Patricia A Zunszain

Patricia A Zunszain

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Patricia A Zunszain

Publications by authors named "Patricia A Zunszain"

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The role of circulatory systemic environment in predicting interferon-alpha-induced depression: The neurogenic process as a potential mechanism.

Brain Behav Immun 2019 Oct 14;81:220-227. Epub 2019 Jun 14.

Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.bbi.2019.06.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934231PMC
October 2019

Intergenerational transmission of depression: clinical observations and molecular mechanisms.

Mol Psychiatry 2019 08 3;24(8):1157-1177. Epub 2018 Oct 3.

Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.

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http://www.nature.com/articles/s41380-018-0265-4
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http://dx.doi.org/10.1038/s41380-018-0265-4DOI Listing
August 2019

Glucocorticoid Resistance: Is It a Requisite for Increased Cytokine Production in Depression? A Systematic Review and Meta-Analysis.

Front Psychiatry 2019 28;10:423. Epub 2019 Jun 28.

Stress, Psychiatry and Immunology Laboratory, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.

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http://dx.doi.org/10.3389/fpsyt.2019.00423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609575PMC
June 2019

Multiple measures of HPA axis function in ultra high risk and first-episode schizophrenia patients.

Psychoneuroendocrinology 2018 06 27;92:72-80. Epub 2018 Mar 27.

Lundbeck Foundation Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Centre Glostrup, University of Copenhagen, Denmark; Center for Neuropsychiatric Schizophrenia Research, Mental Health Centre Glostrup, University of Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.psyneuen.2018.03.015DOI Listing
June 2018

Repeated lipopolysaccharide exposure modifies immune and sickness behaviour response in an animal model of chronic inflammation.

J Psychopharmacol 2018 02 17;32(2):236-247. Epub 2018 Jan 17.

3 MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

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http://dx.doi.org/10.1177/0269881117746902DOI Listing
February 2018

The relationship between salivary C-reactive protein and cognitive function in children aged 11-14years: Does psychopathology have a moderating effect?

Brain Behav Immun 2017 Nov 8;66:221-229. Epub 2017 Jul 8.

Department of Forensic and Neurodevelopmental Sciences, King's College London, London, UK; School of Psychology, Australian Catholic University, Brisbane, Australia; Research Unit for Schizophrenia Epidemiology, School of Psychiatry, University of New South Wales, Sydney, Australia; Neuroscience Research Australia, Sydney, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.bbi.2017.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773474PMC
November 2017

Rescue of IL-1β-induced reduction of human neurogenesis by omega-3 fatty acids and antidepressants.

Brain Behav Immun 2017 Oct 18;65:230-238. Epub 2017 May 18.

Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.bbi.2017.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540223PMC
October 2017

Crosstalk between endocannabinoid and immune systems: a potential dysregulation in depression?

Psychopharmacology (Berl) 2016 May 20;233(9):1591-604. Epub 2015 Oct 20.

Stress, Psychiatry and Immunology Laboratory, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.

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http://dx.doi.org/10.1007/s00213-015-4105-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4828487PMC
May 2016

Improving the treatment for depressive symptoms and major depression with anti-inflammatory drugs.

Evid Based Ment Health 2015 Nov 7;18(4):116. Epub 2015 Sep 7.

Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK;

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http://dx.doi.org/10.1136/eb-2015-102063DOI Listing
November 2015

Cortisol and Inflammatory Biomarkers Predict Poor Treatment Response in First Episode Psychosis.

Schizophr Bull 2015 Sep 31;41(5):1162-70. Epub 2015 Mar 31.

National Institute for Health Research Mental Health Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London, London, UK; Department of Psychosis Studies, King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK;

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http://dx.doi.org/10.1093/schbul/sbv028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535637PMC
September 2015

Neuroimmune and neuroendocrine abnormalities in depression: two sides of the same coin.

Ann N Y Acad Sci 2015 Sep 5;1351:68-79. Epub 2015 May 5.

Stress, Psychiatry, and Immunology Laboratory (SPI-Lab), Department of Psychological Medicine, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom.

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http://dx.doi.org/10.1111/nyas.12781DOI Listing
September 2015

Insufficient glucocorticoid signaling and elevated inflammation in coronary heart disease patients with comorbid depression.

Brain Behav Immun 2015 Aug 12;48:8-18. Epub 2015 Feb 12.

Department of Psychological Medicine, Institute of Psychiatry, King's College London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.bbi.2015.02.002DOI Listing
August 2015

Molecular mechanisms in the regulation of adult neurogenesis during stress.

Nat Rev Neurosci 2015 Apr;16(4):189-200

Institute of Psychiatry, Psychology and Neuroscience, Kings College London, 125 Coldharbour Lane, London, SE5 9NU, UK.

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http://dx.doi.org/10.1038/nrn3855DOI Listing
April 2015

The role of inflammatory cytokines as key modulators of neurogenesis.

Trends Neurosci 2015 Mar 8;38(3):145-57. Epub 2015 Jan 8.

Section of Stress, Psychiatry and Immunology & Perinatal Psychiatry, King's College London, Institute of Psychiatry, Psychology and Neuroscience, Department of Psychological Medicine, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.tins.2014.12.006DOI Listing
March 2015

Immune mechanisms linked to depression via oxidative stress and neuroprogression.

Immunology 2015 03 10;144(3):365-373. Epub 2015 Jan 10.

Stress, Psychiatry and Immunology Laboratory, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.

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http://dx.doi.org/10.1111/imm.12443DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557673PMC
March 2015

Modulation of adult hippocampal neurogenesis by early-life environmental challenges triggering immune activation.

Neural Plast 2014 7;2014:194396. Epub 2014 May 7.

Centre for the Cellular Basis of Behaviour, Institute of Psychiatry, King's College London, The James Black Centre, 125 Coldharbour Lane, London SE5 9NU, UK.

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http://www.hindawi.com/journals/np/2014/194396/
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http://dx.doi.org/10.1155/2014/194396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033517PMC
October 2014

Cortisol awakening response and diurnal cortisol among children at elevated risk for schizophrenia: relationship to psychosocial stress and cognition.

Psychoneuroendocrinology 2014 Aug 29;46:1-13. Epub 2014 Mar 29.

Department of Forensic and Neurodevelopmental Sciences (Box P023), Institute of Psychiatry, De Crespigny Park, London SE5 8AF, United Kingdom; Research Unit for Schizophrenia Epidemiology, School of Psychiatry, University of New South Wales, Sydney, Australia; Schizophrenia Research Institute, Sydney, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.psyneuen.2014.03.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065330PMC
August 2014

Towards a personalized treatment in depression: endocannabinoids, inflammation and stress response.

Pharmacogenomics 2014 Apr;15(5):687-98

Section of Stress, Psychiatry & Immunology, Department of Psychological Medicine, Institute of Psychiatry, King's College London, 125 Coldharbour Lane, London SE5 9NU, UK.

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http://dx.doi.org/10.2217/pgs.14.40DOI Listing
April 2014

Design and synthesis of irreversible inhibitors of foot-and-mouth disease virus 3C protease.

Bioorg Med Chem Lett 2014 Jan 17;24(2):490-4. Epub 2013 Dec 17.

Department of Chemistry, Imperial College London, South Kensington Campus, London SW7 2AZ, United Kingdom; Egerton Court, Liverpool John Moores University, Liverpool L1 2UA, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2013.12.045DOI Listing
January 2014

Inflammation and depression.

Curr Top Behav Neurosci 2013 ;14:135-51

Department of Psychological Medicine, Institute of Psychiatry, King's College London, UK.

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http://dx.doi.org/10.1007/7854_2012_211DOI Listing
August 2013

Role for the kinase SGK1 in stress, depression, and glucocorticoid effects on hippocampal neurogenesis.

Proc Natl Acad Sci U S A 2013 May 6;110(21):8708-13. Epub 2013 May 6.

Stress, Psychiatry and Immunology Laboratory, Department of Psychological Medicine, Institute of Psychiatry, King's College London, London SE5 9NU, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1300886110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666742PMC
May 2013

Glucocorticoid-related molecular signaling pathways regulating hippocampal neurogenesis.

Neuropsychopharmacology 2013 Apr 6;38(5):872-83. Epub 2012 Dec 6.

Section of Perinatal Psychiatry and Stress, Psychiatry and Immunology (SPI-Lab), Institute of Psychiatry, Department of Psychological Medicine, King's College London, London, UK.

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http://dx.doi.org/10.1038/npp.2012.253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672002PMC
April 2013

Chemokines in bipolar disorder: trait or state?

Eur Arch Psychiatry Clin Neurosci 2013 Mar 15;263(2):159-65. Epub 2012 May 15.

Programa de Pós-Graduação em Neurociências, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

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http://dx.doi.org/10.1007/s00406-012-0327-6DOI Listing
March 2013

Depression pathogenesis and treatment: what can we learn from blood mRNA expression?

BMC Med 2013 Feb 5;11:28. Epub 2013 Feb 5.

Section of Perinatal Psychiatry & Stress, Department of Psychological Medicine, Institute of Psychiatry, King's College London, 125 Coldharbour Lane, London, SE5 9NU, UK.

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http://dx.doi.org/10.1186/1741-7015-11-28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606439PMC
February 2013

Interleukin-1β: a new regulator of the kynurenine pathway affecting human hippocampal neurogenesis.

Neuropsychopharmacology 2012 Mar 9;37(4):939-49. Epub 2011 Nov 9.

Section of Perinatal Psychiatry and Stress, Psychiatry and Immunology (SPI-lab), Department of Psychological Medicine, Institute of Psychiatry, King's College London, London, UK.

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http://dx.doi.org/10.1038/npp.2011.277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280640PMC
March 2012

The glucocorticoid receptor: pivot of depression and of antidepressant treatment?

Psychoneuroendocrinology 2011 Apr;36(3):415-25

King's College London, Institute of Psychiatry, Centre for the Cellular Basis of Behaviour (CCBB), Department of Psychological Medicine, Section of Perinatal Psychiatry & Stress, Psychiatry and Immunology (SPI-lab), 125 Coldharbour Lane, London SE5 9NU, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S03064530100008
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http://dx.doi.org/10.1016/j.psyneuen.2010.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3513407PMC
April 2011

Glucocorticoids, cytokines and brain abnormalities in depression.

Prog Neuropsychopharmacol Biol Psychiatry 2011 Apr 18;35(3):722-9. Epub 2010 Apr 18.

Stress, Psychiatry and Immunology Laboratory (SPI-Lab), Department of Psychological Medicine, Institute of Psychiatry, King's College London, 125 Coldharbour Lane, SE59NU London, United Kingdom.

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https://linkinghub.elsevier.com/retrieve/pii/S02785846100014
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http://dx.doi.org/10.1016/j.pnpbp.2010.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3513408PMC
April 2011

Structural basis of binding of fluorescent, site-specific dansylated amino acids to human serum albumin.

J Struct Biol 2011 Apr 19;174(1):84-91. Epub 2010 Oct 19.

Biophysics Section, Blackett Laboratory, Imperial College, Exhibition Road, London SW7 2AZ, United Kingdom.

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http://dx.doi.org/10.1016/j.jsb.2010.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3073228PMC
April 2011

Insights into cleavage specificity from the crystal structure of foot-and-mouth disease virus 3C protease complexed with a peptide substrate.

J Mol Biol 2010 Jan 31;395(2):375-89. Epub 2009 Oct 31.

Biophysics Section, Blackett Laboratory, Imperial College, Exhibition Road, London SW7 2AZ, UK.

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http://dx.doi.org/10.1016/j.jmb.2009.10.048DOI Listing
January 2010

Crystallographic analysis of human serum albumin complexed with 4Z,15E-bilirubin-IXalpha.

J Mol Biol 2008 Aug 12;381(2):394-406. Epub 2008 Jun 12.

Biophysics Section, Blackett Laboratory, Imperial College, South Kensington Campus, Exhibition Road, London SW7 2AZ, UK.

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http://dx.doi.org/10.1016/j.jmb.2008.06.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2568863PMC
August 2008

Genetic engineering of the heme pocket in human serum albumin: modulation of O2 binding of iron protoporphyrin IX by variation of distal amino acids.

J Am Chem Soc 2007 Sep 18;129(36):11286-95. Epub 2007 Aug 18.

Research Institute for Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan.

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http://dx.doi.org/10.1021/ja074179qDOI Listing
September 2007

Foot-and-mouth disease virus 3C protease: recent structural and functional insights into an antiviral target.

Int J Biochem Cell Biol 2007 14;39(1):1-6. Epub 2006 Aug 14.

Biophysics Section, Division of Cell and Molecular Biology, Blackett Laboratory, Imperial College, Exhibition Road, London SW7 2AZ, UK.

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http://dx.doi.org/10.1016/j.biocel.2006.07.006DOI Listing
February 2007

Photosensitized reduction of water to hydrogen using human serum albumin complexed with zinc-protoporphyrin IX.

J Am Chem Soc 2006 Dec;128(50):16297-301

Advanced Research Institute for Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan.

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http://dx.doi.org/10.1021/ja0656806DOI Listing
December 2006

Location of high and low affinity fatty acid binding sites on human serum albumin revealed by NMR drug-competition analysis.

J Mol Biol 2006 Aug 30;361(2):336-51. Epub 2006 Jun 30.

Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, 715 Albany Street Boston, MA 02118, USA.

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http://dx.doi.org/10.1016/j.jmb.2006.06.028DOI Listing
August 2006

O2 and CO binding properties of artificial hemoproteins formed by complexing iron protoporphyrin IX with human serum albumin mutants.

J Am Chem Soc 2005 Nov;127(45):15933-42

Advanced Research Institute for Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan.

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http://dx.doi.org/10.1021/ja054819uDOI Listing
November 2005

Structural basis of the drug-binding specificity of human serum albumin.

J Mol Biol 2005 Oct;353(1):38-52

Biophysics Section, Division of Cell and Molecular Biology, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.

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http://dx.doi.org/10.1016/j.jmb.2005.07.075DOI Listing
October 2005

Search for the pharmacophore in prazosin for Transport-P.

Bioorg Med Chem 2005 Jun;13(11):3681-9

Department of Chemistry, Christopher Ingold Laboratories, University College London, 20 Gordon Street, London WC1H 0AJ, UK.

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http://dx.doi.org/10.1016/j.bmc.2005.03.030DOI Listing
June 2005

Dioxygenation of human serum albumin having a prosthetic heme group in a tailor-made heme pocket.

J Am Chem Soc 2004 Nov;126(44):14304-5

Advanced Research Institute for Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan.

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http://dx.doi.org/10.1021/ja046022tDOI Listing
November 2004

Crystal structural analysis of human serum albumin complexed with hemin and fatty acid.

BMC Struct Biol 2003 Jul 7;3. Epub 2003 Jul 7.

Department of Biological Sciences, Imperial College London, Room 746 Huxley Building, South Kensington Campus, London SW7 2AZ, United Kingdom.

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http://dx.doi.org/10.1186/1472-6807-3-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC166163PMC
July 2003

Structural basis of albumin-thyroxine interactions and familial dysalbuminemic hyperthyroxinemia.

Proc Natl Acad Sci U S A 2003 May 12;100(11):6440-5. Epub 2003 May 12.

Biophysics Section, Department of Biological Sciences, Imperial College London, South Kensington Campus, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1137188100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC164465PMC
May 2003