Paolo Ghia

Paolo Ghia

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Paolo Ghia

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The evolving treatment landscape of chronic lymphocytic leukemia.

Curr Opin Oncol 2019 Nov;31(6):568-573

Strategic Research Program on CLL, IRCCS Ospedale San Raffaele.

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http://dx.doi.org/10.1097/CCO.0000000000000585DOI Listing
November 2019

From Mice to Men: How B Cell Immunology Helped the Understanding of Leukemia Development.

Authors:
Paolo Ghia

Front Immunol 2018 24;9:2402. Epub 2018 Oct 24.

IRCCS Ospedale San Raffaele, Università Vita-Salute San Raffaele, Milan, Italy.

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http://dx.doi.org/10.3389/fimmu.2018.02402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209738PMC
October 2019

Immunoglobulin Gene Analysis in Chronic Lymphocytic Leukemia.

Methods Mol Biol 2019 ;1881:51-62

Institute of Applied Biosciences, Center for Research and Technology, Thessaloniki, Greece.

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http://link.springer.com/10.1007/978-1-4939-8876-1_5
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http://dx.doi.org/10.1007/978-1-4939-8876-1_5DOI Listing
June 2019

The importance of B cell receptor isotypes and stereotypes in chronic lymphocytic leukemia.

Leukemia 2019 02 16;33(2):287-298. Epub 2018 Dec 16.

Department of Leukemia, Unit 428, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1038/s41375-018-0303-xDOI Listing
February 2019

Monoclonal B-cell lymphocytosis: Does the elderly patient need a specialistic approach?

Eur J Intern Med 2018 12 26;58:2-6. Epub 2018 Sep 26.

Strategic Research Program on CLL, Università Vita-Salute San Raffaele and IRCCS Ospedale San Raffaele, Milano, Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S09536205183036
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http://dx.doi.org/10.1016/j.ejim.2018.09.006DOI Listing
December 2018

aberrations in chronic lymphocytic leukemia: an overview of the clinical implications of improved diagnostics.

Haematologica 2018 12 15;103(12):1956-1968. Epub 2018 Nov 15.

Internal Medicine III, Ulm University, Germany and Innere Medizin I, Universitätsklinikum des Saarlandes, Homburg, Germany.

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http://www.haematologica.org/lookup/doi/10.3324/haematol.201
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http://dx.doi.org/10.3324/haematol.2018.187583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269313PMC
December 2018

Splenic marginal zone lymphomas in acquired C1-inhibitor deficiency: clinical and molecular characterization.

Med Oncol 2018 Aug 2;35(9):118. Epub 2018 Aug 2.

Department of Biomedical and Clinical Sciences Luigi Sacco, University of Milan, Luigi Sacco Hospital Milan, Milan, Italy.

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http://dx.doi.org/10.1007/s12032-018-1183-7DOI Listing
August 2018

Minimal residual disease analysis in chronic lymphocytic leukemia: a way for achieving more personalized treatments.

Leukemia 2018 06 26;32(6):1307-1316. Epub 2018 Mar 26.

Haematological Malignancy Diagnostic Service (HMDS), Leeds Teaching Hospitals NHS Trust, Leeds and Department of Health Sciences, University of York, York, UK.

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http://www.nature.com/articles/s41375-018-0109-x
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http://dx.doi.org/10.1038/s41375-018-0109-xDOI Listing
June 2018

Highly similar genomic landscapes in monoclonal B-cell lymphocytosis and ultra-stable chronic lymphocytic leukemia with low frequency of driver mutations.

Haematologica 2018 05 15;103(5):865-873. Epub 2018 Feb 15.

Strategic Research Program on CLL and B-cell Neoplasia Unit, Division of Experimental Oncology, Università Vita-Salute San Raffaele and IRCCS Istituto Scientifico San Raffaele, Milan, Italy

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http://dx.doi.org/10.3324/haematol.2017.177212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927998PMC
May 2018

Distinct molecular genetics of chronic lymphocytic leukemia in Taiwan: clinical and pathogenetic implications.

Haematologica 2017 06 2;102(6):1085-1090. Epub 2017 Mar 2.

Strategic Research Program on CLL and B-cell Neoplasia Unit, Division of Experimental Oncology, Vita-Salute San Raffaele University and IRCCS San Raffaele Scientific Institute, Milan, Italy

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http://dx.doi.org/10.3324/haematol.2016.157552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451340PMC
June 2017

Distinct homotypic B-cell receptor interactions shape the outcome of chronic lymphocytic leukaemia.

Nat Commun 2017 06 9;8:15746. Epub 2017 Jun 9.

Biocrystallography Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, via Olgettina 58, 20132 Milan, Italy.

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http://dx.doi.org/10.1038/ncomms15746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472768PMC
June 2017

Reactivating nuclear PTEN to treat CLL.

Oncotarget 2017 May;8(22):35486-35487

Division of Experimental Oncology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.

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http://dx.doi.org/10.18632/oncotarget.17543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482590PMC
May 2017

Ibrutinib in the real world patient: many lights and some shades.

Haematologica 2016 12;101(12):1448-1450

Department of Medical Sciences, Hematology Unit. University of Ferrara, Italy.

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http://dx.doi.org/10.3324/haematol.2016.155986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479615PMC
December 2016

Similar epidemiological trends of pre-neoplastic precursors and their respective lymphoid malignancies in Taiwan.

Ann Hematol 2016 Oct 19;95(10):1727-9. Epub 2016 Jul 19.

Department of Pathology, Chi-Mei Medical Center, Tainan, Taiwan.

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http://dx.doi.org/10.1007/s00277-016-2747-2DOI Listing
October 2016

Ibrutinib holds promise for patients with 17p deletion CLL.

Authors:
Paolo Ghia

Lancet Oncol 2016 10 13;17(10):1342-1343. Epub 2016 Sep 13.

Strategic Research Program on Chronic Lymphocytic Leukaemia, Division of Experimental Oncology, IRCCS Ospedale San Raffaele and Università Vita-Salute San Raffaele, Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(16)30442-9DOI Listing
October 2016

Chronic lymphocytic leukaemia.

Crit Rev Oncol Hematol 2016 Aug 16;104:169-82. Epub 2016 Jun 16.

Department of Onco-Haematology, Division of Experimental Oncology, IRCCS San Raffaele Hospital, Milan, Italy; University Vita-Salute San Raffaele, Milan, Italy.

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http://dx.doi.org/10.1016/j.critrevonc.2016.06.003DOI Listing
August 2016

Toll-like receptors signaling: A complex network for NF-κB activation in B-cell lymphoid malignancies.

Semin Cancer Biol 2016 08 9;39:15-25. Epub 2016 Jul 9.

Division of Experimental Oncology, IRCCS San Raffaele Hospital, Milano, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.semcancer.2016.07.001DOI Listing
August 2016

B Cell Anergy Modulated by TLR1/2 and the miR-17∼92 Cluster Underlies the Indolent Clinical Course of Chronic Lymphocytic Leukemia Stereotyped Subset #4.

J Immunol 2016 05 8;196(10):4410-7. Epub 2016 Apr 8.

Institute of Applied Biosciences, Centre for Research and Technology Hellas, Thessaloniki 57001, Greece; Hematology Department and Hematopoietic Cell Transplantation Unit, George Papanikolaou Hospital, Thessaloniki 57010, Greece; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala 75105, Sweden

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http://dx.doi.org/10.4049/jimmunol.1502297DOI Listing
May 2016

What does it mean I have a monoclonal B-cell lymphocytosis?: Recent insights and new challenges.

Semin Oncol 2016 Apr 6;43(2):201-8. Epub 2016 Feb 6.

Department of Onco-Haematology and Division of Experimental Oncology, IRCCS San Raffaele Hospital and Università Vita-Salute San Raffaele, Milan, Italy.

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http://dx.doi.org/10.1053/j.seminoncol.2016.02.013DOI Listing
April 2016

Innovation in the prognostication of chronic lymphocytic leukemia: how far beyond TP53 gene analysis can we go?

Haematologica 2016 Mar;101(3):263-5

Division of Experimental Oncology and Department of Onco-Hematology, Università Vita-Salute San Raffaele and IRCCS Instituto Scientifico San Raffaele, Milan, Italy

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http://dx.doi.org/10.3324/haematol.2015.139246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815716PMC
March 2016

A new life for rituximab?

Authors:
Paolo Ghia

Lancet Haematol 2016 Mar;3(3):e103-4

Università Vita-Salute and Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, Milan, MI 20132, Italy. Electronic address:

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http://dx.doi.org/10.1016/S2352-3026(16)00024-7DOI Listing
March 2016

Targeting Macrophages Sensitizes Chronic Lymphocytic Leukemia to Apoptosis and Inhibits Disease Progression.

Cell Rep 2016 Feb 11;14(7):1748-1760. Epub 2016 Feb 11.

Unit of Lymphoid Malignancies, Division of Experimental Oncology, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy; Vita-Salute San Raffaele University, 20132 Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.01.042DOI Listing
February 2016

Antigen Selection Shapes the T-cell Repertoire in Chronic Lymphocytic Leukemia.

Clin Cancer Res 2016 Jan 2;22(1):167-74. Epub 2015 Sep 2.

Institute of Applied Biosciences, Center for Research and Technology Hellas, Thessaloniki, Greece. Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece. Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-3017DOI Listing
January 2016

Long-term remissions after FCR chemoimmunotherapy in previously untreated patients with CLL: updated results of the CLL8 trial.

Blood 2016 Jan 20;127(2):208-15. Epub 2015 Oct 20.

Department I for Internal Medicine and Center of Integrated Oncology, University of Cologne, Cologne, Germany; Cluster of Excellence Cellular Stress Responses in Aging Associated Diseases, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1182/blood-2015-06-651125DOI Listing
January 2016

Acalabrutinib (ACP-196) in Relapsed Chronic Lymphocytic Leukemia.

N Engl J Med 2016 Jan 7;374(4):323-32. Epub 2015 Dec 7.

From the Division of Hematology, Department of Internal Medicine, Ohio State University (J.C. Byrd, J.A.J., F.T.A., J.W., A.J.J.), and the Department of Veterinary Biosciences, College of Veterinary Medicine (B.H.) - both in Columbus; UC Irvine Health Chao Family Comprehensive Cancer Center, University of California, Irvine, Orange (S.O.); University of Oxford, Oxford (A.S.), NHS Foundation Trust, King's College Hospital, London (S.D.), and the Department of Haematology, St. James's University Hospital, Leeds (P.H.) - all in the United Kingdom; Northwest Medical Specialties, Tacoma (J.C.), and the Swedish Cancer Institute, Seattle (J.M.P.) - both in Washington; the Department of Leukemia, Division of Cancer Medicine, University of Texas, and M.D. Anderson Cancer Center - both in Houston (W.G.W.); the Department of Medical Oncology, Dana-Farber Cancer Institute, Boston (J.R.B.); Huntsman Cancer Institute, University of Utah, Salt Lake City (D.M.S.); Università Vita-Salute San Raffaele and Istituto Scientifico San Raffaele, Milan (P.G.); Hofstra North Shore-LIJ School of Medicine, Chronic Lymphocytic Leukemia Research and Treatment Center, Lake Success (J.C. Barrientos), and the Department of Pathology and Cell Biology, Columbia University Medical Center (T.G.D.), and New York-Presbyterian/Weill Cornell Medical Center, New York (R.R.F.) - all in New York; and Acerta Pharma, Oss, the Netherlands (D.J., J.H., X.W., A.K., B.J.L., T.C., M.F., J.M., A.H., W.R., R.I.).

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http://dx.doi.org/10.1056/NEJMoa1509981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862586PMC
January 2016

Ibrutinib as Initial Therapy for Patients with Chronic Lymphocytic Leukemia.

N Engl J Med 2015 Dec 6;373(25):2425-37. Epub 2015 Dec 6.

From the University of Texas MD Anderson Cancer Center, Houston (J.A.B.); Azienda Ospedaliera Niguarda Cà Granda (A.T.) and Università Vita-Salute San Raffaele and IRCCS Istituto Scientifico San Raffaele (P.G.), Milan, and the Department of Translational Medicine, Amedeo Avogadro University of Eastern Piedmont, Novara (G.G.) - all in Italy; Wilmot Cancer Institute, University of Rochester, Rochester, NY (P.M.B.); Medical University of Lodz and Copernicus Memorial Hospital, Lodz (T.R.), the Department of Cancer Prevention, School of Public Health, Medical University of Silesia, Katowice (S.G.), and the Department of Hematology, University Clinical Center of Medical University of Gdansk, Gdansk (A.H.) - all in Poland; Tom Baker Cancer Centre, Calgary, AB, Canada (C.O.); Rabin Medical Center, Beilinson Hospital and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv (O.B.), and Hadassah University Hospital, Hebrew University Medical School, Jerusalem (A.P.) - both in Israel; Leeds Teaching Hospitals, St. James Institute of Oncology, Leeds (P.H.), Kings College Hospital, London (S.D.), Royal Bournemouth Hospital, Bournemouth (H.M.), and University of Oxford, Oxford (A.S.) - all in the United Kingdom; Washington University School of Medicine, St. Louis (N.L.B.); Jiangsu Province Hospital, Nanjing, China (J.L.); North Shore Hospital, Auckland, New Zealand (D. Simpson); Stanford University School of Medicine, Stanford (S.C.), City of Hope National Medical Center, Duarte (T.S.), Pharmacyclics, Sunnyvale (D. Suri, M.C., F.C., L.S., D.F.J.), and Moores Cancer Center, University of California, San Diego, San Diego (T.J.K.) - all in California; St. Vincent's Hospital, University of Melbourne (H.Q.), and Peter MacCallum Cancer Centre and St. Vincent's Hospital (C.S.T.), Melbourne, VIC, Australia; Institute of Blood Pathology and Transfusion Medicine, National Academy of Medical Sciences of Ukraine, Lviv, Ukraine (Z.M.); Norton Cancer Institute, Louisville, KY (D.A.S.);

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http://dx.doi.org/10.1056/NEJMoa1509388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4722809PMC
December 2015

Targeting Hedgehog in haematological malignancies.

Authors:
Paolo Ghia

Lancet Haematol 2015 Aug 26;2(8):e311-2. Epub 2015 Jul 26.

Division of Experimental Oncology and Department of Onco-Hematology, IRCCS Ospedale San Raffaele and Università Vita-Salute San Raffaele, Milan 20132, Italy. Electronic address:

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http://dx.doi.org/10.1016/S2352-3026(15)00112-XDOI Listing
August 2015

Excessive antigen reactivity may underlie the clinical aggressiveness of chronic lymphocytic leukemia stereotyped subset #8.

Blood 2015 Jun 21;125(23):3580-7. Epub 2015 Apr 21.

Division of Experimental Oncology, IRCCS Istituto Scientifico San Raffaele and Department of Onco-Hematology, Ospedale San Raffaele, Milan, Italy; Section of Internal Medicine, Università Vita-Salute San Raffaele, and.

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http://www.bloodjournal.org/content/125/23/3580.full.pdf
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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2014-09-60
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http://dx.doi.org/10.1182/blood-2014-09-603217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458798PMC
June 2015

Not all IGHV3-21 chronic lymphocytic leukemias are equal: prognostic considerations.

Blood 2015 Jan 17;125(5):856-9. Epub 2014 Dec 17.

Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden; Institute of Applied Biosciences, Centre for Research and Technology-Hellas, Thessaloniki, Greece; Hematology Department and Hematopoietic Cell Transplantation Unit, Georgios Papanicolaou Hospital, Thessaloniki, Greece;

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http://www.bloodjournal.org/content/bloodjournal/125/5/856.f
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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2014-09-60
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http://dx.doi.org/10.1182/blood-2014-09-600874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311230PMC
January 2015

Ibrutinib: better combined with other drugs?

Authors:
Paolo Ghia

Lancet Oncol 2014 Sep 20;15(10):1043-4. Epub 2014 Aug 20.

Division of Molecular Oncology and Department of Onco-Hematology, IRCCS Ospedale San Raffaele, Milan 20132, Italy; Università Vita-Salute San Raffaele, Milan 20132, Italy. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(14)70388-2DOI Listing
September 2014

Mouse models in the study of chronic lymphocytic leukemia pathogenesis and therapy.

Blood 2014 Aug 8;124(7):1010-9. Epub 2014 Jul 8.

Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY; Department of Pathology and Cell Biology and Department of Microbiology and Immunology, Columbia University, New York, NY.

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http://dx.doi.org/10.1182/blood-2014-05-577122DOI Listing
August 2014

Immunogenetic studies of chronic lymphocytic leukemia: revelations and speculations about ontogeny and clinical evolution.

Cancer Res 2014 Aug 29;74(16):4211-6. Epub 2014 Jul 29.

Institute of Applied Biosciences, Center for Research and Technology Hellas, Thessaloniki, Greece. Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece. Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Sweden.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-0630DOI Listing
August 2014