Dr Patrice FORT, PhD - Centre de Recherche en Neuroscience de Lyon, CNRS UMR5292, INSERM U1028 - Research Director - CNRS

Dr Patrice FORT

PhD

Centre de Recherche en Neuroscience de Lyon, CNRS UMR5292, INSERM U1028

Research Director - CNRS

Lyon | France

Main Specialties: Biology, Neurology, Sleep Medicine

Additional Specialties: Neuroscience

ORCID logohttps://orcid.org/0000-0003-1211-8631

Dr Patrice FORT, PhD - Centre de Recherche en Neuroscience de Lyon, CNRS UMR5292, INSERM U1028 - Research Director - CNRS

Dr Patrice FORT

PhD

Introduction

Directeur de Recherche (second class, Prof. eqvt) at the Center for Research in Neurosciences of Lyon (CRNL) CNRS UMR5292 - INSERM U1028, University Lyon 1, Lyon (France)

University degrees
1991: PhD in Neurosciences, with honors (University Lyon 1, supervisor Pr Michel Jouvet)
1987: D.EA. (Master degree) in Neuroscience, with honors (University Lyon 1, supervisor Dr Kazuya Sakai)

Post-Doctoral training and professional activities
2010-present: Directeur de Recherche Second class (Prof. eqvt) at CRNL, UMR5292 - CNRS, Lyon (France)
2002-10: Chargé de Recherche first class (Asst. Prof. eqvt), UMR5167 - CNRS , Lyon (France)
1994-00: Chargé de Recherche Second class (Asst. Prof. eqvt), U52 – INSERM, Lyon (France)
1992-94: Post-doctoral fellow, Department of Physiology (Pr. Michel Mühlethaler), Geneva (Switzerland)
1987-91: PhD student, U52 – INSERM (Pr Michel Jouvet), Lyon (France)

Number of articles in peer-reviewed journals: 92
Number of book chapters: 20 Index H = 40,7 (2019)

Primary Affiliation: Centre de Recherche en Neuroscience de Lyon, CNRS UMR5292, INSERM U1028 - Lyon , France

Specialties:

Additional Specialties:

Research Interests:


View Dr Patrice FORT’s Resume / CV

Education

Nov 1990
Université Claude Bernard LYON I
PhD

Experience

May 2010
CNRS
Research Director
INSB - CNRS
May 1994
CNRS
Researcher
INSB- CNRS
Apr 1994
CNRS Délégation Rhône-Auvergne
Research Director
INSB

Publications

160Publications

753Reads

33Profile Views

1158PubMed Central Citations

Targeted recombination in active populations as a new mouse genetic model to study sleep-active neuronal populations: Demonstration that Lhx6+ neurons in the ventral zona incerta are activated during paradoxical sleep hypersomnia.

J Sleep Res 2020 Jan 14:e12976. Epub 2020 Jan 14.

Centre de Recherche en Neurosciences de Lyon (CRNL), Université Claude Bernard Lyon 1, CNRS UMR5292, INSERM U1028, Bron, France.

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http://dx.doi.org/10.1111/jsr.12976DOI Listing
January 2020
3.347 Impact Factor

Neuroanatomical and Neurochemical Bases of Vigilance States.

Handb Exp Pharmacol 2019 ;253:35-58

Team "Physiopathologie des réseaux neuronaux responsables du cycle veille-sommeil", INSERM, U1028, CNRS, UMR5292, Lyon Neuroscience Research Center, Lyon, France.

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http://dx.doi.org/10.1007/164_2017_84DOI Listing
September 2019
11 Reads
1 Citation

A Particular Medullary-Spinal Inhibitory Pathway is Recruited for the Expression of Muscle Atonia During REM Sleep.

J Exp Neurosci 2018 2;12:1179069518808744. Epub 2018 Nov 2.

SLEEP Team, CNRS UMR 5292, INSERM U1028, Centre de Recherche en Neurosciences de Lyon (CRNL), Université Claude Bernard Lyon 1, Lyon, France.

Muscle atonia is a major pathognomonic sign of paradoxical sleep (PS; coined REM Sleep), during which dreams mainly occur. In the 1980s, an idiopathic syndrome called REM sleep behavior disorder (RBD) was described in patients endowed with loss of PS paralysis concomitant to abnormal movements, suggesting a dysfunction of PS networks. Another major clinical RBD feature is its prevalent phenoconversion into synucleinopathies as Parkinson's disease in a delay of 10-15?years after diagnosis. Thus, we undertook experiments in rats to disentangle brainstem networks involved in PS, including atonia. We first identified a contingent of pontine glutamate neurons recruited during PS with inputs to the ventromedial medulla (vmM) where they contact ?-aminobutyric acid (GABA)/glycine inhibitory neurons also activated during PS. Here, we further show that these vmM inhibitory neurons send efferents to somatic spinal motoneurons until lumbar levels. As reported for the pontine generator, the genetic inactivation of the vmM inhibitory neurons abolishes atonia during PS without effects on waking locomotion and is sufficient to recapitulate major RBD symptoms. These original data suggest that RBD may reflect a severe dysfunction and/or degeneration linked to a developing synucleinopathic attack targeting specifically neurons that generate PS-specific atonia.

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http://dx.doi.org/10.1177/1179069518808744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236475PMC
November 2018
10 Reads

Melanin-concentrating hormone-expressing neurons adjust slow-wave sleep dynamics to catalyze paradoxical (REM) sleep.

Sleep 2018 06;41(6)

Centre de Recherche en Neurosciences de Lyon (CRNL), SLEEP Team, CNRS, INSERM, Lyon, France.

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http://dx.doi.org/10.1093/sleep/zsy068DOI Listing
June 2018
5 Reads
1 Citation
4.591 Impact Factor

Nucleus Accumbens, a new sleep-regulating area through the integration of motivational stimuli.

Acta Pharmacol Sin 2018 02 28;39(2):165-166. Epub 2018 Dec 28.

SLEEP Team, Neuroscience Research Center of Lyon - CRNL, CNRS UMR 5292 - INSERM U1028, F-69000 Lyon, France.

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http://dx.doi.org/10.1038/aps.2017.168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800466PMC
February 2018
7 Reads
2.500 Impact Factor

[The neuronal keepers of our dreams identified: are they a target of Parkinson disease?]

Med Sci (Paris) 2017 Oct 10;33(10):828-831. Epub 2017 Oct 10.

SLEEP Team, Centre de recherche en neurosciences de Lyon (CRNL), CNRS UMR 5292, Inserm U1028, 7, rue Guillaume Paradin, F-69008 Lyon, France - SLEEP Team, université Claude Bernard Lyon 1, 7, rue Guillaume Paradin, 69372, Lyon, France - Friedrich Miescher institute for biomedical research, maulbeerstrasse 66 (R-1066.4.28), 4058, Bâle, Suisse.

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http://dx.doi.org/10.1051/medsci/20173310006DOI Listing
October 2017
2 Reads
0.520 Impact Factor

Selective activation of a few limbic structures during paradoxical (REM) sleep by the claustrum and the supramammillary nucleus: evidence and function.

Curr Opin Neurobiol 2017 06 24;44:59-64. Epub 2017 Mar 24.

INSERM, U1028, CNRS, UMR5292, Lyon Neuroscience Research Center, Team "Physiopathologie des réseaux neuronaux responsables du cycle veille-sommeil", Lyon, France; University Lyon 1, Lyon, France.

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http://dx.doi.org/10.1016/j.conb.2017.03.002DOI Listing
June 2017
10 Reads
2 Citations
6.630 Impact Factor

Differential origin of the activation of dorsal and ventral dentate gyrus granule cells during paradoxical (REM) sleep in the rat.

Brain Struct Funct 2017 04 18;222(3):1495-1507. Epub 2016 Aug 18.

UMR 5292 CNRS/U1028 INSERM, Faculté de Médecine RTH Laennec, Centre de Recherche en Neurosciences de Lyon (CRNL), SLEEP Team, Université Claude Bernard Lyon I, 7 Rue Guillaume Paradin, 69372, Lyon Cedex 08, France.

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http://dx.doi.org/10.1007/s00429-016-1289-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640786PMC
April 2017
8 Reads
3 Citations
5.620 Impact Factor

Not a single but multiple populations of GABAergic neurons control sleep.

Sleep Med Rev 2017 04 12;32:85-94. Epub 2016 Mar 12.

UMR 5292 CNRS/U1028 INSERM, "SLEEP" Team, Université Claude Bernard Lyon I, 7 Rue Guillaume Paradin, 69372 Lyon Cedex 08, France.

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http://dx.doi.org/10.1016/j.smrv.2016.03.002DOI Listing
April 2017
35 Reads
15 Citations
8.513 Impact Factor

Genetic inactivation of glutamate neurons in the rat sublaterodorsal tegmental nucleus recapitulates REM sleep behaviour disorder.

Brain 2017 02 21;140(2):414-428. Epub 2016 Dec 21.

Neuroscience Research Center of Lyon (CRNL), CNRS UMR 5292, INSERM U1028, SLEEP Team, Lyon, France

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http://dx.doi.org/10.1093/brain/aww310DOI Listing
February 2017
20 Reads
6 Citations
9.200 Impact Factor

Sleep architecture and homeostasis in mice with partial ablation of melanin-concentrating hormone neurons.

Behav Brain Res 2016 Feb 31;298(Pt B):100-10. Epub 2015 Oct 31.

Neuroscience Research Center of Lyon (CRNL), CNRS UMR 5292, INSERM U1028, SLEEP Team, Lyon, France; Université Claude Bernard, Lyon 1, Lyon, France. Electronic address:

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http://dx.doi.org/10.1016/j.bbr.2015.10.051DOI Listing
February 2016
22 Reads
3 Citations
3.030 Impact Factor

Genetic deletion of melanin-concentrating hormone neurons impairs hippocampal short-term synaptic plasticity and hippocampal-dependent forms of short-term memory.

Hippocampus 2015 Nov 2;25(11):1361-73. Epub 2015 Apr 2.

Centre National De La Recherche Scientifique (CNRS), Unité Mixte De Recherche 5292, Institut National De La Santé Et De La Recherche Médicale (INSERM), Unité 1028, Lyon, France.

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http://dx.doi.org/10.1002/hipo.22442DOI Listing
November 2015
8 Reads
2 Citations
4.162 Impact Factor

Glucose Induces Slow-Wave Sleep by Exciting the Sleep-Promoting Neurons in the Ventrolateral Preoptic Nucleus: A New Link between Sleep and Metabolism.

J Neurosci 2015 Jul;35(27):9900-11

Brain Plasticity Unit, Sleep Neuronal Networks Team, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8249, 75005 Paris, France, Ecole Supérieure de Physique et de Chimie Industrielles ParisTech, 75005 Paris, France,

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http://dx.doi.org/10.1523/JNEUROSCI.0609-15.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6605416PMC
July 2015
148 Reads
6 Citations
6.344 Impact Factor

The supramammillary nucleus and the claustrum activate the cortex during REM sleep.

Sci Adv 2015 Apr 3;1(3):e1400177. Epub 2015 Apr 3.

UMR 5292 CNRS/U1028 INSERM, Centre de Recherche en Neurosciences de Lyon (CRNL), Team "Physiopathologie des réseaux neuronaux responsables du cycle veille-sommeil," Université Claude Bernard Lyon 1, Faculté de Médecine RTH Laennec, 7 Rue Guillaume Paradin, 69372 Lyon Cedex 08, France.

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http://dx.doi.org/10.1126/sciadv.1400177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640625PMC
April 2015
21 Reads
9 Citations

Role of MCH neurons in paradoxical (REM) sleep control.

Sleep 2013 Dec 1;36(12):1775-6. Epub 2013 Dec 1.

INSERM, U1028; CNRS, UMR5292; Lyon Neuroscience Research Center, Team "Physiopathologie des réseaux neuronaux responsables du cycle veillesommeil," Lyon, France, University Lyon 1, Lyon, France.

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http://dx.doi.org/10.5665/sleep.3192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825423PMC
December 2013
17 Reads
8 Citations
4.591 Impact Factor

Paradoxical (REM) sleep genesis by the brainstem is under hypothalamic control.

Curr Opin Neurobiol 2013 Oct 13;23(5):786-92. Epub 2013 Mar 13.

INSERM, U1028, CNRS, UMR5292, Lyon Neuroscience Research Center, Team "Physiopathologie des réseaux neuronaux responsables du cycle veille-sommeil", Lyon, France; University Lyon 1, Lyon, France. Electronic address:

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http://dx.doi.org/10.1016/j.conb.2013.02.006DOI Listing
October 2013
29 Reads
22 Citations
6.630 Impact Factor

New aspects in the pathophysiology of rapid eye movement sleep behavior disorder: the potential role of glutamate, gamma-aminobutyric acid, and glycine.

Sleep Med 2013 Aug 19;14(8):714-8. Epub 2013 Jun 19.

INSERM, U1028, France; CNRS, UMR5292, France.

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http://dx.doi.org/10.1016/j.sleep.2013.02.004DOI Listing
August 2013
19 Reads
10 Citations
3.154 Impact Factor

The lateral hypothalamic area controls paradoxical (REM) sleep by means of descending projections to brainstem GABAergic neurons.

J Neurosci 2012 Nov;32(47):16763-74

INSERM, U1028; CNRS, UMR5292; Centre de Recherche en Neuroscience de Lyon, Team Physiopathologie des réseaux neuronaux du cycle veille-sommeil, F-69372 Lyon, France.

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http://dx.doi.org/10.1523/JNEUROSCI.1885-12.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6621764PMC
November 2012
9 Reads
27 Citations
6.344 Impact Factor

Brainstem mechanisms of paradoxical (REM) sleep generation.

Authors:

Pflugers Archiv : European journal of physiology

http://europepmc.org/abstract/med/22083642

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January 2012
3 Reads

Brainstem mechanisms of paradoxical (REM) sleep generation.

Pflugers Arch 2012 Jan 15;463(1):43-52. Epub 2011 Nov 15.

INSERM, U1028, CNRS, UMR 5292, Lyon Neuroscience Research Center, Team Physiopathologie des réseaux neuronaux responsables du cycle veille-sommeil, Lyon, France.

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http://dx.doi.org/10.1007/s00424-011-1054-yDOI Listing
January 2012
6 Reads
26 Citations
4.101 Impact Factor

The neuronal network responsible for paradoxical sleep and its dysfunctions causing narcolepsy and rapid eye movement (REM) behavior disorder.

Sleep Med Rev 2011 Jun 5;15(3):153-63. Epub 2010 Nov 5.

UMR5167 CNRS, Institut Fédératif des Neurosciences de Lyon (IFR 19), Univ Lyon 1, Université de Lyon, Lyon, France.

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http://dx.doi.org/10.1016/j.smrv.2010.08.002DOI Listing
June 2011
18 Reads
42 Citations
8.513 Impact Factor

Evidence that neurons of the sublaterodorsal tegmental nucleus triggering paradoxical (REM) sleep are glutamatergic.

Sleep 2011 Apr 1;34(4):419-23. Epub 2011 Apr 1.

Physiopathology of the Neuronal Network Responsible for the Sleep-Waking Cycle Team, CNRS UMR5292, INSERM U1028, Lyon Neuroscience, Research Center, Lyon, F-69372, France.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064553PMC
http://dx.doi.org/10.1093/sleep/34.4.419DOI Listing
April 2011
8 Reads
25 Citations
4.591 Impact Factor

Neurochemistry of sleep an overview of animal experimental work.

Handb Clin Neurol 2011 ;98:173-90

Institute Fédératif des Neurosciences de Lyon, Université Claude Bernard Lyon I, Lyon, France.

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http://dx.doi.org/10.1016/B978-0-444-52006-7.00011-3DOI Listing
March 2011
5 Reads
3 Citations

Dopaminergic neurons expressing Fos during waking and paradoxical sleep in the rat.

J Chem Neuroanat 2010 Jul 6;39(4):262-71. Epub 2010 Mar 6.

Université de Lyon, Lyon, université Lyon 1, CNRS, UMR5167, Physiologie et physiopathologie du cycle veille-sommeil, F-69008, France.

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http://dx.doi.org/10.1016/j.jchemneu.2010.03.001DOI Listing
July 2010
6 Reads
12 Citations
2.520 Impact Factor

Impaired hippocampal plasticity and altered neurogenesis in adult Ube3a maternal deficient mouse model for Angelman syndrome.

Exp Neurol 2009 Dec 24;220(2):341-8. Epub 2009 Sep 24.

EA4170-UCBL, Faculté de Médecine Rockefeller, Université Claude Bernard, Lyon cedex 08, France.

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http://dx.doi.org/10.1016/j.expneurol.2009.08.035DOI Listing
December 2009
5 Reads
10 Citations
4.700 Impact Factor

Role of the melanin-concentrating hormone neuropeptide in sleep regulation.

Peptides 2009 Nov 4;30(11):2052-9. Epub 2009 Aug 4.

UMR CNRS, Université Claude Bernard Lyon1, Université de Lyon, Institut Fédératif des Neurosciences de Lyon, France.

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http://dx.doi.org/10.1016/j.peptides.2009.07.022DOI Listing
November 2009
5 Reads
19 Citations
2.620 Impact Factor

Noradrenergic neurons expressing Fos during waking and paradoxical sleep deprivation in the rat.

J Chem Neuroanat 2009 May 27;37(3):149-57. Epub 2008 Dec 27.

Université de Lyon, Lyon, France.

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http://dx.doi.org/10.1016/j.jchemneu.2008.12.008DOI Listing
May 2009
4 Reads
18 Citations
2.520 Impact Factor

Localization of the brainstem GABAergic neurons controlling paradoxical (REM) sleep.

PLoS One 2009 26;4(1):e4272. Epub 2009 Jan 26.

CNRS, UMR5167, Physiopathologie des réseaux neuronaux du cycle veille-sommeil, Lyon, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0004272PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2629845PMC
April 2009
8 Reads
47 Citations
3.234 Impact Factor

Sleep architecture of the melanin-concentrating hormone receptor 1-knockout mice.

Eur J Neurosci 2008 Apr;27(7):1793-800

Research Center for Cellular and Molecular Neurobiology, Unit of Molecular Neurophysiology, University of Liège, 1 Avenue de l'Hôpital, Bat. B-36, 4000 Liège, Belgium.

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http://dx.doi.org/10.1111/j.1460-9568.2008.06129.xDOI Listing
April 2008
5 Reads
23 Citations
3.181 Impact Factor

Paradoxical (REM) sleep genesis: the switch from an aminergic-cholinergic to a GABAergic-glutamatergic hypothesis.

J Physiol Paris 2006 Nov-Dec;100(5-6):271-83. Epub 2007 Jun 8.

UMR5167 CNRS, Faculté de Médecine Laennec, Institut Fédératif des Neurosciences de Lyon (IFR 19), Université Claude Bernard Lyon I, 7, Rue Guillaume Paradin, 69372 Lyon cedex 08, France.

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http://dx.doi.org/10.1016/j.jphysparis.2007.05.006DOI Listing
January 2008
7 Reads
45 Citations
2.350 Impact Factor

Oscillatory and intrinsic membrane properties of guinea pig nucleus prepositus hypoglossi neurons in vitro.

J Neurophysiol 2006 Jul 5;96(1):175-96. Epub 2006 Apr 5.

Laboratoire de Neurobiologie des Réseaux Sensorimoteurs, Centre National de la Recherche Scientifique (CNRS)-Université René Descartes (Paris 5) Unité Mixte de Recherche (UMR) 7060, Paris, France.

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http://dx.doi.org/10.1152/jn.01355.2005DOI Listing
July 2006
4 Reads
9 Citations
2.890 Impact Factor

Localization of the neurons active during paradoxical (REM) sleep and projecting to the locus coeruleus noradrenergic neurons in the rat.

J Comp Neurol 2006 Apr;495(5):573-86

Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5167, Institut Fédératif des Neurosciences de Lyon (IFR19), Lyon F-69372, France.

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http://dx.doi.org/10.1002/cne.20891DOI Listing
April 2006
6 Reads
26 Citations
3.230 Impact Factor

Sleep disturbances in Ube3a maternal-deficient mice modeling Angelman syndrome.

Neurobiol Dis 2005 Nov;20(2):471-8

EA 3734, Claude Bernard University, 8 av. Rockefeller, 69373 Lyon Cedex 08, France.

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http://dx.doi.org/10.1016/j.nbd.2005.04.003DOI Listing
November 2005
37 Reads
26 Citations
5.080 Impact Factor

Paradoxical sleep in mice lacking M3 and M2/M4 muscarinic receptors.

Neuropsychobiology 2005 17;52(3):140-6. Epub 2005 Aug 17.

CNRS UMR 5167, Physiopathologie des Réseaux Neuronaux du Cycle Veille-Sommeil, Institut Fédératif des Neurosciences de Lyon (IFR19), Université C. Bernard, 7 rue Guillaume Paradin, FR-69372 Lyon Cedex 08, France.

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http://dx.doi.org/10.1159/000087560DOI Listing
October 2005
23 Reads
4 Citations
2.261 Impact Factor

GABAergic control of hypothalamic melanin-concentrating hormone-containing neurons across the sleep-waking cycle.

Neuroreport 2005 Jul;16(10):1069-73

CNRS, UMR 5167, Faculté de Medecine, RTH Laennec, 7 rue G. Paradin, 69372 Lyon cedex 08, France.

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http://dx.doi.org/10.1097/00001756-200507130-00008DOI Listing
July 2005
8 Reads
14 Citations
1.644 Impact Factor

Cholinergic and noncholinergic brainstem neurons expressing Fos after paradoxical (REM) sleep deprivation and recovery.

Eur J Neurosci 2005 May;21(9):2488-504

CNRS UMR 5167, Institut Fédératif des Neurosciences de Lyon (IFR 19), Faculté de médecine RTH Laennec, 7, rue Guillaume Paradin, 69372 Lyon Cedex 08, France.

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http://dx.doi.org/10.1111/j.1460-9568.2005.04060.xDOI Listing
May 2005
8 Reads
33 Citations
3.181 Impact Factor

Brainstem structures responsible for paradoxical sleep onset and maintenance.

Arch Ital Biol 2004 Jul;142(4):397-411

UMR5167 CNRS, Institut Fédératif des Neurosciences de Lyon (IFR 19), Université Claude Bernard, Lyon, Cedex 08, France.

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July 2004
1 Read
5 Citations
1.422 Impact Factor

Posterior hypothalamus and regulation of vigilance states.

Arch Ital Biol 2004 Jul;142(4):487-500

CNRS UMR 5167, Institut fédératif des neurosciences de Lyon (IFR 19), Université Claude Bernard Lyon 1, Lyon, Cedex 08 France.

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July 2004
1 Read
1 Citation
1.422 Impact Factor

Effect of the wake-promoting agent modafinil on sleep-promoting neurons from the ventrolateral preoptic nucleus: an in vitro pharmacologic study.

Sleep 2004 Feb;27(1):19-25

UMR 5167 CNRS, Physio-Pathologie des Réseaux Neuronaux du Cycle Veille-Sommeil, Institut Fédératif des Neurosciences de Lyon (IFNL, IFR19), Université Claude Bernard Lyon I, Lyon, France.

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February 2004
28 Reads
25 Citations
4.591 Impact Factor

A role of melanin-concentrating hormone producing neurons in the central regulation of paradoxical sleep.

BMC Neurosci 2003 Sep 9;4:19. Epub 2003 Sep 9.

CNRS UMR5167, Institut Fédératif des Neurosciences de Lyon (IFR 19), Université Claude Bernard Lyon I, 7 Rue Guillaume Paradin, 69372 LYON Cedex 08, FRANCE.

Background: Peptidergic neurons containing the melanin-concentrating hormone (MCH) and the hypocretins (or orexins) are intermingled in the zona incerta, perifornical nucleus and lateral hypothalamic area. Both types of neurons have been implicated in the integrated regulation of energy homeostasis and body weight. Hypocretin neurons have also been involved in sleep-wake regulation and narcolepsy. We therefore sought to determine whether hypocretin and MCH neurons express Fos in association with enhanced paradoxical sleep (PS or REM sleep) during the rebound following PS deprivation. Next, we compared the effect of MCH and NaCl intracerebroventricular (ICV) administrations on sleep stage quantities to further determine whether MCH neurons play an active role in PS regulation.

Results: Here we show that the MCH but not the hypocretin neurons are strongly active during PS, evidenced through combined hypocretin, MCH, and Fos immunostainings in three groups of rats (PS Control, PS Deprived and PS Recovery rats). Further, we show that ICV administration of MCH induces a dose-dependent increase in PS (up to 200%) and slow wave sleep (up to 70%) quantities.

Conclusion: These results indicate that MCH is a powerful hypnogenic factor. MCH neurons might play a key role in the state of PS via their widespread projections in the central nervous system.

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http://dx.doi.org/10.1186/1471-2202-4-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC201018PMC
September 2003
7 Reads
2.665 Impact Factor

Localization of the GABAergic and non-GABAergic neurons projecting to the sublaterodorsal nucleus and potentially gating paradoxical sleep onset.

Eur J Neurosci 2003 Sep;18(6):1627-39

CNRS UMR5167, Institut Fédératif des Neurosciences de Lyon (IFR 19), Université Claude Bernard Lyon I, 7, Rue Guillaume Paradin, 69372 Lyon, Cedex 08, France.

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http://dx.doi.org/10.1046/j.1460-9568.2003.02861.xDOI Listing
September 2003
5 Reads
54 Citations
3.181 Impact Factor

The rat ponto-medullary network responsible for paradoxical sleep onset and maintenance: a combined microinjection and functional neuroanatomical study.

Eur J Neurosci 2002 Nov;16(10):1959-73

CNRS FRE 2469, Institut Fédératif des Neurosciences de Lyon (IFR 19), Université Claude Bernard Lyon I, 8 Avenue Rockefeller, 69373 LYON Cedex 08, France.

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http://dx.doi.org/10.1046/j.1460-9568.2002.02257.xDOI Listing
November 2002
6 Reads
82 Citations
3.181 Impact Factor

Effect of chronic treatment with milnacipran on sleep architecture in rats compared with paroxetine and imipramine.

Pharmacol Biochem Behav 2002 Oct;73(3):557-63

INSERM U480, Neurobiologie des états de sommeil et d'éveil, 8 Avenue Rockefeller, 69373 Lyon, France.

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http://dx.doi.org/10.1016/s0091-3057(02)00812-2DOI Listing
October 2002
5 Reads
4 Citations
2.781 Impact Factor

Anatomical demonstration of a medullary enkephalinergic pathway potentially implicated in the oro-facial muscle atonia of paradoxical sleep in the cat.

Sleep Res Online 1998 ;1(3):102-8

Neurobiologie des tats de Sommeil et d' veil, INSERM U480, Universit Claude Bernard, Lyon 69373, France.

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October 2001
1 Read
5 Citations

Role of the lateral preoptic area in sleep-related erectile mechanisms and sleep generation in the rat.

J Neurosci 2000 Sep;20(17):6640-7

Cleveland Clinic Foundation, Department of Neurology, Cleveland, Ohio 44195, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6772989PMC
September 2000
5 Reads
6 Citations
6.344 Impact Factor

Unrelated course of subthalamic nucleus and globus pallidus neuronal activities across vigilance states in the rat.

Eur J Neurosci 2000 Sep;12(9):3361-74

Laboratoire de Neuropharmacologie et Neurochimie, INSERM U512, Frnace.

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http://dx.doi.org/10.1046/j.1460-9568.2000.00199.xDOI Listing
September 2000
4 Reads
32 Citations
3.181 Impact Factor

Single-unit and polygraphic recordings associated with systemic or local pharmacology: a multi-purpose stereotaxic approach for the awake, anaesthetic-free, and head-restrained rat.

J Neurosci Res 2000 Jul;61(1):88-100

Laboratoire de Neuropharmacologie et Neurochimie, INSERM U512, Université Claude Bernard Lyon 1, Lyon-Cedex, France.

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http://dx.doi.org/10.1002/1097-4547(20000701)61:1<88::AID-JNR11>3.0.CO;2-5DOI Listing
July 2000
2 Reads
6 Citations
2.594 Impact Factor

Role and origin of the GABAergic innervation of dorsal raphe serotonergic neurons.

J Neurosci 2000 Jun;20(11):4217-25

Institut National de la Santé et de la Recherche Médicale (INSERM) U480, INSERM U512, Université Claude Bernard Lyon I, 69373 Lyon cedex 08, France.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6772634PMC
June 2000
1 Read
49 Citations
6.344 Impact Factor

Identification of sleep-promoting neurons in vitro.

Nature 2000 Apr;404(6781):992-5

Département de Physiologie, Centre Médical Universitaire, Genève, Switzerland.

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http://dx.doi.org/10.1038/35010109DOI Listing
April 2000
2 Reads
69 Citations
42.351 Impact Factor

Origins of the glycinergic inputs to the rat locus coeruleus and dorsal raphe nuclei: a study combining retrograde tracing with glycine immunohistochemistry.

Eur J Neurosci 1999 Mar;11(3):1058-66

Neurobiologie des Etats de Sommeil et d'Eveil, INSERM U480, Lyon, France.

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http://dx.doi.org/10.1046/j.1460-9568.1999.00511.xDOI Listing
March 1999
1 Read
8 Citations
3.181 Impact Factor

GABAergic input to cholinergic nucleus basalis neurons.

Neuroscience 1998 Oct;86(3):937-47

Département de Physiologie, CMU, Genève, Switzerland.

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http://dx.doi.org/10.1016/s0306-4522(98)00094-3DOI Listing
October 1998
3 Reads
8 Citations
3.360 Impact Factor

Electrophysiological evidence that noradrenergic neurons of the rat locus coeruleus are tonically inhibited by GABA during sleep.

Eur J Neurosci 1998 Mar;10(3):964-70

Laboratoire de Médecine Expérimentale, INSERM U480, CNRS ERS 5645, Faculté de Pharmacie, Université Claude Bernard Lyon I, France.

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http://dx.doi.org/10.1046/j.1460-9568.1998.00106.xDOI Listing
March 1998
2 Reads
22 Citations
3.181 Impact Factor

Pharmacological characterization and differentiation of non-cholinergic nucleus basalis neurons in vitro.

Neuroreport 1998 Jan;9(1):61-5

Département de Médecine Expérimentale, INSERM U52, CNRS ERS 5645, Lyon, France.

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http://dx.doi.org/10.1097/00001756-199801050-00013DOI Listing
January 1998
2 Reads
7 Citations
1.644 Impact Factor

Modulation of cholinergic nucleus basalis neurons by acetylcholine and N-methyl-D-aspartate.

Neuroscience 1997 Nov;81(1):47-55

Département de Physiologie, CMU, Genève, Switzerland.

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http://dx.doi.org/10.1016/s0306-4522(97)00167-xDOI Listing
November 1997
4 Reads
6 Citations
3.360 Impact Factor

Effect of strychnine on rat locus coeruleus neurones during sleep and wakefulness.

Neuroreport 1996 Dec;8(1):351-5

Département de Médecine Expérimentale, INSERM U52, CNRS ERS 5645, Faculté de Médecine, Lyon, France.

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http://dx.doi.org/10.1097/00001756-199612200-00069DOI Listing
December 1996
1 Read
1 Citation
1.644 Impact Factor

Rhythmic firing of medial septum non-cholinergic neurons.

Neuroscience 1996 Dec;75(3):671-5

Departement de Physiologie, CMU, Genève, Switzerland.

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http://dx.doi.org/10.1016/0306-4522(96)00349-1DOI Listing
December 1996
14 Reads
16 Citations
3.360 Impact Factor

Distribution of glycine-immunoreactive cell bodies and fibers in the rat brain.

Neuroscience 1996 Dec;75(3):737-55

Laboratoire de Médecine Expérimentale, INSERM U52, CNRS, Faculté de Médecine, Lyon, France.

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http://dx.doi.org/10.1016/0306-4522(96)00278-3DOI Listing
December 1996
1 Read
31 Citations
3.360 Impact Factor

Origin of the glycinergic innervation of the rat trigeminal motor nucleus.

Neuroreport 1996 Nov;7(18):3081-5

Laboratoire de Médecine Expérimentale, INSERM U52, CNRS ERS 5645, Faculté de Médecine, Lyon, France.

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http://dx.doi.org/10.1097/00001756-199611250-00058DOI Listing
November 1996
2 Reads
4 Citations
1.644 Impact Factor

Differential oscillatory properties of cholinergic and noncholinergic nucleus basalis neurons in guinea pig brain slice.

Eur J Neurosci 1996 Jan;8(1):169-82

Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1111/j.1460-9568.1996.tb01178.xDOI Listing
January 1996
4 Reads
19 Citations
3.181 Impact Factor

Lower brainstem catecholamine afferents to the rat dorsal raphe nucleus.

J Comp Neurol 1996 Jan;364(3):402-413

INSERM U52, Université Claude Bernard, Lyon, France.

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http://dx.doi.org/10.1002/(SICI)1096-9861(19960115)364:3<402::AID-CNE2>3.0.CO;2-8DOI Listing
January 1996
1 Read
28 Citations
3.230 Impact Factor

Origin of the dopaminergic innervation of the rat dorsal raphe nucleus.

Neuroreport 1995 Dec;6(18):2527-31

Departement de Medecine Experimentale, Universite Claude Bernard, Lyon cedex, France.

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http://dx.doi.org/10.1097/00001756-199512150-00019DOI Listing
December 1995
2 Reads
13 Citations
1.644 Impact Factor

Cholinergic nucleus basalis neurons are excited by histamine in vitro.

Neuroscience 1995 Nov;69(2):495-506

Département de Physiologie, CMU, Genève, Switzerland.

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http://dx.doi.org/10.1016/0306-4522(95)00264-jDOI Listing
November 1995
1 Read
17 Citations
3.360 Impact Factor

Rhythmical bursts induced by NMDA in guinea-pig cholinergic nucleus basalis neurones in vitro.

J Physiol 1995 Sep;487 ( Pt 3):623-38

Département de Physiologie, CMU, Genève, Switzerland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1156650PMC
http://dx.doi.org/10.1113/jphysiol.1995.sp020905DOI Listing
September 1995
18 Reads
8 Citations
5.040 Impact Factor

Noradrenergic modulation of cholinergic nucleus basalis neurons demonstrated by in vitro pharmacological and immunohistochemical evidence in the guinea-pig brain.

Eur J Neurosci 1995 Jul;7(7):1502-11

Département de Physiologie, Centre Médical Universitaire, Geneva 4, Switzerland.

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http://dx.doi.org/10.1111/j.1460-9568.1995.tb01145.xDOI Listing
July 1995
1 Read
21 Citations
3.181 Impact Factor

Afferents to the nucleus reticularis parvicellularis of the cat medulla oblongata: a tract-tracing study with cholera toxin B subunit.

J Comp Neurol 1994 Apr;342(4):603-18

Département de Médecine Expérimentale, U52 INSERM, URA 1195 CNRS, Université Claude Bernard, Lyon, France.

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http://dx.doi.org/10.1002/cne.903420408DOI Listing
April 1994
1 Read
5 Citations
3.230 Impact Factor

Glycine-immunoreactive neurones in the cat brain stem reticular formation.

Neuroreport 1993 Sep;4(9):1123-6

Département de Médecine Expérimentale, INSERM U52, CNRS UA1195, Faculté de Médecine, Université Claude Bernard, Lyon, France.

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September 1993
1 Read
6 Citations
1.644 Impact Factor

Pharmacological and immunohistochemical evidence for serotonergic modulation of cholinergic nucleus basalis neurons.

Eur J Neurosci 1993 May;5(5):541-7

Département de Physiologie, Centre Médical Universitaire, Geneva, Switzerland.

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http://dx.doi.org/10.1111/j.1460-9568.1993.tb00519.xDOI Listing
May 1993
2 Reads
9 Citations
3.181 Impact Factor

Anatomical and electrophysiological evidence for a glycinergic inhibitory innervation of the rat locus coeruleus.

Neurosci Lett 1991 Jul;128(1):33-6

Département de Médecine Expérimentale, INSERM U52, CNRS URA 1195, Faculté de Médecine, Université Claude Bernard, Lyon, France.

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http://dx.doi.org/10.1016/0304-3940(91)90754-hDOI Listing
July 1991
1 Read
2.060 Impact Factor

Catecholaminergic afferents to the cat median eminence as determined by double-labelling methods.

Neuroscience 1990 ;36(2):491-505

Département de Médecine Expérimentale, INSERM U 52, CNRS UA 1195, Université Claude Bernard, Lyon, France.

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http://dx.doi.org/10.1016/0306-4522(90)90443-8DOI Listing
November 1990
1 Read
3.360 Impact Factor

Nuclei of origin of monoaminergic, peptidergic, and cholinergic afferents to the cat trigeminal motor nucleus: a double-labeling study with cholera-toxin as a retrograde tracer.

J Comp Neurol 1990 Nov;301(2):262-75

Département de Médecine Expérimentale, INSERM U. 52, URA 1195, Université Claude, Bernard, Lyon, France.

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http://dx.doi.org/10.1002/cne.903010209DOI Listing
November 1990
8 Reads
11 Citations
3.230 Impact Factor

Iontophoretic application of unconjugated cholera toxin B subunit (CTb) combined with immunohistochemistry of neurochemical substances: a method for transmitter identification of retrogradely labeled neurons.

Brain Res 1990 Nov;534(1-2):209-24

Département de Médecine Expérimentale, INSERM U. 52, C.N.R.S. UA1195, Université Claude Bernard, Lyon, France.

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http://dx.doi.org/10.1016/0006-8993(90)90131-tDOI Listing
November 1990
39 Citations
2.843 Impact Factor

[Glycine immunoreactive neurons in the medulla oblongata in cats].

C R Acad Sci III 1990 ;311(5):205-12

Département de Médecine expérimentale, Faculté de Médecine, I.N.S.E.R.M.-U n 52, C.N.R.S. (U.R.A. n 1195) Université Claude-Bernard.

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November 1990
2 Reads

Lower brainstem afferents to the cat posterior hypothalamus: a double-labeling study.

Brain Res Bull 1990 Mar;24(3):437-55

Département de Médecine Expérimentale, INSERM U 52, CNRS UA 1195, Université Claude Bernard, Lyon, France.

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http://dx.doi.org/10.1016/0361-9230(90)90098-kDOI Listing
March 1990
3 Reads
7 Citations
2.720 Impact Factor

Adrenergic input from medullary ventrolateral C1 cells to the nucleus raphe pallidus of the cat, as demonstrated by a double immunostaining technique.

Neurosci Lett 1989 Nov;106(1-2):29-35

Département de Médecine Expérimentale, INSERM U52, CNRS UA1195, Faculté de Médecine, Université Claude Bernard, Lyon, France.

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http://dx.doi.org/10.1016/0304-3940(89)90197-3DOI Listing
November 1989
1 Read
2 Citations
2.060 Impact Factor

Forebrain afferents to the cat posterior hypothalamus: a double labeling study.

Brain Res Bull 1989 Jul-Aug;23(1-2):83-104

Département de Médecine Expérimentale, INSERM U 52, CNRS UA 1195, Université Claude Bernard, Lyon, France.

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http://dx.doi.org/10.1016/0361-9230(89)90167-6DOI Listing
November 1989
2 Reads
1 Citation
2.720 Impact Factor

Monoaminergic, peptidergic, and cholinergic afferents to the cat facial nucleus as evidenced by a double immunostaining method with unconjugated cholera toxin as a retrograde tracer.

J Comp Neurol 1989 May;283(2):285-302

Département de Médecine Expérimentale, INSERM U.52, CNRS UA 1195, Faculté de Médecine, Lyon, France.

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http://dx.doi.org/10.1002/cne.902830209DOI Listing
May 1989
5 Reads
12 Citations
3.230 Impact Factor

The nuclei of origin of monoaminergic, peptidergic, and cholinergic afferents to the cat nucleus reticularis magnocellularis: a double-labeling study with cholera toxin as a retrograde tracer.

J Comp Neurol 1988 Nov;277(1):1-20

Département de Médecine Expérimentale, INSERM U52, CNRS UA 1192, Faculté de Médecine, Lyon, France.

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http://dx.doi.org/10.1002/cne.902770102DOI Listing
November 1988
5 Reads
2 Citations
3.230 Impact Factor

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M Jouvet
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Université Claude Bernard

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Denise Salvert

Université de Lyon

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Christelle Peyron
Christelle Peyron

Université Claude Bernard Lyon I

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Centre Médical Universitaire

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Nippon Medical School

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Duke University Medical Center

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