Publications by authors named "Parth Patel"

316 Publications

Telemedicine for Retinal Disease During the COVID-19 Pandemic: Survey of the Patient Perspective.

Ophthalmol Ther 2022 Aug 3. Epub 2022 Aug 3.

University Retina and Macula Associates, 6320 W 159th St suite A, Oak Forest, IL, 60452, USA.

Introduction: Amidst the COVID-19 pandemic, telemedicine has emerged as a safe and cost-effective alternative to traditional ophthalmology clinic visits. This study evaluated patient attitudes towards telemedicine at a full-service, retina-only practice to identify areas for growth in implementation.

Methods: A survey was distributed to established patients at University Retina and Macula Associates following the completion of a telemedicine encounter in July 2021. On a 5-point Likert scale, patients compared telemedicine to in-person visits for six domains: ability to ease COVID-related anxiety, efficiency, patient education, quality of care, fulfillment of personal needs, and convenience. Pearson's χ and Fisher's exact test were used to assess correlations between demographic factors and patient attitudes or preference towards telemedicine.

Results: Among 103 respondents, two-thirds (68.7%) preferred in-person compared to telemedicine encounters. Overall, patients had a neutral attitude towards telemedicine [mean Likert rating (SD) = 3.11/5 ± 0.82]. Questions assessing "patient education" and "telemedicine efficiency" received the greatest proportion of positive and negative responses, respectively. Positive attitudes were more frequent among patients with prior telemedicine experience (87.5%) compared to never-users (71.8%; p = 0.046). Patients ≥ 75 years old tended to negatively assess telemedicine regarding reduction of COVID-19-related anxiety, efficiency, patient education, and physician facetime (p < 0.05 for all). A positive but non-significant trend was observed between higher education level and positive attitude towards telemedicine (p = 0.18). Telehealth never-users more often negatively rated receiving adequate facetime with the physician virtually (54.7%) compared to prior users (25.6%; p = 0.004). Younger age, prior history of telemedicine use, and higher education level were associated with increased preference for telemedicine (p < 0.05 for all).

Conclusion: Our findings revealed hesitance remains among patients towards adoption of telemedicine. Targeting age-, experience-, and education-related barriers will be invaluable for increasing acceptance of this healthcare delivery model.
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http://dx.doi.org/10.1007/s40123-022-00555-2DOI Listing
August 2022

Sex Differences in the Impact of Aortic Valve Calcium Score on Mortality After Transcatheter Aortic Valve Replacement.

Circ Cardiovasc Imaging 2022 Aug 3:101161CIRCIMAGING122014034. Epub 2022 Aug 3.

Division of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL (A.E.S., N.S., A.C.M.-L., P.P., M.Y., P.P., C.L., D.A.).

Background: Transcatheter aortic valve replacement (TAVR) is now an approved alternative to surgical aortic valve replacement for the treatment of severe aortic stenosis. As the clinical adoption of TAVR expands, it remains important to identify predictors of mortality after TAVR. We aimed to evaluate the impact of sex differences in aortic valve calcium score (AVCS) on long-term mortality following TAVR in a large patient sample.

Methods: We included consecutive patients who successfully underwent TAVR for treatment of severe native aortic valve stenosis from June 2010 to May 2021 across all US Mayo Clinic sites with follow-up through July 2021. AVCS values were obtained from preoperative computed tomography of the chest. Additional clinical data were abstracted from medical records. Kaplan-Meier curves and Cox-proportional hazard regression models were employed to evaluate the effect of AVCS on long-term mortality.

Results: A total of 2543 patients were evaluated in the final analysis. Forty-one percent were women, median age was 82 years (Q1: 76, Q3: 86), 18.4% received a permanent pacemaker following TAVR, and 88.5% received a balloon expandable valve. We demonstrate an increase in mortality risk with higher AVCS after multivariable adjustment (<0.001). When stratified by sex, every 500-unit increase in AVCS was associated with a 7% increase in mortality risk among women (adjusted hazard ratio, 1.07 [95% CI, 1.02-1.12]) but not in men.

Conclusions: We demonstrate a notable sex difference in the association between AVCS and long-term mortality in a large TAVR patient sample. This study highlights the potential value of AVCS in preprocedural risk stratification, specifically among women undergoing TAVR. Additional studies are needed to validate this finding.
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http://dx.doi.org/10.1161/CIRCIMAGING.122.014034DOI Listing
August 2022

An Analysis of Ophthalmic Plastic and Reconstructive Surgery Fellowship Program Directors in the United States.

Cureus 2022 Jun 23;14(6):e26268. Epub 2022 Jun 23.

Ophthalmology, University of Texas Southwestern Medical Center, Dallas, USA.

Purpose This study aims to examine the demographic features, academic backgrounds, and scholarly achievements of ophthalmic plastic and reconstructive surgery (OPRS) fellowship program directors (PDs) in the United States. Methods In this cross-sectional analysis, publicly accessible sources were accessed in March 2022 to collate the demographic and academic profiles of PDs of American Society of Ophthalmic Plastic and Reconstructive Surgery (ASOPRS)-accredited OPRS fellowships. Differences by gender and program rank were assessed using the Mann-Whitney Utest. Results Fifty-four PDs were identified, the majority of whom were males (88.89% (n = 48)). The average age was 58.48 years. Of the PDs, 96.3% (n = 53) obtained a medical degree, and all completed residency training in the United States. In addition, 9.26% (n = 5) had another degree, either a Doctor of Philosophy (n = 3) or master's degree (n = 2). A substantial proportion of individuals completed medical school (20.37% (n = 11)), residency (20.37% (n = 11)), or fellowship (31.48% (n = 17)) at an institution affiliated with the program where they were PDs. The most common additional fellowship obtained was neuro-ophthalmology (16.67% (n = 9)). The average h-index was 19.30 (range, 0-60), average five-year h-index was 4.85 (range, 0-36), and average m-quotient was 0.63 (range, 0-2.22). A significant difference in the median five-year h-index was observed between females and males (7 (range, 3-36) versus 4 (range, 0-10); p= 0.038). Conclusions This analysis indicated that OPRS PDs in the United States were principally males with extensive scholarly productivity. As women remain underrepresented in OPRS, increased gender parity at this leadership position should be encouraged in order to expand the recruitment of women into the field.
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http://dx.doi.org/10.7759/cureus.26268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9312361PMC
June 2022

The A to E (ABCDE) Pit Crew Model: A Novel Approach to Team Based Care of Critical Patients in the Prehospital Setting.

Health Psychol Res 2022 28;10(3):36960. Epub 2022 Jul 28.

emergency medicine, University of Central Florida.

Background: This study aimed to evaluate the effectiveness of a Pit Crew intervention to improve team dynamics and time to performance of critical actions in a prehospital critical care scenario. The primary outcome was successful completion of critical actions and time to completion of these critical actions. Secondary outcomes included effectiveness of communication and overall team functioning.

Methods: The study was conducted with a fire-based Emergency Medical Services (EMS) system with 233 paramedics and 115 Emergency Medical Technicians (EMT). Eight EMS crews comprised of five members each were randomly selected and assigned to either the intervention or the control group. The intervention group (n=20) watched a thirty-minute video prior to the training describing the "Pit Crew Approach;" the control group (n=20) did not watch the video. Each crew was given the same simulation scenario of a pediatric patient that had overdosed on a beta-blocker. Completion of predetermined critical tasks were noted and timestamped. A survey was administered to the participants following the training to assess team dynamics and level of confidence.

Results: Three outcomes were statistically significant between the two arms: The interventional group felt they themselves had a more defined role in the resuscitation in comparison to the non-interventional group (p= 0.021). The interventional group also felt that their team members had a clearer and more defined role than the nonintervention group (p= 0.018). The interventional group also felt more confident managing a beta blocker overdose than the nonintervention group (p.007). The only statistically significant secondary outcome finding was in scene departure decision: the interventional arm spent more time on-scene (p=0.031). Of note, the non-intervention group missed performing tasks more often than the interventional group and team leaders of these groups often performed task(s) while also directing the patient care.

Conclusion: The Pit Crew model was developed to optimize communication and team function. Our data identified that a formal instruction of the pit crew approach to a critical care scenario improved comfort in patient care. Future studies are needed evaluate other methods of training and the effects of continued formal pit-crew training over time.
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http://dx.doi.org/10.52965/001c.36960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9334154PMC
July 2022

Surface modifications of gold nanoparticles: stabilization and recent applications in cancer therapy.

Pharm Dev Technol 2022 Jul 29:1-19. Epub 2022 Jul 29.

Institute of Pharmacy, Nirma University, Ahmedabad, India.

Gold nanoparticles (GNPs) are noble metal nanocarriers that have been recently researched upon for pharmaceutical applications, imaging, and diagnosis. These metallic nanocarriers are easy to synthesize using chemical reduction techniques as their surface can be easily modified. Also, the properties of GNP are significantly affected by its size and shape which mandates its stabilization using suitable techniques of surface modification. Over the past decade, research has focused on surface modification of GNP and its stabilization using polymers, polysaccharides, proteins, dendrimers, and phase-stabilizers like gel phase or ionic liquid phase. The use of GNP for pharmaceutical applications requires its surface modification using biocompatible and inert surface modifiers. The stabilizers used, interact with the surface of GNP to provide either electrostatic stabilization or steric stabilization. This review extensively discusses the surface modification techniques for GNP and the related molecular level interactions involved in the same. The influence of various factors like the concentration of stabilizers used, their characteristics like chain length and thickness, pH of the surrounding media, etc., on the surface of GNP resulting in stability have been discussed in detail. Further, this review highlights the recent applications of surface-modified GNP in the management of tumor microenvironment and cancer therapy.
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http://dx.doi.org/10.1080/10837450.2022.2103825DOI Listing
July 2022

A Dorsal Epidural Herniated Disc Fragment Initially Presenting as Guillain-Barré Syndrome.

Cureus 2022 Jun 7;14(6):e25719. Epub 2022 Jun 7.

Neurology, Mercy Hospital, Catholic Health, Rockville Centre, USA.

Guillain-Barré syndrome (GBS) is a rare autoimmune disorder that presents with neurological symptoms that can mimic other conditions. This mimicry can hide other important neurological diagnoses. Here, we present a rare case of thoracic myelopathy secondary to a sequestered dorsal epidural herniated disc fragment that initially presented with the classic findings of GBS. A 58-year-old female presented with progressing bilateral lower extremity weakness, paresthesias, and absent bilateral lower extremity deep tendon reflexes. Lumbar magnetic resonance imaging (MRI) findings were disproportionate to presentation, and lumbar puncture fluid analysis revealed clear, colorless fluid with albuminocytological dissociation. The patient was diagnosed with GBS and treated with a short course of intravenous steroids followed by intravenous immunoglobulin. The patient later developed new-onset ulnar distribution paresthesias, lower extremity spasticity, constipation, and urinary retention that caused a decline in functional progress. Further investigation prompted evaluation with cervical and thoracic MRIs, which revealed a left dorsal epidural lesion at the T9-T10 level causing severe cord compression. The patient was definitively treated with a T9-T10 laminectomy and excision of the offending lesion. Pathology revealed collagenous tissue with fibroblastic proliferation, consistent with a sequestered fragment of the herniated intervertebral disc. The patient was further treated with both acute and subacute rehabilitation. She was eventually discharged home and was able to ambulate independently with a walker. Dependency on positive albuminocytological dissociation in cases of potential GBS can lead to errors in diagnostic accuracy and delay appropriate treatment. Clinicians should remain mindful that GBS is a diagnosis of exclusion and MRI of the entire spine should be considered when the diagnosis of GBS is uncertain.
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http://dx.doi.org/10.7759/cureus.25719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261972PMC
June 2022

Spontaneous Coronary Artery Dissection and Its Management: A Case Report.

Cureus 2022 May 30;14(5):e25474. Epub 2022 May 30.

Department of Cardiothoracic Surgery, Flowers Medical Group, Dothan, USA.

We illustrate a notable case of an elderly male presenting to a community hospital with six out of 10 substernal chest discomfort and electrocardiogram changes consistent with an anterolateral myocardial infarction. Percutaneous Coronary Intervention (PCI) was initiated following aspirin and anticoagulation administration, which further revealed a critical distal left main spontaneous coronary artery dissection (SCAD). Cardiothoracic and Vascular Surgery consults led to the recommendation of emergent two-vessel Coronary Artery Bypass Grafting (CABG). The patient's clinical status resolved to full recovery and was discharged on postoperative day five. The incidence of SCAD in older men has not been well documented in current literature. Prevalence in older males is 0.02%. However, it rises to 10.8% in females less than 50 years of age and with acute coronary syndromes (ACS) and ST-segment elevation. Our aim is to incorporate this case report into the current literature and help improve early diagnosis and treatment based on current recommendations.
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http://dx.doi.org/10.7759/cureus.25474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246454PMC
May 2022

Risk of Hepatocellular Carcinoma in Patients with Various HFE Genotypes.

Dig Dis Sci 2022 Jul 5. Epub 2022 Jul 5.

Section of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine, Houston, USA.

Background And Aims: Hereditary hemochromatosis (HH) is associated with increased risk of hepatocellular carcinoma (HCC). However, HCC risk factors within this population and across various HFE genotypes remain unclear.

Methods: We conducted a retrospective cohort study of patients with ≥ 1 HFE genotype test in the Veterans Health Administration. We followed patients until HCC, death, or 6/30/19. We calculated incidence rates (IRs) and used Cox proportional hazards models to estimate HCC risk. In patients with type-1 HH genotypes (C282Y/C282Y or C282Y/H63D), we examined risk factors for HCC.

Results: We identified 5225 patients: 260 were C282Y/C282Y; 227 were C282Y/H63D; 436 were H63D heterozygous; 535 had other HFE mutations; 3767 without mutation. IR for C282Y/C282Y homozygotes (5.59/1000 PYs) and C282Y/H63D compound heterozygotes (4.12/1000 PYs) were significantly higher than controls (0.92/1000 PYs) with adjusted hazard ratio (adj HR), 95% CI 8.80, 4.17-18.54; and 5.25, 2.24-12.32, respectively. HCC risk was higher in H63D heterozygote than controls (adj HR = 2.82, 95% CI 1.21-6.58); cases were related to non-alcoholic fatty liver disease. Among patients with HH, age ≥ 65 (adj HR = 2.2, 95% CI 0.47-10.27), diabetes (adj HR 3.74, 95% CI 1.25-11.20) and high baseline aspartate-aminotransferase to platelet ratio-index (APRI, adj HR = 3.91, 95% CI 1.29-11.89) had higher risk. Among patients with high baseline ferritin, persistent ferritin > 250 ng/mL had higher risk.

Conclusion: HCC risk was high in C282Y homozygous and C282Y/H63D patients. These HFE genotypes, older age, diabetes, high APRI/ferritin levels were associated with increased risk. While H63D heterozygous genotype was associated with HCC risk, this association might be due to metabolic factors.
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http://dx.doi.org/10.1007/s10620-022-07602-9DOI Listing
July 2022

Migrants' primary care utilisation before and during the COVID-19 pandemic in England: An interrupted time series analysis.

Lancet Reg Health Eur 2022 Sep 30;20:100455. Epub 2022 Jun 30.

Institute of Health Informatics, University College London, 222 Euston Rd, London NW1 2DA, United Kingdom.

Background: How international migrants access and use primary care in England is poorly understood. We aimed to compare primary care consultation rates between international migrants and non-migrants in England before and during the COVID-19 pandemic (2015-2020).

Methods: Using data from the Clinical Practice Research Datalink (CPRD) GOLD, we identified migrants using country-of-birth, visa-status or other codes indicating international migration. We linked CPRD to Office for National Statistics deprivation data and ran a controlled interrupted time series (ITS) using negative binomial regression to compare rates before and during the pandemic.

Findings: In 262,644 individuals, pre-pandemic consultation rates per person-year were 4.35 (4.34-4.36) for migrants and 4.60 (4.59-4.60) for non-migrants (RR:0.94 [0.92-0.96]). Between 29 March and 26 December 2020, rates reduced to 3.54 (3.52-3.57) for migrants and 4.2 (4.17-4.23) for non-migrants (RR:0.84 [0.8-0.88]). The first year of the pandemic was associated with a widening of the gap in consultation rates between migrants and non-migrants to 0.89 (95% CI 0.84-0.94) times the ratio before the pandemic. This widening in ratios was greater for children, individuals whose first language was not English, and individuals of White British, White non-British and Black/African/Caribbean/Black British ethnicities. It was also greater in the case of telephone consultations, particularly in London.

Interpretation: Migrants were less likely to use primary care than non-migrants before the pandemic and the first year of the pandemic exacerbated this difference. As GP practices retain remote and hybrid models of service delivery, they must improve services and ensure primary care is accessible and responsive to migrants' healthcare needs.

Funding: This study was funded by the Medical Research Council (MC_PC 19070 and MR/V028375/1) and a Wellcome Clinical Research Career Development Fellowship (206602).
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http://dx.doi.org/10.1016/j.lanepe.2022.100455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243519PMC
September 2022

Altmetric Analysis of the Most Mentioned Articles Online in Plastic Surgery.

Aesthet Surg J 2022 Jul 5. Epub 2022 Jul 5.

Hansjörg Wyss Department of Plastic Surgery, NYU Langone Health, New York, NY, USA.

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http://dx.doi.org/10.1093/asj/sjac186DOI Listing
July 2022

Smartphone Addiction among Students and Its Harmful Effects on Mental Health, Oxidative Stress, and Neurodegeneration towards Future Modulation of Anti-Addiction Therapies: A Comprehensive Survey Based on SLR, Research Questions, and Network Visualization Techniques.

CNS Neurol Disord Drug Targets 2022 Jun 14. Epub 2022 Jun 14.

IoT Research Center, College of Computer Science and Software Engineering, Shenzhen University, Shenzhen, Guangdong 518060, China.

Background: Addiction is always harmful to the human body. Smartphone addiction also affects students' mental and physical health.

Aim: This study aims to determine the research volume conducted on students who are affected by smartphone addiction and design a database. We intended to highlight critical problems for future research. In addition, this paper enterprises a comprehensive and opinion-based image of the smartphone-addicted students.

Methodology: We used two types of systematic literature review and research questions and Scopus database to complete this study. We found 27 research articles and 11885 subjects (mean ±SD: 440.185 ±513.580) using the PRISMA technique in this study. Additionally, we have deeply investigated evidence to retrieve the current understanding of smartphone addiction from physical changes, mental changes, behavioral changes, impact on performance, and significant concepts. Furthermore, the effect of this addiction has been linked to cancers, oxidative stress, and neurodegenerative disorders.

Results: This work has also revealed the future direction and research gap on smartphone addiction among students and has also tried to provide goals for upcoming research to be accomplished more significantly and scientifically.

Conclusion: This study suggests future analysis towards identifying novel molecules and pathways for the treatment and decreasing the severity of mobile addiction.
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http://dx.doi.org/10.2174/1871527321666220614121439DOI Listing
June 2022

Predictive Value of Voiding Efficiency After Active Void Trial in Men Undergoing BPH Surgery.

Urology 2022 Jun 10. Epub 2022 Jun 10.

Department of Urology, David Geffen School of Medicine, University of California, Los Angeles, CA.

Objectives: To determine the predictive value of voiding efficiency on acute urinary retention after discharge from BPH surgery.

Materials And Methods: We performed a prospective observational cohort study of three surgeons' practices from 2019 to present. All men included underwent trial of void on post-operative day one after transurethral resection of prostate or Holmium enucleation of prostate . Active filling void trials were performed on all patients and voiding efficiency (percent of bladder volume emptied) was calculated. Multivariable logistic regression was performed to determine predictors of developing acute urinary retention.

Results: During the study period, 188 men met inclusion criteria. 110 (59%) men underwent Holmium enucleation of prostate , and 78 (41%) underwent transurethral resection of prostate. The median age of our cohort was 70 (IQR 65-75). The median prostate size was 100g (IQR 61-138g). Nineteen patients (10%) returned after discharge with acute urinary retention requiring catheterization. On post-operative day one, the median voiding efficiency was 75% (IQR 55%-94%). On multivariable analysis, patients with a voiding efficiency less than 50% were 3.8 times more likely (95% confidence interval 1.1-12.8) to develop subsequent retention compared to a voiding efficiency of greater than 75%. Increasing pre-operative prostate size was associated with lower risk of urinary retention after discharge (aOR 0.8, 95%CI 0.6-0.9).

Conclusions: Voiding efficiency after an active void trial helps stratify risk of urinary retention in patients undergoing benign prostate surgery. High-risk patients include those with voiding efficiencies less than 50% and smaller pre-operative prostate sizes (<80g).
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http://dx.doi.org/10.1016/j.urology.2022.05.035DOI Listing
June 2022

The Relative Citation Ratio: A Brief Primer on the National institutes of Health-Supported Bibliometric.

Semin Ophthalmol 2022 07 13;37(5):539-540. Epub 2022 Jun 13.

L.V. Prasad Eye Institute, Road No 2, Banjara Hills, Hyderabad 500034, India.

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http://dx.doi.org/10.1080/08820538.2022.2088981DOI Listing
July 2022

Quantitative CT and machine learning classification of fibrotic interstitial lung diseases.

Eur Radiol 2022 Jun 9. Epub 2022 Jun 9.

Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

Objectives: To evaluate quantitative computed tomography (QCT) features and QCT feature-based machine learning (ML) models in classifying interstitial lung diseases (ILDs). To compare QCT-ML and deep learning (DL) models' performance.

Methods: We retrospectively identified 1085 patients with pathologically proven usual interstitial pneumonitis (UIP), nonspecific interstitial pneumonitis (NSIP), and chronic hypersensitivity pneumonitis (CHP) who underwent peri-biopsy chest CT. Kruskal-Wallis test evaluated QCT feature associations with each ILD. QCT features, patient demographics, and pulmonary function test (PFT) results trained eXtreme Gradient Boosting (training/validation set n = 911) yielding 3 models: M1 = QCT features only; M2 = M1 plus age and sex; M3 = M2 plus PFT results. A DL model was also developed. ML and DL model areas under the receiver operating characteristic curve (AUC) and 95% confidence intervals (CIs) were compared for multiclass (UIP vs. NSIP vs. CHP) and binary (UIP vs. non-UIP) classification performances.

Results: The majority (69/78 [88%]) of QCT features successfully differentiated the 3 ILDs (adjusted p ≤ 0.05). All QCT-ML models achieved higher AUC than the DL model (multiclass AUC micro-averages 0.910, 0.910, 0.925, and 0.798 and macro-averages 0.895, 0.893, 0.925, and 0.779 for M1, M2, M3, and DL respectively; binary AUC 0.880, 0.899, 0.898, and 0.869 for M1, M2, M3, and DL respectively). M3 demonstrated statistically significant better performance compared to M2 (∆AUC: 0.015, CI: [0.002, 0.029]) for multiclass prediction.

Conclusions: QCT features successfully differentiated pathologically proven UIP, NSIP, and CHP. While QCT-based ML models outperformed a DL model for classifying ILDs, further investigations are warranted to determine if QCT-ML, DL, or a combination will be superior in ILD classification.

Key Points: • Quantitative CT features successfully differentiated pathologically proven UIP, NSIP, and CHP. • Our quantitative CT-based machine learning models demonstrated high performance in classifying UIP, NSIP, and CHP histopathology, outperforming a deep learning model. • While our quantitative CT-based machine learning models performed better than a DL model, additional investigations are needed to determine whether either or a combination of both approaches delivers superior diagnostic performance.
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http://dx.doi.org/10.1007/s00330-022-08875-4DOI Listing
June 2022

Open-Form Configurational Isomers of a Tricyanofuran-Type Metastable-State Photoacid.

ACS Omega 2022 May 18;7(21):17538-17543. Epub 2022 May 18.

Department of Chemistry, University of Central Florida, Orlando, Florida 32816, United States.

We determine the presence of four open-form configurational isomers for an unsubstituted metastable-state photoacid (mPAH) of the tricyanofuran (TCF) type in solution, at room temperature, via 2D NMR experiments. Electronic structure calculations are carried out to predict the relative stability of the isomers found experimentally and their isomerization barriers. According to the calculated rate constants for isomerization, the molecule can freely interconvert between the open-form isomers, thereby providing a thermal pathway between the isomers that might be better suited to access the cyclized closed-form configuration and those that are not. In establishing the open form isomeric makeup of the TCF mPAH under study, this work establishes the need to consider the four isomers in further studies on the thermal and excited-state isomerization processes and substituent effect thereon.
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http://dx.doi.org/10.1021/acsomega.1c06623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9161401PMC
May 2022

Trends and Distribution of Political Contributions from Ophthalmologists in the United States.

Ophthalmic Epidemiol 2022 Jun 1:1-4. Epub 2022 Jun 1.

Department of Ophthalmology, Loma Linda University Medical Center, Loma Linda, California, USA.

Purpose: To describe the magnitude, party affiliation, temporal trend, and geographic distribution of political contributions made by ophthalmologists in the United States.

Methods: This cross-sectional study used public finance data from the Federal Election Commission website to identify political donations from ophthalmologists between 2003-2019. Contributions were filtered for occupation lines matching either "ophthalmologist," or "eye surgeon," and each contribution was cross-referenced to catalogue donations as "Republican," "Democratic," or "Independent."

Results: From 2003-2019, a total of 31,855 political donations were made by self-identified ophthalmologists, totaling $11,603,672. Of all dollars, 10.7%, 19.5%, and 69.8% went to Democratic, Republican, and Independent committees, respectively. Political contributions directed towards the American Academy of Ophthalmology Political Action Committee (OPHTHPAC) constituted the majority (59.8%) of overall contributions. From 2003 to 2019, the total number of unique contributions increased significantly from 1135 to 3208 (? = 0.63; P < .01). In dollars, this translated to an increase from $482,300 donated in 2003 to $640,695 donated in 2019, although this trend was non-significant (? = 0.18; P = .48). Conversely, the average amount of each contribution significantly declined from $425 to $203 (? = -0.35; P < .001). As expected, larger states such as California, Texas, Florida, Illinois, Michigan, and New York had the highest contribution dollars, in that order.

Conclusions: Political contributions from ophthalmologists have significantly risen since 2003, however there remain opportunities for growth in engagement with OPHTHPAC. Future analysis of how this involvement translates to representative health policy is warranted.
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http://dx.doi.org/10.1080/09286586.2022.2084117DOI Listing
June 2022

The evolutionary history of small RNAs in Solanaceae.

Plant Physiol 2022 06;189(2):644-665

Donald Danforth Plant Science Center, St. Louis, Missouri 63132, USA.

The Solanaceae or "nightshade" family is an economically important group with remarkable diversity. To gain a better understanding of how the unique biology of the Solanaceae relates to the family's small RNA (sRNA) genomic landscape, we downloaded over 255 publicly available sRNA data sets that comprise over 2.6 billion reads of sequence data. We applied a suite of computational tools to predict and annotate two major sRNA classes: (1) microRNAs (miRNAs), typically 20- to 22-nucleotide (nt) RNAs generated from a hairpin precursor and functioning in gene silencing and (2) short interfering RNAs (siRNAs), including 24-nt heterochromatic siRNAs typically functioning to repress repetitive regions of the genome via RNA-directed DNA methylation, as well as secondary phased siRNAs and trans-acting siRNAs generated via miRNA-directed cleavage of a polymerase II-derived RNA precursor. Our analyses described thousands of sRNA loci, including poorly understood clusters of 22-nt siRNAs that accumulate during viral infection. The birth, death, expansion, and contraction of these sRNA loci are dynamic evolutionary processes that characterize the Solanaceae family. These analyses indicate that individuals within the same genus share similar sRNA landscapes, whereas comparisons between distinct genera within the Solanaceae reveal relatively few commonalities.
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http://dx.doi.org/10.1093/plphys/kiac089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9157080PMC
June 2022

Using Intraoperative Portable CT Scan to Minimize Reintervention Rates in PCNL: A Prospective Trial.

J Endourol 2022 May 27. Epub 2022 May 27.

Loyola University Medical Center, 25815, Urology, Maywood, Illinois, United States;

Background And Purpose: More than 40% of patients undergoing PCNL are left with residual stone fragments and often require secondary procedures. Portable CT (PCT) technology allows surgeons to obtain intraoperative cross-sectional imaging, identify and extract residual stones immediately, and thereby reduce the need for subsequent procedures. This prospective trial evaluates how incorporation of PCT during PCNL affects perioperative outcomes.

Patients And Methods: We prospectively enrolled eligible patients undergoing initial PCNL for this trial (n=60), which entailed a single intraoperative CT-abdomen and ipsilateral antegrade ureteroscopy when the surgeon felt stone treatment was visually complete. If residual fragments were identified, the surgeon continued nephroscopy to find and remove them; if not, the procedure was concluded. These patients were compared to a retrospective cohort (n=174) who underwent initial PCNL with post-operative imaging performed the following day.

Results: The two cohorts had similar demographic properties and stone characteristics, and location of percutaneous access. In the prospective arm, 50% of intraoperative PCT scans identified residual fragments, prompting continuation of surgery to remove them. This cohort had significantly higher stone-free rate (82% vs. 36%, p<0.01), lower rate of planned reintervention (7% vs. 32%, p<0.01), lower rate of urgent presentation with ureteral obstruction (0% vs. 7%, p=0.04), lower total CT-based effective radiation dose (8.4 vs. 14.6 mSv, p<0.01), and shorter length of stay (2.3 vs. 3.5 days, p<0.01) when compared to the retrospective cohort that did not use intraoperative PCT.

Conclusions: Obtaining an intraoperative portable CT scan during PCNL can substantially improve perioperative outcomes. Further evaluation of this modality through a randomized-controlled trial is warranted.
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http://dx.doi.org/10.1089/end.2022.0049DOI Listing
May 2022

Bibliometric analysis of the 100 most-disruptive articles in ophthalmology.

Clin Exp Ophthalmol 2022 Aug 28;50(6):690-695. Epub 2022 May 28.

Gavin Herbert Eye Institute, University of California, Irvine, California, USA.

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http://dx.doi.org/10.1111/ceo.14109DOI Listing
August 2022

Controlled assembly of cobalt embedded N-doped graphene nanosheets ([email protected]) by pyrolysis of a mixed ligand Co(ii) MOF as a sacrificial template for high-performance electrocatalysts.

RSC Adv 2021 Jun 15;11(34):21179-21188. Epub 2021 Jun 15.

Analytical and Environmental Science Division and Centralized Instrument Facility, CSIR - Central Salt and Marine Chemicals Research Institute G. B. Marg Bhavnagar-364 002 Gujarat India

The development of high-efficiency and durable bifunctional electrocatalysts is an important and challenging topic in the area of energy storage/conversion. Herein, we prepared metallic cobalt nanoparticle decorated N-doped graphitic sheets ([email protected]) by adopting facile pyrolysis of a mixed ligand cobalt-based MOF (CoMOF-2) as a sacrificial template displaying good OER and HER activity. The catalytic material harvested at three different pyrolytic temperatures was characterized by various analytical methods such as PXRD, SEM, TEM, Raman, and XPS analyses. The catalytic activity of the obtained hybrid composite materials towards oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) was studied. [email protected] was found to be an efficient bifunctional electrocatalyst and 10 mA cm current density was afforded at an overpotential of 390 mV for OER and 340 mV for HER respectively. This study provides insight for the development of cost-effective nonprecious element-based electrocatalysts for water splitting which has relevance in energy storage and conversion. Catalytic performance is governed by the synergistic compositional effect of metallic cobalt/nitrogen-doping in the graphitic carbon increasing the electrical conductivity/active sites of the composite material.
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http://dx.doi.org/10.1039/d1ra03691bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9034053PMC
June 2021

Workplace contact patterns in England during the COVID-19 pandemic: Analysis of the Virus Watch prospective cohort study.

Lancet Reg Health Eur 2022 May 22;16:100352. Epub 2022 Apr 22.

Institute of Epidemiology and Health Care, University College London, London WC1E 7HB, UK.

Background: Workplaces are an important potential source of SARS-CoV-2 exposure; however, investigation into workplace contact patterns is lacking. This study aimed to investigate how workplace attendance and features of contact varied between occupations across the COVID-19 pandemic in England.

Methods: Data were obtained from electronic contact diaries (November 2020-November 2021) submitted by employed/self-employed prospective cohort study participants (=4,616). We used mixed models to investigate the effects of occupation and time for: workplace attendance, number of people sharing workspace, time spent sharing workspace, number of close contacts, and usage of face coverings.

Findings: Workplace attendance and contact patterns varied across occupations and time. The predicted probability of intense space sharing during the day was highest for healthcare (78% [95% CI: 75-81%]) and education workers (64% [59%-69%]), who also had the highest probabilities for larger numbers of close contacts (36% [32%-40%] and 38% [33%-43%] respectively). Education workers also demonstrated relatively low predicted probability (51% [44%-57%]) of wearing a face covering during close contact. Across all occupational groups, workspace sharing and close contact increased and usage of face coverings decreased during phases of less stringent restrictions.

Interpretation: Major variations in workplace contact patterns and mask use likely contribute to differential COVID-19 risk. Patterns of variation by occupation and restriction phase may inform interventions for future waves of COVID-19 or other respiratory epidemics. Across occupations, increasing workplace contact and reduced face covering usage is concerning given ongoing high levels of community transmission and emergence of variants.

Funding: Medical Research Council; HM Government; Wellcome Trust.
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http://dx.doi.org/10.1016/j.lanepe.2022.100352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023315PMC
May 2022

Optimal brain protection in aortic arch surgery.

Indian J Thorac Cardiovasc Surg 2022 Apr 29;38(Suppl 1):36-43. Epub 2021 Jul 29.

Division of Cardiovascular and Thoracic Surgery, Department of Surgery, Duke University Medical Center, Duke University, 2301 Erwin Road, 8660 HAFS Building, Durham, NC 27710 USA.

There is considerable debate with regard to the optimal cerebral protection strategy during aortic arch surgery. There are three contemporary techniques in use which include straight deep hypothermic circulatory arrest (DHCA), DHCA with retrograde cerebral perfusion (DHCA + RCP), and moderate hypothermic circulatory arrest with antegrade cerebral perfusion (MHCA + ACP). Appropriate application of these methods ensures appropriate cerebral, myocardial, and visceral protection. Each of these techniques has benefits and drawbacks and ensuring coordinated circulation management strategy is critical to safe performance of aortic arch surgery. In this report, we will review various cannulation strategies, review logistics of hypothermia, and review the relevant literature to outline the strengths and weaknesses of these various cerebral protection strategies.
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http://dx.doi.org/10.1007/s12055-021-01212-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8980966PMC
April 2022

Occupation, work-related contact and SARS-CoV-2 anti-nucleocapsid serological status: findings from the Virus Watch prospective cohort study.

Occup Environ Med 2022 Apr 21. Epub 2022 Apr 21.

UCL Institute of Epidemiology and Health Care, University College London, London, UK.

Objectives: Risk of SARS-CoV-2 infection varies across occupations; however, investigation into factors underlying differential risk is limited. We aimed to estimate the total effect of occupation on SARS-CoV-2 serological status, whether this is mediated by workplace close contact, and how exposure to poorly ventilated workplaces varied across occupations.

Methods: We used data from a subcohort (n=3775) of adults in the UK-based Virus Watch cohort study who were tested for SARS-CoV-2 anti-nucleocapsid antibodies (indicating natural infection). We used logistic decomposition to investigate the relationship between occupation, contact and seropositivity, and logistic regression to investigate exposure to poorly ventilated workplaces.

Results: Seropositivity was 17.1% among workers with daily close contact vs 10.0% for those with no work-related close contact. Compared with other professional occupations, healthcare, indoor trade/process/plant, leisure/personal service, and transport/mobile machine workers had elevated adjusted total odds of seropositivity (1.80 (1.03 to 3.14) - 2.46 (1.82 to 3.33)). Work-related contact accounted for a variable part of increased odds across occupations (1.04 (1.01 to 1.08) - 1.23 (1.09 to 1.40)). Occupations with raised odds of infection after accounting for work-related contact also had greater exposure to poorly ventilated workplaces.

Conclusions: Work-related close contact appears to contribute to occupational variation in seropositivity. Reducing contact in workplaces is an important COVID-19 control measure.
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http://dx.doi.org/10.1136/oemed-2021-107920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072780PMC
April 2022

Ring-opening hydrolysis of spiro-epoxyoxindoles using a reusable sulfonic acid functionalized nitrogen rich carbon catalyst.

RSC Adv 2021 Mar 1;11(21):12808-12814. Epub 2021 Apr 1.

Inorganic Materials and Catalysis Division, CSIR-Central Salt & Marine Chemicals Research Institute G. B. Marg Bhavnagar-364002 Gujarat India

Controlling the product selectivity of a ring-opening hydrolysis reaction remains a great challenge with mineral acids and to an extent with homogeneous catalysts. In addition, even trace amounts of metal impurities in a bioactive product hinder the reaction progress. This has necessitated the development of robust and metal-free catalysts to offer an alternative sustainable route. We report a nitrogen-rich sulfonated carbon as a catalyst derived from an inexpensive precursor for the synthesis of bioactive vicinal diols of spiro-oxindole derivatives. The well-characterized catalyst shows wide generality with different electronic and steric substituents in the substrates under mild reaction conditions. Hot filtration test confirms no leaching of the acid moiety and the catalyst could be reused for four cycles with retention of activities.
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http://dx.doi.org/10.1039/d1ra01161hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8697273PMC
March 2021

Acing the Fundamentals of Radiology: An Online Series for Medical Students and Interns.

J Comput Assist Tomogr 2022 Jul-Aug 01;46(4):614-620. Epub 2022 Apr 8.

Department of Abdominal Imaging, University of Texas MD Anderson Cancer Center, Houston, TX.

Purpose: The current undergraduate radiology education predominantly integrates radiology with other disciplines during preclerkship years and is often taught by nonradiologists. Early exposure to radiology and profound understanding of scientific fundamentals of imaging modalities and techniques are essential for a better understanding and interest in the specialty. Furthermore, the COVID-19 pandemic-related impact on in-person medical education aggravated the need for alternative virtual teaching initiatives to provide essential knowledge to medical students.

Methods: The authors designed an online 7-session course on the principles of imaging modalities for medical students and fresh graduates in the United States and abroad. The course was delivered online and taught by radiologists from different US institutions. Pretests and posttests were delivered before and after each session, respectively, to assess change in knowledge. At the end of the course, a survey was distributed among students to collect their assessment and feedback.

Results: A total of 162 students and interns initially enrolled in the program by completing a sign-up interest form. An average of 65 participants attended each live session, with the highest attendance being 93 live attendees. An average of 44 attendees completed both the pretest and posttest for each session. There was a statistically significant increase in posttest scores compared with pretest scores ( P < 0.01) for each session; on average, the posttest scores were 48% higher than the pretest scores. A total of 84 participants answered the end-of-course survey. A total of 11% of the respondents described themselves as first year, 17% as second year, 18% as third year, 21% as fourth year, and 33% as "other." Attendees were enrolled in medical schools across 21 different countries with 35% of the respondents studying medicine in the United States. More than 76% of the respondents stated that they "strongly agree" that the program increased their understanding of radiology, increased their interest in radiology, and would be useful in their clinical practice in the future. Eighty-three percent of the respondents stated that they "strongly agree" that "this course was a worthwhile experience." Particularly, more than 84% of the respondents stated that among the most important components in enhancing their understanding of radiology were "the interpretation of normal imaging" and "interpretation of clinical cases." Ninety-two percent of the respondents stated that "the amount of effort to complete the requirements for this program was just right." Participants were also asked to rate each of the 8 sessions using the following scale: poor = 1 point, fair = 2, good = 3, and excellent = 4. The average rating for all 8 sessions was 3.61 points (SD = 0.55), which translates to 96% of the sessions being rated good or excellent. Eighty percent of the participants reported that the topics presented in the program were "excellent and clinically important to learn," and 20% of the participants reported that the topics presented were "good and somewhat important to learn." The participants were asked to evaluate their confidence regarding basic radiology skills before and after the program using the following scale: not confident at all = 1 point, somewhat confident = 2, moderately confident = 3, and very confident = 4. Figure 2 summarizes the responses of the participants.

Conclusions: An online course to teach the fundamentals of imaging modalities could be delivered through a webinar format to medical students and interns in several countries to address the potential gaps in radiology education, therefore increasing their understanding of the different imaging modalities and their proper use in medicine.
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http://dx.doi.org/10.1097/RCT.0000000000001306DOI Listing
July 2022

Predicting Usual Interstitial Pneumonia Histopathology From Chest CT Imaging With Deep Learning.

Chest 2022 Apr 8. Epub 2022 Apr 8.

Mayo Clinic, Rochester, MN.

Background: Idiopathic pulmonary fibrosis (IPF) is a progressive, often fatal form of interstitial lung disease (ILD) characterized by the absence of a known cause and usual interstitial pneumonitis (UIP) pattern on chest CT imaging and/or histopathology. Distinguishing UIP/IPF from other ILD subtypes is essential given different treatments and prognosis. Lung biopsy is necessary when noninvasive data are insufficient to render a confident diagnosis.

Research Question: Can we improve noninvasive diagnosis of UIP be improved by predicting ILD histopathology from CT scans by using deep learning?

Study Design And Methods: This study retrospectively identified a cohort of 1,239 patients in a multicenter database with pathologically proven ILD who had chest CT imaging. Each case was assigned a label based on histopathologic diagnosis (UIP or non-UIP). A custom deep learning model was trained to predict class labels from CT images (training set, n = 894) and was evaluated on a 198-patient test set. Separately, two subspecialty-trained radiologists manually labeled each CT scan in the test set according to the 2018 American Thoracic Society IPF guidelines. The performance of the model in predicting histopathologic class was compared against radiologists' performance by using area under the receiver-operating characteristic curve as the primary metric. Deep learning model reproducibility was compared against intra-rater and inter-rater radiologist reproducibility.

Results: For the entire cohort, mean patient age was 62 ± 12 years, and 605 patients were female (49%). Deep learning performance was superior to visual analysis in predicting histopathologic diagnosis (area under the receiver-operating characteristic curve, 0.87 vs 0.80, respectively; P < .05). Deep learning model reproducibility was significantly greater than radiologist inter-rater and intra-rater reproducibility (95% CI for difference in Krippendorff's alpha did not include zero).

Interpretation: Deep learning may be superior to visual assessment in predicting UIP/IPF histopathology from CT imaging and may serve as an alternative to invasive lung biopsy.
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http://dx.doi.org/10.1016/j.chest.2022.03.044DOI Listing
April 2022

Age Alters Prevalence of Left Atrial Enlargement and Nonstenotic Carotid Plaque in Embolic Stroke of Undetermined Source.

Stroke 2022 07 31;53(7):2260-2267. Epub 2022 Mar 31.

Department of Neurology, Cooper University Hospital, Camden, NJ (R.G., J.M.T., J.E.S.).

Background: Nonstenotic carotid plaque and undetected atrial fibrillation are potential mechanisms of embolic stroke of undetermined source (ESUS), but it is unclear which is more likely to be the contributing stroke mechanism. We explored the relationship between left atrial enlargement (LAE) and nonstenotic carotid plaque across age ranges in an ESUS population.

Methods: A retrospective multicenter cohort of consecutive patients with unilateral, anterior circulation ESUS was queried (2015 to 2021). LAE and plaque thickness were determined by transthoracic echocardiography and computed tomography angiography, respectively. Descriptive statistics were used to compare plaque features in relation to age and left atrial dimensions.

Results: Among the 4155 patients screened, 273 (7%) met the inclusion criteria. The median age was 65 years (interquartile range [IQR] 54-74), 133 (48.7%) were female, and the median left atrial diameter was 3.5 cm (IQR 3.1-4.1). Patients with any LAE more frequently had hypertension (85.9% versus 67.2%, <0.01), diabetes (41.0% versus 25.6%, =0.01), dyslipidemia (56.4% versus 40.0%, =0.01), and coronary artery disease (22.8% versus 11.3%, =0.02). Carotid plaque thickness was greater ipsilateral versus contralateral to the stroke hemisphere in the overall cohort (median 1.9 mm [IQR 0-3] versus 1.5 mm [IQR 0-2.6], <0.01); however, this was largely driven by the subgroup of patients without any LAE (median 1.8 mm [IQR 0-2.9] versus 1.5 mm [IQR 0-2.5], <0.01). Compared with patients ≥70 years, younger patients had more carotid plaque ipsilateral versus contralateral (mean difference 0.42 mm±1.24 versus 0.08 mm±1.54, =0.047) and less moderate-to-severe LAE (6.3% versus 15.3%, =0.02).

Conclusions: Younger patients with ESUS had greater prevalence of ipsilateral nonstenotic plaque, while the elderly had more LAE. The differential effect of age on the probability of specific mechanisms underlying ESUS should be considered in future studies.
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http://dx.doi.org/10.1161/STROKEAHA.121.037522DOI Listing
July 2022

Analyzing fecal loading and retention patterns by abdominal X-rays of hospitalized older adults: A retrospective study.

Aging Med (Milton) 2022 Mar 17;5(1):38-44. Epub 2022 Feb 17.

Uniformed Services University of the Health Sciences Bethesda Maryland USA.

Background: Aging may affect ascending colon (AC) differently from descending colon (DC) and increase the risk of fecal loading (FL) in AC.

Methods: Patients aged ≥65 years admitted to a community hospital were analyzed by abdominal x-ray for fecal loads and stool retention patterns. FL was scored between 0 and 5 (severe) on each segment of colon with a possible total score 20. Mean segment scores ≥3.5 were designated as high scores for both AC and DC. Logistic regression was performed between groups to identify factors associated with FL patterns.

Results: Groups identified were high FL in both AC and DC (N = 21, 17.2%), FL predominantly in AC (N = 38, 31.1%), low FL in both AC and DC (N=60, 49.2%), and FL low in AC and high in DC (N = 3, 2.5%). Among 71 patients with total FL scores ≥13 (indicating significant stool retention), 37 (52.1%) had the FL predominantly in AC. Patients prescribed antibiotic(s) prior to hospitalization had lower odds of FL predominantly in AC (adjusted odds ratio = 0.18, 95% confidence interval = 0.04-0.84) compared to the group of low FL in both AC and DC with the adjustment of confounders.

Conclusion: This study found that 52.1% of those with significant stool retention on x-ray had the FL predominantly in AC. Antibiotic use was associated with lower odds of having FL predominately in AC. This study provided insights of FL distribution in colon and AC could be an area for significant stool burden in older adults with stool retention.
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http://dx.doi.org/10.1002/agm2.12199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8917260PMC
March 2022

Assessing the Effectiveness of Cationic Lipid Nanoparticles with a Triple Adjuvant for Intranasal Vaccination against the Respiratory Pathogen .

Mol Pharm 2022 06 18;19(6):1814-1824. Epub 2022 Mar 18.

University of Saskatchewan, College of Pharmacy and Nutrition, 107 Wiggins Road, Saskatoon, Saskatchewan S7N 5E5, Canada.

Continuous outbreaks of pertussis around the world suggest inadequate immune protection in infants and weakened immune responses induced over time by the acellular pertussis vaccine. Vaccine adjuvants provide a means to improve vaccine immunogenicity and support long-term adaptive immunity against pertussis. An acellular pertussis vaccine was prepared with pertactin, pertussis toxin, and fimbriae 2/3 antigens combined with a triple-adjuvant system consisting of innate defense regulator peptide IDR 1002, a Toll-like receptor-3 agonist poly(I:C), and a polyphosphazene in a fixed combination. The vaccine was delivered intranasally in a cationic lipid nanoparticle formulation fabricated by simple admixture and two schema for addition of antigens (LT-A, antigens associated outside of L-TriAdj, and LAT, antigens associated inside of L-TriAdj) to optimize particle size and cationic surface charge. In the former, antigens were associated with the lipidic formulation of the triple adjuvant by electrostatic attraction. In the latter, the antigens resided in the interior of the lipid nanoparticle. Two dose levels of antigens were used with adjuvant comprised of the triple adjuvant with or without the lipid nanoparticle carrier. Formulation of vaccines with the triple adjuvant stimulated systemic and mucosal immune responses. The lipid nanoparticle vaccines favored a Th1 type of response with higher IgG2a and IgA serum antibody titers particularly for pertussis toxin and pertactin formulated at the 5 μg dose level in the admixed formulation. Additionally, the lipid nanoparticle vaccines resulted in high nasal SIgA antibodies and an early (4 weeks post vaccination) response after a single vaccination dose. The LT-A nanoparticles trended toward higher titers of serum antibodies compared to LAT. The cationic lipid-based vaccine nanoparticles formulated with a triple adjuvant showed encouraging results as a potential formulation for intranasally administered pertussis vaccines.
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http://dx.doi.org/10.1021/acs.molpharmaceut.1c00852DOI Listing
June 2022

Devitalized Prostatic Adenoma Causing Bladder Outlet Obstruction: An Unusual Complication After Prostatic Artery Embolization Requiring Salvage Laser Enucleation.

Cardiovasc Intervent Radiol 2022 07 16;45(7):1027-1029. Epub 2022 Mar 16.

Department of Urology, David Geffen School of Medicine, University of California, 10945 Le Conte Avenue, Ueberroth #3361, Los Angeles, CA, 90095, USA.

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http://dx.doi.org/10.1007/s00270-022-03098-yDOI Listing
July 2022
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