Patricia J Sime

Patricia J Sime

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Patricia J Sime

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Quenching the fires: Pro-resolving mediators, air pollution, and smoking.

Pharmacol Ther 2019 May 10;197:212-224. Epub 2019 Feb 10.

Division of Pulmonary and Critical Care Medicine, University of Rochester School of Medicine and Dentistry Rochester, NY 14642, United States; Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, United States; Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, United States. Electronic address:

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http://dx.doi.org/10.1016/j.pharmthera.2019.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537608PMC
May 2019

Activated human T lymphocytes inhibit TGFβ-induced fibroblast to myofibroblast differentiation via prostaglandins D and E.

Am J Physiol Lung Cell Mol Physiol 2018 04 20;314(4):L569-L582. Epub 2017 Dec 20.

Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry , Rochester, New York.

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http://dx.doi.org/10.1152/ajplung.00565.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966783PMC
April 2018

Cigarette smoke dampens antiviral signaling in small airway epithelial cells by disrupting TLR3 cleavage.

Am J Physiol Lung Cell Mol Physiol 2018 03 14;314(3):L505-L513. Epub 2017 Dec 14.

Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry , Rochester, New York.

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http://dx.doi.org/10.1152/ajplung.00406.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900359PMC
March 2018

Management of Platelet Disorders and Platelet Transfusions in ICU Patients.

Transfus Med Rev 2017 10 4;31(4):252-257. Epub 2017 May 4.

Pulmonary and Critical Care, Department of Medicine, Strong Memorial Hospital and Golisano Children's Hospital, University of Rochester Medical Center, Rochester, NY.

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http://dx.doi.org/10.1016/j.tmrv.2017.04.002DOI Listing
October 2017

Comparison of in vitro toxicological effects of biomass smoke from different sources of animal dung.

Toxicol In Vitro 2017 Sep 30;43:76-86. Epub 2017 May 30.

Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, United States; Division of Pulmonary and Critical Care Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, United States; Lung Biology and Disease Program, University of Rochester, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, United States. Electronic address:

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http://dx.doi.org/10.1016/j.tiv.2017.05.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736384PMC
September 2017

Development of an accurate and sensitive method for lactate analysis in exhaled breath condensate by LC MS/MS.

J Chromatogr B Analyt Technol Biomed Life Sci 2017 Sep 24;1061-1062:468-473. Epub 2017 Jul 24.

Department of Medicine, University of Rochester Medical Center, United States.

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http://dx.doi.org/10.1016/j.jchromb.2017.07.041DOI Listing
September 2017

Antifibrotic Actions of Peroxisome Proliferator-Activated Receptor γ Ligands in Corneal Fibroblasts Are Mediated by β-Catenin-Regulated Pathways.

Am J Pathol 2017 Aug 10;187(8):1660-1669. Epub 2017 Jun 10.

Flaum Eye Institute, University of Rochester, Rochester, New York; Center for Visual Science, University of Rochester, Rochester, New York. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2017.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5530905PMC
August 2017

Dung biomass smoke activates inflammatory signaling pathways in human small airway epithelial cells.

Am J Physiol Lung Cell Mol Physiol 2016 Dec 11;311(6):L1222-L1233. Epub 2016 Nov 11.

Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York;

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http://dx.doi.org/10.1152/ajplung.00183.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206396PMC
December 2016

Human lung fibroblasts produce proresolving peroxisome proliferator-activated receptor-γ ligands in a cyclooxygenase-2-dependent manner.

Am J Physiol Lung Cell Mol Physiol 2016 Nov 9;311(5):L855-L867. Epub 2016 Sep 9.

Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York;

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http://dx.doi.org/10.1152/ajplung.00272.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5130533PMC
November 2016

Resolvin D2 decreases TLR4 expression to mediate resolution in human monocytes.

FASEB J 2016 09 2;30(9):3181-93. Epub 2016 Jun 2.

Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA; and Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA

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http://dx.doi.org/10.1096/fj.201600375RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001508PMC
September 2016

Pilot Metabolome-Wide Association Study of Benzo(a)pyrene in Serum From Military Personnel.

J Occup Environ Med 2016 08;58(8 Suppl 1):S44-52

Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University, Atlanta, Georgia (Mr Walker, Drs Uppal and Jones); Department of Civil and Environmental Engineering, Tufts University, Medford, Massachusetts (Mr Walker, Dr Pennell); Center for Air Resources Engineering and Science, Clarkson University, Potsdam (Drs Xia, Hopke); Pulmonary Division, Department of Medicine (Drs Utell, Phipps, Sime), Department of Environmental Medicine, University of Rochester Medical Center, New York (Drs Utell, Phipps, Sime); 779th Aerospace Medicine Squadron, 79th Medical Wing, Joint Base Andrews, MD (Dr Rohrbeck); and Professor, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814 (Dr Mallon).

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http://dx.doi.org/10.1097/JOM.0000000000000772DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837056PMC
August 2016

MicroRNAs as Novel Biomarkers of Deployment Status and Exposure to Polychlorinated Dibenzo-p-Dioxins/Dibenzofurans.

J Occup Environ Med 2016 08;58(8 Suppl 1):S89-96

Department of Environmental Medicine (Dr Woeller, Mr Pollock, Ms Croasdell, Dr Sime, Dr Utell, and Dr Phipps), Department of Medicine (Dr Thatcher, Dr Sime, Dr Utell, and Dr Phipps), Microbiology and Immunology (Mr Van Twisk, Dr Thakar, and Dr Phipps), and Department of Biostatistics and Computational Biology (Mr Van Twisk, Dr Thakar), University of Rochester Medical Center; Center for Air Resources Engineering and Science, Clarkson University, Potsdam, New York (Dr Hopke, Dr Xia); and Professor, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814 (Dr Mallon).

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http://dx.doi.org/10.1097/JOM.0000000000000769DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978134PMC
August 2016

Normal Human Lung Epithelial Cells Inhibit Transforming Growth Factor-β Induced Myofibroblast Differentiation via Prostaglandin E2.

PLoS One 2015 6;10(8):e0135266. Epub 2015 Aug 6.

Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, United States of America; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, United States of America; Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, United States of America; Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester NY, 14642, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0135266PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527711PMC
May 2016

Resolvin D1 Dampens Pulmonary Inflammation and Promotes Clearance of Nontypeable Haemophilus influenzae.

J Immunol 2016 Mar 3;196(6):2742-52. Epub 2016 Feb 3.

Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642; Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642; and Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642

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http://dx.doi.org/10.4049/jimmunol.1502331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779746PMC
March 2016

Specialized proresolving mediators (SPMs) inhibit human B-cell IgE production.

Eur J Immunol 2016 Jan 2;46(1):81-91. Epub 2015 Nov 2.

Department of Microbiology and Immunology, University of Rochester, Rochester, NY, USA.

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http://dx.doi.org/10.1002/eji.201545673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710564PMC
January 2016

Endogenous ligands of the aryl hydrocarbon receptor regulate lung dendritic cell function.

Immunology 2016 Jan 10;147(1):41-54. Epub 2015 Nov 10.

Division of Pulmonary and Critical Care Medicine, University of Rochester, Rochester, NY, USA.

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http://dx.doi.org/10.1111/imm.12540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693882PMC
January 2016

Pharmacologic inhibition of lactate production prevents myofibroblast differentiation.

Am J Physiol Lung Cell Mol Physiol 2015 Dec 25;309(11):L1305-12. Epub 2015 Sep 25.

University of Rochester Department of Medicine, Rochester, New York; University of Rochester Department of Environmental Medicine, Rochester, New York; and University of Rochester Lung Biology and Disease Program, Rochester, New York

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http://dx.doi.org/10.1152/ajplung.00058.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669339PMC
December 2015

Resolvin D1 Reduces Emphysema and Chronic Inflammation.

Am J Pathol 2015 Dec 24;185(12):3189-201. Epub 2015 Oct 24.

Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, Rochester, New York; Division of Pulmonary and Critical Care Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York; Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2015.08.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729265PMC
December 2015

PPARγ and the Innate Immune System Mediate the Resolution of Inflammation.

PPAR Res 2015 2;2015:549691. Epub 2015 Dec 2.

Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA ; Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA ; Department of Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA.

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http://dx.doi.org/10.1155/2015/549691DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4680113PMC
December 2015

Resolvins attenuate inflammation and promote resolution in cigarette smoke-exposed human macrophages.

Am J Physiol Lung Cell Mol Physiol 2015 Oct 21;309(8):L888-901. Epub 2015 Aug 21.

Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York; Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, Rochester, New York; Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York; and

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http://dx.doi.org/10.1152/ajplung.00125.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609942PMC
October 2015

Inhibitory effects of PPARγ ligands on TGF-β1-induced CTGF expression in cat corneal fibroblasts.

Exp Eye Res 2015 Sep 2;138:52-8. Epub 2015 Jul 2.

Flaum Eye Institute, University of Rochester, Rochester, NY, USA; Center for Visual Science, University of Rochester, Rochester, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.exer.2015.06.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4553125PMC
September 2015

Resolvin D1 attenuates polyinosinic-polycytidylic acid-induced inflammatory signaling in human airway epithelial cells via TAK1.

J Immunol 2014 Nov 15;193(10):4980-7. Epub 2014 Oct 15.

Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642; and Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642

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http://dx.doi.org/10.4049/jimmunol.1400313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409010PMC
November 2014

Serotonin and corticosterone rhythms in mice exposed to cigarette smoke and in patients with COPD: implication for COPD-associated neuropathogenesis.

PLoS One 2014 10;9(2):e87999. Epub 2014 Feb 10.

Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0087999PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919731PMC
October 2014

Cigarette smoke exposure exacerbates lung inflammation and compromises immunity to bacterial infection.

J Immunol 2014 Jun 21;192(11):5226-35. Epub 2014 Apr 21.

Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263;

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http://dx.doi.org/10.4049/jimmunol.1302584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066560PMC
June 2014

SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism.

Am J Physiol Lung Cell Mol Physiol 2014 May 14;306(9):L816-28. Epub 2014 Mar 14.

Dept. of Environmental Medicine, Univ. of Rochester Medical Center, Box 850, 601 Elmwood Ave., Rochester, NY 14642.

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http://dx.doi.org/10.1152/ajplung.00323.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010647PMC
May 2014

Inhibitory effects of PPARγ ligands on TGF-β1-induced corneal myofibroblast transformation.

Am J Pathol 2014 May 17;184(5):1429-45. Epub 2014 Mar 17.

Flaum Eye Institute, University of Rochester, Rochester, New York; Center for Visual Science, University of Rochester, Rochester, New York. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2014.01.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005981PMC
May 2014

The triterpenoid CDDO-Me inhibits bleomycin-induced lung inflammation and fibrosis.

PLoS One 2013 31;8(5):e63798. Epub 2013 May 31.

The Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Rochester, Rochester, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0063798PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669327PMC
February 2014

New light is shed on the enigmatic origin of the lung myofibroblast.

Am J Respir Crit Care Med 2013 Oct;188(7):765-6

1 Division of Pulmonary and Critical Care Brigham and Women's Hospital Boston Massachusetts and Harvard Medical School Boston Massachusetts.

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http://dx.doi.org/10.1164/rccm.201308-1494EDDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826276PMC
October 2013

Attenuation of inflammatory mediator production by the NF-κB member RelB is mediated by microRNA-146a in lung fibroblasts.

Am J Physiol Lung Cell Mol Physiol 2013 Jun 5;304(11):L774-81. Epub 2013 Apr 5.

Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.

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http://dx.doi.org/10.1152/ajplung.00352.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680764PMC
June 2013

PPARs: Regulators and Translational Targets in the Lung.

PPAR Res 2012 4;2012:342924. Epub 2012 Nov 4.

Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University and Atlanta VA Medical Center, Atlanta, GA 30033, USA.

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http://dx.doi.org/10.1155/2012/342924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503434PMC
December 2012

Emerging PPARγ-Independent Role of PPARγ Ligands in Lung Diseases.

PPAR Res 2012 18;2012:705352. Epub 2012 Jun 18.

Division of Pulmonary and Critical Care, Department of Medicine, University of Rochester School of Medicine and Dentistry, Box 692, Rochester, NY 14642, USA.

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http://dx.doi.org/10.1155/2012/705352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3385049PMC
August 2012

Spiruchostatin A inhibits proliferation and differentiation of fibroblasts from patients with pulmonary fibrosis.

Am J Respir Cell Mol Biol 2012 May 12;46(5):687-94. Epub 2012 Jan 12.

Sir Henry Wellcome Laboratories, Southampton General Hospital, South Block, Southampton, United Kingdom.

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http://dx.doi.org/10.1165/rcmb.2011-0040OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854311PMC
May 2012

Genetic ablation of the aryl hydrocarbon receptor causes cigarette smoke-induced mitochondrial dysfunction and apoptosis.

J Biol Chem 2011 Dec 7;286(50):43214-28. Epub 2011 Oct 7.

Research Institute of the McGill University Health Centre, McGill University, Montreal, Quebec H2X 2P2, Canada.

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http://dx.doi.org/10.1074/jbc.M111.258764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234839PMC
December 2011

Transglutaminase 2 and its role in pulmonary fibrosis.

Am J Respir Crit Care Med 2011 Sep 23;184(6):699-707. Epub 2011 Jun 23.

University of Rochester, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Rochester, NY 14642, USA.

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http://dx.doi.org/10.1164/rccm.201101-0013OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3208598PMC
September 2011

The Role of PPARs in Lung Fibrosis.

PPAR Res 2007 ;2007:71323

Department of Environmental Medicine, University of Rochester, Rochester, NY 14642, USA.

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http://dx.doi.org/10.1155/2007/71323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1940051PMC
July 2011

Role of peroxisome proliferator-activated receptor gamma and its ligands in the treatment of hematological malignancies.

PPAR Res 2008 ;2008:834612

Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.

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http://dx.doi.org/10.1155/2008/834612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2408681PMC
July 2011

Ocular fibroblast diversity: implications for inflammation and ocular wound healing.

Invest Ophthalmol Vis Sci 2011 Jul 1;52(7):4859-65. Epub 2011 Jul 1.

Department of Ophthalmology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA.

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http://dx.doi.org/10.1167/iovs.10-7066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3175934PMC
July 2011

Lung-targeted overexpression of the NF-κB member RelB inhibits cigarette smoke-induced inflammation.

Am J Pathol 2011 Jul 5;179(1):125-33. Epub 2011 May 5.

Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA.

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http://dx.doi.org/10.1016/j.ajpath.2011.03.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3123857PMC
July 2011

Yin yang 1 is a novel regulator of pulmonary fibrosis.

Am J Respir Crit Care Med 2011 Jun 17;183(12):1689-97. Epub 2010 Dec 17.

Department of Medicine, University of Rochester Medical School, Rochester, New York 14642, USA.

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http://www.atsjournals.org/doi/abs/10.1164/rccm.201002-0232O
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http://dx.doi.org/10.1164/rccm.201002-0232OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136995PMC
June 2011

PPAR-γ ligands repress TGFβ-induced myofibroblast differentiation by targeting the PI3K/Akt pathway: implications for therapy of fibrosis.

PLoS One 2011 Jan 6;6(1):e15909. Epub 2011 Jan 6.

The Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0015909PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017065PMC
January 2011

Differences in the TGF-{beta}1-induced profibrotic response of anterior and posterior corneal keratocytes in vitro.

Invest Ophthalmol Vis Sci 2010 Apr 11;51(4):1935-42. Epub 2009 Nov 11.

Flaum Eye Institute, University of Rochester Medical Center, Rochester, New York, USA.

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http://dx.doi.org/10.1167/iovs.09-3823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846206PMC
April 2010

Determinants of initiation and progression of idiopathic pulmonary fibrosis.

Respirology 2009 Sep;14(7):917-33

University of Rochester School of Medicine, Rochester, NY 14642, USA.

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http://dx.doi.org/10.1111/j.1440-1843.2009.01624.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3884519PMC
September 2009

RelB is differentially regulated by IkappaB Kinase-alpha in B cells and mouse lung by cigarette smoke.

Am J Respir Cell Mol Biol 2009 Feb 7;40(2):147-58. Epub 2008 Aug 7.

Department of Environmental Medicine, University of Rochester Medical Center, Box 850, 601 Elmwood Ave., Rochester, NY 14642, USA.

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http://dx.doi.org/10.1165/rcmb.2008-0207OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2633139PMC
February 2009

Cigarette smoke-induced expression of heme oxygenase-1 in human lung fibroblasts is regulated by intracellular glutathione.

Am J Physiol Lung Cell Mol Physiol 2008 Oct 8;295(4):L624-36. Epub 2008 Aug 8.

University of Rochester School of Medicine and Dentistry, Dept. of Environmental Medicine, Rochester, NY 14642, USA.

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http://www.physiology.org/doi/10.1152/ajplung.90215.2008
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http://dx.doi.org/10.1152/ajplung.90215.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575948PMC
October 2008

The aryl hydrocarbon receptor attenuates tobacco smoke-induced cyclooxygenase-2 and prostaglandin production in lung fibroblasts through regulation of the NF-kappaB family member RelB.

J Biol Chem 2008 Oct 12;283(43):28944-57. Epub 2008 Aug 12.

Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA.

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http://dx.doi.org/10.1074/jbc.M800685200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570856PMC
October 2008

High-dose but not low-dose mainstream cigarette smoke suppresses allergic airway inflammation by inhibiting T cell function.

Am J Physiol Lung Cell Mol Physiol 2008 Sep 20;295(3):L412-21. Epub 2008 Jun 20.

Department of Medicine, Univ. of Rochester, Rochester, NY 14642, USA.

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http://dx.doi.org/10.1152/ajplung.00392.2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2536795PMC
September 2008

PPARgamma: a novel molecular target in lung disease.

J Investig Med 2008 Feb;56(2):515-7

Division of Pulmonary, Allergy and Critical Care Medicine, Emory University Medical Centers, Atlanta, GA, USA.

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http://dx.doi.org/10.2310/JIM.0b013e318165e89dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4487779PMC
February 2008

The antifibrogenic potential of PPARgamma ligands in pulmonary fibrosis.

Authors:
Patricia J Sime

J Investig Med 2008 Feb;56(2):534-8

Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA.

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http://dx.doi.org/10.2310/JIM.0b013e31816464e9DOI Listing
February 2008

Asbestos-related lung disease.

Am Fam Physician 2007 Mar;75(5):683-8

Southampton General Hospital, Southampton, United Kingdom.

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March 2007

More than structural cells, fibroblasts create and orchestrate the tumor microenvironment.

Immunol Invest 2006 ;35(3-4):297-325

Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, and Lymphoma Biology Program, James P. Wilmot Cancer Center, Rochester, New York 14642, USA.

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http://dx.doi.org/10.1080/08820130600754960DOI Listing
October 2006

Differential induction of apoptosis by cigarette smoke extract in primary human lung fibroblast strains: implications for emphysema.

Am J Physiol Lung Cell Mol Physiol 2006 Jul 27;291(1):L19-29. Epub 2006 Jan 27.

Univ. of Rochester School of Medicine and Dentistry, Dept. of Environmental Medicine, 601 Elmwood Ave, Rochester, NY 14642, USA.

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http://ajplung.physiology.org/content/ajplung/291/1/L19.full
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http://ajplung.physiology.org/cgi/doi/10.1152/ajplung.00306.
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http://dx.doi.org/10.1152/ajplung.00306.2005DOI Listing
July 2006

Oropharyngeal aspiration of a silica suspension produces a superior model of silicosis in the mouse when compared to intratracheal instillation.

Exp Lung Res 2006 May;32(5):181-99

Department of Environmental Medicine and Lung Biology and Disease Program, University of Rochester, Rochester, New York 14642, USA.

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http://dx.doi.org/10.1080/01902140600817465DOI Listing
May 2006

A new direction in the pathogenesis of idiopathic pulmonary fibrosis?

Respir Res 2002 26;3. Epub 2001 Sep 26.

Department of Pathology and Molecular Medicine, Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC64807PMC
January 2006

Isolation and phenotypic characterization of lung fibroblasts.

Methods Mol Med 2005 ;117:115-27

Department of Environmental Medicine, University of Rochester, NY, USA.

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http://dx.doi.org/10.1385/1-59259-940-0:115DOI Listing
September 2005

Sensitivity to bleomycin-induced lung injury is not moderated by an antigen-limited T-cell repertoire.

Exp Lung Res 2005 Sep;31(7):685-700

Department of Microbiology and Immunology, Division of Pulmonary and Critical Care Medicine, University of Rochester, Rochester, New York 14642, USA.

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http://dx.doi.org/10.1080/01902140591007218DOI Listing
September 2005

TGF-beta1 gene transfer to the mouse colon leads to intestinal fibrosis.

Am J Physiol Gastrointest Liver Physiol 2005 Jul 18;289(1):G116-28. Epub 2005 Mar 18.

Division of Gastroenterology, British Columbia's Children's Hospital, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1152/ajpgi.00051.2005DOI Listing
July 2005

Crystalline and amorphous silica differentially regulate the cyclooxygenase-prostaglandin pathway in pulmonary fibroblasts: implications for pulmonary fibrosis.

Am J Physiol Lung Cell Mol Physiol 2005 Jun 21;288(6):L1010-6. Epub 2005 Jan 21.

Department of Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA.

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http://dx.doi.org/10.1152/ajplung.00024.2004DOI Listing
June 2005

PPARgamma agonists inhibit TGF-beta induced pulmonary myofibroblast differentiation and collagen production: implications for therapy of lung fibrosis.

Am J Physiol Lung Cell Mol Physiol 2005 Jun 25;288(6):L1146-53. Epub 2005 Feb 25.

Department of Environmental Medicine, Univ. of Rochester School of Medicine, 601 Elmwood Ave., Rochester, NY 14642, USA.

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http://dx.doi.org/10.1152/ajplung.00383.2004DOI Listing
June 2005

Asbestos-derived reactive oxygen species activate TGF-beta1.

Lab Invest 2004 Aug;84(8):1013-23

Lung Biology Program, Department of Pathology, Tulane University Health Science Center, New Orleans, LA, USA.

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http://dx.doi.org/10.1038/labinvest.3700109DOI Listing
August 2004

A novel ELISpot method for adherent cells.

J Immunol Methods 2004 Aug;291(1-2):63-70

Department of Environmental Medicine, University of Rochester, 601 Elmwood Ave, Rochester, NY 14642, USA.

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http://dx.doi.org/10.1016/j.jim.2004.04.023DOI Listing
August 2004

Expression of CD154 (CD40 ligand) by human lung fibroblasts: differential regulation by IFN-gamma and IL-13, and implications for fibrosis.

J Immunol 2004 Feb;172(3):1862-71

Department of Microbiology and Immunology, Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.

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http://dx.doi.org/10.4049/jimmunol.172.3.1862DOI Listing
February 2004

Differences in the fibrogenic response after transfer of active transforming growth factor-beta1 gene to lungs of "fibrosis-prone" and "fibrosis-resistant" mouse strains.

Am J Respir Cell Mol Biol 2002 Aug;27(2):141-50

Department of Pathology and Molecular Medicine and Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1165/ajrcmb.27.2.4674DOI Listing
August 2002