Paolo Tortorella

Paolo Tortorella

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Paolo Tortorella

Publications by authors named "Paolo Tortorella"

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Bisphosfonate matrix metalloproteinase inhibitors for the treatment of periodontitis: An in vitro study.

Int J Mol Med 2018 Jul 25;42(1):651-657. Epub 2018 Apr 25.

Department of Pharmacy, University 'G. d'Annunzio' Chieti‑Pescara, I‑66100 Chieti, Italy.

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http://dx.doi.org/10.3892/ijmm.2018.3641DOI Listing
July 2018

[The Adherence's indicators of cancer patients to oral chemotherapy. A sistematic literature review].

Prof Inferm 2018 Apr-Jun;71(2):67-78

Professore Associato. Dipartimento di Sanità pubblica, Sezione di Igiene, Università Cattolica del S. Cuore - Roma.

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http://dx.doi.org/10.7429/pi.2018.712067DOI Listing
July 2018

Clinical Features and Complications of the HLA-B27-associated Acute Anterior Uveitis: A Metanalysis.

Semin Ophthalmol 2017 12;32(6):689-701. Epub 2016 Jul 12.

a Department of Ophthalmology , "Sapienza" University of Rome , Rome , Italy.

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http://dx.doi.org/10.3109/08820538.2016.1170158DOI Listing
December 2017

Selective inhibition of matrix metalloproteinase-2 in the multiple myeloma-bone microenvironment.

Oncotarget 2017 Jun;8(26):41827-41840

Tumor Biology Department, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.

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http://dx.doi.org/10.18632/oncotarget.18103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522031PMC
June 2017

Bone-Seeking Matrix Metalloproteinase-2 Inhibitors Prevent Bone Metastatic Breast Cancer Growth.

Mol Cancer Ther 2017 03 9;16(3):494-505. Epub 2017 Jan 9.

Tumor Biology Department, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.

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http://dx.doi.org/10.1158/1535-7163.MCT-16-0315-TDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5337166PMC
March 2017

Follow-Up Study of Over Three Years of Patients with Uveitis after Cataract Phacoemulsification: Outcomes and Complications.

Semin Ophthalmol 2016 20;31(6):532-41. Epub 2015 Feb 20.

a Department of Ophthalmology , University of Rome "Sapienza" , Rome , Italy.

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http://dx.doi.org/10.3109/08820538.2015.1009554DOI Listing
February 2017

Catechol-based matrix metalloproteinase inhibitors with additional antioxidative activity.

J Enzyme Inhib Med Chem 2016 24;31(sup4):25-37. Epub 2016 Aug 24.

b Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi "A. Moro" di Bari , Bari , Italy.

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http://dx.doi.org/10.1080/14756366.2016.1217853DOI Listing
February 2017

In vitro comparison of new bisphosphonic acids and zoledronate effects on human gingival fibroblasts viability, inflammation and matrix turnover.

Clin Oral Investig 2016 Nov 22;20(8):2013-2021. Epub 2015 Dec 22.

Section of Human Anatomy, Department of Pharmacy, University "G. d'Annunzio", Chieti-Pescara, via dei Vestini 31, 66100, Chieti, Italy.

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http://dx.doi.org/10.1007/s00784-015-1690-2DOI Listing
November 2016

Phosphonate Emerging Zinc Binding Group in Matrix Metalloproteinase Inhibitors.

Curr Drug Targets 2015 ;16(14):1634-44

Dipartimento di Farmacia- Scienze del Farmaco, Università degli Studi "Aldo Moro" di Bari, via Orabona 4, 70126 Bari, Italy.

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September 2016

Fragment-Based Discovery of 5-Arylisatin-Based Inhibitors of Matrix Metalloproteinases 2 and 13.

ChemMedChem 2016 09 15;11(17):1892-8. Epub 2016 Jul 15.

Chemistry Department, Lomonosov Moscow State University, 119991, GSP-2, Leninskie gory, 1/3, Moscow, Russia.

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http://dx.doi.org/10.1002/cmdc.201600266DOI Listing
September 2016

Non-Zinc-Binding Inhibitors of MMP-13: GRID-Based Approaches to Rationalize the Binding Process.

Curr Top Med Chem 2016 ;16(4):449-59

Dipartimento di Farmacia- Scienze del Farmaco, Universita "A. Moro" di Bari, via Orabona 4, 70125 Bari, Italy.

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July 2016

An Effective Virtual Screening Protocol To Identify Promising p53-MDM2 Inhibitors.

J Chem Inf Model 2016 06 7;56(6):1216-27. Epub 2016 Jun 7.

Dipartimento di Farmacia, Università "G. d'Annunzio" Chieti , Via dei Vestini 31, 66100 Chieti, Italy.

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http://dx.doi.org/10.1021/acs.jcim.5b00747DOI Listing
June 2016

Screening of saponins and sapogenins from Medicago species as potential PPARγ agonists and X-ray structure of the complex PPARγ/caulophyllogenin.

Sci Rep 2016 06 10;6:27658. Epub 2016 Jun 10.

Istituto di Cristallografia, Consiglio Nazionale delle Ricerche, Montelibretti, 00015 Monterotondo Stazione, Roma, Italy.

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http://dx.doi.org/10.1038/srep27658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4901321PMC
June 2016

Correlation between Visual Acuity, Inner Segment/Outer Segment Junction, and Cone Outer Segment Tips Line Integrity in Uveitic Macular Edema.

Biomed Res Int 2015 8;2015:853728. Epub 2015 Jun 8.

Chorioretinal Diagnostic Service UOC Ophthalmology C, Department of Ophthalmology, "Sapienza" University of Rome, Viale del Policlinico, 15500161 Rome, Italy.

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http://dx.doi.org/10.1155/2015/853728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475742PMC
April 2016

Spectral domain optical coherence tomography imaging of tubercular chorioretinitis and intraretinal granuloma. Intraretinal tuberculosis: a case report.

Int Ophthalmol 2015 Jun 27;35(3):445-50. Epub 2015 Mar 27.

Diagnostic Chorioretinal Service, Department of Ophthalmology, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.

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http://link.springer.com/10.1007/s10792-015-0061-y
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http://dx.doi.org/10.1007/s10792-015-0061-yDOI Listing
June 2015

Structural development studies of PPARs ligands based on tyrosine scaffold.

Eur J Med Chem 2015 Jan 31;89:817-25. Epub 2014 Oct 31.

Dipartimento di Farmacia, Università "G. d'Annunzio", Via dei Vestini 31, 66100 Chieti, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2014.10.083DOI Listing
January 2015

Epiretinal membranes in patients with uveitis: morphological and functional analysis with spectral domain optical coherence tomography.

Biomed Res Int 2013 5;2013:284821. Epub 2013 Nov 5.

Department of Ophthalmology, Sapienza University of Rome, 15500161 Rome, Italy ; Servizio di Immunovirologia Oculare, Sapienza Università di Roma, Viale del Policlinico, 15500161 Rome, Italy.

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http://dx.doi.org/10.1155/2013/284821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835473PMC
June 2014

Dual carbonic anhydrase/matrix metalloproteinase inhibitors incorporating bisphosphonic acid moieties targeting bone tumors.

Bioorg Med Chem Lett 2014 Jun 30;24(12):2617-20. Epub 2014 Apr 30.

Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi 'Aldo Moro' di Bari, Via Orabona 4, 70126 Bari, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2014.04.077DOI Listing
June 2014

Management of uveitis-related choroidal neovascularization: from the pathogenesis to the therapy.

J Ophthalmol 2014 27;2014:450428. Epub 2014 Apr 27.

Department of Ophthalmology, "Sapienza" University of Rome, Viale del Policlinico 155, 00161 Rome, Italy.

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http://dx.doi.org/10.1155/2014/450428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020300PMC
June 2014

Penetrating fish-hook ocular injury: management of an unusual intraocular foreign body.

Case Rep Med 2014 13;2014:901285. Epub 2014 Apr 13.

Department of Ophthalmology, "Sapienza" University of Rome, Viale del Policlinico 155, 00161 Rome, Italy.

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http://dx.doi.org/10.1155/2014/901285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005098PMC
May 2014

Arylamino bisphosphonates: potent and selective inhibitors of the tumor-associated carbonic anhydrase XII.

Bioorg Med Chem Lett 2014 Apr 12;24(8):1941-3. Epub 2014 Mar 12.

Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi 'Aldo Moro' di Bari, Via Orabona 4, 70126 Bari, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2014.03.001DOI Listing
April 2014

Arylamino methylene bisphosphonate derivatives as bone seeking matrix metalloproteinase inhibitors.

Bioorg Med Chem 2013 Nov 4;21(21):6456-65. Epub 2013 Sep 4.

Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi 'Aldo Moro' di Bari, Via Orabona 4, 70126 Bari, Italy.

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http://dx.doi.org/10.1016/j.bmc.2013.08.054DOI Listing
November 2013

Morphological features of choroidal metastases: an OCT analysis.

Indian J Ophthalmol 2013 Nov;61(11):663-4

Department of Ophthalmology, "Sapienza" University of Rome, Italy.

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http://dx.doi.org/10.4103/0301-4738.121148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959084PMC
November 2013

Effects of biphenyl sulfonylamino methyl bisphosphonic acids on Porphyromonas gingivalis and cytokine secretion by oral epithelial cells.

Med Chem 2013 Sep;9(6):855-60

Department of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, PR China.

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September 2013

Synthesis and cytotoxic activity evaluation of 2,3-thiazolidin-4-one derivatives on human breast cancer cell lines.

Bioorg Med Chem Lett 2013 Sep 26;23(17):4990-5. Epub 2013 Jun 26.

Department of Pharmaceutical Science, Division of Biomedicine, University of Salerno, Fisciano, SA 84084, Italy.

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http://dx.doi.org/10.1016/j.bmcl.2013.06.051DOI Listing
September 2013

Probing the S1' site for the identification of non-zinc-binding MMP-2 inhibitors.

ChemMedChem 2013 Sep 19;8(9):1475-82, 1421. Epub 2013 Jul 19.

Dipartimento di Farmacia, Università "G. d'Annunzio" Chieti, Via dei Vestini 31, 66013 Chieti, Italy.

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http://dx.doi.org/10.1002/cmdc.201300186DOI Listing
September 2013

Spectral-domain optical coherence tomography in uveitic macular edema: morphological features and prognostic factors.

Ophthalmologica 2012 14;228(1):13-8. Epub 2012 Apr 14.

Department of Ophthalmology, Sapienza University of Rome, Rome, Italy. l.iannetti @ policlinicoumberto1.it

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http://dx.doi.org/10.1159/000337234DOI Listing
September 2012

Identification of novel matrix metalloproteinase inhibitors by screening of phenol fragments library.

Arch Pharm (Weinheim) 2011 Sep 21;344(9):557-63. Epub 2011 Jun 21.

Dipartimento Farmaco-Chimico, Università degli Studi "Aldo Moro", Bari, Italy.

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http://dx.doi.org/10.1002/ardp.201000350DOI Listing
September 2011

Peptidyl 3-substituted 1-hydroxyureas as isosteric analogues of succinylhydroxamate MMP inhibitors.

Eur J Med Chem 2008 May 15;43(5):1008-14. Epub 2007 Jul 15.

Dipartimento di Scienze del Farmaco, Università G. d'Annunzio, Via dei Vestini 31, 66013 Chieti, Italy.

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http://dx.doi.org/10.1016/j.ejmech.2007.07.002DOI Listing
May 2008

Collagenase-2 deficiency or inhibition impairs experimental autoimmune encephalomyelitis in mice.

J Biol Chem 2008 Apr 1;283(14):9465-74. Epub 2008 Feb 1.

Departamento de Bioquímica y Biología Molecular, and Biología Funcional, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, and Servicio de Anatomía Patológica, Hospital Central de Asturias, Oviedo 33006, Spain.

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http://dx.doi.org/10.1074/jbc.M709522200DOI Listing
April 2008

Molecular switch for CLC-K Cl- channel block/activation: optimal pharmacophoric requirements towards high-affinity ligands.

Proc Natl Acad Sci U S A 2008 Jan 23;105(4):1369-73. Epub 2008 Jan 23.

Unità di Farmacologia and Dipartimento Farmacochimico, Dipartimento Farmacobiologico, Facoltà di Farmacia, Università di Bari, Bari 70125, Italy.

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http://dx.doi.org/10.1073/pnas.0708977105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234145PMC
January 2008

A chemoenzymatic scalable route to optically active (R)-1-(pyridin-3-yl)-2-aminoethanol, valuable moiety of beta3-adrenergic receptor agonists.

Bioorg Med Chem 2006 Feb 10;14(4):1207-14. Epub 2005 Oct 10.

Dipartimento Farmaco-Chimico, Università degli Studi di Bari, Italy.

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http://dx.doi.org/10.1016/j.bmc.2005.09.046DOI Listing
February 2006

AMBER force field implementation of the boronate function to simulate the inhibition of beta-lactamases by alkyl and aryl boronic acids.

Eur J Med Chem 2005 Nov 8;40(11):1134-42. Epub 2005 Sep 8.

Dipartimento Farmaco-Chimico-Tecnologico, Università degli Studi di Siena, Via Aldo Moro, I-53100 Siena, Italy.

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http://dx.doi.org/10.1016/j.ejmech.2005.06.011DOI Listing
November 2005

Synthesis and evaluation of new tripeptide phosphonate inhibitors of MMP-8 and MMP-2.

Eur J Med Chem 2005 Mar 19;40(3):271-9. Epub 2005 Jan 19.

Dipartimento di Scienze del Farmaco, Università G. d'Annunzio, Via dei Vestini 31, 66013 Chieti, Italy.

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http://dx.doi.org/10.1016/j.ejmech.2004.10.013DOI Listing
March 2005

Optically active mexiletine analogues as stereoselective blockers of voltage-gated Na(+) channels.

J Med Chem 2003 Nov;46(24):5238-48

Dipartimento Farmaco-Chimico and Farmaco-Biologico, Università degli Studi di Bari - Via E Orabona 4, 70125 Bari, Italy.

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http://dx.doi.org/10.1021/jm030865yDOI Listing
November 2003

Dualistic actions of cromakalim and new potent 2H-1,4-benzoxazine derivatives on the native skeletal muscle K ATP channel.

Br J Pharmacol 2003 May;139(2):255-62

Department of Pharmacobiology, Faculty of Pharmacy, via Orabona no. 4, University of Bari, I-70126 Bari, Italy.

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http://dx.doi.org/10.1038/sj.bjp.0705233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1573836PMC
May 2003

Synthesis and antiplatelet activity of gemfibrozil chiral analogues.

Bioorg Med Chem Lett 2002 Mar;12(5):817-21

Dipartimento di Scienze del Farmaco, Università degli Studi G. D'Annunzio, Via dei Vestini, 66100, Chieti, Italy.

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March 2002