Pascal Timshel

Pascal Timshel

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Pascal Timshel

Pascal Timshel

Publications by authors named "Pascal Timshel"

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Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences.

Nat Genet 2019 02 14;51(2):245-257. Epub 2019 Jan 14.

Department of Economics, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/s41588-018-0309-3DOI Listing
February 2019

Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.

Nat Genet 2018 07 23;50(8):1112-1121. Epub 2018 Jul 23.

National Bureau of Economic Research, Cambridge, MA, USA.

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http://www.nature.com/articles/s41588-018-0147-3
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http://dx.doi.org/10.1038/s41588-018-0147-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393768PMC
July 2018

Profiling of G protein-coupled receptors in vagal afferents reveals novel gut-to-brain sensing mechanisms.

Mol Metab 2018 06 3;12:62-75. Epub 2018 Apr 3.

Division of Hypothalamic Research and Department of Internal Medicine, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22128778183020
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http://dx.doi.org/10.1016/j.molmet.2018.03.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001940PMC
June 2018

Gq and Gs signaling acting in synergy to control GLP-1 secretion.

Mol Cell Endocrinol 2017 07 28;449:64-73. Epub 2016 Nov 28.

NNF Center for Basic Metabolic Research, Section for Metabolic Receptology, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen, Denmark; Laboratory for Molecular Pharmacology, Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2016.11.024DOI Listing
July 2017

GPR119, a Major Enteroendocrine Sensor of Dietary Triglyceride Metabolites Coacting in Synergy With FFA1 (GPR40).

Endocrinology 2016 Dec 25;157(12):4561-4569. Epub 2016 Oct 25.

NNF Center for Basic Metabolic Research (J.H.E., M.H., L.V.K., A.N.M., M.S.E., A.-S.H., R.S., K.L.E., B.H., T.W.S.), Section for Metabolic Receptology; Laboratory for Molecular Pharmacology (J.H.E., M.H., L.V.K., M.S.E., A.-S.H., R.S., K.L.E., B.H., T.W.S.), Department of Neuroscience and Pharmacology; and Danish Diabetes Academy (M.S.E.), 5000 Odense, Denmark; Novo Nordisk Foundation Center for Basic Metabolic Research (P.T.), Section for Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark; Merck Research Laboratories (T.J.K., A.D.H.), Kenilworth, New Jersey 07033; Cambridge Institute for Medical Research and MRC Metabolic Diseases Unit (F.M.G., F.R.), University of Cambridge, Cambridge, CB20QQ United Kingdom; Department of Drug Design and Pharmacology (H.S.H.), University of Copenhagen, DK-2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1210/en.2016-1334DOI Listing
December 2016

Genome-wide association study identifies 74 loci associated with educational attainment.

Authors:
Aysu Okbay Jonathan P Beauchamp Mark Alan Fontana James J Lee Tune H Pers Cornelius A Rietveld Patrick Turley Guo-Bo Chen Valur Emilsson S Fleur W Meddens Sven Oskarsson Joseph K Pickrell Kevin Thom Pascal Timshel Ronald de Vlaming Abdel Abdellaoui Tarunveer S Ahluwalia Jonas Bacelis Clemens Baumbach Gyda Bjornsdottir Johannes H Brandsma Maria Pina Concas Jaime Derringer Nicholas A Furlotte Tessel E Galesloot Giorgia Girotto Richa Gupta Leanne M Hall Sarah E Harris Edith Hofer Momoko Horikoshi Jennifer E Huffman Kadri Kaasik Ioanna P Kalafati Robert Karlsson Augustine Kong Jari Lahti Sven J van der Lee Christiaan deLeeuw Penelope A Lind Karl-Oskar Lindgren Tian Liu Massimo Mangino Jonathan Marten Evelin Mihailov Michael B Miller Peter J van der Most Christopher Oldmeadow Antony Payton Natalia Pervjakova Wouter J Peyrot Yong Qian Olli Raitakari Rico Rueedi Erika Salvi Börge Schmidt Katharina E Schraut Jianxin Shi Albert V Smith Raymond A Poot Beate St Pourcain Alexander Teumer Gudmar Thorleifsson Niek Verweij Dragana Vuckovic Juergen Wellmann Harm-Jan Westra Jingyun Yang Wei Zhao Zhihong Zhu Behrooz Z Alizadeh Najaf Amin Andrew Bakshi Sebastian E Baumeister Ginevra Biino Klaus Bønnelykke Patricia A Boyle Harry Campbell Francesco P Cappuccio Gail Davies Jan-Emmanuel De Neve Panos Deloukas Ilja Demuth Jun Ding Peter Eibich Lewin Eisele Niina Eklund David M Evans Jessica D Faul Mary F Feitosa Andreas J Forstner Ilaria Gandin Bjarni Gunnarsson Bjarni V Halldórsson Tamara B Harris Andrew C Heath Lynne J Hocking Elizabeth G Holliday Georg Homuth Michael A Horan Jouke-Jan Hottenga Philip L de Jager Peter K Joshi Astanand Jugessur Marika A Kaakinen Mika Kähönen Stavroula Kanoni Liisa Keltigangas-Järvinen Lambertus A L M Kiemeney Ivana Kolcic Seppo Koskinen Aldi T Kraja Martin Kroh Zoltan Kutalik Antti Latvala Lenore J Launer Maël P Lebreton Douglas F Levinson Paul Lichtenstein Peter Lichtner David C M Liewald Anu Loukola Pamela A Madden Reedik Mägi Tomi Mäki-Opas Riccardo E Marioni Pedro Marques-Vidal Gerardus A Meddens George McMahon Christa Meisinger Thomas Meitinger Yusplitri Milaneschi Lili Milani Grant W Montgomery Ronny Myhre Christopher P Nelson Dale R Nyholt William E R Ollier Aarno Palotie Lavinia Paternoster Nancy L Pedersen Katja E Petrovic David J Porteous Katri Räikkönen Susan M Ring Antonietta Robino Olga Rostapshova Igor Rudan Aldo Rustichini Veikko Salomaa Alan R Sanders Antti-Pekka Sarin Helena Schmidt Rodney J Scott Blair H Smith Jennifer A Smith Jan A Staessen Elisabeth Steinhagen-Thiessen Konstantin Strauch Antonio Terracciano Martin D Tobin Sheila Ulivi Simona Vaccargiu Lydia Quaye Frank J A van Rooij Cristina Venturini Anna A E Vinkhuyzen Uwe Völker Henry Völzke Judith M Vonk Diego Vozzi Johannes Waage Erin B Ware Gonneke Willemsen John R Attia David A Bennett Klaus Berger Lars Bertram Hans Bisgaard Dorret I Boomsma Ingrid B Borecki Ute Bültmann Christopher F Chabris Francesco Cucca Daniele Cusi Ian J Deary George V Dedoussis Cornelia M van Duijn Johan G Eriksson Barbara Franke Lude Franke Paolo Gasparini Pablo V Gejman Christian Gieger Hans-Jörgen Grabe Jacob Gratten Patrick J F Groenen Vilmundur Gudnason Pim van der Harst Caroline Hayward David A Hinds Wolfgang Hoffmann Elina Hyppönen William G Iacono Bo Jacobsson Marjo-Riitta Järvelin Karl-Heinz Jöckel Jaakko Kaprio Sharon L R Kardia Terho Lehtimäki Steven F Lehrer Patrik K E Magnusson Nicholas G Martin Matt McGue Andres Metspalu Neil Pendleton Brenda W J H Penninx Markus Perola Nicola Pirastu Mario Pirastu Ozren Polasek Danielle Posthuma Christine Power Michael A Province Nilesh J Samani David Schlessinger Reinhold Schmidt Thorkild I A Sørensen Tim D Spector Kari Stefansson Unnur Thorsteinsdottir A Roy Thurik Nicholas J Timpson Henning Tiemeier Joyce Y Tung André G Uitterlinden Veronique Vitart Peter Vollenweider David R Weir James F Wilson Alan F Wright Dalton C Conley Robert F Krueger George Davey Smith Albert Hofman David I Laibson Sarah E Medland Michelle N Meyer Jian Yang Magnus Johannesson Peter M Visscher Tõnu Esko Philipp D Koellinger David Cesarini Daniel J Benjamin

Nature 2016 05 11;533(7604):539-42. Epub 2016 May 11.

Center for Economic and Social Research, University of Southern California, Los Angeles, California 90089-3332, USA.

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http://dx.doi.org/10.1038/nature17671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4883595PMC
May 2016

Comprehensive analysis of schizophrenia-associated loci highlights ion channel pathways and biologically plausible candidate causal genes.

Hum Mol Genet 2016 Mar 10;25(6):1247-54. Epub 2016 Jan 10.

Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA 02115, USA, Medical and Population Genetics Program and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA

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http://dx.doi.org/10.1093/hmg/ddw007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764200PMC
March 2016

SNPsnap: a Web-based tool for identification and annotation of matched SNPs.

Bioinformatics 2015 Feb 13;31(3):418-20. Epub 2014 Oct 13.

Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA 02115, Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, MA 2142, USA, Department of Systems Biology, Center for Biological Sequence Analysis, Technical University of Denmark, 2800 Lyngby, Denmark and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA 02115, Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, MA 2142, USA, Department of Systems Biology, Center for Biological Sequence Analysis, Technical University of Denmark, 2800 Lyngby, Denmark and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA 02115, Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, MA 2142, USA, Department of Systems Biology, Center for Biological Sequence Analysis, Technical University of Denmark, 2800 Lyngby, Denmark and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1093/bioinformatics/btu655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308663PMC
February 2015