Patricia Amara

Patricia Amara

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Patricia Amara

Patricia Amara

Publications by authors named "Patricia Amara"

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Crystal Structure of the Transcription Regulator RsrR Reveals a [2Fe-2S] Cluster Coordinated by Cys, Glu, and His Residues.

J Am Chem Soc 2019 Feb 1;141(6):2367-2375. Epub 2019 Feb 1.

Université Grenoble Alpes, CEA, CNRS , IBS , Metalloproteins Unit, F-38044 Grenoble , France.

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http://dx.doi.org/10.1021/jacs.8b10823DOI Listing
February 2019

Radical S-Adenosyl-l-methionine Tryptophan Lyase (NosL): How the Protein Controls the Carboxyl Radical •CO Migration.

J Am Chem Soc 2018 12 16;140(48):16661-16668. Epub 2018 Nov 16.

Univ. Grenoble Alpes, CEA, CNRS, IBS , Metalloproteins Unit , F-38000 Grenoble , France.

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http://pubs.acs.org/doi/10.1021/jacs.8b09142
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http://dx.doi.org/10.1021/jacs.8b09142DOI Listing
December 2018

Crystallographic evidence for unexpected selective tyrosine hydroxylations in an aerated achiral Ru-papain conjugate.

Metallomics 2018 10 3;10(10):1452-1459. Epub 2018 Sep 3.

Univ. Grenoble Alpes, CEA, CNRS, IBS, Metalloproteins, F-38000 Grenoble, France.

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http://dx.doi.org/10.1039/c8mt00160jDOI Listing
October 2018

Crystallographic Trapping of Reaction Intermediates in Quinolinic Acid Synthesis by NadA.

ACS Chem Biol 2018 05 19;13(5):1209-1217. Epub 2018 Apr 19.

Univ. Grenoble Alpes, CEA , CNRS, IBS, Metalloproteins Unit , F-38000 Grenoble , France.

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http://dx.doi.org/10.1021/acschembio.7b01104DOI Listing
May 2018

Human viperin catalyzes the modification of GPP and FPP potentially affecting cholesterol synthesis.

FEBS Lett 2018 01 9;592(2):199-208. Epub 2018 Jan 9.

Univ. Grenoble Alpes, CNRS, CEA, IBS, Grenoble, France.

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http://dx.doi.org/10.1002/1873-3468.12941DOI Listing
January 2018

1,2-Diol Dehydration by the Radical SAM Enzyme AprD4: A Matter of Proton Circulation and Substrate Flexibility.

J Am Chem Soc 2018 01 19;140(4):1365-1371. Epub 2018 Jan 19.

Department of Chemistry, Fudan University , Shanghai 200433, China.

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http://pubs.acs.org/doi/10.1021/jacs.7b10501
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http://dx.doi.org/10.1021/jacs.7b10501DOI Listing
January 2018

Crystal Structures of Quinolinate Synthase in Complex with a Substrate Analogue, the Condensation Intermediate, and Substrate-Derived Product.

J Am Chem Soc 2016 09 30;138(36):11802-9. Epub 2016 Aug 30.

Metalloproteins Unit, Institut de Biologie Structurale, CEA, CNRS, Université Grenoble-Alpes , 71, Avenue des Martyrs, 38044 Grenoble Cedex 9, France.

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http://dx.doi.org/10.1021/jacs.6b05884DOI Listing
September 2016

Carbon-sulfur bond-forming reaction catalysed by the radical SAM enzyme HydE.

Nat Chem 2016 05 4;8(5):491-500. Epub 2016 Apr 4.

Metalloproteins Unit, Institut de Biologie Structurale, CEA, CNRS, UGA, 71 Avenue des Martyrs, 38044 Grenoble Cedex 9, France.

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http://dx.doi.org/10.1038/nchem.2490DOI Listing
May 2016

Fine-tuning of a radical-based reaction by radical S-adenosyl-L-methionine tryptophan lyase.

Science 2016 Mar;351(6279):1320-3

Metalloproteins Unit, Institut de Biologie Structurale, CEA, CNRS, Université Grenoble-Alpes, 71, Avenue des Martyrs, 38044 Grenoble Cedex 9, France.

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http://dx.doi.org/10.1126/science.aad8995DOI Listing
March 2016

Crystal structure of HydG from Carboxydothermus hydrogenoformans: a trifunctional [FeFe]-hydrogenase maturase.

Chembiochem 2015 Feb 10;16(3):397-402. Epub 2014 Dec 10.

Metalloproteins Unit, Institut de Biologie Structurale, UMR5075, CEA, CNRS, Université Grenoble Alpes, 71, Avenue des Martyrs, CS 10090, 38044 Grenoble cedex 9 (France).

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http://dx.doi.org/10.1002/cbic.201402661DOI Listing
February 2015

Crystal structure of tryptophan lyase (NosL): evidence for radical formation at the amino group of tryptophan.

Angew Chem Int Ed Engl 2014 Oct 5;53(44):11840-4. Epub 2014 Sep 5.

Metalloproteins Unit, Institut de Biologie Structurale, UMR5075, CEA, CNRS, Université Grenoble-Alpes, 71, avenue des Martyrs, CS 10090, 38044 Grenoble cedex 9 (France).

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http://dx.doi.org/10.1002/anie.201407320DOI Listing
October 2014

The crystal structure of Fe₄S₄ quinolinate synthase unravels an enzymatic dehydration mechanism that uses tyrosine and a hydrolase-type triad.

J Am Chem Soc 2014 Apr 26;136(14):5253-6. Epub 2014 Mar 26.

Metalloproteins Unit, Institut de Biologie Structurale, Commissariat à l'Energie Atomique-Centre National de la Recherche Scientifique, Université Grenoble-Alpes , 6 rue Jules Horowitz, 38000 Grenoble, France.

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http://dx.doi.org/10.1021/ja501431bDOI Listing
April 2014

Structural foundations for the O2 resistance of Desulfomicrobium baculatum [NiFeSe]-hydrogenase.

Chem Commun (Camb) 2013 Aug;49(63):7061-3

Metalloproteins Unit, Institut de Biologie Structurale J.P. Ebel, CEA, CNRS, Université Grenoble Alpes UMR 5075, 41 rue Jules Horowitz, 38027 Grenoble, France.

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http://dx.doi.org/10.1039/c3cc43619eDOI Listing
August 2013

An artificial oxygenase built from scratch: substrate binding site identified using a docking approach.

Angew Chem Int Ed Engl 2013 Apr 25;52(14):3922-5. Epub 2013 Feb 25.

Laboratoire Chimie et Biologie des Métaux, Université Joseph Fourier-Grenoble 1, CEA, DSV/iRTSV, LCBM, CNRS, UMR5249, 38041 Grenoble, France.

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http://doi.wiley.com/10.1002/anie.201209021
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http://dx.doi.org/10.1002/anie.201209021DOI Listing
April 2013

The structural plasticity of the proximal [4Fe3S] cluster is responsible for the O2 tolerance of membrane-bound [NiFe] hydrogenases.

Angew Chem Int Ed Engl 2013 Feb 7;52(7):2002-6. Epub 2013 Jan 7.

Laboratoire de Chimie Inorganique et Biologique UMR-E 3 CEA-UJF, Institut de Nanosciences et Cryogénie, CEA-Grenoble, 17 avenue des Martyrs, 38054 Grenoble, France.

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http://dx.doi.org/10.1002/anie.201209063DOI Listing
February 2013

Studies of inhibitor binding to the [4Fe-4S] cluster of quinolinate synthase.

Angew Chem Int Ed Engl 2012 Jul 19;51(31):7711-4. Epub 2012 Jun 19.

Laboratoire de Chimie de Biologie des Métaux, UMR 5249, Université Joseph Fourier, Grenoble-1, CNRS-CEA 17, Rue des Martyrs, 38054 Grenoble Cedex 9, France.

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http://dx.doi.org/10.1002/anie.201202261DOI Listing
July 2012

The structure of the periplasmic nickel-binding protein NikA provides insights for artificial metalloenzyme design.

J Biol Inorg Chem 2012 Jun 21;17(5):817-29. Epub 2012 Apr 21.

Institut de Biologie Structurale Jean-Pierre Ebel, Groupe Métalloproteines, UMR 5075, CEA, CNRS, Université Joseph Fourier Grenoble 1, 41 rue Horowitz, 38027, Grenoble Cedex 1, France.

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http://link.springer.com/content/pdf/10.1007/s00775-012-0899
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http://link.springer.com/10.1007/s00775-012-0899-7
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http://dx.doi.org/10.1007/s00775-012-0899-7DOI Listing
June 2012

(IscS-IscU)2 complex structures provide insights into Fe2S2 biogenesis and transfer.

Angew Chem Int Ed Engl 2012 May 18;51(22):5439-42. Epub 2012 Apr 18.

Metalloproteins Unit, Institut de Biologie Structurale J. P. Ebel, Commissariat à l'Énergie Atomique, Centre National de la Recherche Scientifique, Université Joseph Fourier, Grenoble, France.

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http://doi.wiley.com/10.1002/anie.201201708
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http://dx.doi.org/10.1002/anie.201201708DOI Listing
May 2012

X-ray crystallographic and computational studies of the O2-tolerant [NiFe]-hydrogenase 1 from Escherichia coli.

Proc Natl Acad Sci U S A 2012 Apr 19;109(14):5305-10. Epub 2012 Mar 19.

Metalloproteins Unit, Institut de Biologie Structurale J.-P. Ebel, Commissariat à l'Energie Atomique-Centre National de la Recherche Scientifique-l'Université Joseph Fourier, 41 Rue Jules Horowitz, 38027 Grenoble, France.

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http://dx.doi.org/10.1073/pnas.1119806109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325689PMC
April 2012

Carbon monoxide dehydrogenase reaction mechanism: a likely case of abnormal CO2 insertion to a Ni-H(-) bond.

Inorg Chem 2011 Mar 19;50(5):1868-78. Epub 2011 Jan 19.

Laboratoire de Cristallographie et de Cristallogenèse des Protéines, Institut de Biologie Structurale J.P. Ebel CEA, CNRS, Université Joseph Fourier 41, rue Jules Horowitz, 38027 Grenoble, France.

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http://dx.doi.org/10.1021/ic102304mDOI Listing
March 2011

Unexpected electron transfer mechanism upon AdoMet cleavage in radical SAM proteins.

Proc Natl Acad Sci U S A 2009 Sep 17;106(35):14867-71. Epub 2009 Aug 17.

Laboratoire de Cristallographie et Cristallogenèse des Protéines, Institut de Biologie Structurale J.P. Ebel, Commissariat à l'Energie Atomique, Centre National de la Recherche Scientifique, Université Joseph Fourier, 41 rue Jules Horowitz, 38027 Grenoble, France.

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http://dx.doi.org/10.1073/pnas.0904385106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736464PMC
September 2009

Structure-function relationships of anaerobic gas-processing metalloenzymes.

Nature 2009 Aug;460(7257):814-22

Laboratoire de Cristallographie et Cristallogenèse des Protéines, Institut de Biologie Structurale J.P. Ebel, CEA, CNRS, Université Joseph Fourier, 41 rue J. Horowitz, 38027 Grenoble Cedex 1, France.

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http://dx.doi.org/10.1038/nature08299DOI Listing
August 2009

X-ray structure of the [FeFe]-hydrogenase maturase HydE from Thermotoga maritima.

J Biol Chem 2008 Jul 8;283(27):18861-72. Epub 2008 Apr 8.

Laboratoire de Cristallographie et Cristallogenèse des Protéines, Institut de Biologie Structurale J.P. Ebel, Commissariat à l'Energie Atomique, CNRS, Université J. Fourier, 41 Rue J. Horowitz, 38027 Grenoble Cedex 1, France.

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http://dx.doi.org/10.1074/jbc.M801161200DOI Listing
July 2008

The enamine intermediate may not be universal to thiamine catalysis.

Angew Chem Int Ed Engl 2008 ;47(4):628

Laboratoire de Dynamique Moléculaire, Institut de Biologie Structurale Jean-Pierre Ebel, CEA; CNRS; UJF, 41 rue Jules Horowitz, 38027 Grenoble, France, Fax: (+33)4-3878-4217.

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http://dx.doi.org/10.1002/anie.200890003DOI Listing
March 2008

The enamine intermediate may not be universal to thiamine catalysis.

Angew Chem Int Ed Engl 2007 ;46(47):9019-22

Laboratoire de Dynamique Moléculaire, Institut de Biologie Structurale Jean-Pierre Ebel, CEA, 41 rue Jules Horowitz, 38027 Grenoble, France.

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http://dx.doi.org/10.1002/anie.200702993DOI Listing
January 2008

Raman-assisted crystallography reveals end-on peroxide intermediates in a nonheme iron enzyme.

Science 2007 Apr;316(5823):449-53

Institut de Biologie Structurale (IBS) Jean-Pierre Ebel, Commissariat à l'Energie Atomique (CEA), Centre National de la Recherche Scientifique (CNRS), Université Joseph Fourier, 41 rue Jules Horowitz, F-38027 Grenoble, France.

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http://dx.doi.org/10.1126/science.1138885DOI Listing
April 2007

Specific radiation damage to acidic residues and its relation to their chemical and structural environment.

J Synchrotron Radiat 2007 Jan 15;14(Pt 1):84-91. Epub 2006 Dec 15.

Laboratoire de Biophysique Moléculaire, Institut de Biologie Structurale J.-P. Ebel, CEA CNRS UJF, 41 Rue Jules Horowitz, 38027 Grenoble CEDEX 1, France.

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http://dx.doi.org/10.1107/S0909049506038623DOI Listing
January 2007

Functional flexibility of Bacillus stearothermophilus formamidopyrimidine DNA-glycosylase.

DNA Repair (Amst) 2006 Aug 18;5(8):947-58. Epub 2006 Jul 18.

Laboratoire de Dynamique Moléculaire, 41 rue Jules Horowitz, 38027 Grenoble Cedex 1, France.

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http://dx.doi.org/10.1016/j.dnarep.2006.05.042DOI Listing
August 2006

A quantum chemical study of the reaction mechanism of acetyl-coenzyme a synthase.

J Am Chem Soc 2005 Mar;127(8):2776-84

Laboratoire de Dynamique Moléculaire and Laboratoire de Cristallographie et Cristallogenèse des Protéines, Institut de Biologie Structurale - Jean-Pierre Ebel, CEA/CNRS/UJF, 41, rue Jules Horowitz, F-38027 Grenoble Cedex 01, France.

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http://dx.doi.org/10.1021/ja0439221DOI Listing
March 2005

Insights into the DNA repair process by the formamidopyrimidine-DNA glycosylase investigated by molecular dynamics.

Protein Sci 2004 Aug;13(8):2009-21

Laboratoire de Dynamique Moléculaire, Institut de Biologie Structurale Jean-Pierre Ebel Commissariat à l'énergie Atomique/Centre National de la Recherche Scientifique/Université Joseph Fourier, 38027 Grenoble 1, France.

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http://dx.doi.org/10.1110/ps.04772404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2279820PMC
August 2004

Parametrization of a force field for metals complexed to biomacromolecules: applications to Fe(II), Cu(II) and Pb(II).

J Comput Aided Mol Des 2002 Aug-Sep;16(8-9):635-51

Département d'Informatique et de Recherche Opérationnelle, Université de Montréal, C.P. 6128, Succ. Centre-Ville, Montréal, Québec, Canada H3C 3J7.

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http://dx.doi.org/10.1023/a:1021962616650DOI Listing
August 2003