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1210/en.2018-00577DOI Listing
August 2018

Glucagon-like Peptide-2 and the Regulation of Intestinal Growth and Function.

Compr Physiol 2018 06 18;8(3):1185-1210. Epub 2018 Jun 18.

Departments of Physiology and Medicine, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/cphy.c170055DOI Listing
June 2018

The Cardiac Glucagonlike Peptide-1 Receptor: Whither Art Thou?

Endocrinology 2018 04;159(4):1842-1843

Department of Physiology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1210/en.2018-00186DOI Listing
April 2018

Elucidating the Biological Roles of Insulin and Its Receptor in Murine Intestinal Growth and Function.

Endocrinology 2017 08;158(8):2453-2469

Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1210/en.2017-00195DOI Listing
August 2017

Species-Dependent Mechanisms Regulating Glucose-Dependent GLP-1 Secretion?

Diabetes 2017 08;66(8):2063-2065

Departments of Physiology and Medicine, University of Toronto, Toronto, Ontario, Canada

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http://dx.doi.org/10.2337/dbi17-0020DOI Listing
August 2017

Comment on Ussar et al. Regulation of Glucose Uptake and Enteroendocrine Function by the Intestinal Epithelial Insulin Receptor. Diabetes 2017;66:886-896.

Diabetes 2017 05;66(5):e5

Departments of Physiology and Medicine, University of Toronto, Toronto, Canada

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http://dx.doi.org/10.2337/db17-0099DOI Listing
May 2017

Current and potential therapeutic targets of glucagon-like peptide-2.

Curr Opin Pharmacol 2016 12 28;31:13-18. Epub 2016 Aug 28.

Department of Physiology, Rm 3366 Medical Sciences Building, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada; Department of Medicine, Rm 3366 Medical Sciences Building, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.coph.2016.08.008DOI Listing
December 2016

The Endocrine Society Centennial: Cleavage Matters.

Endocrinology 2016 11;157(11):4091-4093

Departments of Physiology and Medicine, University of Toronto, Toronto, Ontario, Canada M5S 1A8.

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http://dx.doi.org/10.1210/en.2016-1667DOI Listing
November 2016

On the horizon: trophic peptide growth factors as therapy for neonatal short bowel syndrome.

Expert Opin Ther Targets 2016 Jul 1;20(7):819-30. Epub 2016 Mar 1.

d Departments of Physiology and Medicine , University of Toronto , Toronto , ON , Canada.

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http://dx.doi.org/10.1517/14728222.2016.1146695DOI Listing
July 2016

Glucagon-Like Peptide-2 Requires a Full Complement of Bmi-1 for Its Proliferative Effects in the Murine Small Intestine.

Endocrinology 2016 07 17;157(7):2660-70. Epub 2016 May 17.

Departments of Physiology (B.R.S., H.Y.M.P., P.L.B.) and Medicine (P.L.B.), University of Toronto, Toronto, Ontario, Canada M5S 1A8.

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http://dx.doi.org/10.1210/en.2016-1127DOI Listing
July 2016

Glucagon-like peptide-1: The missing link in the metabolic clock?

J Diabetes Investig 2016 Apr 14;7 Suppl 1:70-5. Epub 2016 Mar 14.

Department of Physiology University of Toronto Toronto Ontario Canada.

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http://dx.doi.org/10.1111/jdi.12477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854508PMC
April 2016

High-Fat Diet and Palmitate Alter the Rhythmic Secretion of Glucagon-Like Peptide-1 by the Rodent L-cell.

Endocrinology 2016 Feb 8;157(2):586-99. Epub 2015 Dec 8.

Departments of Physiology (M.G.-L., W.K.W., A.M., P.L.B.) and Medicine (P.L.B.), University of Toronto, Toronto, Ontario, Canada M5S 1A8.

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http://dx.doi.org/10.1210/en.2015-1732DOI Listing
February 2016

Chronic Exposure to TNFα Impairs Secretion of Glucagon-Like Peptide-1.

Endocrinology 2015 Nov 13;156(11):3950-60. Epub 2015 Aug 13.

Departments of Physiology (J.G., M.S., W.Z., H.M.S., S.C.W., S.-S.B., P.L.B.) and Medicine (P.L.B.), University of Toronto, Toronto, Ontario, M5S 1A8 Canada; and Centre for Microvascular Medicine (S.-S.B.), University of Toronto and Li Ka Shing Knowledge Institute at St Michael's Hospital, Toronto, Ontario, M5B 1T8 Canada.

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https://academic.oup.com/endo/article-lookup/doi/10.1210/en.
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http://dx.doi.org/10.1210/en.2015-1361DOI Listing
November 2015

Ghrelin Is a Novel Regulator of GLP-1 Secretion.

Diabetes 2015 May 20;64(5):1513-21. Epub 2014 Nov 20.

Department of Physiology, University of Toronto, Toronto, Ontario, Canada Department of Medicine, University of Toronto, Toronto, Ontario, Canada

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http://dx.doi.org/10.2337/db14-1176DOI Listing
May 2015

GLP-1R agonists promote normal and neoplastic intestinal growth through mechanisms requiring Fgf7.

Cell Metab 2015 Mar;21(3):379-91

Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G1X5, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2015.02.005DOI Listing
March 2015

IGF binding protein-4 is required for the growth effects of glucagon-like peptide-2 in murine intestine.

Endocrinology 2015 Feb 16;156(2):429-36. Epub 2014 Dec 16.

Departments of Physiology (K.A., N.A.I., P.L.B.) and Medicine (P.L.B.), University of Toronto, Toronto, Ontario, Canada M5S 1A8; and Department of Neuroscience and Cell Biology (J.E.P.), Rutgers Robert Wood Johnson Medical School, Piscataway, New Jersey 08854.

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http://dx.doi.org/10.1210/en.2014-1829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298331PMC
February 2015

Circadian secretion of the intestinal hormone GLP-1 by the rodent L cell.

Diabetes 2014 Nov 1;63(11):3674-85. Epub 2014 May 1.

Department of Physiology, University of Toronto, Toronto, Ontario, Canada Department of Medicine, University of Toronto, Toronto, Ontario, Canada

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http://dx.doi.org/10.2337/db13-1501DOI Listing
November 2014

Exogenous glucagon-like peptide-2 improves outcomes of intestinal adaptation in a distal-intestinal resection neonatal piglet model of short bowel syndrome.

Pediatr Res 2014 Oct 4;76(4):370-7. Epub 2014 Jul 4.

1] Department of General Surgery, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada [2] Department of Paediatrics, University of Alberta, Edmonton, Alberta, Canada [3] Research Institute, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

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https://tspace.library.utoronto.ca/bitstream/1807/35140/1/Su
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http://www.nature.com/doifinder/10.1038/pr.2014.97
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http://dx.doi.org/10.1038/pr.2014.97DOI Listing
October 2014

Gut hormones fulfill their destiny: from basic physiology to the clinic.

Annu Rev Physiol 2014 4;76:515-7. Epub 2013 Sep 4.

Departments of Physiology and Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada; email:

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http://dx.doi.org/10.1146/annurev-physiol-073013-094026DOI Listing
September 2014

Corticotropin-releasing hormone and the sympathoadrenal system are major mediators in the effects of peripherally administered exendin-4 on the hypothalamic-pituitary-adrenal axis of male rats.

Endocrinology 2014 Jul 14;155(7):2511-23. Epub 2014 Apr 14.

Laboratory of Endocrinology (M.G.-L., M.R.-P., V.O., E.V., L.C.G.-M., F.M.), Center for Biomedical Research, Campus As Lagoas-Marcosende, University of Vigo, E-36310 Vigo, Spain; and Department of Physiology (M.G.-L., P.L.B.), University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1210/en.2013-1718DOI Listing
July 2014

From diarrhea to obesity in prohormone convertase 1/3 deficiency: age-dependent clinical, pathologic, and enteroendocrine characteristics.

J Clin Gastroenterol 2013 Nov-Dec;47(10):834-43

Divisions of *Gastroenterology, Hepatology and Nutrition †Pathology §Endocrinology, The Hospital for Sick Children ‡Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, ON ∥Alberta Children's Hospital Intestinal Rehabilitation Program, Alberta Children's Hospital and University of Calgary, Calgary, AB, Canada ¶Department of Pediatrics, Mattel Children's Hospital, David Geffen School of Medicine at the University of California, Los Angeles, CA.

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http://dx.doi.org/10.1097/MCG.0b013e3182a89fc8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842618PMC
June 2014

Role of vesicle-associated membrane protein 2 in exocytosis of glucagon-like peptide-1 from the murine intestinal L cell.

Diabetologia 2014 Apr 20;57(4):809-18. Epub 2013 Dec 20.

Department of Physiology, Medical Sciences Building, 1 King's College Circle, University of Toronto, Toronto, ON, M5S 1A8, Canada.

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http://link.springer.com/10.1007/s00125-013-3143-2
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http://dx.doi.org/10.1007/s00125-013-3143-2DOI Listing
April 2014

The intestinal epithelial insulin-like growth factor-1 receptor links glucagon-like peptide-2 action to gut barrier function.

Endocrinology 2014 Feb 21;155(2):370-9. Epub 2013 Nov 21.

Departments of Physiology (C.X.D., W.Z., C.S., K.J.R., P.L.B.), Pediatrics (T.G.), and Medicine (P.L.B.), University of Toronto, Toronto, Ontario M5S 1A8 Canada; Department of Paediatric Laboratory Medicine (C.A.), and Physiology and Experimental Medicine, Research Institute (T.G.), The Hospital for Sick Children, Toronto M5G 1X8, Canada; Centre National de la Recherche Scientifique (S.R.), Institut Curie, Paris, 75248 France; and Inserm (M.H.), Hôpital St-Antoine, Paris, 75005 France.

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https://tspace.library.utoronto.ca/bitstream/1807/31923/1/Ro
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http://press.endocrine.org/doi/abs/10.1210/en.2013-1871
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http://dx.doi.org/10.1210/en.2013-1871DOI Listing
February 2014

R-spondin1 deficiency enhances β-Cell neogenesis in a murine model of diabetes.

Pancreas 2014 Jan;43(1):93-102

From the *Department of Physiology, University of Toronto, Toronto, Ontario, Canada; †Centre for Neuroscience, UC Davis, Davis, CA; ‡iBV, INSERM U1091, CNRS UMR7277, University of Nice Sophia-Antipolis, UFR Sciences, F-06108 Nice, France; and §Departments of Physiology and Medicine, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/MPA.0b013e3182a70bfbDOI Listing
January 2014

Effects of prolonged exendin-4 administration on hypothalamic-pituitary-adrenal axis activity and water balance.

Am J Physiol Endocrinol Metab 2013 May 26;304(10):E1105-17. Epub 2013 Mar 26.

Laboratory of Endocrinology, Center for Biomedical Research, Campus As Lagoas-Marcosende, University of Vigo, Vigo, Spain.

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http://www.physiology.org/doi/10.1152/ajpendo.00529.2012
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http://dx.doi.org/10.1152/ajpendo.00529.2012DOI Listing
May 2013

Ghrelin, the proglucagon-derived peptides and peptide YY in nutrient homeostasis.

Nat Rev Gastroenterol Hepatol 2012 Dec 2;9(12):705-15. Epub 2012 Oct 2.

Department of Physiology, Medical Sciences Building, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada.

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http://dx.doi.org/10.1038/nrgastro.2012.185DOI Listing
December 2012

A beautiful cell (or two or three?).

Endocrinology 2012 Jul;153(7):2945-8

Department of Physiology, University of Toronto, Toronto, Ontario, Canada M5S 1A8.

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http://dx.doi.org/10.1210/en.2012-1549DOI Listing
July 2012

Glucagon-like peptide-2 increases dysplasia in rodent models of colon cancer.

Am J Physiol Gastrointest Liver Physiol 2012 Apr 9;302(8):G840-9. Epub 2012 Feb 9.

Department of 1Physiology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1152/ajpgi.00505.2011DOI Listing
April 2012

Novel biological action of the dipeptidylpeptidase-IV inhibitor, sitagliptin, as a glucagon-like peptide-1 secretagogue.

Endocrinology 2012 Feb 20;153(2):564-73. Epub 2011 Dec 20.

Department of Physiology, Medical Sciences Building, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8 Canada.

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http://dx.doi.org/10.1210/en.2011-1732DOI Listing
February 2012

Loss of glucagon-like peptide-2-induced proliferation following intestinal epithelial insulin-like growth factor-1-receptor deletion.

Gastroenterology 2011 Dec 16;141(6):2166-2175.e7. Epub 2011 Sep 16.

Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1053/j.gastro.2011.09.014DOI Listing
December 2011

Mechanisms underlying metformin-induced secretion of glucagon-like peptide-1 from the intestinal L cell.

Endocrinology 2011 Dec 4;152(12):4610-9. Epub 2011 Oct 4.

Department of Physiology, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1210/en.2011-1485DOI Listing
December 2011

The "cryptic" mechanism of action of glucagon-like peptide-2.

Am J Physiol Gastrointest Liver Physiol 2011 Jul 28;301(1):G1-8. Epub 2011 Apr 28.

Department of Physiology, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1152/ajpgi.00039.2011DOI Listing
July 2011

Essential role for protein kinase Cζ in oleic acid-induced glucagon-like peptide-1 secretion in vivo in the rat.

Endocrinology 2011 Apr 15;152(4):1244-52. Epub 2011 Feb 15.

Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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https://academic.oup.com/endo/article-lookup/doi/10.1210/en.
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http://dx.doi.org/10.1210/en.2010-1352DOI Listing
April 2011

R-spondin-1 is a novel beta-cell growth factor and insulin secretagogue.

J Biol Chem 2010 Jul 4;285(28):21292-302. Epub 2010 May 4.

Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1074/jbc.M110.129874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898385PMC
July 2010

Minireview: update on incretin biology: focus on glucagon-like peptide-1.

Endocrinology 2010 May 19;151(5):1984-9. Epub 2010 Mar 19.

Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1210/en.2010-0115DOI Listing
May 2010

The rho guanosine 5'-triphosphatase, cell division cycle 42, is required for insulin-induced actin remodeling and glucagon-like peptide-1 secretion in the intestinal endocrine L cell.

Endocrinology 2009 Dec 9;150(12):5249-61. Epub 2009 Oct 9.

Department of Physiology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1210/en.2009-0508DOI Listing
December 2009

Glucagon-like peptide-2 increases intestinal lipid absorption and chylomicron production via CD36.

Gastroenterology 2009 Sep 29;137(3):997-1005, 1005.e1-4. Epub 2009 May 29.

Molecular Structure and Function, Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1053/j.gastro.2009.05.051DOI Listing
September 2009

Carcinogenic effects of exogenous and endogenous glucagon-like peptide-2 in azoxymethane-treated mice.

Endocrinology 2009 Sep 4;150(9):4033-43. Epub 2009 Jun 4.

Departments of Physiology, University of Toronto, Toronto, Ontario, Canada.

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https://academic.oup.com/endo/article-lookup/doi/10.1210/en.
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http://dx.doi.org/10.1210/en.2009-0295DOI Listing
September 2009

GPR119 is essential for oleoylethanolamide-induced glucagon-like peptide-1 secretion from the intestinal enteroendocrine L-cell.

Diabetes 2009 May 10;58(5):1058-66. Epub 2009 Feb 10.

Department of Physiology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.2337/db08-1237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671052PMC
May 2009

Insulin regulates glucagon-like peptide-1 secretion from the enteroendocrine L cell.

Endocrinology 2009 Feb 25;150(2):580-91. Epub 2008 Sep 25.

Department of Physiology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1210/en.2008-0726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5393261PMC
February 2009

Epac is involved in cAMP-stimulated proglucagon expression and hormone production but not hormone secretion in pancreatic alpha- and intestinal L-cell lines.

Am J Physiol Endocrinol Metab 2009 Jan 14;296(1):E174-81. Epub 2008 Oct 14.

Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, 101 College St., Toronto, Ontario M5G 1L7.

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http://dx.doi.org/10.1152/ajpendo.90419.2008DOI Listing
January 2009

Life in the crypt: a role for glucagon-like peptide-2?

Mol Cell Endocrinol 2008 Jun 29;288(1-2):63-70. Epub 2008 Feb 29.

Department of Physiology, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.mce.2008.02.014DOI Listing
June 2008

Cross talk between the insulin and Wnt signaling pathways: evidence from intestinal endocrine L cells.

Endocrinology 2008 May 7;149(5):2341-51. Epub 2008 Feb 7.

Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5G 1L7.

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https://academic.oup.com/endo/article-lookup/doi/10.1210/en.
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http://dx.doi.org/10.1210/en.2007-1142DOI Listing
May 2008

Glucagon-like peptide-2 activates beta-catenin signaling in the mouse intestinal crypt: role of insulin-like growth factor-I.

Endocrinology 2008 Jan 20;149(1):291-301. Epub 2007 Sep 20.

Department of Physiology, University of Toronto, Ontario, Canada M5S 1A8.

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http://dx.doi.org/10.1210/en.2007-0561DOI Listing
January 2008

Role of glial cell-line derived neurotropic factor family receptor alpha2 in the actions of the glucagon-like peptides on the murine intestine.

Am J Physiol Gastrointest Liver Physiol 2007 Aug 21;293(2):G461-8. Epub 2007 Jun 21.

Department of Physiology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1152/ajpgi.00424.2006DOI Listing
August 2007

Incretin-based therapies: mimetics versus protease inhibitors.

Trends Endocrinol Metab 2007 Aug 12;18(6):240-5. Epub 2007 Jul 12.

Departments of Physiology and Medicine, University of Toronto, Toronto, Ontario, Canada.

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http://linkinghub.elsevier.com/retrieve/pii/S104327600700092
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http://dx.doi.org/10.1016/j.tem.2007.06.005DOI Listing
August 2007

Frontiers in glucagon-like peptide-2: multiple actions, multiple mediators.

Am J Physiol Endocrinol Metab 2007 Aug 24;293(2):E460-5. Epub 2007 Jul 24.

Department of Physiology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1152/ajpendo.00149.2007DOI Listing
August 2007

A mathematical model of the oral glucose tolerance test illustrating the effects of the incretins.

Ann Biomed Eng 2007 Jul 29;35(7):1286-300. Epub 2007 Mar 29.

Department of Physiology, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1007/s10439-007-9274-1DOI Listing
July 2007

Role of phosphatidylinositol-3 kinase-gamma in the actions of glucagon-like peptide-2 on the murine small intestine.

Am J Physiol Endocrinol Metab 2007 Jun 6;292(6):E1599-606. Epub 2007 Feb 6.

Department of Physiology, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8 Canada.

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http://www.physiology.org/doi/10.1152/ajpendo.00429.2006
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http://dx.doi.org/10.1152/ajpendo.00429.2006DOI Listing
June 2007

Protein kinase Czeta is required for oleic acid-induced secretion of glucagon-like peptide-1 by intestinal endocrine L cells.

Endocrinology 2007 Mar 16;148(3):1089-98. Epub 2006 Nov 16.

Department of Physiology, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8.

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http://dx.doi.org/10.1210/en.2006-1403DOI Listing
March 2007

The essential role of insulin-like growth factor-1 in the intestinal tropic effects of glucagon-like peptide-2 in mice.

Gastroenterology 2006 Aug;131(2):589-605

Department of Physiology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1053/j.gastro.2006.05.055DOI Listing
August 2006

Role of phosphatidylinositol 3-kinasegamma in the beta-cell: interactions with glucagon-like peptide-1.

Endocrinology 2006 Jul 30;147(7):3318-25. Epub 2006 Mar 30.

Department of Physiology, University of Toronto, Toronto, Ontario, Canada M5S 1A8.

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https://academic.oup.com/endo/article-lookup/doi/10.1210/en.
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http://dx.doi.org/10.1210/en.2006-0155DOI Listing
July 2006

The glucagon-like peptides: pleiotropic regulators of nutrient homeostasis.

Ann N Y Acad Sci 2006 Jul;1070:10-26

Department of Physiology, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8 Canada.

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http://dx.doi.org/10.1196/annals.1317.006DOI Listing
July 2006

Adventure travel and type 1 diabetes: the complicating effects of high altitude.

Diabetes Care 2005 Oct;28(10):2563-72

Department of Physiology, Room 3366 Medical Sciences Bldg., University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada.

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http://dx.doi.org/10.2337/diacare.28.10.2563DOI Listing
October 2005

Peripheral exendin-4 and peptide YY(3-36) synergistically reduce food intake through different mechanisms in mice.

Endocrinology 2005 Sep 2;146(9):3748-56. Epub 2005 Jun 2.

Department of Physiology, Room 3366, Medical Sciences Building, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8.

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September 2005

PKA independent and cell type specific activation of the expression of caudal homeobox gene Cdx-2 by cyclic AMP.

FEBS J 2005 Jun;272(11):2746-59

Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, Toronto, Ontario.

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http://dx.doi.org/10.1111/j.1742-4658.2005.04694.xDOI Listing
June 2005

Mucosal adaptation to enteral nutrients is dependent on the physiologic actions of glucagon-like peptide-2 in mice.

Gastroenterology 2005 May;128(5):1340-53

Department of Physiology, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1053/j.gastro.2005.02.033DOI Listing
May 2005

beta-Cell Pdx1 expression is essential for the glucoregulatory, proliferative, and cytoprotective actions of glucagon-like peptide-1.

Diabetes 2005 Feb;54(2):482-91

Department of Medicine, University of Toronto, Banting and Best Diabetes Centre, Toronto General Hospital, 200 Elizabeth St., MBRW 4R402-2, Toronto, Canada M5G 2C4.

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http://dx.doi.org/10.2337/diabetes.54.2.482DOI Listing
February 2005

TCF-4 mediates cell type-specific regulation of proglucagon gene expression by beta-catenin and glycogen synthase kinase-3beta.

J Biol Chem 2005 Jan 2;280(2):1457-64. Epub 2004 Nov 2.

Division of Cell & Molecular Biology, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Ontario, M5G 2M1, Canada.

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http://dx.doi.org/10.1074/jbc.M411487200DOI Listing
January 2005

Direct and indirect mechanisms regulating secretion of glucagon-like peptide-1 and glucagon-like peptide-2.

Can J Physiol Pharmacol 2003 Nov;81(11):1005-12

Department of Physiology, University of Toronto, ON, Canada.

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http://dx.doi.org/10.1139/y03-107DOI Listing
November 2003

Glucagon-like peptide-2 receptor activation in the rat intestinal mucosa.

Endocrinology 2003 Oct 3;144(10):4385-92. Epub 2003 Jul 3.

Department of Physiology, University of Toronto, Toronto, Canada M5S 1A8.

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http://dx.doi.org/10.1210/en.2003-0309DOI Listing
October 2003

Muscarinic receptors control glucagon-like peptide 1 secretion by human endocrine L cells.

Endocrinology 2003 Jul;144(7):3244-50

Department of Physiology, Medical Sciences Building, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8.

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http://dx.doi.org/10.1210/en.2003-0143DOI Listing
July 2003

Glucagon-like peptide-2 and common therapeutics in a murine model of ulcerative colitis.

J Pharmacol Exp Ther 2003 Jul;306(1):347-54

Department of Physiology, University of Toronto, Medical Sciences Building, Room 3366, 1 King's College Circle, Toronto, Ontario, M5S 1A8, Canada.

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http://dx.doi.org/10.1124/jpet.103.051771DOI Listing
July 2003

Role of leptin in the regulation of glucagon-like peptide-1 secretion.

Diabetes 2003 Feb;52(2):252-9

Department of Physiology, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.2337/diabetes.52.2.252DOI Listing
February 2003

Pax-6 activates endogenous proglucagon gene expression in the rodent gastrointestinal epithelium.

Diabetes 2003 Feb;52(2):425-33

Department of Medicine, Banting and Best Diabetes Center, Toronto General Hospital, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.2337/diabetes.52.2.425DOI Listing
February 2003

Transcriptional activation of the proglucagon gene by lithium and beta-catenin in intestinal endocrine L cells.

J Biol Chem 2003 Jan 5;278(2):1380-7. Epub 2002 Nov 5.

Division of Cell & Molecular Biology, Toronto General Research Institute, University Health Network, Ontario M5G 2M1, Canada.

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January 2003

Elevated glucagon-like peptide-1-(7-36)-amide, but not glucose, associated with hyperinsulinemic compensation for fat feeding.

J Clin Endocrinol Metab 2002 Nov;87(11):5191-8

Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, 1333 San Pablo Street, Los Angeles, CA 90089-9142, USA.

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http://dx.doi.org/10.1210/jc.2002-020002DOI Listing
November 2002

Foxa3 (HNF-3gamma) binds to and activates the rat proglucagon gene promoter but is not essential for proglucagon gene expression.

Biochem J 2002 Sep;366(Pt 2):633-41

Department of Medicine, Banting and Best Diabetes Centre, Toronto General Hospital, University of Toronto, 101 College Street CCRW3-845, Toronto, Canada M5G 2C4.

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http://dx.doi.org/10.1042/BJ20020095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1222783PMC
September 2002

Prolonged gastrointestinal transit in a patient with a glucagon-like peptide (GLP)-1- and -2-producing neuroendocrine tumor.

J Clin Endocrinol Metab 2002 Jul;87(7):3078-83

Departments of Physiology, University of Toronto, Room 3366 Medical Sciences Building, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada.

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July 2002

Muscarinic receptors control postprandial release of glucagon-like peptide-1: in vivo and in vitro studies in rats.

Endocrinology 2002 Jun;143(6):2420-6

Department of Physiology, University of Toronto, Toronto, Ontario, Canada M5S 1A8.

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June 2002