Publications by authors named "Pascual Sanz"

81Publications

Neuroinflammation and progressive myoclonus epilepsies: from basic science to therapeutic opportunities.

Expert Rev Mol Med 2020 09 17;22:e4. Epub 2020 Sep 17.

IIS Fundación Jimenez Diaz and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Madrid, Spain.

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http://dx.doi.org/10.1017/erm.2020.5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7520540PMC
September 2020

Reactive Glia Inflammatory Signaling Pathways and Epilepsy.

Int J Mol Sci 2020 Jun 8;21(11). Epub 2020 Jun 8.

Department of Biotechnology, Escuela Técnica Superior de Ingeniería Agronómica y del Medio Natural (ETSIAMN), Universitat Politècnica de València, 46022 Valencia, Spain.

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http://dx.doi.org/10.3390/ijms21114096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312833PMC
June 2020

The 5th International Lafora Epilepsy Workshop: Basic science elucidating therapeutic options and preparing for therapies in the clinic.

Epilepsy Behav 2020 02 10;103(Pt A):106839. Epub 2020 Jan 10.

Lafora Epilepsy Cure Initiative (LECI), USA; Laboratory of Neurology, IIS-Jimenez Diaz Foundation, UAM, 28045 Madrid, Spain; Biomedical Research Networking Center on Rare Diseases (CIBERER), 28029 Madrid, Spain.

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http://dx.doi.org/10.1016/j.yebeh.2019.106839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024738PMC
February 2020

Regulation of the autophagic PI3KC3 complex by laforin/malin E3-ubiquitin ligase, two proteins involved in Lafora disease.

Biochim Biophys Acta Mol Cell Res 2020 02 21;1867(2):118613. Epub 2019 Nov 21.

Instituto de Biomedicina de Valencia, Consejo Superior de Investigaciones Científicas, Valencia, Spain; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Valencia, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.bbamcr.2019.118613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937399PMC
February 2020

Metformin treatment reduces motor and neuropsychiatric phenotypes in the zQ175 mouse model of Huntington disease.

Exp Mol Med 2019 06 5;51(6):1-16. Epub 2019 Jun 5.

Research Group in Molecular, Cellular and Genomic Biomedicine, Health Research Institute La Fe (Hospital Universitario y Politécnico La Fe), València, Spain.

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http://dx.doi.org/10.1038/s12276-019-0264-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6549163PMC
June 2019

Lafora Disease: A Ubiquitination-Related Pathology.

Cells 2018 Jul 26;7(8). Epub 2018 Jul 26.

Centro de Investigación Biomédica en Red de Enfermedades Raras, (CIBERER), 46010 Valencia, Spain.

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http://www.mdpi.com/2073-4409/7/8/87
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http://dx.doi.org/10.3390/cells7080087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116066PMC
July 2018

A novel EPM2A mutation yields a slow progression form of Lafora disease.

Epilepsy Res 2018 09 21;145:169-177. Epub 2018 Jul 21.

IBV-CSIC. Instituto de Biomedicina de Valencia, Consejo Superior de Investigaciones Científicas, Valencia, Spain; CIBERER. Centro de Investigación Biomédica en Red de Enfermedades Raras, Valencia, Spain; Lafora Epilepsy Cure Initiative, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09201211183027
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http://dx.doi.org/10.1016/j.eplepsyres.2018.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087489PMC
September 2018

Degradation of altered mitochondria by autophagy is impaired in Lafora disease.

FEBS J 2018 06 23;285(11):2071-2090. Epub 2018 Apr 23.

Centro de Investigación Príncipe Felipe, Valencia, Spain.

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http://dx.doi.org/10.1111/febs.14468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986609PMC
June 2018

AMPK Protein Interaction Analyses by Yeast Two-Hybrid.

Methods Mol Biol 2018 ;1732:143-157

Department of Biotecnología, Escuela Técnica Superior de Ingeniería Agronómica y del Medio Natural (ETSIAMN), University of Politécnica de Valencia, Valencia, Spain.

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http://dx.doi.org/10.1007/978-1-4939-7598-3_9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895849PMC
January 2019

Astrocytes: new players in progressive myoclonus epilepsy of Lafora type.

Hum Mol Genet 2018 04;27(7):1290-1300

Instituto de Biomedicina de Valencia, Consejo Superior de Investigaciones Científicas (IBV-CSIC), Valencia, Spain.

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http://dx.doi.org/10.1093/hmg/ddy044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6059194PMC
April 2018

An Attachment-Independent Biochemical Timer of the Spindle Assembly Checkpoint.

Mol Cell 2017 Nov 9;68(4):715-730.e5. Epub 2017 Nov 9.

Laboratory of Biosignaling & Therapeutics, Department of Cellular and Molecular Medicine, University of Leuven, 3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2017.10.011DOI Listing
November 2017

4-Phenylbutyric acid and metformin decrease sensitivity to pentylenetetrazol-induced seizures in a malin knockout model of Lafora disease.

Neuroreport 2017 Mar;28(5):268-271

aDepartment of Neuroscience, Laboratory of Neurology, IIS-Jiménez Díaz Foundation, UAM and Biomedical Research Network Center on Rare Diseases (CIBERER), Madrid bDepartment of Nutrient Signalling, Institute of Biomedicine of Valencia, CSIC, and CIBERER, Valencia, Spain.

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http://dx.doi.org/10.1097/WNR.0000000000000751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491969PMC
March 2017

AMPK in Yeast: The SNF1 (Sucrose Non-fermenting 1) Protein Kinase Complex.

Exp Suppl 2016;107:353-374

Department of Biotecnología, Escuela Técnica Superior de Ingeniería Agronómica y del Medio Natural (ETSIAMN), Universitat Politécnica de Valencia, Valencia, Spain.

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http://dx.doi.org/10.1007/978-3-319-43589-3_14DOI Listing
June 2017

Assessing the Biological Activity of the Glucan Phosphatase Laforin.

Methods Mol Biol 2016 ;1447:107-19

Instituto de Biomedicina de Valencia, CSIC, Valencia, Spain.

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http://dx.doi.org/10.1007/978-1-4939-3746-2_7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339740PMC
January 2018

Inflammation in Lafora Disease: Evolution with Disease Progression in Laforin and Malin Knock-out Mouse Models.

Mol Neurobiol 2017 07 4;54(5):3119-3130. Epub 2016 Apr 4.

Institut de Neuropatologia, Servei Anatomia Patologica, Hospital Universitari de Bellvitge, Carrer Feixa Llarga sn, Hospitalet de Llobregat, 08907, Barcelona, Spain.

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http://dx.doi.org/10.1007/s12035-016-9884-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472678PMC
July 2017

Homeostasis of the astrocytic glutamate transporter GLT-1 is altered in mouse models of Lafora disease.

Biochim Biophys Acta 2016 06 11;1862(6):1074-83. Epub 2016 Mar 11.

Instituto de Biomedicina de Valencia (CSIC) and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Valencia, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2016.03.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472677PMC
June 2016

The interaction between AMPKβ2 and the PP1-targeting subunit R6 is dynamically regulated by intracellular glycogen content.

Biochem J 2016 Apr 1;473(7):937-47. Epub 2016 Feb 1.

Department of Molecular Genetics, CARIM School for Cardiovascular Diseases, Maastricht University, 6200 MD Maastricht, The Netherlands

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http://dx.doi.org/10.1042/BJ20151035DOI Listing
April 2016

Ubiquitin conjugating enzyme E2-N and sequestosome-1 (p62) are components of the ubiquitination process mediated by the malin-laforin E3-ubiquitin ligase complex.

Int J Biochem Cell Biol 2015 Dec 3;69:204-14. Epub 2015 Nov 3.

Instituto de Biomedicina de Valencia, CSIC and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Jaime Roig 11, 46010 Valencia, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.biocel.2015.10.030DOI Listing
December 2015

The laforin/malin E3-ubiquitin ligase complex ubiquitinates pyruvate kinase M1/M2.

BMC Biochem 2015 Oct 23;16:24. Epub 2015 Oct 23.

Instituto de Biomedicina de Valencia, CSIC, and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Jaime Roig 11, 46010, Valencia, Spain.

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http://dx.doi.org/10.1186/s12858-015-0053-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619252PMC
October 2015

Increased oxidative stress and impaired antioxidant response in Lafora disease.

Free Radic Biol Med 2014 Oct 10;75 Suppl 1:S47. Epub 2014 Dec 10.

Instituto de Biomedicina de Valencia (CSIC), Laboratory of Nutrient Signalling, Valencia, Spain.

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http://dx.doi.org/10.1016/j.freeradbiomed.2014.10.809DOI Listing
October 2014

Structure-Function Analysis of PPP1R3D, a Protein Phosphatase 1 Targeting Subunit, Reveals a Binding Motif for 14-3-3 Proteins which Regulates its Glycogenic Properties.

PLoS One 2015 26;10(6):e0131476. Epub 2015 Jun 26.

Instituto de Biomedicina de Valencia, CSIC, and Centro de Investigación en Red de Enfermedades Raras (CIBERER), Jaime Roig 11, Valencia, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0131476PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482762PMC
May 2016

Oxidative stress, a new hallmark in the pathophysiology of Lafora progressive myoclonus epilepsy.

Free Radic Biol Med 2015 Nov 10;88(Pt A):30-41. Epub 2015 Feb 10.

Fundación Investigación Clinico de Valencia, Instituto de Investigación Sanitaria, Valencia, Spain; Department of Physiology, School of Medicine and Dentistry, University of Valencia, E46010 Valencia, Spain; Centro de Investigación Biomédica en Red de Enfermedades Raras, Valencia, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2015.01.034DOI Listing
November 2015

Pharmacological Interventions to Ameliorate Neuropathological Symptoms in a Mouse Model of Lafora Disease.

Mol Neurobiol 2016 Mar 28;53(2):1296-1309. Epub 2015 Jan 28.

Instituto de Biomedicina de Valencia (CSIC), Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Jaime Roig 11, 46010, Valencia, Spain.

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http://dx.doi.org/10.1007/s12035-015-9091-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474477PMC
March 2016

Increased oxidative stress and impaired antioxidant response in Lafora disease.

Mol Neurobiol 2015 17;51(3):932-46. Epub 2014 May 17.

Instituto de Biomedicina de Valencia, Consejo Superior de Investigaciones Científicas (IBV-CSIC), C/Jaime Roig, 11, 46010, Valencia, Spain.

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http://link.springer.com/10.1007/s12035-014-8747-0
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http://dx.doi.org/10.1007/s12035-014-8747-0DOI Listing
March 2016

Dimerization of the glucan phosphatase laforin requires the participation of cysteine 329.

PLoS One 2013 26;8(7):e69523. Epub 2013 Jul 26.

Instituto de Biomedicina de Valencia, CSIC and Centro de Investigación Biomédica en Red de Enfermedades Raras, Valencia, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0069523PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724922PMC
April 2014

Lafora disease fibroblasts exemplify the molecular interdependence between thioredoxin 1 and the proteasome in mammalian cells.

Free Radic Biol Med 2013 Dec 9;65:347-359. Epub 2013 Jul 9.

Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Valencia, Spain; Fundación del Hospital Clínico Universitat de Valencia-INCLIVA, Valencia, Spain; Department of Physiology, University of Valencia, 46010 Valencia, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2013.07.001DOI Listing
December 2013

AMPKβ subunits: more than just a scaffold in the formation of AMPK complex.

FEBS J 2013 Aug 24;280(16):3723-33. Epub 2013 Jun 24.

Instituto de Biomedicina de Valencia, CSIC and Centro de Investigación en Red de Enfermedades Raras (CIBERER), Valencia, Spain.

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http://dx.doi.org/10.1111/febs.12364DOI Listing
August 2013

Glycogenic activity of R6, a protein phosphatase 1 regulatory subunit, is modulated by the laforin-malin complex.

Int J Biochem Cell Biol 2013 Jul 26;45(7):1479-88. Epub 2013 Apr 26.

Instituto de Biomedicina de Valencia, CSIC, and Centro de Investigación en Red de Enfermedades Raras, Jaime Roig 11, 46010 Valencia, Spain.

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http://dx.doi.org/10.1016/j.biocel.2013.04.019DOI Listing
July 2013

Sumoylation of AMPKβ2 subunit enhances AMP-activated protein kinase activity.

Mol Biol Cell 2013 Jun 3;24(11):1801-11, S1-4. Epub 2013 Apr 3.

Instituto de Biomedicina de Valencia, Consejo Superior de Investigaciones Científicas, and Centro de Investigación en Red de Enfermedades Raras, 46010-Valencia, Spain.

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http://dx.doi.org/10.1091/mbc.E12-11-0806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667731PMC
June 2013

Glucose-dependent regulation of AMP-activated protein kinase in MIN6 beta cells is not affected by the protein kinase A pathway.

FEBS Lett 2012 Nov 29;586(23):4241-7. Epub 2012 Oct 29.

Instituto de Biomedicina de Valencia, CSIC and Centro de Investigación en Red de Enfermecedes Raras (CIBERER), Jaime Roig 11, 46010 Valencia, Spain.

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http://dx.doi.org/10.1016/j.febslet.2012.10.032DOI Listing
November 2012

Deciphering the role of malin in the lafora progressive myoclonus epilepsy.

IUBMB Life 2012 Oct 20;64(10):801-8. Epub 2012 Jul 20.

Instituto de Biomedicina de Valencia, CSIC and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Valencia, Spain.

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http://dx.doi.org/10.1002/iub.1072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458166PMC
October 2012

Laforin, a protein with many faces: glucan phosphatase, adapter protein, et alii.

FEBS J 2013 Jan 16;280(2):525-37. Epub 2012 Mar 16.

Department of Molecular and Cellular Biochemistry and Center for Structural Biology, University of Kentucky, Lexington, KY, USA.

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http://dx.doi.org/10.1111/j.1742-4658.2012.08549.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371293PMC
January 2013

Histone carbonylation occurs in proliferating cells.

Free Radic Biol Med 2012 Apr 2;52(8):1453-64. Epub 2012 Feb 2.

Centro de Investigación Biomédica en Red de Enfermedades Raras, FIHCUV-Incliva, Universitat de Valencia, E46010 Valencia, Spain.

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http://dx.doi.org/10.1016/j.freeradbiomed.2012.01.022DOI Listing
April 2012

Plasmodium falciparum inhibitor-3 homolog increases protein phosphatase type 1 activity and is essential for parasitic survival.

J Biol Chem 2012 Jan 28;287(2):1306-21. Epub 2011 Nov 28.

Center for Infection and Immunity of Lille, Inserm U1019-CNRS UMR 8204, University of Lille Nord de France, Institut Pasteur de Lille, 1 Rue du Professeur Calmette, 59019 Lille Cedex, France.

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http://dx.doi.org/10.1074/jbc.M111.276865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256872PMC
January 2012

Laforin, a dual specificity phosphatase involved in Lafora disease, is present mainly as monomeric form with full phosphatase activity.

PLoS One 2011 26;6(8):e24040. Epub 2011 Aug 26.

Department of Molecular and Cellular Biochemistry and Center for Structural Biology, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0024040PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162602PMC
February 2012

Lafora disease E3-ubiquitin ligase malin is related to TRIM32 at both the phylogenetic and functional level.

BMC Evol Biol 2011 Jul 28;11:225. Epub 2011 Jul 28.

Instituto de Biomedicina de Valencia, CSIC and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Valencia, Spain.

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http://dx.doi.org/10.1186/1471-2148-11-225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160408PMC
July 2011

A PTG variant contributes to a milder phenotype in Lafora disease.

PLoS One 2011 30;6(6):e21294. Epub 2011 Jun 30.

Laboratorio de Neurología-Unidad de Epilepsia, Servicio de Neurología, Instituto Investigación Sanitaria Fundación Jiménez Díaz, and Centro de Investigación Biomédica en Red de Enfermedades Raras, Madrid, Spain.

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http://digital.csic.es/bitstream/10261/37651/1/Plos%20One%20
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http://dx.plos.org/10.1371/journal.pone.0021294
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0021294PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3127956PMC
December 2011

Laforin, a dual specificity phosphatase involved in Lafora disease, regulates insulin response and whole-body energy balance in mice.

Hum Mol Genet 2011 Jul 14;20(13):2571-84. Epub 2011 Apr 14.

Instituto de Biomedicina de Valencia, CSIC and Centro de Investigación Biomédica en Red de Enfermedades Raras, Jaime Roig 11, Valencia, Spain.

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http://dx.doi.org/10.1093/hmg/ddr157DOI Listing
July 2011

The PP1-R6 protein phosphatase holoenzyme is involved in the glucose-induced dephosphorylation and inactivation of AMP-activated protein kinase, a key regulator of insulin secretion, in MIN6 beta cells.

FASEB J 2010 Dec 19;24(12):5080-91. Epub 2010 Aug 19.

Instituto de Biomedicina de Valencia, Consejo Superior de Investigaciones Cientificas and Centro de Investigación en Red de Enfermecedes Raras, Valencia, Spain.

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http://dx.doi.org/10.1096/fj.10-166306DOI Listing
December 2010

The laforin-malin complex, involved in Lafora disease, promotes the incorporation of K63-linked ubiquitin chains into AMP-activated protein kinase beta subunits.

Mol Biol Cell 2010 Aug 9;21(15):2578-88. Epub 2010 Jun 9.

Instituto de Biomedicina de Valencia, Consejo Superior de Investigaciones Cientificas and Centro de Investigación Biomédica en Red de Enfermedades Raras, 46010 Valencia, Spain.

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http://dx.doi.org/10.1091/mbc.e10-03-0227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912345PMC
August 2010

Laforin, the most common protein mutated in Lafora disease, regulates autophagy.

Hum Mol Genet 2010 Jul 7;19(14):2867-76. Epub 2010 May 7.

Laboratory of Cellular Biology, Centro de Investigación Príncipe Felipe and CIBERER, Avda. Autopista del Saler 16, 46012 Valencia, Spain.

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http://dx.doi.org/10.1093/hmg/ddq190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2893813PMC
July 2010

Two-hybrid analysis identifies PSMD11, a non-ATPase subunit of the proteasome, as a novel interaction partner of AMP-activated protein kinase.

Int J Biochem Cell Biol 2009 Dec 16;41(12):2431-9. Epub 2009 Jul 16.

Instituto de Biomedicina de Valencia, CSIC and CIBER de Enfermedades Raras (CIBERER), Jaime Roig 11, 46010 Valencia, Spain.

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http://dx.doi.org/10.1016/j.biocel.2009.07.002DOI Listing
December 2009

AMP-activated protein kinase: structure and regulation.

Authors:
Pascual Sanz

Curr Protein Pept Sci 2008 Oct;9(5):478-92

Instituto de Biomedicina de Valencia, Consejo Superior de Inverstigaciones Cientificas, Jaime Roig 11, Valencia, Spain.

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http://dx.doi.org/10.2174/138920308785915254DOI Listing
October 2008

A769662, a novel activator of AMP-activated protein kinase, inhibits non-proteolytic components of the 26S proteasome by an AMPK-independent mechanism.

FEBS Lett 2008 Jul 30;582(17):2650-4. Epub 2008 Jun 30.

Instituto de Biomedicina de Valencia, CSIC, Jaime Roig 11, Valencia, Spain.

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http://doi.wiley.com/10.1016/j.febslet.2008.06.044
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http://dx.doi.org/10.1016/j.febslet.2008.06.044DOI Listing
July 2008

Human pancreatic beta-cell glucokinase: subcellular localization and glucose repression signalling function in the yeast cell.

Biochem J 2008 Oct;415(2):233-9

Departamento de Bioquímica y Biología Molecular. Universidad de Oviedo, 33006-Oviedo, Spain.

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http://dx.doi.org/10.1042/BJ20080797DOI Listing
October 2008

Role of AMP-activated protein kinase in autophagy and proteasome function.

Biochem Biophys Res Commun 2008 May 6;369(3):964-8. Epub 2008 Mar 6.

Instituto de Biomedicina de Valencia, CSIC, Nutrient signaling, Jaime Roig 11, 46010 Valencia, Spain; Centre for Biomedical Research on Rare Diseases (CIBERER), Valencia, Spain.

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http://dx.doi.org/10.1016/j.bbrc.2008.02.126DOI Listing
May 2008

Biochemical characterization of novel glucokinase mutations isolated from Spanish maturity-onset diabetes of the young (MODY2) patients.

J Hum Genet 2008 6;53(5):460-466. Epub 2008 Mar 6.

Instituto de Biomedicina de Valencia (CSIC) and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Jaime Roig 11, 46010, Valencia, Spain.

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http://dx.doi.org/10.1007/s10038-008-0271-5DOI Listing
July 2008

A complex of catalytically inactive protein phosphatase-1 sandwiched between Sds22 and inhibitor-3.

Biochemistry 2007 Aug 14;46(31):8909-19. Epub 2007 Jul 14.

Laboratory of Biosignaling and Therapeutics, Department of Molecular Cell Biology, Faculty of Medicine, Catholic University of Leuven, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1021/bi7003119DOI Listing
August 2007

A conserved sequence immediately N-terminal to the Bateman domains in AMP-activated protein kinase gamma subunits is required for the interaction with the beta subunits.

J Biol Chem 2007 Jun 2;282(22):16117-25. Epub 2007 Apr 2.

Instituto de Biomedicina de Valencia, Consejo Superior de Investigaciones Científicas, Jaime Roig 11, 46010 Valencia, Spain.

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http://dx.doi.org/10.1074/jbc.M611804200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2156106PMC
June 2007

YPI1 and SDS22 proteins regulate the nuclear localization and function of yeast type 1 phosphatase Glc7.

J Biol Chem 2007 Feb 1;282(5):3282-92. Epub 2006 Dec 1.

Instituto de Biomedicina de Valencia, Consejo Superior de Investigaciones Científicas (CSIC), Jaime Roig 11, 46010 Valencia, Spain.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M607171200
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http://dx.doi.org/10.1074/jbc.M607171200DOI Listing
February 2007

Yeast as a model system to study glucose-mediated signalling and response.

Authors:
Pascual Sanz

Front Biosci 2007 Jan 1;12:2358-71. Epub 2007 Jan 1.

Instituto de Biomedicina de Valencia, CSIC, Jaime Roig 11, 46010-Valencia, Spain.

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http://dx.doi.org/10.2741/2238DOI Listing
January 2007

TRIP6 transcriptional co-activator is a novel substrate of AMP-activated protein kinase.

Cell Signal 2006 Oct 6;18(10):1702-12. Epub 2006 Mar 6.

Instituto de Biomedicina de Valencia CSIC, Jaime Roig 11, 46010-Valencia, Spain.

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http://dx.doi.org/10.1016/j.cellsig.2006.01.021DOI Listing
October 2006

Frataxin interacts functionally with mitochondrial electron transport chain proteins.

Hum Mol Genet 2005 Aug 16;14(15):2091-8. Epub 2005 Jun 16.

Department of Genomics and Proteomics, Instituto de Biomedicina, CSIC, C/Jaume Roig 11, 46010 Valencia, Spain.

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http://academic.oup.com/hmg/article/14/15/2091/551598/Fratax
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http://dx.doi.org/10.1093/hmg/ddi214DOI Listing
August 2005

TOR kinase pathway and 14-3-3 proteins regulate glucose-induced expression of HXT1, a yeast low-affinity glucose transporter.

Yeast 2005 Apr;22(6):471-9

Instituto de Biomedicina de Valencia (CSIC), Jaime Roig 11, 46010-Valencia, Spain.

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http://dx.doi.org/10.1002/yea.1224DOI Listing
April 2005

Severe persistent hyperinsulinemic hypoglycemia due to a de novo glucokinase mutation.

Diabetes 2004 Aug;53(8):2164-8

Hospital Carlos Haya Foundation and Department of Endocrinology, Diabetes and Nutrition of Carlos Haya University Hospital, Málaga, Spain.

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http://dx.doi.org/10.2337/diabetes.53.8.2164DOI Listing
August 2004

Expression of the HXT1 low affinity glucose transporter requires the coordinated activities of the HOG and glucose signalling pathways.

J Biol Chem 2004 May 10;279(21):22010-9. Epub 2004 Mar 10.

Instituto de Biomedicina de Valencia, Jaime Roig 11, 46010 Valencia, Spain.

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http://dx.doi.org/10.1074/jbc.M400609200DOI Listing
May 2004

Glucose and type 2A protein phosphatase regulate the interaction between catalytic and regulatory subunits of AMP-activated protein kinase.

J Mol Biol 2003 Oct;333(1):201-9

Instituto de Biomedicina de Valencia (CSIC), Jaime Roig 11, E-46010 Valencia, Spain.

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http://dx.doi.org/10.1016/j.jmb.2003.08.022DOI Listing
October 2003

Molecular characterization of Ypi1, a novel Saccharomyces cerevisiae type 1 protein phosphatase inhibitor.

J Biol Chem 2003 Nov 23;278(48):47744-52. Epub 2003 Sep 23.

Instituto de Biomedicina de Valencia Consejo Superior de Investigaciones Científicas, Jaime Roig 11, 46010-Valencia, Spain.

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http://dx.doi.org/10.1074/jbc.M306157200DOI Listing
November 2003

Saccharomyces cerevisiae 14-3-3 proteins Bmh1 and Bmh2 participate in the process of catabolite inactivation of maltose permease.

FEBS Lett 2003 Jun;544(1-3):160-4

Instituto de Biomedicina de Valencia (CSIC), Jaime Roig 11, Spain.

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http://dx.doi.org/10.1016/s0014-5793(03)00498-8DOI Listing
June 2003

New mutations of Saccharomyces cerevisiae that partially relieve both glucose and galactose repression activate the protein kinase Snf1.

FEMS Yeast Res 2003 Mar;3(1):77-84

Instituto de Investigaciones Biomédicas 'Alberto Sols' CSIC-UAM, Unidad de Bioquímica y Genética de Levaduras, C/Arturo Duperier 4, 28029, Madrid, Spain.

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http://dx.doi.org/10.1111/j.1567-1364.2003.tb00141.xDOI Listing
March 2003

Active Snf1 protein kinase inhibits expression of the Saccharomyces cerevisiae HXT1 glucose transporter gene.

Biochem J 2002 Dec;368(Pt 2):657-63

Instituto de Biomedicina de Valencia (CSIC), Jaime Roig 11, 46010-Valencia, Spain.

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http://dx.doi.org/10.1042/BJ20020984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1223017PMC
December 2002

Convergence of the target of rapamycin and the Snf1 protein kinase pathways in the regulation of the subcellular localization of Msn2, a transcriptional activator of STRE (Stress Response Element)-regulated genes.

J Biol Chem 2002 Sep 1;277(38):35650-6. Epub 2002 Jul 1.

Instituto de Biomedicina de Valencia (Consejo Superior Investigaciones Cientificas), Jaime Roig 11, 46010 Valencia, Spain.

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http://dx.doi.org/10.1074/jbc.M204198200DOI Listing
September 2002