Publications by authors named "Paolo Montuschi"

85Publications

eNose breath prints as a surrogate biomarker for classifying patients with asthma by atopy.

J Allergy Clin Immunol 2020 Nov 10;146(5):1045-1055. Epub 2020 Jun 10.

Department of Respiratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands; Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands; Department of Paediatric Respiratory Medicine, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2020.05.038DOI Listing
November 2020

NMR-Based Metabolomics for the Assessment of Inhaled Pharmacotherapy in Chronic Obstructive Pulmonary Disease Patients.

J Proteome Res 2020 01 7;19(1):64-74. Epub 2019 Nov 7.

Department of Pharmacology, Faculty of Medicine, Catholic University of the Sacred Heart, Largo F. Vito, 1, Rome, Italy 00168

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http://dx.doi.org/10.1021/acs.jproteome.9b00345DOI Listing
January 2020

Comparison of two exhaled biomarkers in children with and without sleep disordered breathing.

Sleep Med 2018 05 10;45:83-88. Epub 2018 Feb 10.

Pediatric Unit Sant'Andrea Hospital, NESMOS Department, Faculty of Medicine and Psychology, "Sapienza" University, Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.sleep.2018.01.011DOI Listing
May 2018

The discovery and development of aclidinium bromide for the treatment of chronic obstructive pulmonary disease.

Expert Opin Drug Discov 2018 06 4;13(6):563-577. Epub 2018 Apr 4.

c Department of Pharmacology, Faculty of Medicine , Catholic University of the Sacred Heart , Rome , Italy.

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https://www.tandfonline.com/doi/full/10.1080/17460441.2018.1
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http://dx.doi.org/10.1080/17460441.2018.1455661DOI Listing
June 2018

Single-inhaler triple therapy utilizing the once-daily combination of fluticasone furoate, umeclidinium and vilanterol in the management of COPD: the current evidence base and future prospects.

Ther Adv Respir Dis 2018 Jan-Dec;12:1753466618760779

Department of Pharmacology, Faculty of Medicine, Catholic University of the Sacred Heart, Agostino Gemelli, University Hospital Foundation, Largo Francesco Vito, 1 - 00168, Rome, Italy.

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http://dx.doi.org/10.1177/1753466618760779DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941662PMC
January 2019

The potential role of endothelial dysfunction and platelet activation in the development of thrombotic risk in COPD patients.

Expert Rev Hematol 2017 09 12;10(9):821-832. Epub 2017 Jul 12.

e Department of Medical and Surgical Sciences , University of Modena-Reggio Emilia , Modena , Italy.

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http://dx.doi.org/10.1080/17474086.2017.1353416DOI Listing
September 2017

Investigational beta-2 adrenergic agonists for the treatment of chronic obstructive pulmonary disease.

Expert Opin Investig Drugs 2017 Mar 6;26(3):319-329. Epub 2017 Feb 6.

e Department of Respiratory Medicine , Royal Brompton & Harefield NHS Trust, Harefield Hospital , Harefield , UK.

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http://dx.doi.org/10.1080/13543784.2017.1287172DOI Listing
March 2017

Dupilumab for the treatment of asthma.

Expert Opin Investig Drugs 2017 Mar 7;26(3):357-366. Epub 2017 Feb 7.

a Department of Pharmacology, Faculty of Medicine , Catholic University of the Sacred Heart, University Hospital Agostino Gemelli Foundation , Rome , Italy.

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http://dx.doi.org/10.1080/13543784.2017.1282458DOI Listing
March 2017

Triple inhaled therapy for chronic obstructive pulmonary disease.

Drug Discov Today 2016 11 21;21(11):1820-1827. Epub 2016 Jul 21.

Department of Pharmacology, Faculty of Medicine, University Hospital Agostino Gemelli, Catholic University of the Sacred Heart, Rome, Italy.

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http://dx.doi.org/10.1016/j.drudis.2016.07.009DOI Listing
November 2016

Vilanterol trifenatate for the treatment of COPD.

Expert Rev Respir Med 2016 07 25;10(7):719-31. Epub 2016 May 25.

d Department of Respiratory Medicine , Royal Brompton & Harefield NHS Trust, Harefield Hospital , Middlesex , UK.

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http://dx.doi.org/10.1080/17476348.2016.1184976DOI Listing
July 2016

Investigational prostaglandin D2 receptor antagonists for airway inflammation.

Expert Opin Investig Drugs 2016 Jun 25;25(6):639-52. Epub 2016 Apr 25.

a Department of Pharmacology, Faculty of Medicine , Catholic University of the Sacred Heart , Rome , Italy.

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http://dx.doi.org/10.1080/13543784.2016.1175434DOI Listing
June 2016

Electronic Nose and Exhaled Breath NMR-based Metabolomics Applications in Airways Disease.

Curr Top Med Chem 2016 ;16(14):1610-30

Department of Pharmacology, Faculty of Medicine, Catholic University of the Sacred Heart, Largo Francesco Vito, 1, 00168 Rome, Italy.

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http://dx.doi.org/10.2174/1568026616666151223113540DOI Listing
December 2016

Comparison of classification methods in breath analysis by electronic nose.

J Breath Res 2015 Dec 15;9(4):046002. Epub 2015 Dec 15.

Department of Intensive Care, Academic Medical Center, Amsterdam, The Netherlands. Department of Medical Informatics, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1088/1752-7155/9/4/046002DOI Listing
December 2015

The Combined Impact of Exhaled Nitric Oxide and Sputum Eosinophils Monitoring in Asthma Treatment: A Prospective Cohort Study.

Curr Pharm Des 2015 ;21(32):4752-62

Department of Internal Medicine, University of Brescia, AOU Spedali Civili - Pzza Spedali Civili 1 - 25100 Brescia, Italy.

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http://dx.doi.org/10.2174/1871524915666150710123415DOI Listing
September 2016

Bronchodilating drugs for chronic obstructive pulmonary disease: current status and future trends.

J Med Chem 2015 May 9;58(10):4131-64. Epub 2015 Feb 9.

Department of Pharmacology, Faculty of Medicine, Catholic University of the Sacred Heart, Largo Francesco Vito, 1, Rome, 00168, Italy.

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http://dx.doi.org/10.1021/jm5013227DOI Listing
May 2015

Role of beta-blockers in patients with COPD: current perspective.

Drug Discov Today 2015 Jan 17;20(1):129-35. Epub 2014 Sep 17.

Department of Translational Medicine, Division of Internal Medicine, Università del Piemonte Orientale 'A. Avogadro', Novara, Italy.

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http://dx.doi.org/10.1016/j.drudis.2014.09.005DOI Listing
January 2015

Pharmacological treatment of chronic obstructive pulmonary disease: from evidence-based medicine to phenotyping.

Drug Discov Today 2014 Dec 23;19(12):1928-35. Epub 2014 Aug 23.

Pneumology Department, Hospital Universitari Vall d'Hebron, CIBER de Enfermedades Respiratorias (CIBERES), Barcelona, Spain.

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http://dx.doi.org/10.1016/j.drudis.2014.08.004DOI Listing
December 2014

Exhaled nitric oxide as a biomarker in COPD and related comorbidities.

Biomed Res Int 2014 27;2014:271918. Epub 2014 Feb 27.

Department of Clinical and Biological Sciences, University of Torino, San Luigi Hospital, Regione Gonzole 10, 10043 Orbassano, Italy.

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http://dx.doi.org/10.1155/2014/271918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955647PMC
December 2014

Liquid chromatography-mass spectrometry measurement of leukotrienes in asthma and other respiratory diseases.

J Chromatogr B Analyt Technol Biomed Life Sci 2014 Aug 12;964:12-25. Epub 2014 Mar 12.

Department of Pharmacology, Faculty of Medicine, Catholic University of the Sacred Heart , Rome, Italy.

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http://dx.doi.org/10.1016/j.jchromb.2014.02.059DOI Listing
August 2014

Separating smoking-related diseases using NMR-based metabolomics of exhaled breath condensate.

J Proteome Res 2013 Mar 12;12(3):1502-11. Epub 2013 Feb 12.

Department of Respiratory Medicine, AO Monaldi, Faculty of Medicine, University of Naples Federico II, Naples, Italy.

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http://dx.doi.org/10.1021/pr301171pDOI Listing
March 2013

The electronic nose in respiratory medicine.

Respiration 2013 25;85(1):72-84. Epub 2012 Sep 25.

Department of Pharmacology, Faculty of Medicine, Catholic University of the Sacred Heart, Rome, Italy.

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http://dx.doi.org/10.1159/000340044DOI Listing
May 2013

Drugs for chronic obstructive pulmonary disease.

Authors:
Paolo Montuschi

Curr Med Chem 2013 ;20(12):1461-3

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http://dx.doi.org/10.2174/0929867311320120001DOI Listing
November 2013

Exhaled nitric oxide measurement in patients affected by nasal polyposis.

Otolaryngol Head Neck Surg 2012 Aug 2;147(2):351-6. Epub 2012 Apr 2.

ENT Institute, Catholic University of Sacred Heart Rome, Rome, Italy.

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http://dx.doi.org/10.1177/0194599812442322DOI Listing
August 2012

New perspectives in pharmacological treatment of mild persistent asthma.

Drug Discov Today 2011 Dec 10;16(23-24):1084-91. Epub 2011 Sep 10.

Department of Pharmacology, Faculty of Medicine, Catholic University of Sacred Heart, Largo Francesco Vito, 1-00168 Rome, Italy.

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http://dx.doi.org/10.1016/j.drudis.2011.09.005DOI Listing
December 2011

Pharmacotherapy of patients with mild persistent asthma: strategies and unresolved issues.

Authors:
Paolo Montuschi

Front Pharmacol 2011 14;2:35. Epub 2011 Jul 14.

Department of Pharmacology, Faculty of Medicine, Catholic University of the Sacred Heart Rome, Italy.

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http://dx.doi.org/10.3389/fphar.2011.00035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139104PMC
November 2011

Role of Leukotrienes and Leukotriene Modifiers in Asthma.

Authors:
Paolo Montuschi

Pharmaceuticals (Basel) 2010 Jun 2;3(6):1792-1811. Epub 2010 Jun 2.

Department of Pharmacology, Faculty of Medicine, Catholic University of the Sacred Heart, Largo Francesco Vito, 1-00168 Rome, Italy.

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http://dx.doi.org/10.3390/ph3061792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033953PMC
June 2010

Measurement of 8-isoprostane in exhaled breath condensate.

Methods Mol Biol 2010 ;594:73-84

Department of Pharmacology, Catholic University of the Sacred Heart, Rome, Italy.

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http://dx.doi.org/10.1007/978-1-60761-411-1_5DOI Listing
April 2010

Toward a personalized pharmacotherapy of respiratory diseases.

Authors:
Paolo Montuschi

Front Pharmacol 2010 5;1:131. Epub 2010 Nov 5.

Department of Pharmacology, Faculty of Medicine, Catholic University of the Sacred Heart Rome, Italy.

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http://dx.doi.org/10.3389/fphar.2010.00131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153006PMC
November 2011

Pharmacotherapy of asthma: regular treatment or on demand?

Ther Adv Respir Dis 2009 Aug 11;3(4):175-91. Epub 2009 Aug 11.

Department of Pharmacology, Faculty of Medicine, Catholic University of the Sacred Heart, Rome, Italy.

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http://dx.doi.org/10.1177/1753465809343711DOI Listing
August 2009

Acute effects of air pollution on pulmonary function, airway inflammation, and oxidative stress in asthmatic children.

Environ Health Perspect 2009 Apr 28;117(4):668-74. Epub 2008 Nov 28.

Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1289/ehp11813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679614PMC
April 2009

LC/MS/MS analysis of leukotriene B4 and other eicosanoids in exhaled breath condensate for assessing lung inflammation.

Authors:
Paolo Montuschi

J Chromatogr B Analyt Technol Biomed Life Sci 2009 May 2;877(13):1272-80. Epub 2009 Feb 2.

Department of Pharmacology, Faculty of Medicine, Catholic University of the Sacred Heart, Largo Francesco Vito 1, Rome 00168, Italy.

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http://dx.doi.org/10.1016/j.jchromb.2009.01.036DOI Listing
May 2009

8-Isoprostane in exhaled breath condensate and exercise-induced bronchoconstriction in asthmatic children and adolescents.

Chest 2009 Jan 27;135(1):66-73. Epub 2008 Aug 27.

Department of Pharmacology, Faculty of Medicine, Catholic University of the Sacred Hearth, Rome, Italy.

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http://dx.doi.org/10.1378/chest.08-0722DOI Listing
January 2009

Exhaled 8-isoprostane and prostaglandin E(2) in patients with stable and unstable cystic fibrosis.

Free Radic Biol Med 2008 Sep 30;45(6):913-9. Epub 2008 Jun 30.

Department of Pediatrics, Cystic Fibrosis Unit, Ospedale Pediatrico Bambino Gesù, Rome, Italy.

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http://linkinghub.elsevier.com/retrieve/pii/S089158490800395
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http://dx.doi.org/10.1016/j.freeradbiomed.2008.06.026DOI Listing
September 2008

Leukotrienes, antileukotrienes and asthma.

Authors:
Paolo Montuschi

Mini Rev Med Chem 2008 Jun;8(7):647-56

Department of Pharmacology, Faculty of Medicine, Catholic University of the Sacred Heart, Largo F. Vito, 1, 00168 Rome, Italy.

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http://dx.doi.org/10.2174/138955708784567395DOI Listing
June 2008

Effects of montelukast treatment and withdrawal on fractional exhaled nitric oxide and lung function in children with asthma.

Chest 2007 Dec;132(6):1876-81

Department of Pharmacology, Faculty of Medicine, Catholic University of the Sacred Heart, Largo F. Vito, 1, 00168 Rome, Italy.

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http://dx.doi.org/10.1378/chest.07-1587DOI Listing
December 2007

Pharmacological treatment of chronic obstructive pulmonary disease.

Authors:
Paolo Montuschi

Int J Chron Obstruct Pulmon Dis 2006 ;1(4):409-23

Department of Pharmacology, Faculty of Medicine, Catholic University of the Sacred Heart, Rome, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2707800PMC
http://dx.doi.org/10.2147/copd.2006.1.4.409DOI Listing
January 2008

Analysis of exhaled breath condensate in respiratory medicine: methodological aspects and potential clinical applications.

Authors:
Paolo Montuschi

Ther Adv Respir Dis 2007 Oct;1(1):5-23

Department of Pharmacology, Faculty of Medicine, Catholic University of the Sacred Heart, Rome, Italy.

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http://journals.sagepub.com/doi/10.1177/1753465807082373
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http://dx.doi.org/10.1177/1753465807082373DOI Listing
October 2007

Pharmacological modulation of the leukotriene pathway in allergic airway disease.

Drug Discov Today 2007 May 23;12(9-10):404-12. Epub 2007 Mar 23.

Department of Pharmacology, Faculty of Medicine, Catholic University of the Sacred Heart, Rome, Italy.

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http://sistints01.rm.unicatt.it/allegati_pubblicazioni_istit
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http://linkinghub.elsevier.com/retrieve/pii/S135964460700104
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http://dx.doi.org/10.1016/j.drudis.2007.03.004DOI Listing
May 2007

Insights into oxidative stress: the isoprostanes.

Curr Med Chem 2007 ;14(6):703-17

Department of Pharmacology, Faculty of Medicine, Catholic University of the Sacred Heart, Largo F. Vito 1, 00168 Rome, Italy.

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http://dx.doi.org/10.2174/092986707780059607DOI Listing
April 2007

Effects of a leukotriene receptor antagonist on exhaled leukotriene E4 and prostanoids in children with asthma.

J Allergy Clin Immunol 2006 Aug 3;118(2):347-53. Epub 2006 Jul 3.

Department of Pharmacology, Faculty of Medicine, Catholic University of the Sacred Heart, Largo F. Vito 1, 00168 Rome, Italy.

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http://dx.doi.org/10.1016/j.jaci.2006.04.010DOI Listing
August 2006

Inflammatory response to sputum induction measured by exhaled markers.

Respiration 2005 Nov-Dec;72(6):594-9. Epub 2005 Jul 1.

Department of Pneumology and Allergology, Medical University of Lodz, Kopcinskiego str. 22, PL-90-153 Lodz, Poland.

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http://dx.doi.org/10.1159/000086721DOI Listing
February 2006

Exhaled breath condensate analysis in patients with COPD.

Authors:
Paolo Montuschi

Clin Chim Acta 2005 Jun 23;356(1-2):22-34. Epub 2005 Mar 23.

Department of Pharmacology, Faculty of Medicine, Catholic University of the Sacred Heart, Largo F. Vito, 1, 00168 Rome, Italy.

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http://dx.doi.org/10.1016/j.cccn.2005.01.012DOI Listing
June 2005

Isoprostanes: markers and mediators of oxidative stress.

FASEB J 2004 Dec;18(15):1791-800

Department of Pharmacology, School of Medicine, Catholic University of the Sacred Heart, Rome, Italy.

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http://dx.doi.org/10.1096/fj.04-2330revDOI Listing
December 2004

Ion trap liquid chromatography/tandem mass spectrometry analysis of leukotriene B4 in exhaled breath condensate.

Rapid Commun Mass Spectrom 2004 ;18(22):2723-9

Department of Pharmacology, Faculty of Medicine, Catholic University of the Sacred Heart, Rome, Italy.

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http://dx.doi.org/10.1002/rcm.1682DOI Listing
December 2004

Effects of inhaled corticosteroids on exhaled leukotrienes and prostanoids in asthmatic children.

J Allergy Clin Immunol 2004 Oct;114(4):761-7

Department of Immunodermatology, Istituto Dermopatico dell'Immacolata, IDI, IRCCS, Rome.

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http://dx.doi.org/10.1016/j.jaci.2004.06.054DOI Listing
October 2004

[Pharmacological therapy of chronic obstructive pulmonary disease].

Authors:
Paolo Montuschi

Ann Ist Super Sanita 2003 ;39(4):557-72

Istituto di Farmacologia, Facoltà di Medicina e Chirurgia "A. Gemelli", Università Cattolica del Sacro Cuore, Roma.

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September 2004

Increased exhaled 8-isoprostane in childhood asthma.

Chest 2003 Jul;124(1):25-31

Department of Pediatrics (Drs. Baraldi, Ghiro, Piovan, and Carraro), School of Medicine, University of Padova, Padova, Italy.

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http://dx.doi.org/10.1378/chest.124.1.25DOI Listing
July 2003

Ozone-induced increase in exhaled 8-isoprostane in healthy subjects is resistant to inhaled budesonide.

Free Radic Biol Med 2002 Nov;33(10):1403-8

Department of Pharmacology, School of Medicine, Catholic University of the Sacred Heart, Rome, Italy.

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http://dx.doi.org/10.1016/s0891-5849(02)01084-5DOI Listing
November 2002

Diagnosing nonimmediate reactions to penicillins by in vivo tests.

Int Arch Allergy Immunol 2002 Oct;129(2):169-74

Department of Internal Medicine and Geriatrics, UCSC Allergy Unit, Complesso Integrato Columbus, Rome, Italy.

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http://dx.doi.org/10.1159/000065876DOI Listing
October 2002

Increased exhaled cysteinyl-leukotrienes and 8-isoprostane in aspirin-induced asthma.

Am J Respir Crit Care Med 2002 Aug;166(3):301-6

Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College, London, UK.

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http://dx.doi.org/10.1164/rccm.2101021DOI Listing
August 2002

Indirect monitoring of lung inflammation.

Authors:
Paolo Montuschi

Nat Rev Drug Discov 2002 Mar;1(3):238-42

Department of Pharmacology, School of Medicine, Catholic University of the Sacred Heart, L.go F. Vito 1-00168, Rome, Italy.

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http://dx.doi.org/10.1038/nrd751DOI Listing
March 2002

Analysis of exhaled breath condensate for monitoring airway inflammation.

Trends Pharmacol Sci 2002 May;23(5):232-7

Dept of Pharmacology, School of Medicine, Catholic University of the Sacred Heart, 00168 Rome, Italy.

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http://www.sagepublications.com/promos/tar_lung_inflammation
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http://www.cell.com/trends/pharmacological-sciences/pdf/S016
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http://dx.doi.org/10.1016/s0165-6147(02)02020-5DOI Listing
May 2002

Exhaled leukotrienes and prostaglandins in asthma.

J Allergy Clin Immunol 2002 Apr;109(4):615-20

Department of Pharmacology, School of Medicine, Catholic University of the Sacred Heart, Rome, Italy.

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http://dx.doi.org/10.1067/mai.2002.122461DOI Listing
April 2002