Publications by authors named "Pascal Chanez"

100Publications

Will the asthma revolution fostered by biologics also benefit adult ICU patients?

Allergy 2020 Dec 7. Epub 2020 Dec 7.

Aix Marseille Univ, APHM, Hôpital NORD, CIC 9502, Clinique des bronches allergies et sommeil, Chemin des Bourrely, 13015, Marseille, France.

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December 2020

Global Quality Standard for Identification and Management of Severe Asthma.

Adv Ther 2020 09 28;37(9):3645-3659. Epub 2020 Jul 28.

Royal Brompton and Harefield NHS Foundation Trust, London, UK.

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September 2020

Discordant courses of COVID-19 in a cohabiting couple of lung transplant recipients.

Transpl Infect Dis 2020 Jul 12:e13410. Epub 2020 Jul 12.

Microbes, Evolution, Phylogeny and Infection (MEΦI), Aix-Marseille Université UM63, Institut de Recherche pour le Développement IRD 198, Assistance Publique - Hôpitaux de Marseille (AP-HM), Marseille, France.

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July 2020

Letter from France.

Respirology 2020 07 8;25(7):766-768. Epub 2020 Jun 8.

Université de Montpellier, CHU Montpellier, PhyMedExp, INSERM, CNRS, Montpellier, France.

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July 2020

: Transcriptional Activity and HLA-E Mobilization.

Front Immunol 2019 17;10:2986. Epub 2020 Jan 17.

Aix-Marseille University, CNRS, EFS, ADES, "Biologie des Groupes Sanguins", Marseille, France.

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December 2020

Baseline blood eosinophil count as a predictor of treatment response to the licensed dose of mepolizumab in severe eosinophilic asthma.

Respir Med 2019 11 3;159:105806. Epub 2019 Nov 3.

Department of Allergy, Hospital La Paz Institute for Health Research (IdiPAZ), CIBER de Enfermedades Respiratorias CIBERES, Madrid, Spain. Electronic address:

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November 2019

Efficacy of Intravenous Reslizumab in Oral Corticosteroid-Dependent Asthma.

J Allergy Clin Immunol Pract 2020 02 15;8(2):555-564. Epub 2019 Oct 15.

Department of Respiratory Diseases, Aix-Marseille University, Marseille, France.

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February 2020

Relationship between gender and survival in a real-life cohort of patients with COPD.

Respir Res 2019 Aug 22;20(1):191. Epub 2019 Aug 22.

Respiratory and Intensive Care Medicine Department, Cochin Hospital, AP-HP and Paris Descartes University (EA 2511), Sorbonne Paris Cité, Paris, France.

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August 2019

Randomized controlled trials of pharmacological treatments to prevent COPD exacerbations: applicability to real-life patients.

BMC Pulm Med 2019 Jul 12;19(1):127. Epub 2019 Jul 12.

Clinique des bronches allergies et sommeil, Aix Marseille Univ, APHM, CIC 9502, 13015, Marseille, France.

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July 2019

COPD beyond proximal bronchial obstruction: phenotyping and related tools at the bedside.

Eur Respir Rev 2019 Jun 8;28(152). Epub 2019 Jul 8.

Clinique des Bronches, Allergies et Sommeil, Hôpital Nord, Assistance Publique des Hôpitaux de Marseille, Aix Marseille Université, Marseille, France

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June 2019

Bronchial Epithelial Calcium Metabolism Impairment in Smokers and Chronic Obstructive Pulmonary Disease. Decreased ORAI3 Signaling.

Am J Respir Cell Mol Biol 2019 10;61(4):501-511

Department of Respiratory Diseases and Addictology, Hôpital Arnaud de Villeneuve, Centre Hospitalier Universitaire Montpellier, Montpellier, France.

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October 2019

Adverse publicity of serious side effects to healthy volunteers has limited effect on willingness-to-participate in clinical trials.

Clin Trials 2019 08 29;16(4):440-442. Epub 2019 Mar 29.

3 Department of Respiratory Diseases, University of Montpellier, CHU Montpellier, Montpellier, France.

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August 2019

Randomised controlled trials in severe asthma: selection by phenotype or stereotype.

Eur Respir J 2019 02 7;53(2). Epub 2019 Feb 7.

Aix Marseille Univ, APHM, CIC 9502, Clinique des bronches, allergies et sommeil, Marseille, France.

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February 2019

Severe asthma treated by bronchial thermoplasty: A success not due to the small airways?

Respirology 2019 05 29;24(5):402-403. Epub 2019 Jan 29.

Université de Montpellier, PhyMedExp, INSERM, CNRS, CHU de Montpellier, Department of Respiratory Diseases, Montpellier, France.

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May 2019

Early decreases in blood eosinophil levels with reslizumab.

J Allergy Clin Immunol 2019 04 14;143(4):1653-1655. Epub 2019 Jan 14.

Allergy, Asthma, and Pulmonary Research, Boys Town National Research Hospital, Omaha, Neb.

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April 2019

KIT as a therapeutic target for non-oncological diseases.

Pharmacol Ther 2019 05 14;197:11-37. Epub 2018 Dec 14.

Aix Marseille Université, INSERM, INRA, C2VN, Marseille, France; Clinique des Bronches, Allergies et Sommeil, Hôpital Nord, AP-HM, Marseille, France. Electronic address:

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May 2019

Reply to Upham: The Bronchial Epithelial Secretory IgA System in Asthma.

Am J Respir Crit Care Med 2018 11;198(9):1236-1238

1 Université Catholique de Louvain Brussels, Belgium.

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November 2018

Bronchial Thermoplasty in Severe Asthma: Best Practice Recommendations from an Expert Panel.

Respiration 2018;95(5):289-300. Epub 2018 Apr 17.

MAHSC, University of Manchester and Manchester Foundation Trust, Manchester, United Kingdom.

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October 2018

Haplotypes Are Differentially Associated with Asthmatic Features.

Front Immunol 2018 23;9:278. Epub 2018 Feb 23.

UMR7268 Anthropologie bio-culturelle, Droit, Ethique et Santé (ADES), "Biologie des Groupes Sanguins", Aix Marseille Université, CNRS, Établissement Français du Sang (EFS), Marseille, France.

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March 2019

Asthma, COPD, and overlap in a national cohort: ACO on a gradient.

J Allergy Clin Immunol 2018 04 31;141(4):1516-1518. Epub 2018 Jan 31.

INSERM U 1046, Arnaud de Villeneuve Hospital, Crastes de Paulet Building, Montpellier, France; Department of Medical Information, Montpellier University Hospitals, La Colombière Hospital, Montpellier Cedex, France; Alexander Grothendieck Institut at Montpellier, CNRS, Montpellier University, Montpellier, France.

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April 2018

Mortality: a neglected outcome in OCS-treated severe asthma.

Eur Respir J 2017 11 30;50(5). Epub 2017 Nov 30.

Assistance Publique - Hôpitaux de Marseille, Clinique des bronches, allergies et sommeil, Hôpital Nord, Marseille, France

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November 2017

Lung development, regeneration and plasticity: From disease physiopathology to drug design using induced pluripotent stem cells.

Pharmacol Ther 2018 03 4;183:58-77. Epub 2017 Oct 4.

Department of Respiratory Diseases, Hôpital Arnaud de Villeneuve, Montpellier F34000, France; Université de MONTPELLIER, UFR de Médecine, Montpellier F34000, France; INSERM, U1046, PhyMedExp, Montpellier F34000, France. Electronic address:

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March 2018

Mepolizumab for Eosinophilic Chronic Obstructive Pulmonary Disease.

N Engl J Med 2017 10 11;377(17):1613-1629. Epub 2017 Sep 11.

From the Respiratory Medicine Unit and Oxford Respiratory Biomedical Research Centre, Nuffield Department of Medicine, University of Oxford, Oxford (I.D.P.), and Clinical Statistics, GlaxoSmithKline, Uxbridge (B.M.) - both in the United Kingdom; the Department of Respiratory Medicine and CIC Nord, Aix-Marseille University, Marseille, France (P.C.); the Department of Thoracic Medicine and Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia (G.J.C.); the Department of Pulmonary Medicine and Tuberculosis, University of Groningen and University Medical Center Groningen, Groningen, the Netherlands (H.A.M.K.); the Pulmonary Department, Mainz University Hospital, Mainz, Germany (S.K.); the Division of Pulmonary, Allergy, and Critical Care Medicine, Duke University, Durham (N.L.), and the Respiratory Medical Franchise (F.C.A.) and the Respiratory Therapeutic Area (E.S.B., S.S.H., D.B.R., S.W.Y.), GlaxoSmithKline, Research Triangle Park - all in North Carolina; the Department of Pneumology, Centre Hospitalier Universitaire-Université Catholique de Louvain, Namur, Namur, Belgium (J.-B.M.); the Division of Allergology and Respiratory Medicine, Showa University School of Medicine, Tokyo (H.S.); and the Department of Medicine, University of Pittsburgh, Pittsburgh (F.C.S.).

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October 2017

How effective is bronchial thermoplasty for severe asthma in clinical practice?

Eur Respir J 2017 08 31;50(2). Epub 2017 Aug 31.

Inserm U1067 and CNRS UMR7733, Dept of Respiratory Diseases, APHM Aix-Marseille University, Marseille, France.

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August 2017

Novel Treatments for Airway Disease.

N Engl J Med 2017 08;377(6):595-6

Aix Marseille Université, Marseille, France

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August 2017

Novel Treatments for Airway Disease

N Engl J Med 2017 08 10;377(6):595-6. Epub 2017 Aug 10.

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August 2017

Relationship between blood eosinophils, clinical characteristics, and mortality in patients with COPD.

Int J Chron Obstruct Pulmon Dis 2017 20;12:1819-1824. Epub 2017 Jun 20.

Respiratory and Intensive Care Medicine Dpt, Cochin Hospital, AP-HP and Paris Descartes University (EA2511), Sorbonne Paris Cité, Paris, France.

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April 2018

Managing asthma in the era of biological therapies.

Lancet Respir Med 2017 05 24;5(5):376-378. Epub 2017 Apr 24.

Département de Pneumologie et Addictologie-Hôpital Arnaud de Villeneuve-Montpellier, France; PhyMedExp, University of Montpellier, INSERM U1046, CNRS UMR 9214, Montpellier, France. Electronic address:

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May 2017

Severe eosinophilic asthma: a roadmap to consensus.

Eur Respir J 2017 05 1;49(5). Epub 2017 May 1.

Dept of Clinical and Experimental Sciences, University of Southampton, Southampton, UK

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May 2017

Cypress Pollinosis: from Tree to Clinic.

Clin Rev Allergy Immunol 2019 Apr;56(2):174-195

Armand Trousseau Children Hospital, AP-HP, Biochemistry Department, Allergy and Environment Research team, Paris, France.

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April 2019

Bronchial Epithelial Cells from Asthmatic Patients Display Less Functional HLA-G Isoform Expression.

Front Immunol 2017 23;8. Epub 2017 Jan 23.

Etablissement Français du Sang Alpes Méditerranée, Marseille, France; Aix-Marseille Univ, CNRS, EFS, ADES, "Biologie des Groupes Sanguins", Marseille, France.

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January 2017

Switch of noninvasive ventilation (NIV) to continuous positive airway pressure (CPAP) in patients with obesity hypoventilation syndrome: a pilot study.

BMC Pulm Med 2017 03 14;17(1):50. Epub 2017 Mar 14.

Clinique des Bronches, Allergies et du Sommeil, Assistance Publique Hôpitaux de Marseille, France et INSERM U1067, CNRS UMR 7333 Aix Marseille Université, 13015, Marseille, France.

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March 2017

A place for Apnea Hypopnea Index telemonitoring in preventing heart failure exacerbation?

Sleep Med 2017 01 5;29:18-19. Epub 2016 Nov 5.

Clinique des Bronches, Allergies et du Sommeil, Assistance Publique Hôpitaux de Marseille, France et INSERM U1067, CNRS UMR 7333 Aix Marseille Université, France.

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January 2017

Club cell secretory protein serum concentration is a surrogate marker of small-airway involvement in asthmatic patients.

J Allergy Clin Immunol 2017 08 17;140(2):581-584. Epub 2017 Jan 17.

Department of Respiratory Diseases, Montpellier University Hospital, Montpellier, France; PhyMedExp, University of Montpellier, INSERM U1046, Montpellier University Hospital, Montpellier, France; APARD: Association pour l'Assistance et la Réhabilitation à Domicile, Montpellier, France. Electronic address:

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August 2017

Rising total costs and mortality rates associated with admissions due to COPD exacerbations.

Respir Res 2016 11 14;17(1):149. Epub 2016 Nov 14.

PhyMedExp, University of Montpellier, INSERM U1046, CNRS UMR 9214, Montpellier hospital, Montpellier, France.

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November 2016

Effectiveness of bronchial thermoplasty in patients with severe refractory asthma: Clinical and histopathologic correlations.

J Allergy Clin Immunol 2017 Apr 5;139(4):1176-1185. Epub 2016 Sep 5.

Inserm UMR1152, Physiopathology and Epidemiology of Respiratory Diseases, Paris, France; Paris Diderot University, Faculty of Medicine, Bichat campus, Paris, France; Laboratory of Excellence, INFLAMEX, Université Sorbonne Paris Cité, and DHU FIRE, Paris, France; Department of Pneumology A, Bichat-Claude Bernard University Hospital, Paris, France; Assistance Publique des Hôpitaux de Paris, Paris, France. Electronic address:

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April 2017

Impact of current cough on health-related quality of life in patients with COPD.

Int J Chron Obstruct Pulmon Dis 2016 13;11:2091-2097. Epub 2016 Sep 13.

Department of Respiratory Diseases, Cochin Hospital, AP-HP and University Paris Descartes, Sorbonne Paris Cité, Paris.

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August 2017

New sociology for better understanding severe eosinophilic asthma: introducing the SOCS family.

Eur Respir J 2016 09;48(3):608-10

UMR INSERM 1067/CNRS 7333, Marseille, France Aix-Marseille Université, Marseille, France APHM (Assistance Publique Hôpitaux de Marseille), Clinique des Bronches, de l'Allergie et du Sommeil, Hôpital Nord, Marseille, France.

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September 2016

[How to consider triggers and comorbid conditions in severe asthma in adults].

Presse Med 2016 Nov 18;45(11):1030-1042. Epub 2016 Aug 18.

AP-HM, Aix-Marseille université, département des maladies respiratoires, UMR 7333 CNRS, Inserm U1067, 13015 Marseille, France. Electronic address:

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November 2016

Assessment of nanoparticles and metal exposure of airport workers using exhaled breath condensate.

J Breath Res 2016 07 13;10(3):036006. Epub 2016 Jul 13.

University of Grenoble Alpes, F-38000 France. Medical Biology Laboratory (LBM), NanoSafety Platform (SPNS), CEA, 17 rue des martyrs, F-38054 Grenoble, France.

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July 2016

Bronchial epithelium in children: a key player in asthma.

Eur Respir Rev 2016 Jun;25(140):158-69

UMR Inserm U1067 CNRS 7333, Aix Marseille University, Marseille, France.

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June 2016

The lung microbiome: the perfect culprit for COPD exacerbations?

Eur Respir J 2016 Apr;47(4):1034-6

Dept of Respiratory Diseases APHM, INSERM CNRS U 1067, UMR7333, Aix-Marseille University, Marseille France

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April 2016

Airway lipoxin A4/formyl peptide receptor 2-lipoxin receptor levels in pediatric patients with severe asthma.

J Allergy Clin Immunol 2016 06 11;137(6):1796-1806. Epub 2016 Mar 11.

Institute of Biomedicine and Molecular Immunology, Unit of Immunopathology and Pharmacology of the Respiratory System, Italian National Research Council, Palermo, Italy.

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June 2016

Asthma phenotypes and IgE responses.

Eur Respir J 2016 Jan 17;47(1):304-19. Epub 2015 Dec 17.

Institut de Recherche Expérimentale et Clinique, Pôle de Pneumologie, Université catholique de Louvain, Brussels and Walloon Institute for Excellence in Lifesciences and Biotechnology (WELBIO), Belgium Dept of Chest Medicine, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium

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January 2016

Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells.

Science 2015 Sep;349(6252):1106-10

Laboratory of Immunoregulation, VIB Inflammation Research Center, Ghent, Belgium. Department of Internal Medicine, Ghent University, Ghent, Belgium.

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September 2015

[Heroin makes asthma difficult and sometimes nearly fatal].

Presse Med 2015 Oct 31;44(10):1072-5. Epub 2015 Aug 31.

Clinique des bronches, allergies et du sommeil, Assistance Publique Hôpitaux de Marseille, Aix-Marseille université, Inserm 1067, CNRS UFR 7333, hôpital Nord, chemin des Bourrely, 13915 Marseille cedex 20, France.

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October 2015

Effects of Bronchial Thermoplasty on Airway Smooth Muscle and Collagen Deposition in Asthma.

Ann Am Thorac Soc 2015 Nov;12(11):1612-8

1 Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval, Québec, Québec, Canada; and.

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November 2015

Modified Medical Research Council scale vs Baseline Dyspnea Index to evaluate dyspnea in chronic obstructive pulmonary disease.

Int J Chron Obstruct Pulmon Dis 2015 18;10:1663-72. Epub 2015 Aug 18.

Service de Pneumologie, Groupe Hospitalier Cochin Broca Hotel Dieu, AP HP et Université René Descartes, Paris, France.

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April 2016

Hospitalizations for COPD Exacerbations: Trends and Determinants of Death.

COPD 2015 11;12(6):621-7. Epub 2015 Aug 11.

b INSERM U1046, Université Montpellier 1 et 2 , Hôpital Arnaud de Villeneuve, CHU Montpellier, France.

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September 2016

External Validity of Randomized Controlled Trials in Severe Asthma.

Am J Respir Crit Care Med 2015 Jul;192(2):259-61

1 Assistance Publique-Hôpitaux de Marseille Marseille, France.

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July 2015

Club cells and CC16: another "smoking gun"? (With potential bullets against COPD).

Eur Respir J 2015 Jun;45(6):1519-20

U1046 INSERM, UMR9214 CNRS, Montpellier University, Montpellier, France Dept of Respiratory Diseases, CHRU Montpellier, Montpellier, France

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June 2015

Omalizumab: a treatment for severe asthma in real life?

Rev Port Pneumol (2006) 2015 May-Jun;21(3):111-2

Département des Maladies Respiratoires, AP-HM, INSERM CNRS U 1067, UMR7733, Aix Marseille Université, Marseille, France. Electronic address:

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April 2016

Clinically relevant outcome measures for new therapies of asthma using pharmaceutical and biologic agents.

Curr Opin Allergy Clin Immunol 2015 Jun;15(3):213-9

aQuebec Heart and Lung Institute, Laval University, Québec City, Quebec, Canada bDépartement des Maladies Respiratoires APHM, Laboratoire INSERM CNRS U, 1067, UMR7333, Aix-Marseille University, Marseille, France.

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June 2015

We should prohibit warfarin in idiopathic pulmonary fibrosis.

Am J Respir Crit Care Med 2015 Apr;191(8):958-60

1 Aix Marseille Université Marseille, France.

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April 2015

Persistent severe hypereosinophilic asthma is not associated with airway remodeling.

Respir Med 2015 Feb 3;109(2):180-7. Epub 2015 Jan 3.

Department of Respiratory Disease, CHU Montpellier, Montpellier, France; INSERM U1046, Université Montpellier I et II, Montpellier, France. Electronic address:

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February 2015