Paresh Vyas

Paresh Vyas

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Paresh Vyas

Publications by authors named "Paresh Vyas"

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The Inflammasome: More Than a Protective Innate Immune Mechanism.

Immunity 2019 Jul;51(1):3-5

MRC MHU, BRC Haematology Theme, Oxford Biomedical Research Centre, Oxford Centre for Haematology, WIMM, Radcliffe Department of Medicine, University of Oxford, Oxford, UK; Department of Haematology, Oxford University Hospitals NHS Trust, Oxford, UK. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2019.06.022DOI Listing
July 2019

DOT1L inhibition reveals a distinct subset of enhancers dependent on H3K79 methylation.

Nat Commun 2019 06 26;10(1):2803. Epub 2019 Jun 26.

MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, NIHR Oxford Biomedical Research Centre Haematology Theme, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DS, UK.

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http://dx.doi.org/10.1038/s41467-019-10844-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594956PMC
June 2019

From genomics to targeted treatment in haematological malignancies: a focus on acute myeloid leukaemia.

Clin Med (Lond) 2018 04;18(Suppl 2):s47-s53

MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK and Department of Haematology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK

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http://dx.doi.org/10.7861/clinmedicine.18-2-s47DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334029PMC
April 2018

The U2AF1S34F mutation induces lineage-specific splicing alterations in myelodysplastic syndromes.

J Clin Invest 2017 Jun 24;127(6):2206-2221. Epub 2017 Apr 24.

Bloodwise Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, and BRC Blood Theme, National Institute for Health Research (NIHR) Oxford Biomedical Centre, Oxford University Hospital, Oxford, United Kingdom.

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http://dx.doi.org/10.1172/JCI91363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451246PMC
June 2017

Heterogeneous leukemia stem cells in myeloid blast phase chronic myeloid leukemia.

Blood Adv 2016 Dec 14;1(3):160-169. Epub 2016 Dec 14.

Medical Research Council Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1182/bloodadvances.2016000810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737170PMC
December 2016

Transient Abnormal Myelopoiesis and AML in Down Syndrome: an Update.

Curr Hematol Malig Rep 2016 10;11(5):333-41

Department of Paediatrics, Children's Hospital, University of Oxford, John Radcliffe Hospital, OX3 9DU, Oxford, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031718PMC
http://dx.doi.org/10.1007/s11899-016-0338-xDOI Listing
October 2016

Assessment of Minimal Residual Disease in Standard-Risk AML.

N Engl J Med 2016 Feb 20;374(5):422-33. Epub 2016 Jan 20.

From the Molecular Oncology Unit and Cancer Genetics Laboratory, Department of Medical and Molecular Genetics, Guy's Hospital (A.I.), the Department of Medical and Molecular Genetics (M.A.S., J.V.J., E.S., D.G.) and Department of Asthma, Allergy and Respiratory Science (H.F., F.M.), Faculty of Life Sciences and Medicine, King's College London, the Department of Haematology, University College London (Y.P., D.C.L., R.E.G.), and the Innovation Department, Cancer Research UK (N.B.), London, the Experimental Cancer Medicine Centre (A. Gilkes) and Department of Haematology (R.K.H., A.K.B.), Cardiff University School of Medicine, and the Haematology Clinical Trials Unit, Cardiff University (A. Grech), Cardiff, West Midlands Regional Genetics Laboratory, Birmingham (J.M., K.W., S.A., M.G.), MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine and Department of Haematology, University of Oxford and Oxford University Hospitals NHS Trust, and the National Institute for Health Research Oxford Biomedical Research Centre (P.V.), Oxford, the Department of Clinical Immunology, University of Birmingham, Birmingham (S.D.F.), and the Centre for Clinical Haematology, Nottingham University Hospital, Nottingham (N.R.) - all in the United Kingdom.

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http://dx.doi.org/10.1056/NEJMoa1507471DOI Listing
February 2016

Comparison of a restrictive versus liberal red cell transfusion policy for patients with myelodysplasia, aplastic anaemia, and other congenital bone marrow failure disorders.

Cochrane Database Syst Rev 2015 Oct 5(10):CD011577. Epub 2015 Oct 5.

Haematology, NHS/ University of Oxford, Headley Way,, Headington, Oxford, Oxfordshire, UK, OX3 9DU.

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http://dx.doi.org/10.1002/14651858.CD011577.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650197PMC
October 2015

Factors influencing success of clinical genome sequencing across a broad spectrum of disorders.

Authors:
Jenny C Taylor Hilary C Martin Stefano Lise John Broxholme Jean-Baptiste Cazier Andy Rimmer Alexander Kanapin Gerton Lunter Simon Fiddy Chris Allan A Radu Aricescu Moustafa Attar Christian Babbs Jennifer Becq David Beeson Celeste Bento Patricia Bignell Edward Blair Veronica J Buckle Katherine Bull Ondrej Cais Holger Cario Helen Chapel Richard R Copley Richard Cornall Jude Craft Karin Dahan Emma E Davenport Calliope Dendrou Olivier Devuyst Aimée L Fenwick Jonathan Flint Lars Fugger Rodney D Gilbert Anne Goriely Angie Green Ingo H Greger Russell Grocock Anja V Gruszczyk Robert Hastings Edouard Hatton Doug Higgs Adrian Hill Chris Holmes Malcolm Howard Linda Hughes Peter Humburg David Johnson Fredrik Karpe Zoya Kingsbury Usha Kini Julian C Knight Jonathan Krohn Sarah Lamble Craig Langman Lorne Lonie Joshua Luck Davis McCarthy Simon J McGowan Mary Frances McMullin Kerry A Miller Lisa Murray Andrea H Németh M Andrew Nesbit David Nutt Elizabeth Ormondroyd Annette Bang Oturai Alistair Pagnamenta Smita Y Patel Melanie Percy Nayia Petousi Paolo Piazza Sian E Piret Guadalupe Polanco-Echeverry Niko Popitsch Fiona Powrie Chris Pugh Lynn Quek Peter A Robbins Kathryn Robson Alexandra Russo Natasha Sahgal Pauline A van Schouwenburg Anna Schuh Earl Silverman Alison Simmons Per Soelberg Sørensen Elizabeth Sweeney John Taylor Rajesh V Thakker Ian Tomlinson Amy Trebes Stephen Rf Twigg Holm H Uhlig Paresh Vyas Tim Vyse Steven A Wall Hugh Watkins Michael P Whyte Lorna Witty Ben Wright Chris Yau David Buck Sean Humphray Peter J Ratcliffe John I Bell Andrew Om Wilkie David Bentley Peter Donnelly Gilean McVean

Nat Genet 2015 Jul 18;47(7):717-726. Epub 2015 May 18.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/ng.3304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601524PMC
July 2015

Comparison of a restrictive versus liberal red cell transfusion policy for patients with myelodysplasia, aplastic anaemia, and other congenital bone marrow failure disorders.

Cochrane Database Syst Rev 2015 03;3

MRC Molecular Haematology Unit and Department of Haematology, University of Oxford and Oxford University Hospitals NHS Trust, Oxford, UK.

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http://dx.doi.org/10.1002/14651858.CD011577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4430822PMC
March 2015

Down syndrome preleukemia and leukemia.

Pediatr Clin North Am 2015 Feb;62(1):121-37

MRC Molecular Haematology Unit, Department of Haematology, Weatherall Institute of Molecular Medicine, Oxford University Hospitals NHS Trust, University of Oxford, Oxford OX3 9DS, UK.

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http://dx.doi.org/10.1016/j.pcl.2014.09.009DOI Listing
February 2015

Reprint of: Allogeneic hematopoietic cell transplantation for acute myeloid leukemia.

Biol Blood Marrow Transplant 2015 Feb;21(2 Suppl):S3-10

Queen Elizabeth Hospital, Birmingham, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.bbmt.2014.12.032DOI Listing
February 2015

Allogeneic hematopoietic cell transplantation for acute myeloid leukemia.

Biol Blood Marrow Transplant 2015 Jan 13;21(1):8-15. Epub 2014 Nov 13.

Queen Elizabeth Hospital, Birmingham, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.bbmt.2014.10.026DOI Listing
January 2015

Targeting HIF function: the debate continues.

Authors:
Paresh Vyas

Blood 2014 Dec;124(24):3510-1

UNIVERSITY OF OXFORD AND OXFORD UNIVERSITY HOSPITALS.

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http://dx.doi.org/10.1182/blood-2014-10-605055DOI Listing
December 2014

Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo.

Cancer Cell 2014 Jun 15;25(6):794-808. Epub 2014 May 15.

Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK; Departments of Cell and Molecular Biology, Medicine Huddinge, and Laboratory Medicine, Huddinge, Karolinska Institutet and Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2014.03.036DOI Listing
June 2014

The impact of trisomy 21 on foetal haematopoiesis.

Blood Cells Mol Dis 2013 Dec 7;51(4):277-81. Epub 2013 Aug 7.

Centre for Haematology, Imperial College London, UK. Electronic address:

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http://linkinghub.elsevier.com/retrieve/pii/S107997961300159
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http://dx.doi.org/10.1016/j.bcmd.2013.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727253PMC
December 2013

Acute myeloid leukemia creates an arginase-dependent immunosuppressive microenvironment.

Blood 2013 Aug 3;122(5):749-58. Epub 2013 Jun 3.

Medical Research Council Human Immunology Unit, Radcliffe Department ofMedicine, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1182/blood-2013-01-480129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731930PMC
August 2013

Impact of isolated germline JAK2V617I mutation on human hematopoiesis.

Blood 2013 May 27;121(20):4156-65. Epub 2013 Mar 27.

Haematopoietic Stem Cell Biology Laboratory, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1182/blood-2012-05-430926DOI Listing
May 2013

Uncoupling VEGFA functions in arteriogenesis and hematopoietic stem cell specification.

Dev Cell 2013 Jan 11;24(2):144-58. Epub 2013 Jan 11.

MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford University, OX3 9DS Oxford, UK.

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http://dx.doi.org/10.1016/j.devcel.2012.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560039PMC
January 2013

Development of real-time quantitative polymerase chain reaction assays to track treatment response in retinoid resistant acute promyelocytic leukemia.

Front Oncol 2011 25;1:35. Epub 2011 Oct 25.

Cancer Genetics Laboratory, Department of Medical and Molecular Genetics, King's College London School of Medicine London, UK.

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http://dx.doi.org/10.3389/fonc.2011.00035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356041PMC
August 2012

Biology and management of transient abnormal myelopoiesis (TAM) in children with Down syndrome.

Semin Fetal Neonatal Med 2012 Aug 14;17(4):196-201. Epub 2012 Mar 14.

MRC Molecular Haematology Unit and Department of Haematology, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S1744165X120003
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http://dx.doi.org/10.1016/j.siny.2012.02.010DOI Listing
August 2012

Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia.

Sci Transl Med 2012 Aug;4(149):149ra118

Program in Cancer Biology, Cancer Institute, Institute for Stem Cell Biology and Regenerative Medicine, and Ludwig Center, Stanford University School of Medicine, Palo Alto, CA 94305, USA.

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http://dx.doi.org/10.1126/scitranslmed.3004315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045621PMC
August 2012

Enigmatic variation.

Blood 2011 Dec;118(26):6723-4

Imperial College London, University of Oxford, UK.

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http://dx.doi.org/10.1182/blood-2011-09-376145DOI Listing
December 2011

Methotrexate dose delivery is more important than ciclosporin level in graft-versus-host disease prophylaxis following T-replete reduced-intensity sibling allogeneic stem cell transplant.

Int J Hematol 2011 Sep 7;94(3):266-278. Epub 2011 Sep 7.

Department of Haematology, Oxford Radcliffe Hospitals NHS Trust, Cancer and Haematology Centre, Churchill Hospital, Old Road, Headington, Oxford, OX3 7LJ, UK.

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http://dx.doi.org/10.1007/s12185-011-0920-xDOI Listing
September 2011

Cardiac iron overload in transfusion-dependent patients with myelodysplastic syndromes.

Br J Haematol 2011 Aug 21;154(4):521-4. Epub 2011 Jun 21.

Molecular Haematology Unit, Weatherall Institute of Molecular Medicine Department of Cardiology, Oxford, UK.

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http://dx.doi.org/10.1111/j.1365-2141.2011.08749.xDOI Listing
August 2011

SCL-mediated regulation of the cell-cycle regulator p21 is critical for murine megakaryopoiesis.

Blood 2011 Jul 19;118(3):723-35. Epub 2011 May 19.

Medical Research Council Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.

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http://www.bloodjournal.org/content/118/3/723.full.pdf
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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2011-01-32
Publisher Site
http://dx.doi.org/10.1182/blood-2011-01-328765DOI Listing
July 2011

Clever leukemic stem cells branch out.

Cell Stem Cell 2011 Mar;8(3):242-4

MRC Molecular Haematology Unit, Radcliffe Hospital, Oxford OX3 9DU, UK.

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http://dx.doi.org/10.1016/j.stem.2011.02.015DOI Listing
March 2011

Assessment of minimal residual disease in acute myeloid leukemia.

Curr Opin Oncol 2010 Nov;22(6):656-63

Department of Medical & Molecular Genetics, King's College London School of Medicine, Guy's & St. Thomas' NHS Foundation Trust, London, UK.

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http://dx.doi.org/10.1097/CCO.0b013e32833ed831DOI Listing
November 2010

Genome-wide identification of TAL1's functional targets: insights into its mechanisms of action in primary erythroid cells.

Genome Res 2010 Aug 21;20(8):1064-83. Epub 2010 Jun 21.

MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford University, Oxford OX3 9DS, United Kingdom.

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http://dx.doi.org/10.1101/gr.104935.110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909570PMC
August 2010

Lineage-specific combinatorial action of enhancers regulates mouse erythroid Gata1 expression.

Blood 2010 Apr 12;115(17):3463-71. Epub 2010 Feb 12.

Medical Research Council Molecular Haematology Unit, John Radcliffe Hospital, Oxford, UK.

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http://dx.doi.org/10.1182/blood-2009-07-232876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2918365PMC
April 2010

Acute leukemias in children with Down syndrome.

Hematol Oncol Clin North Am 2010 Feb;24(1):19-34

Department of Pediatric Oncology/Hematology, Erasmus MC/Sophia Children's Hospital, Dr Molewaterplein 60, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.hoc.2009.11.009DOI Listing
February 2010

Acute megakaryoblastic leukaemia (AMKL) and transient myeloproliferative disorder (TMD) in Down syndrome: a multi-step model of myeloid leukaemogenesis.

Br J Haematol 2009 Oct 6;147(1):3-12. Epub 2009 Jul 6.

Department of Haematology, Imperial College London, London, UK.

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http://dx.doi.org/10.1111/j.1365-2141.2009.07789.xDOI Listing
October 2009

Molecular targeting of cancer stem cells.

Cell Stem Cell 2009 Aug;5(2):125-6

MRC Molecular Haematology Unit, The Weatherall Institue of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1016/j.stem.2009.07.006DOI Listing
August 2009

GATA-2 regulates granulocyte-macrophage progenitor cell function.

Blood 2008 Dec 7;112(13):4862-73. Epub 2008 Oct 7.

Medical Research Council Hematology Unit, Weatherall Institute for Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1182/blood-2008-01-136564DOI Listing
December 2008

Characterization of megakaryocyte GATA1-interacting proteins: the corepressor ETO2 and GATA1 interact to regulate terminal megakaryocyte maturation.

Blood 2008 Oct 14;112(7):2738-49. Epub 2008 Jul 14.

Medical Research Council (MRC) Molecular Haematology Unit and Department of Haematology, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom.

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http://dx.doi.org/10.1182/blood-2008-03-146605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2556610PMC
October 2008

Good news for the aging population?

Blood 2008 Oct;112(8):3001

Weatherall Institute of Molecular Medicine, USA.

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http://dx.doi.org/10.1182/blood-2008-08-171223DOI Listing
October 2008

Differential use of SCL/TAL-1 DNA-binding domain in developmental hematopoiesis.

Blood 2008 Aug 12;112(4):1056-67. Epub 2008 Jun 12.

Department of Haematology, Medical Research Council, Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1182/blood-2007-12-128900DOI Listing
August 2008

Acute leukemias in children with Down syndrome.

Pediatr Clin North Am 2008 Feb;55(1):53-70, x

Department of Pediatric Oncology/Hematology, Erasmus MC/Sophia Children's Hospital, Dr Molewaterplein 60, Rotterdam, The Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S003139550700160
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http://dx.doi.org/10.1016/j.pcl.2007.11.001DOI Listing
February 2008

Haematology of Down syndrome.

Arch Dis Child Fetal Neonatal Ed 2007 Nov 5;92(6):F503-7. Epub 2007 Sep 5.

Department of Haematology and MRC Molecular Haematology Unit, John Radcliffe Hospital and Weatherall Institute of Molecular Medicine, Oxford OX3 9DU, England.

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http://dx.doi.org/10.1136/adc.2006.104638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2675407PMC
November 2007

Severe TMD/AMKL with GATA1 mutation in a stillborn fetus with Down syndrome.

Nat Clin Pract Oncol 2007 Jul;4(7):433-8

Center for Personalized Genetic Healthcare, Cleveland Clinic, Cleveland, OH 44195, USA.

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http://dx.doi.org/10.1038/ncponc0876DOI Listing
July 2007

Molecular insights into Down syndrome-associated leukemia.

Curr Opin Pediatr 2007 Feb;19(1):9-14

Department of Haematology, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1097/MOP.0b013e328013e7b2DOI Listing
February 2007

Down myeloid disorders: a paradigm for childhood preleukaemia and leukaemia and insights into normal megakaryopoiesis.

Early Hum Dev 2006 Dec 24;82(12):767-73. Epub 2006 Oct 24.

Department of Haematology, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital and University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1016/j.earlhumdev.2006.09.016DOI Listing
December 2006