Publications by authors named "Paolo Taddeucci"

17 Publications

  • Page 1 of 1

Reticular erythematous mucinosis: a clinical challenge.

Ital J Dermatol Venerol 2021 May 13. Epub 2021 May 13.

Dermatology Section, Department of Clinical Medicine and Immunological Science, University of Siena, Siena, Italy.

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http://dx.doi.org/10.23736/S2784-8671.21.06946-7DOI Listing
May 2021

Usefulness of in vivo reflectance confocal microscopy in Morbihan syndrome.

Skin Res Technol 2021 Jan 17. Epub 2021 Jan 17.

Department of Medical, Surgical and Neurological Science, Dermatology Section, S. Maria alle Scotte Hospital, University of Siena, Siena, Italy.

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http://dx.doi.org/10.1111/srt.13002DOI Listing
January 2021

Extrapalmoplantar pustolosis in Sonozaki Syndrome.

Ital J Dermatol Venerol 2021 Apr 9;156(2):264-265. Epub 2020 Oct 9.

Section of Dermatology, Department of Medical, Surgical and Neurological Science, S. Maria alle Scotte Hospital, University of Siena, Siena, Italy.

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http://dx.doi.org/10.23736/S0392-0488.20.06635-3DOI Listing
April 2021

Treatment of childhood pyogenic granuloma of the nail bed with topical timolol.

Dermatol Ther 2020 07 29;33(4):e13710. Epub 2020 Jun 29.

Dermatology Unit, Department of Medical, Surgical and Neurological Science, S. Maria Alle Scotte Hospital, University of Siena, Siena, Italy.

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http://dx.doi.org/10.1111/dth.13710DOI Listing
July 2020

Amenorrhea secondary to vismodegib: An adverse event to consider especially in female patients with Gorlin-Goltz syndrome.

Dermatol Ther 2020 07 26;33(4):e13527. Epub 2020 May 26.

Department of Medical, Surgical and Neurological Science, Dermatology Section, University of Siena, S. Maria alle Scotte Hospital, Siena, Italy.

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http://dx.doi.org/10.1111/dth.13527DOI Listing
July 2020

Efficacy of Dupilumab in two patients with severe and recalcitrant atopic dermatitis previously treated with extracorporeal photopheresis.

Dermatol Ther 2020 05 2;33(3):e13284. Epub 2020 Mar 2.

Department of Medical, Surgical and Neurological Science, Dermatology Section, University of Siena, S. Maria alle Scotte Hospital, Siena, Italy.

Atopic dermatitis (AD) is a complex disease and can often be a clinical challenge for dermatologists. When standard immunosuppressive therapies fail, extracorporeal phototherapy (ECP) can be considered as a therapeutic option. In recent years, better understanding of the pathogenesis of AD allowed to improve treatment strategies with many emerging therapeutic options. Currently, Dupilumab, a monoclonal antibody that selectively inhibits IL-4 and IL-13, is the only biological drug authorized for the treatment of severe adult atopic dermatitis, refractory to traditional firstline and secondline therapies. ECP, compared to biological therapy, is associated with some disadvantages: it is costly and time-consuming for patients and personnel to administer. Moreover, it should be noted that the completion of the entire procedure takes about 3 hr and must be done in a hospital, while the administration of Dupilumab can be carried out by patients themselves at home. For these reasons and on the basis of our experience, it would be necessary to evaluate whether all patients with refractory atopic dermatitis in treatment with ECP with unsatisfactory clinical response should be switched to recent available target therapies.
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http://dx.doi.org/10.1111/dth.13284DOI Listing
May 2020

Pigmentary demarcation lines of Voigt-Futcher: Dermoscopic and reflectance confocal microscopy features.

Skin Res Technol 2020 05 28;26(3):440-442. Epub 2019 Sep 28.

Dermatology Section, Department of Medical, Surgical and Neurological Science, S. Maria alle Scotte Hospital, University of Siena, Siena, Italy.

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http://dx.doi.org/10.1111/srt.12795DOI Listing
May 2020

Pyoderma gangrenosum secondary to total hip replacement.

G Ital Dermatol Venereol 2019 Apr 23. Epub 2019 Apr 23.

Dermatology Section, Department of Clinical Medicine and Immunological Science, University of Siena, Siena, Italy.

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http://dx.doi.org/10.23736/S0392-0488.19.06256-4DOI Listing
April 2019

BCC and vismodegib: can we treat and remold at the same time?

G Ital Dermatol Venereol 2020 Feb 16;155(1):119-120. Epub 2018 May 16.

Section of Dermatology, Department of Clinical Medicine and Immunological Science, University of Siena, Siena, Italy.

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http://dx.doi.org/10.23736/S0392-0488.18.06043-1DOI Listing
February 2020

Solitary vulvar neurofibroma in a patient without neurofibromatosis.

G Ital Dermatol Venereol 2018 Aug;153(4):591-593

Dermatology Section, Department of Clinical Medicine and Immunological Science, University of Siena, Siena, Italy.

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http://dx.doi.org/10.23736/S0392-0488.17.05706-6DOI Listing
August 2018

Neglected skin carcinomas and Vismodegib: our experience.

G Ital Dermatol Venereol 2019 Oct 7;154(5):597-599. Epub 2018 Feb 7.

Department of Dermatology, Misericordia Hospital, Grosseto, Italy.

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http://dx.doi.org/10.23736/S0392-0488.18.05873-XDOI Listing
October 2019

Searching Novel Therapeutic Targets for Scleroderma: P2X7-Receptor Is Up-regulated and Promotes a Fibrogenic Phenotype in Systemic Sclerosis Fibroblasts.

Front Pharmacol 2017 13;8:638. Epub 2017 Sep 13.

Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Siena, Italy.

Systemic sclerosis (SSc) is a connective tissue disorder presenting fibrosis of the skin and internal organs, for which no effective treatments are currently available. Increasing evidence indicates that the P2X7 receptor (P2X7R), a nucleotide-gated ionotropic channel primarily involved in the inflammatory response, may also have a key role in the development of tissue fibrosis in different body districts. This study was aimed at investigating P2X7R expression and function in promoting a fibrogenic phenotype in dermal fibroblasts from SSc patients, also analyzing putative underlying mechanistic pathways. Fibroblasts were isolated by skin biopsy from 9 SSc patients and 8 healthy controls. P2X7R expression, and function (cytosolic free Ca fluxes, α-smooth muscle actin [α-SMA] expression, cell migration, and collagen release) were studied. Moreover, the role of cytokine (interleukin-1β, interleukin-6) and connective tissue growth factor (CTGF) production, and extracellular signal-regulated kinases (ERK) activation in mediating P2X7R-dependent pro-fibrotic effects in SSc fibroblasts was evaluated. P2X7R expression and Ca permeability induced by the selective P2X7R agonist 2'-3'-O-(4-benzoylbenzoyl)ATP (BzATP) were markedly higher in SSc than control fibroblasts. Moreover, increased αSMA expression, cell migration, CTGF, and collagen release were observed in lipopolysaccharides-primed SSc fibroblasts after BzATP stimulation. While P2X7-induced cytokine changes did not affect collagen production, it was completely abrogated by inhibition of the ERK pathway. In SSc fibroblasts, P2X7R is overexpressed and its stimulation induces Ca-signaling activation and a fibrogenic phenotype characterized by increased migration and collagen production. These data point to the P2X7R as a potential, novel therapeutic target for controlling exaggerated collagen deposition and tissue fibrosis in patients with SSc.
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http://dx.doi.org/10.3389/fphar.2017.00638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5602350PMC
September 2017

Computer-assisted melanoma diagnosis: a new integrated system.

Melanoma Res 2015 Dec;25(6):537-42

aDepartment of Medical, Surgical and Neurological Science, Dermatology Section, Siena University Hospital bDepartment of Medicine, Surgery and Neurosurgery, Section of Pathological Anatomy, Policlinico Santa Maria alle Scotte cDepartment of Medical Biotechnologies, University of Siena, Siena, Italy.

In dermatology, attempts at synergy between man and machine have mainly been made to improve melanoma diagnosis. The aim of the present study was to test an 'integrated digital dermoscopy analysis' (i-DDA) system with a series of melanocytic lesions that were benign and malignant in nature, and to evaluate its discriminating power with respect to histological diagnosis. In a retrospective study we used an i-DDA system to evaluate a series of 856 excised, clinically atypical pigmented skin lesions (584 benign and 272 malignant). The system evaluated 48 parameters to be studied as possible discriminant variables, grouped into four categories (geometries, colours, textures and islands of colour) integrated with three personal metadata items (sex, age and site of lesion) and presence/absence of three dermoscopic patterns (regression structures, blue-white veil and polymorphic vascular structures). Stepwise multivariate logistic regression of i-DDA data selected nine variables with the highest possible discriminant power. At the end of the stepwise procedure the percentage of cases correctly classified by i-DDA was 89.2% (100% sensitivity and 40.8% specificity). The limitations of the study included those associated with a retrospective design and the 'a priori' exclusion of nonmelanocytic skin lesions. By incorporating numerical digital features with personal data and some dermoscopic patterns into the learning process, the proposed i-DDA improved the performance of assisted melanoma diagnosis, with the advantage that our results can be objectively repeated in any other clinical setting.
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http://dx.doi.org/10.1097/CMR.0000000000000209DOI Listing
December 2015

Sclerotherapy for penile venous malformations.

Dermatol Surg 2006 Jul;32(7):955-7; discussion 957

Department of Clinical Medicine and Immunological Sciences, Section of Dermatology, University of Siena, Siena, Italy.

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http://dx.doi.org/10.1111/j.1524-4725.2006.32203.xDOI Listing
July 2006

Autologous epidermal cultures and narrow-band ultraviolet B in the surgical treatment of vitiligo.

Dermatol Surg 2005 Feb;31(2):155-9

Department of Dermatology, University of Siena, Policlinico S. Maria alle Scotte, Siena, Italy.

Background: Vitiligo is an acquired skin disorder with a great social impact. It can be successfully treated with autologous epidermal grafting.

Objective: To evaluate the possibility of treating vitiligo by autologous grafting of epidermal cells and narrow-band ultraviolet B (UVB).

Methods: Autologous epidermal cultures were prepared starting from small biopsies of normally pigmented skin. Cells were cultured on hyaluronic acid membranes using medium supplemented with patient's serum. Cell cultures were grafted onto laser-abraded depigmented areas. Patients underwent narrow-band UVB therapy 3 weeks after grafting.

Results: Repigmentation of the grafted areas started 1 month after transplant and continued until 4 months after grafting. All patients were evaluated 3, 6, 12, and 18 months after grafting. At the 18-month follow-up, repigmentation was observed in 75% of patients with focal and segmental vitiligo and in 30% of patients with generalized vitiligo.

Conclusions: This therapy can be considered for the treatment of stable vitiligo (especially focal and segmental) resistant to standard therapies. Their results are encouraging from the clinical and esthetic point of view, although the treatment is costly and highly specialized.
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http://dx.doi.org/10.1111/j.1524-4725.2005.31036DOI Listing
February 2005

Skin allograft in the treatment of toxic epidermal necrolysis (TEN).

Dermatol Surg 2002 Dec;28(12):1173-6

Department of Dermatology and Skin Bank, Siena, Italy.

Background: TEN is a severe form of exfoliative dermatitis. Its course is acute and its outcome fatal in 40% of cases. Wound cover to prevent fluid/protein loss and infections and to control pain, is the first step, as for burns. Skin allograft can be successfully used for this purpose.

Objective: We report two cases of TEN with de-epithelialization of 50 and 70% of the total body surface area. The patients were given support therapy and treated with human glycerol-preserved skin allografts for wound cover.

Methods: Patients were grafted with glycerol-preserved donor skin, obtained from a skin bank.

Results: Re-epithelization of treated areas was complete in 8 days; pain relief was obtained soon after the graft.

Conclusions: Glycerol-preserved skin allograft is an effective treatment in extensive skin loss, for its barrier and analgesic effect. Quality standards of this product ensure safety and simplicity of use at limited cost.
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http://dx.doi.org/10.1046/j.1524-4725.2002.02119.xDOI Listing
December 2002