Dr.  Partha Ray, PhD - UCSD - Assistant Adjunct Professor

Dr. Partha Ray

PhD

UCSD

Assistant Adjunct Professor

San Diego , CA | United States

Main Specialties: Other

Additional Specialties: Aptamer Therapeutics


Top Author

Dr.  Partha Ray, PhD - UCSD - Assistant Adjunct Professor

Dr. Partha Ray

PhD

Introduction

Primary Affiliation: UCSD - San Diego , CA , United States

Specialties:

Additional Specialties:

Research Interests:

Education

Dec 2016
Duke University
Senior Research Associate
Dec 2013
Duke University
Post Doctoral Associate
Sep 2008
Albert Einstein College of Medicine
Ph.D.

Publications

11Publications

135Reads

1968Profile Views

61PubMed Central Citations

A Syngeneic Pancreatic Cancer Mouse Model to Study the Effects of Irreversible Electroporation.

J Vis Exp 2018 06 8(136). Epub 2018 Jun 8.

Moores Cancer Center, University California San Diego;

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http://dx.doi.org/10.3791/57265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101643PMC
June 2018
17 Reads

Cell-SELEX Identifies a “Sticky” RNA Aptamer

Volume 2017 (2017), Article ID 4943072, 9 pages

Journal of Nucleic Acids

Cell-SELEX is performed to select for cell binding aptamers. We employed an additional selection pressure by using RNAse to remove surface-binding aptamers and select for cell-internalizing aptamers. A common RNA sequence was identified from independent cell-SELEX procedures against two different pancreatic cancer cell lines, indicating a strong selection pressure towards this sequence from the large pool of other available sequences present in the aptamer library. The aptamer is not specific for the pancreatic cancer cell lines, and a similar sequence motif is present in previously published internalizing aptamers. The identified sequence forms a structural motif that binds to a surface protein, which either is highly abundant or has strong affinity for the selected aptamer sequence. Deselecting (removing) this sequence during cell-SELEX may increase the probability of identifying aptamers against cell type-specific targets on the cell surface.

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January 2017
8 Reads

In Vivo Selection Against Human Colorectal Cancer Xenografts Identifies an Aptamer That Targets RNA Helicase Protein DHX9.

Mol Ther Nucleic Acids 2016 Apr 26;5:e315. Epub 2016 Apr 26.

Department of Surgery, University of California at San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.1038/mtna.2016.27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014527PMC
April 2016
25 Reads
7 Citations

Utilizing RNA aptamers for Biomarker Discovery in a Novel Cell Culture System for Hepatocellular Carcinoma

Journal of Surgical Research. 02/2014; 186(2):680. DOI: 10.1016/j.jss.2013.11.904

Journal of Surgical Research

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February 2014
8 Reads

Further characterization of the target of a potential aptamer biomarker for pancreatic cancer: cyclophilin B and its posttranslational modifications.

Nucleic Acid Ther 2013 Dec 23;23(6):435-42. Epub 2013 Oct 23.

Department of Surgery, Duke University School of Medicine , Durham, North Carolina.

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http://dx.doi.org/10.1089/nat.2013.0439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868381PMC
December 2013
17 Reads
2 Citations
2.890 Impact Factor

Application of aptamers for targeted therapeutics.

Arch Immunol Ther Exp (Warsz) 2013 Aug 7;61(4):255-71. Epub 2013 Apr 7.

Department of Surgery, Duke University Medical Center, DUMC Box 103035, Durham, NC 27710, USA.

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http://dx.doi.org/10.1007/s00005-013-0227-0DOI Listing
August 2013
12 Reads
10 Citations
3.180 Impact Factor

Aptamer-mediated delivery of chemotherapy to pancreatic cancer cells.

Nucleic Acid Ther 2012 Oct;22(5):295-305

Department of Surgery, Duke University School of Medicine, Durham, NC, USA.

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http://dx.doi.org/10.1089/nat.2012.0353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464421PMC
October 2012
8 Reads
13 Citations
2.890 Impact Factor

Comparing human pancreatic cell secretomes by in vitro aptamer selection identifies cyclophilin B as a candidate pancreatic cancer biomarker.

J Clin Invest 2012 May 9;122(5):1734-41. Epub 2012 Apr 9.

Department of Surgery, Duke University School of Medicine, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1172/JCI62385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3336995PMC
May 2012
14 Reads
13 Citations
13.215 Impact Factor

Aptamers for Targeted Drug Delivery

Pharmaceuticals 2010, 3, 1761-1778; doi:10.3390/ph3061761

Pharmaceuticals

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May 2010
9 Reads

The Saccharomyces cerevisiae 60 S ribosome biogenesis factor Tif6p is regulated by Hrr25p-mediated phosphorylation.

J Biol Chem 2008 Apr 5;283(15):9681-91. Epub 2008 Feb 5.

Department of Developmental and Molecular Biology, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1074/jbc.M710294200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442299PMC
April 2008
14 Reads
16 Citations
4.573 Impact Factor

Activation of S phase checkpoint by cigarette smoke extract in Schizosaccharomyces pombe.

Yeast 2005 Nov;22(15):1223-38

Dr B.C. Guha Centre for Genetic Engineering and Biotechnology, Department of Biochemistry, University of Calcutta, 35 B.C. Road, Kolkata 700019, India.

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http://dx.doi.org/10.1002/yea.1309DOI Listing
November 2005
28 Reads
1.634 Impact Factor

Top co-authors

Bruce A Sullenger
Bruce A Sullenger

Duke University Medical Center

4
Rebekah R White
Rebekah R White

Duke University Medical Center

4
Uttiya Basu
Uttiya Basu

College of Physicians and Surgeons

1
Romit Majumdar
Romit Majumdar

Albert Einstein College of Medicine of Yeshiva University

1
Andrew D Ellington
Andrew D Ellington

Institute for Cellular and Molecular Biology

1
Barbara Ramsay Shaw
Barbara Ramsay Shaw

Duke University

1
Emanuela Veras
Emanuela Veras

The University of Texas Medical School at Houston

1
Haiteng Deng
Haiteng Deng

MOE Key Laboratory of Bioinformatics

1