Publications by authors named "Paolo E Porporato"

51Publications

Iron: An Essential Element of Cancer Metabolism.

Cells 2020 Dec 3;9(12). Epub 2020 Dec 3.

Molecular Biotechnology Center, Department of Molecular Biotechnology and Health Sciences, University of Torino, 10126 Turin, Italy.

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December 2020

Tumour acidosis evaluated in vivo by MRI-CEST pH imaging reveals breast cancer metastatic potential.

Br J Cancer 2021 Jan 1;124(1):207-216. Epub 2020 Dec 1.

Institute of Biostructures and Bioimaging (IBB), Italian National Research Council (CNR), Via Nizza 52, Torino, Italy.

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January 2021

Cachexia, a Systemic Disease beyond Muscle Atrophy.

Int J Mol Sci 2020 Nov 14;21(22). Epub 2020 Nov 14.

Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, 10126 Turin, Italy.

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November 2020

Editorial: Metabolism Meets Function: Untangling the Cross-Talk Between Signaling and Metabolism.

Front Oncol 2020 20;10:607511. Epub 2020 Oct 20.

Department of Molecular Biotechnology and Health Science, Molecular Biotechnology Center, University of Torino, Torino, Italy.

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October 2020

An EPR Study Using Cyclic Hydroxylamines To Assess The Level of Mitochondrial ROS in Superinvasive Cancer Cells.

Cell Biochem Biophys 2020 Sep 1;78(3):249-254. Epub 2020 Jun 1.

Biomedical Magnetic Resonance, Louvain Drug Research Institute (LDRI), Université catholique de Louvain (UCLouvain), Brussels, Belgium.

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September 2020

Monocarboxylate transporters in cancer.

Mol Metab 2020 03 27;33:48-66. Epub 2019 Jul 27.

Pole of Pharmacology & Therapeutics, Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain (UCLouvain), Brussels, Belgium. Electronic address:

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March 2020

Pro- and antitumor effects of mitochondrial reactive oxygen species.

Cancer Metastasis Rev 2019 06;38(1-2):189-203

Pole of Pharmacology, Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain (UCLouvain), Avenue Hippocrate 57 box B1.57.04, 1200, Brussels, Belgium.

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June 2019

Assessing Metabolic Dysregulation in Muscle During Cachexia.

Methods Mol Biol 2019 ;1928:337-352

Department of Molecular Biotechnology and Health Science, Molecular Biotechnology Center, University of Torino, Torino, Italy.

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June 2019

Annual Meeting of the International Society of Cancer Metabolism (ISCaM): Cancer Metabolism.

Front Oncol 2018 3;8:329. Epub 2018 Oct 3.

Pole of Pharmacology, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium.

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October 2018

(+)-Catechin in a 1:2 Complex with Lysine Inhibits Cancer Cell Migration and Metastatic Take in Mice.

Front Pharmacol 2017 4;8:869. Epub 2017 Dec 4.

Pole of Pharmacology, Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain (UCL), Brussels, Belgium.

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December 2017

Ffar2 expression regulates leukaemic cell growth in vivo.

Br J Cancer 2017 Oct 5;117(9):1336-1340. Epub 2017 Sep 5.

Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Université Catholique de Louvain, Avenue Mounier 73, Box B1.73.11, Brussels 1200, Belgium.

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October 2017

MDA-MB-231 breast cancer cells fuel osteoclast metabolism and activity: A new rationale for the pathogenesis of osteolytic bone metastases.

Biochim Biophys Acta Mol Basis Dis 2017 12 1;1863(12):3254-3264. Epub 2017 Sep 1.

Orthopaedic Pathophysiology and Regenerative Medicine Unit, Istituto Ortopedico Rizzoli, Bologna, Italy. Electronic address:

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December 2017

Monocarboxylate Transporter MCT1 Promotes Tumor Metastasis Independently of Its Activity as a Lactate Transporter.

Cancer Res 2017 10 21;77(20):5591-5601. Epub 2017 Aug 21.

Pole of Pharmacology, Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain (UCL), Brussels, Belgium.

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October 2017

Cancer metabolism in space and time: Beyond the Warburg effect.

Biochim Biophys Acta Bioenerg 2017 Aug 4;1858(8):556-572. Epub 2017 Feb 4.

Pole of Pharmacology and Therapeutics, Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain (UCL), Avenue Emmanuel Mounier 52 box B1.53.09, 1200 Brussels, Belgium; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Via Nizza 52, 10126 Torino Italy. Electronic address:

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August 2017

Multimodality Imaging Identifies Distinct Metabolic Profiles In Vitro and In Vivo.

Neoplasia 2016 Dec 24;18(12):742-752. Epub 2016 Nov 24.

Biomedical Magnetic Resonance Research Group, Louvain Drug Research Institute (LDRI), Université catholique de Louvain, Brussels, Belgium. Electronic address:

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December 2016

Energy metabolism in osteoclast formation and activity.

Int J Biochem Cell Biol 2016 10 30;79:168-180. Epub 2016 Aug 30.

Orthopaedic Pathophysiology and Regenerative Medicine Unit, Istituto Ortopedico Rizzoli (IOR), via di Barbiano 1/10, 40136 Bologna, Italy. Electronic address:

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October 2016

Paving the way for therapeutic prevention of tumor metastasis with agents targeting mitochondrial superoxide.

Mol Cell Oncol 2015 Jul-Sep;2(3):e968043. Epub 2014 Oct 29.

Pole of Pharmacology, Institut de Recherche Expérimentale et Clinique (IREC); Université catholique de Louvain (UCL) ; Brussels, Belgium.

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June 2016

Direct Evidence of the Link Between Energetic Metabolism and Proliferation Capacity of Cancer Cells In Vitro.

Adv Exp Med Biol 2016 ;876:209-214

Biomedical Magnetic Resonance Research Group, Université catholique de Louvain (UCL), Avenue Mounier 73 (B1.73.08), 1200, Brussels, Belgium.

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May 2016

Application of Electron Paramagnetic Resonance (EPR) Oximetry to Monitor Oxygen in Wounds in Diabetic Models.

PLoS One 2015 14;10(12):e0144914. Epub 2015 Dec 14.

Biomedical Magnetic Resonance Research Group, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium.

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July 2016

Metabolic changes associated with tumor metastasis, part 2: Mitochondria, lipid and amino acid metabolism.

Cell Mol Life Sci 2016 Apr 8;73(7):1349-63. Epub 2015 Dec 8.

Pole of Pharmacology, Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain (UCL), Avenue Emmanuel Mounier 52, box B1.53.09, 1200, Brussels, Belgium.

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April 2016

Lactate promotes glutamine uptake and metabolism in oxidative cancer cells.

Cell Cycle 2016 ;15(1):72-83

a From the Pole of Pharmacology, Institute of Experimental and Clinical Research (IREC), Université catholique de Louvain (UCL) Medical School , Brussels , Belgium.

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October 2016

Metabolic changes associated with tumor metastasis, part 1: tumor pH, glycolysis and the pentose phosphate pathway.

Cell Mol Life Sci 2016 Apr 1;73(7):1333-48. Epub 2015 Dec 1.

Pole of Pharmacology, Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain (UCL), Avenue Emmanuel Mounier 52, box B1.53.09, 1200, Brussels, Belgium.

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April 2016

Non-invasive in vivo imaging of early metabolic tumor response to therapies targeting choline metabolism.

Int J Cancer 2016 Apr 9;138(8):2043-9. Epub 2015 Dec 9.

Biomedical Magnetic Resonance Group, Louvain Drug Research Institute, Université Catholique De Louvain (UCL), Avenue Mounier, 73 Box B1.73.08, Brussels, Belgium.

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April 2016

PLGA nanoparticles loaded with host defense peptide LL37 promote wound healing.

J Control Release 2014 Nov 27;194:138-47. Epub 2014 Aug 27.

Université catholique de Louvain, Louvain Drug Research Institute (LDRI), Advanced Drug Delivery and Biomaterials, Avenue E. Mounier 73 box B1.73.12, 1200 Brussels, Belgium. Electronic address:

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November 2014

A mitochondrial switch promotes tumor metastasis.

Cell Rep 2014 Aug 24;8(3):754-66. Epub 2014 Jul 24.

Institut de Recherche Expérimentale et Clinique (IREC), Pole of Pharmacology (FATH), Université catholique de Louvain (UCL), Brussels 1200, Belgium. Electronic address:

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August 2014

Reprogramming of tumor metabolism by targeting mitochondria improves tumor response to irradiation.

Acta Oncol 2015 Feb 9;54(2):266-74. Epub 2014 Jul 9.

Center for Molecular Imaging, Radiotherapy and Oncology, Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain (UCL) , Brussels , Belgium.

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February 2015

Multimodal cell tracking of a spontaneous metastasis model: comparison between MRI, electron paramagnetic resonance and bioluminescence.

Contrast Media Mol Imaging 2014 Mar-Apr;9(2):143-53

Louvain Drug Research Institute, Biomedical Magnetic Resonance Research Group, Université catholique de Louvain, Brussels, Belgium.

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October 2014

Role of AMP-activated protein kinase in regulating hypoxic survival and proliferation of mesenchymal stem cells.

Cardiovasc Res 2014 Jan 8;101(1):20-9. Epub 2013 Oct 8.

Pôle de Recherche Cardiovasculaire, Université catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Avenue Hippocrate, 55, B1.55.05, Brussels B-1200, Belgium.

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January 2014

Optimization of tumor radiotherapy with modulators of cell metabolism: toward clinical applications.

Semin Radiat Oncol 2013 Oct;23(4):262-72

Biomedical Magnetic Resonance Research Group, Louvain Drug Research Institute (LDRI), Université catholique de Louvain (UCL) Medical School, Brussels, Belgium; Pole of Pharmacology, Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain (UCL) Medical School, Brussels, Belgium.

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October 2013

Acylated and unacylated ghrelin impair skeletal muscle atrophy in mice.

J Clin Invest 2013 Feb 2;123(2):611-22. Epub 2013 Jan 2.

Department of Translational Medicine, Interdisciplinary Research Center of Autoimmune Diseases (IRCAD), and Biotechnology Center for Applied Medical Research (BRMA), Università del Piemonte Orientale "Amedeo Avogadro" — Alessandria, Novara, Vercelli, Italy.

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February 2013

Lactate activates HIF-1 in oxidative but not in Warburg-phenotype human tumor cells.

PLoS One 2012 17;7(10):e46571. Epub 2012 Oct 17.

Pole of Pharmacology, Institut de Recherches Expérimentales et Cliniques (IREC), Université catholique de Louvain (UCL), Brussels, Belgium.

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April 2013

Lactate stimulates angiogenesis and accelerates the healing of superficial and ischemic wounds in mice.

Angiogenesis 2012 Dec 3;15(4):581-92. Epub 2012 Jun 3.

Pole of Pharmacology, Université catholique de Louvain (UCL), Avenue Emmanuel Mounier 53 box B1.53.09, 1200, Brussels, Belgium.

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December 2012

Anticancer targets in the glycolytic metabolism of tumors: a comprehensive review.

Front Pharmacol 2011 25;2:49. Epub 2011 Aug 25.

Pole of Pharmacology and Therapeutics, Institute of Experimental and Clinical Research, University of Louvain Medical School Brussels, Belgium.

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November 2011

Differential expression of microRNAs between eutopic and ectopic endometrium in ovarian endometriosis.

J Biomed Biotechnol 2010 10;2010:369549. Epub 2010 Mar 10.

Laboratory of Oncological Gynecology, Department of Clinical and Experimental Medicine, and Biotechnology Center for Applied Medical Research, University of Piemonte Orientale Amedeo Avogadro, 28100 Novara, Italy.

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June 2010

Diacylglycerol kinase alpha mediates HGF-induced Rac activation and membrane ruffling by regulating atypical PKC and RhoGDI.

Proc Natl Acad Sci U S A 2010 Mar 16;107(9):4182-7. Epub 2010 Feb 16.

Department of Clinical and Experimental Medicine and Biotecnologie per la Ricerca Medica Applicata, University Amedeo Avogadro of Piemonte Orientale, 28100 Novara, Italy.

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March 2010